AU704266B2 - Thrombopoietin - Google Patents
Thrombopoietin Download PDFInfo
- Publication number
- AU704266B2 AU704266B2 AU15146/95A AU1514695A AU704266B2 AU 704266 B2 AU704266 B2 AU 704266B2 AU 15146/95 A AU15146/95 A AU 15146/95A AU 1514695 A AU1514695 A AU 1514695A AU 704266 B2 AU704266 B2 AU 704266B2
- Authority
- AU
- Australia
- Prior art keywords
- mpl ligand
- seq
- polypeptide
- mpl
- dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/524—Thrombopoietin, i.e. C-MPL ligand
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Vehicle Body Suspensions (AREA)
- Information Transfer Systems (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU40207/99A AU749175B2 (en) | 1994-01-03 | 1999-07-19 | Thrombopoietin |
Applications Claiming Priority (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17655394A | 1994-01-03 | 1994-01-03 | |
US08/176553 | 1994-01-03 | ||
US18560794A | 1994-01-21 | 1994-01-21 | |
US08/185607 | 1994-01-21 | ||
US08/196,689 US8357513B1 (en) | 1994-01-03 | 1994-02-15 | Nucleic acids encoding mpl ligand (thrombopoietin) and fragments thereof |
US08/196689 | 1994-02-15 | ||
US22326394A | 1994-04-04 | 1994-04-04 | |
US08/223263 | 1994-04-04 | ||
US08/249376 | 1994-05-25 | ||
US08/249,376 US8192955B1 (en) | 1994-01-03 | 1994-05-25 | Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof |
US34865894A | 1994-12-02 | 1994-12-02 | |
US08/348658 | 1994-12-02 | ||
US08/348657 | 1994-12-02 | ||
US08/348,657 US6660256B1 (en) | 1994-01-03 | 1994-12-02 | Porcine mpl ligand |
PCT/US1994/014553 WO1995018858A1 (en) | 1994-01-03 | 1994-12-28 | Thrombopoietin |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU40207/99A Division AU749175B2 (en) | 1994-01-03 | 1999-07-19 | Thrombopoietin |
Publications (2)
Publication Number | Publication Date |
---|---|
AU1514695A AU1514695A (en) | 1995-08-01 |
AU704266B2 true AU704266B2 (en) | 1999-04-15 |
Family
ID=27569151
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU15146/95A Expired AU704266B2 (en) | 1994-01-03 | 1994-12-28 | Thrombopoietin |
Country Status (28)
Country | Link |
---|---|
EP (1) | EP0738323A1 (no) |
JP (2) | JPH09508262A (no) |
CN (1) | CN1134539C (no) |
AU (1) | AU704266B2 (no) |
BG (1) | BG63639B1 (no) |
CA (1) | CA2178482C (no) |
CZ (1) | CZ296130B6 (no) |
DK (1) | DK149194A (no) |
ES (1) | ES2114786B1 (no) |
FI (1) | FI121573B (no) |
FR (1) | FR2714670B1 (no) |
GB (1) | GB2285446B (no) |
HR (1) | HRP941020A2 (no) |
HU (1) | HUT75657A (no) |
IE (1) | IE72517B1 (no) |
IL (1) | IL112184A (no) |
IT (1) | IT1283770B1 (no) |
LU (1) | LU88573A1 (no) |
LV (1) | LV11632B (no) |
NL (1) | NL9500010A (no) |
NO (1) | NO326903B1 (no) |
NZ (1) | NZ278726A (no) |
PT (1) | PT101627B (no) |
RO (1) | RO117110B1 (no) |
SG (1) | SG47030A1 (no) |
SI (1) | SI9420079A (no) |
SK (1) | SK282265B6 (no) |
WO (1) | WO1995018858A1 (no) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5968502A (en) | 1991-11-05 | 1999-10-19 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
US6270989B1 (en) | 1991-11-05 | 2001-08-07 | Transkaryotic Therapies, Inc. | Protein production and delivery |
US5795569A (en) * | 1994-03-31 | 1998-08-18 | Amgen Inc. | Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation |
