NO902925L - Derivatiserte dtpa-komplekser, fremgangsmaate for fremstilling, samt anvendelse derav. - Google Patents
Derivatiserte dtpa-komplekser, fremgangsmaate for fremstilling, samt anvendelse derav.Info
- Publication number
- NO902925L NO902925L NO90902925A NO902925A NO902925L NO 902925 L NO902925 L NO 902925L NO 90902925 A NO90902925 A NO 90902925A NO 902925 A NO902925 A NO 902925A NO 902925 L NO902925 L NO 902925L
- Authority
- NO
- Norway
- Prior art keywords
- represent
- hydrogen atom
- denote
- complexs
- procedure
- Prior art date
Links
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 229910021645 metal ion Inorganic materials 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
- C07F15/025—Iron compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/94—Bismuth compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Indole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3922005A DE3922005A1 (de) | 1989-06-30 | 1989-06-30 | Derivatisierte dtpa-komplexe, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO902925D0 NO902925D0 (no) | 1990-06-29 |
| NO902925L true NO902925L (no) | 1991-01-02 |
| NO179203B NO179203B (no) | 1996-05-20 |
| NO179203C NO179203C (no) | 1996-08-28 |
Family
ID=6384290
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO902925A NO179203C (no) | 1989-06-30 | 1990-06-29 | Derivatiserte DPTA-komplekser samt anvendelse derav ved NMR- og röntgendiagnostikk |
| NO2005013C NO2005013I2 (no) | 1989-06-30 | 2005-05-23 | Derivatiserte DTPA-komplekser samt anvendelse derav ved NMR-og rontgendiagnostikk |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO2005013C NO2005013I2 (no) | 1989-06-30 | 2005-05-23 | Derivatiserte DTPA-komplekser samt anvendelse derav ved NMR-og rontgendiagnostikk |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0405704B1 (no) |
| JP (1) | JP2603357B2 (no) |
| KR (1) | KR100190808B1 (no) |
| AT (1) | ATE115546T1 (no) |
| AU (1) | AU637111B2 (no) |
| CA (1) | CA2020142C (no) |
| CZ (1) | CZ277926B6 (no) |
| DD (1) | DD296276B5 (no) |
| DE (3) | DE3922005A1 (no) |
| DK (1) | DK0405704T3 (no) |
| ES (1) | ES2066113T3 (no) |
| FI (1) | FI102168B (no) |
| HK (1) | HK1002810A1 (no) |
| HU (1) | HU210208B (no) |
| IE (1) | IE65676B1 (no) |
| IL (1) | IL94818A (no) |
| NL (1) | NL300182I2 (no) |
| NO (2) | NO179203C (no) |
| NZ (1) | NZ234295A (no) |
| PT (1) | PT94541B (no) |
| RU (1) | RU2086554C1 (no) |
| TW (1) | TW219356B (no) |
| UA (1) | UA27275C2 (no) |
| ZA (1) | ZA905129B (no) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4011684A1 (de) | 1990-04-06 | 1991-10-10 | Schering Ag | Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung |
| DE4302289A1 (de) * | 1993-01-25 | 1994-07-28 | Schering Ag | Verfahren zur Herstellung C-substituierter Diethylentriamine |
| DE4302287A1 (de) * | 1993-01-25 | 1994-07-28 | Schering Ag | Derivatisierte DTPA-Komplexe, diese Verbindungen enthaltende pharmazeutische Mittel, ihre Verwendung und Verfahren zu deren Herstellung |
| DE4341724A1 (de) * | 1993-12-03 | 1995-06-08 | Schering Ag | Halogenaryl-substituierte Metallkomplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik, sowie Verfahren zur Herstellung der Komplexe und Mittel |
