DK149194A - Thrombopoietin - Google Patents

Thrombopoietin

Info

Publication number
DK149194A
DK149194A DK149194A DK149194A DK149194A DK 149194 A DK149194 A DK 149194A DK 149194 A DK149194 A DK 149194A DK 149194 A DK149194 A DK 149194A DK 149194 A DK149194 A DK 149194A
Authority
DK
Denmark
Prior art keywords
thrombopoietin
Prior art date
Application number
DK149194A
Other languages
Danish (da)
English (en)
Inventor
Dan L Eaton
Frederic J De Sauvage
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/196,689 external-priority patent/US8357513B1/en
Priority claimed from US08/249,376 external-priority patent/US8192955B1/en
Priority claimed from US08/348,657 external-priority patent/US6660256B1/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DK149194A publication Critical patent/DK149194A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Vehicle Body Suspensions (AREA)
  • Information Transfer Systems (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK149194A 1994-01-03 1994-12-28 Thrombopoietin DK149194A (da)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US17655394A 1994-01-03 1994-01-03
US18560794A 1994-01-21 1994-01-21
US08/196,689 US8357513B1 (en) 1994-01-03 1994-02-15 Nucleic acids encoding mpl ligand (thrombopoietin) and fragments thereof
US22326394A 1994-04-04 1994-04-04
US08/249,376 US8192955B1 (en) 1994-01-03 1994-05-25 Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof
US34865894A 1994-12-02 1994-12-02
US08/348,657 US6660256B1 (en) 1994-01-03 1994-12-02 Porcine mpl ligand

Publications (1)

Publication Number Publication Date
DK149194A true DK149194A (da) 1995-07-04

Family

ID=27569151

Family Applications (1)

Application Number Title Priority Date Filing Date
DK149194A DK149194A (da) 1994-01-03 1994-12-28 Thrombopoietin

Country Status (28)