HU218893B (hu) * | 1994-03-31 | 2000-12-28 | Amgen Inc. | A megakariocita szaporodás és differenciálódás stimulálására szolgáló módszerek és vízoldható készítmények |
US5986049A (en) * | 1994-12-30 | 1999-11-16 | Zymogenetics, Inc. | Purified thrombopoietin and method of making it |
TW387940B (en) * | 1995-01-17 | 2000-04-21 | Kirin Brewery | Anti-tpo monodonal antibody |
AU4658596A (en) | 1995-02-03 | 1996-08-21 | G.D. Searle & Co. | Novel c-mpl ligands |
CN1161468C (zh) * | 1995-02-15 | 2004-08-11 | 安姆根有限公司 | Mpl配体类似物 |
US5989538A (en) * | 1995-02-15 | 1999-11-23 | Amgen Inc. | Mpl ligand analogs |
US5696250A (en) * | 1995-02-15 | 1997-12-09 | Amgen Inc. | DNA encoding megakaryocyte growth and development factor analogs |
TW434021B (en) * | 1995-03-15 | 2001-05-16 | Kirin Brewery | Methods for preventing adsorption of thrombopoietin (TPO), and stable TPO-containing compositions |
TW434020B (en) * | 1995-03-15 | 2001-05-16 | Kirin Brewery | Methods for preventing adsorption of thrombopoietin (TPO), and stable top-containing compositions |
ZA964382B (en) * | 1995-06-06 | 1997-12-01 | Genentech Inc | Lymphotoxin and thrombopoietin for use in the treatment of cancer. |
US6251864B1 (en) | 1995-06-07 | 2001-06-26 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
BR9608587A (pt) | 1995-06-07 | 1999-01-05 | Glaxo Group Ltd | Composto que se liga ao receptor de trombopoietina composição farmacêutica e processo para o tratamento de um paciente sofrendo de um distúrbio |
US5869451A (en) * | 1995-06-07 | 1999-02-09 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
TW497972B (en) * | 1995-06-08 | 2002-08-11 | Kirin Brewery | Stable thrombopoietin (TPO)-containing lyophilized compositions |
US6066318A (en) * | 1995-10-05 | 2000-05-23 | G.D. Searle & Co. | Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors |
US6031071A (en) * | 1996-01-24 | 2000-02-29 | Biophage, Inc. | Methods of generating novel peptides |
US5879673A (en) * | 1996-01-25 | 1999-03-09 | Genentech, Inc. | Administration of thrombopoietin on a single day only |
US7091311B2 (en) | 1996-06-07 | 2006-08-15 | Smithkline Beecham Corporation | Peptides and compounds that bind to a receptor |
NZ334103A (en) * | 1996-08-13 | 2000-09-29 | Zymogenetics Inc | an expression vector used to transform or transfect a host cell to make a thrombopoietin polypeptide, the cultured yeast cell thereof and the thrombopoietin polypeptide |
CA2288964A1 (en) * | 1997-05-21 | 1998-11-26 | Genentech, Inc. | Novel administration of thrombopoietin |
US5980893A (en) * | 1997-07-17 | 1999-11-09 | Beth Israel Deaconess Medical Center, Inc. | Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis |
US6342220B1 (en) | 1997-08-25 | 2002-01-29 | Genentech, Inc. | Agonist antibodies |
US20030228666A1 (en) | 1998-06-30 | 2003-12-11 | Daewoong Pharmaceutical Co., Ltd. | Novel human thrombopoietin mutein |
KR20000006549A (ko) * | 1998-06-30 | 2000-01-25 | 윤재승 | 생체내혈소판증식효능이향상된신규한트롬보포이에틴유도체 |
AU773891C (en) | 1998-10-23 | 2005-02-17 | Kirin-Amgen Inc. | Dimeric thrombopoietin peptide mimetics binding to MP1 receptor and having thrombopoietic activity |
US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
CY2010012I2 (el) * | 2000-05-25 | 2020-05-29 | Novartis Ag | Μιμητικα θρομβοποιητινης |
UY26317A1 (es) * | 2000-08-30 | 2000-10-31 | Alfonso Cayota Carlos Pritsch | Sistema de produccion de trombopoyetina humana por celulas de mamiferos en cultivo |
US6673580B2 (en) | 2000-10-27 | 2004-01-06 | Genentech, Inc. | Identification and modification of immunodominant epitopes in polypeptides |
US7332474B2 (en) | 2001-10-11 | 2008-02-19 | Amgen Inc. | Peptides and related compounds having thrombopoietic activity |
EP1452093A4 (en) | 2001-11-15 | 2007-08-15 | Kirin Brewery | CHIMERIC ANIMALS |
KR100467750B1 (ko) * | 2001-11-29 | 2005-01-24 | 씨제이 주식회사 | 생체내 에리스로포이에틴 활성이 증진된 융합단백질 |
US20030191056A1 (en) | 2002-04-04 | 2003-10-09 | Kenneth Walker | Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins |
NZ566812A (en) | 2002-09-18 | 2009-07-31 | Ortho Mcneil Pharm Inc | Methods of increasing platelet and hematopoietic stem cell production |
US7576056B2 (en) | 2003-08-28 | 2009-08-18 | Ortho-Mcneil Pharmaceutical, Inc. | Peptides and compounds that bind to a receptor |
US7723295B2 (en) | 2003-08-28 | 2010-05-25 | Ortho-Mcneil Pharmaceutical, Inc. | Peptides and compounds that bind to a receptor |
NZ551447A (en) * | 2004-05-18 | 2010-08-27 | Intrexon Corp | Methods for dynamic vector assembly of DNA cloning vector plasmids |
EP1773400A2 (en) | 2004-07-08 | 2007-04-18 | Amgen Inc. | Therapeutic peptides |
US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
US9012605B2 (en) | 2006-01-23 | 2015-04-21 | Amgen Inc. | Crystalline polypeptides |
WO2007098547A1 (en) * | 2006-03-01 | 2007-09-07 | Apollo Life Sciences Limited | A molecule and chimeric molecules thereof |
US7981425B2 (en) | 2006-06-19 | 2011-07-19 | Amgen Inc. | Thrombopoietic compounds |
AU2007278748B2 (en) | 2006-07-24 | 2013-08-15 | The University Of Queensland | Method of producing a population of cells |
CA2687141C (en) | 2007-05-22 | 2014-04-01 | Amgen Inc. | Compositions and methods for producing bioactive fusion proteins |
WO2010085086A2 (ko) | 2009-01-20 | 2010-07-29 | 한올바이오파마 주식회사 | 변형된 인간 트롬보포이에틴 폴리펩타이드 절편 및 그의 제조방법 |
WO2014089478A1 (en) * | 2012-12-07 | 2014-06-12 | University Of Tennessee Research Foundation | Methods of numerical analysis for platelet disorders and computer-readable media and systems for performing the same |
CA3177929A1 (en) * | 2012-12-21 | 2014-06-26 | Astellas Institute For Regenerative Medicine | Methods for production of platelets from pluripotent stem cells and compositions thereof |
CN103555760B (zh) * | 2013-10-18 | 2015-05-20 | 江苏康禾生物制药有限公司 | 一种重组人血小板生成素的制备方法及其制剂 |
TR201807610T1 (tr) * | 2015-12-21 | 2018-06-21 | Brainon Inc | Hafizanin, öğrenme beceri̇si̇ni̇n ve bi̇li̇şsel beceri̇ni̇n geli̇şti̇ri̇lmesi̇ i̇çi̇n kompozi̇syon |
GB201700621D0 (en) | 2017-01-13 | 2017-03-01 | Guest Ryan Dominic | Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue |
US20230212565A1 (en) * | 2019-09-20 | 2023-07-06 | Ractigen Therapeutics | Nucleic acid molecule for treating thrombocytopenia and application thereof |
KR20220119439A (ko) | 2019-12-20 | 2022-08-29 | 인스틸 바이오 유케이 리미티드 | 종양 침윤 림프구를 분리하기 위한 장치 및 방법 및 그것의 용도 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5260417A (en) | 1989-04-03 | 1993-11-09 | Genetics Institute, Inc. | Megakaryocyte growth promoting activity protein |