Country Link
EP (1) EP0738323A1 (no)
JP (2) JPH09508262A (no)
CN (1) CN1134539C (no)
AU (1) AU704266B2 (no)
BG (1) BG63639B1 (no)
CA (1) CA2178482C (no)
CZ (1) CZ296130B6 (no)
DK (1) DK149194A (no)
ES (1) ES2114786B1 (no)
FI (1) FI121573B (no)
FR (1) FR2714670B1 (no)
GB (1) GB2285446B (no)
HR (1) HRP941020A2 (no)
HU (1) HUT75657A (no)
IE (1) IE72517B1 (no)
IL (1) IL112184A (no)
IT (1) IT1283770B1 (no)
LU (1) LU88573A1 (no)
LV (1) LV11632B (no)
NL (1) NL9500010A (no)
NO (1) NO326903B1 (no)
NZ (1) NZ278726A (no)
PT (1) PT101627B (no)
RO (1) RO117110B1 (no)
SG (1) SG47030A1 (no)
SI (1) SI9420079A (no)
SK (1) SK282265B6 (no)
WO (1) WO1995018858A1 (no)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6270989B1 (en) * 1991-11-05 2001-08-07 Transkaryotic Therapies, Inc. Protein production and delivery
US5733761A (en) 1991-11-05 1998-03-31 Transkaryotic Therapies, Inc. Protein production and protein delivery
US5795569A (en) * 1994-03-31 1998-08-18 Amgen Inc. Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
WO1995026746A1 (en) * 1994-03-31 1995-10-12 Amgen Inc. Compositions and methods for stimulating megakaryocyte growth and differentiation
US5986049A (en) * 1994-12-30 1999-11-16 Zymogenetics, Inc. Purified thrombopoietin and method of making it
TW387940B (en) * 1995-01-17 2000-04-21 Kirin Brewery Anti-tpo monodonal antibody
EP0807181A1 (en) 1995-02-03 1997-11-19 G.D. Searle & Co. NOVEL c-MPL LIGANDS
US5696250A (en) * 1995-02-15 1997-12-09 Amgen Inc. DNA encoding megakaryocyte growth and development factor analogs
US5989538A (en) * 1995-02-15 1999-11-23 Amgen Inc. Mpl ligand analogs
CA2209298C (en) * 1995-02-15 2001-12-18 Amgen Inc. Mpl ligand analogs
TW434020B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable top-containing compositions
TW434021B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable TPO-containing compositions
ZA964382B (en) * 1995-06-06 1997-12-01 Genentech Inc Lymphotoxin and thrombopoietin for use in the treatment of cancer.
US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
EP1961760A3 (en) * 1995-06-07 2008-09-03 Glaxo Group Limited Peptides and compounds that bind to a thrombopoietin receptor
US6251864B1 (en) 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
TW497972B (en) * 1995-06-08 2002-08-11 Kirin Brewery Stable thrombopoietin (TPO)-containing lyophilized compositions
US6066318A (en) * 1995-10-05 2000-05-23 G.D. Searle & Co. Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
US6031071A (en) * 1996-01-24 2000-02-29 Biophage, Inc. Methods of generating novel peptides
US5879673A (en) * 1996-01-25 1999-03-09 Genentech, Inc. Administration of thrombopoietin on a single day only
US7091311B2 (en) 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
WO1998006849A1 (en) * 1996-08-13 1998-02-19 Zymogenetics, Inc. Expression vectors, cells, and methods for preparing thrombopoietin polypeptides
AU7589898A (en) * 1997-05-21 1998-12-11 Genentech Inc. Novel administration of thrombopoietin
US5980893A (en) * 1997-07-17 1999-11-09 Beth Israel Deaconess Medical Center, Inc. Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis
US6342220B1 (en) 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
KR20000006549A (ko) * 1998-06-30 2000-01-25 윤재승 생체내혈소판증식효능이향상된신규한트롬보포이에틴유도체
US20030228666A1 (en) 1998-06-30 2003-12-11 Daewoong Pharmaceutical Co., Ltd. Novel human thrombopoietin mutein
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
AU773891C (en) 1998-10-23 2005-02-17 Kirin-Amgen Inc. Dimeric thrombopoietin peptide mimetics binding to MP1 receptor and having thrombopoietic activity
CY2010012I2 (el) * 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
UY26317A1 (es) * 2000-08-30 2000-10-31 Alfonso Cayota Carlos Pritsch Sistema de produccion de trombopoyetina humana por celulas de mamiferos en cultivo
US6673580B2 (en) 2000-10-27 2004-01-06 Genentech, Inc. Identification and modification of immunodominant epitopes in polypeptides
US7332474B2 (en) 2001-10-11 2008-02-19 Amgen Inc. Peptides and related compounds having thrombopoietic activity
EP1452093A4 (en) 2001-11-15 2007-08-15 Kirin Brewery CHIMERIC ANIMALS
KR100467750B1 (ko) * 2001-11-29 2005-01-24 씨제이 주식회사 생체내 에리스로포이에틴 활성이 증진된 융합단백질
US20030191056A1 (en) 2002-04-04 2003-10-09 Kenneth Walker Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
DK1542714T3 (da) 2002-09-18 2014-05-26 Janssen Pharmaceuticals Inc Fremgangsmåder til forøgelse af produktion af blodplader og hæmatopoietiske stamceller
US7723295B2 (en) 2003-08-28 2010-05-25 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to a receptor
CN102241742B (zh) 2003-08-28 2014-04-02 奥索-麦克尼尔药品公司 结合血小板生成素受体的肽和化合物
WO2005116231A1 (en) 2004-05-18 2005-12-08 Intrexon Corporation Methods for dynamic vector assembly of dna cloning vector plasmids
MX2007000216A (es) 2004-07-08 2007-03-15 Amgen Inc Peptidos terapeuticos.
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
WO2007102946A2 (en) 2006-01-23 2007-09-13 Amgen Inc. Crystalline polypeptides
WO2007098547A1 (en) * 2006-03-01 2007-09-07 Apollo Life Sciences Limited A molecule and chimeric molecules thereof
US7981425B2 (en) 2006-06-19 2011-07-19 Amgen Inc. Thrombopoietic compounds
US8173427B2 (en) 2006-07-24 2012-05-08 The University Of Queensland Method of producing a population of post-mitotic cells of the neutrophil lineage
TW200902708A (en) 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
AU2008262490B2 (en) 2007-05-22 2011-11-17 Amgen Inc. Compositions and methods for producing bioactive fusion proteins
EP2390261A4 (en) 2009-01-20 2012-11-14 Hanall Biopharma Co Ltd MODIFIED HUMAN THROMBOPOIETIN POLYPEPTIDE FRAGMENT AND METHOD FOR THE PRODUCTION THEREOF
WO2014089478A1 (en) * 2012-12-07 2014-06-12 University Of Tennessee Research Foundation Methods of numerical analysis for platelet disorders and computer-readable media and systems for performing the same
WO2014100779A1 (en) * 2012-12-21 2014-06-26 Advanced Cell Technology, Inc. Methods ofr production of platelets from pluripotent stem cells and compositions thereof
CN103555760B (zh) * 2013-10-18 2015-05-20 江苏康禾生物制药有限公司 一种重组人血小板生成素的制备方法及其制剂
RU2694064C1 (ru) * 2015-12-21 2019-07-09 Браинон Инк. Композиция для улучшения памяти, способности к обучению и когнитивных способностей
GB201700621D0 (en) 2017-01-13 2017-03-01 Guest Ryan Dominic Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue
CA3148158A1 (en) * 2019-09-20 2021-03-25 Longcheng Li Nucleic acid molecule for treating thrombocytopenia and use thereof
MX2022007598A (es) 2019-12-20 2022-09-23 Instil Bio Uk Ltd Dispositivos y métodos para el aislamiento de linfocitos infiltrantes de tumores y usos de los mismos.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260417A (en) 1989-04-03 1993-11-09 Genetics Institute, Inc. Megakaryocyte growth promoting activity protein
WO1990012877A1 (en) * 1989-04-19 1990-11-01 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
US5223408A (en) * 1991-07-11 1993-06-29 Genentech, Inc. Method for making variant secreted proteins with altered properties
DK0616645T3 (da) * 1991-12-06 2001-10-08 Genentech Inc Prohormonconvertasetransformerede celler
IL139335A (en) 1994-01-03 2005-08-31 Genentech Inc Mpl ligand polypeptides, nucleic acids encoding them, vectors and host cells comprising such nucleic acids, processes for producing such polypeptides pharmaceutical compositions containing them and use thereof in the preparation of medicaments for treating thrombocytopenia

Also Published As

Publication number Publication date
SG47030A1 (en) 1998-03-20
NO962783L (no) 1996-09-03
JPH09508262A (ja) 1997-08-26
NO962783D0 (no) 1996-07-02
IL112184A (en) 2004-07-25
RO117110B1 (ro) 2001-10-30
SI9420079A (en) 1997-02-28
NO326903B1 (no) 2009-03-16
FR2714670A1 (fr) 1995-07-07
ES2114786B1 (es) 1999-01-01
CA2178482A1 (en) 1995-07-13
GB2285446A (en) 1995-07-12
LU88573A1 (de) 1995-06-01
GB2285446B (en) 1999-07-28
SK282265B6 (sk) 2001-12-03
SK87596A3 (en) 1997-11-05
LV11632A (lv) 1996-12-20
PT101627B (pt) 1996-11-29
NZ278726A (en) 1998-06-26
HUT75657A (en) 1997-05-28
IE72517B1 (en) 1997-04-23
ITTO950002A1 (it) 1995-07-03
HRP941020A2 (en) 1997-04-30
EP0738323A1 (en) 1996-10-23
IE950002A1 (en) 1995-07-12
ES2114786A1 (es) 1998-06-01
IL112184A0 (en) 1995-03-15
PT101627A (pt) 1995-11-30
CZ296130B6 (cs) 2006-01-11
AU1514695A (en) 1995-08-01
BG100693A (en) 1998-01-30
BG63639B1 (bg) 2002-07-31
HU9601805D0 (en) 1996-08-28
CA2178482C (en) 2012-01-03
CN1134539C (zh) 2004-01-14
LV11632B (en) 1997-04-20
FI962723A (fi) 1996-09-03
GB9425831D0 (en) 1995-02-22
ITTO950002A0 (it) 1995-01-02
CN1141061A (zh) 1997-01-22
CZ192296A3 (en) 1997-05-14
FI121573B (fi) 2011-01-14
FI962723A0 (fi) 1996-07-02
JPH10113186A (ja) 1998-05-06
FR2714670B1 (fr) 1997-01-10
NL9500010A (nl) 1995-08-01
WO1995018858A1 (en) 1995-07-13
IT1283770B1 (it) 1998-04-30
AU704266B2 (en) 1999-04-15

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Legal Events

Date Code Title Description
PBP Patent lapsed
PHB Application deemed withdrawn due to non-payment or other reasons

Effective date: 20140916