WO1990012877A1 (en) * | 1989-04-19 | 1990-11-01 | Cetus Corporation | Multifunctional m-csf proteins and genes encoding therefor |
US5223408A (en) * | 1991-07-11 | 1993-06-29 | Genentech, Inc. | Method for making variant secreted proteins with altered properties |
CA2123430C (en) * | 1991-12-06 | 2004-02-10 | Cornelia M. Gorman | Prohormone convertase transformed cells |
IL139335A (en) | 1994-01-03 | 2005-08-31 | Genentech Inc | Mpl ligand polypeptides, nucleic acids encoding them, vectors and host cells comprising such nucleic acids, processes for producing such polypeptides pharmaceutical compositions containing them and use thereof in the preparation of medicaments for treating thrombocytopenia |
-
1994
- 1994-12-21 SG SG1996003050A patent/SG47030A1/en unknown
- 1994-12-21 GB GB9425831A patent/GB2285446B/en not_active Expired - Lifetime
- 1994-12-27 HR HR08/348,658A patent/HRP941020A2/hr not_active Application Discontinuation
- 1994-12-28 CN CNB941947513A patent/CN1134539C/zh not_active Expired - Lifetime
- 1994-12-28 EP EP95906653A patent/EP0738323A1/en not_active Withdrawn
- 1994-12-28 JP JP7518499A patent/JPH09508262A/ja active Pending
- 1994-12-28 CZ CZ0192296A patent/CZ296130B6/cs not_active IP Right Cessation
- 1994-12-28 DK DK149194A patent/DK149194A/da not_active Application Discontinuation
- 1994-12-28 RO RO96-01347A patent/RO117110B1/ro unknown
- 1994-12-28 SI SI9420079A patent/SI9420079A/sl unknown
- 1994-12-28 WO PCT/US1994/014553 patent/WO1995018858A1/en active IP Right Grant
- 1994-12-28 NZ NZ278726A patent/NZ278726A/en not_active IP Right Cessation
- 1994-12-28 SK SK875-96A patent/SK282265B6/sk not_active IP Right Cessation
- 1994-12-28 CA CA2178482A patent/CA2178482C/en not_active Expired - Lifetime
- 1994-12-28 HU HU9601805A patent/HUT75657A/hu not_active Application Discontinuation
- 1994-12-28 AU AU15146/95A patent/AU704266B2/en not_active Expired
- 1994-12-29 IL IL11218494A patent/IL112184A/en not_active IP Right Cessation
- 1994-12-30 ES ES09402681A patent/ES2114786B1/es not_active Expired - Fee Related
- 1994-12-30 PT PT101627A patent/PT101627B/pt not_active IP Right Cessation
-
1995
- 1995-01-02 FR FR9500007A patent/FR2714670B1/fr not_active Expired - Lifetime
- 1995-01-02 IT IT95TO000002A patent/IT1283770B1/it active IP Right Grant
- 1995-01-03 IE IE950002A patent/IE72517B1/en not_active IP Right Cessation
- 1995-01-03 NL NL9500010A patent/NL9500010A/nl active Search and Examination
- 1995-01-03 LU LU88573A patent/LU88573A1/de unknown
-
1996
- 1996-07-02 NO NO19962783A patent/NO326903B1/no not_active IP Right Cessation
- 1996-07-02 FI FI962723A patent/FI121573B/fi not_active IP Right Cessation
- 1996-07-02 BG BG100693A patent/BG63639B1/bg unknown
- 1996-07-24 LV LVP-96-315A patent/LV11632B/xx unknown
-
1997
- 1997-03-27 JP JP9074906A patent/JPH10113186A/ja active Pending
Non-Patent Citations (3)
Title |
---|
EXPERIMANTALHEMEATOLOGYVOL17NO.8SEP1989MCDONALDPP865-871 * |
EXPERIMENTALHEMEATOLOGYVOL16NO.3MARCH1988MCDONALDPP201-205 * |
EXPERIMENTALHEMEATOLOGYVOL2NO.6SEP1974MCDONALDPP 8-21 * |
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
CH | Opposition withdrawn |
Opponent name: KIRIN BREWERY CO, LTD |
|
FGA | Letters patent sealed or granted (standard patent) |