| US5582814A (en) * | 1994-04-15 | 1996-12-10 | Metasyn, Inc. | 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging |
| US5672335A (en) * | 1994-11-30 | 1997-09-30 | Schering Aktiengesellschaft | Use of metal complexes as liver and gallbladder X-ray diagnostic agents |
| CN1167443A (zh) * | 1994-11-30 | 1997-12-10 | 舍林股份公司 | 金属复合物作为肝胆放射造影剂的应用 |
| TW319763B (no) | 1995-02-01 | 1997-11-11 | Epix Medical Inc | |
| WO1996024381A2 (de) * | 1995-02-09 | 1996-08-15 | Schering Aktiengesellschaft | Kontrastmittelhaltige liposomen für die darstellung des intravasalraumes |
| DE19507820A1 (de) * | 1995-02-21 | 1996-08-22 | Schering Ag | Neuartig substituierte DTPA-Derivate, deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik, sowie Verfahren zur Herstellung der Komplexe und Mittel |
| JP2759627B2 (ja) * | 1995-07-21 | 1998-05-28 | 東北大学長 | 非エステル結合性ｄｔｐａ誘導体およびその製造方法 |
| DE19641197C2 (de) * | 1996-09-24 | 1999-02-18 | Schering Ag | Ionenpaare und ihre Verwendung als Kontrastmittel |
| DE19646762B4 (de) * | 1996-11-04 | 2004-05-13 | Schering Ag | Verwendung von Metallverbindungen zur Herstellung von Mitteln zur Strahlentherapie von Tumoren |
| DE19712012A1 (de) * | 1997-03-13 | 1998-09-24 | Schering Ag | Verfahren zur Herstellung kristalliner 3,6,9-Triaza-3,6-9-tris(carboxymethyl)-4-(4- ethoxybenzyl)-undecandisäure |
| US6495118B1 (en) | 1997-09-26 | 2002-12-17 | Schering Aktiengesellschaft | Lipophilic metal complexes for necrosis and infarction imaging |
| DE19744004C1 (de) * | 1997-09-26 | 1999-07-22 | Schering Ag | Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging |
| US6534040B2 (en) * | 1999-12-23 | 2003-03-18 | Health Research, Inc. | Chlorin and bacteriochlorin-based aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals |
| FR2867473B1 (fr) | 2004-03-12 | 2006-06-23 | Guerbet Sa | Compose de porphyrines et utilisation a haut champ en irm |
| KR100749087B1 (ko) * | 2006-06-02 | 2007-08-14 | 경북대학교 산학협력단 | 신규한 ｄｔｐａ-비스-아미드 리간드들 및 이들이 결합된가돌리늄 착물 |
| SE533165C2 (sv) * | 2008-06-13 | 2010-07-13 | Chemseq Internat Ab | Kemikalie och förfarande för komplexbindning av metalljoner, som är minst tvåvärda |
| EP2338874A1 (en) * | 2009-12-16 | 2011-06-29 | Bracco Imaging S.p.A | Process for the preparation of chelated compounds |
| DE102010023890A1 (de) | 2010-06-11 | 2011-12-15 | Bayer Schering Pharma Aktiengesellschaft | Verfahren zur Herstellung kristalliner 3,6,9-Triaza-3,6,9-tris(carboxymethyl)-4-(ethoxybenzyl)-undecandinsäure und die Verwendung zur Herstellung von Primovist |
| CN103068790A (zh) | 2010-06-11 | 2013-04-24 | 拜耳知识产权有限责任公司 | 用于制备结晶的3,6,9-三氮杂-3,6,9-三(羧甲基)-4-(4-乙氧基苄基)十一烷二酸的方法以及用于制备普美显*（Primovist*）的用途 |
| CN104761461A (zh) * | 2014-09-09 | 2015-07-08 | 山东富创医药科技有限公司 | 一种新的钆塞酸二钠中间体的制备方法 |
| ES2973718T3 (es) * | 2016-05-30 | 2024-06-24 | Biophore India Pharmaceuticals Pvt Ltd | Nuevo proceso para la preparación de complejo de gadolinio de (4s)-4-(4-etoxibencil)-3,6,9-tris(carboxilometil)-3,6,9-triazaundecanodioico disódico (gadoxetato disódico) |
| JP6867639B2 (ja) * | 2016-10-11 | 2021-05-12 | 学校法人 聖マリアンナ医科大学 | 非イオン性ヨード造影剤の結合体 |
| EP4059925A1 (en) | 2021-03-15 | 2022-09-21 | Bayer Aktiengesellschaft | New contrast agent for use in magnetic resonance imaging |
| EP4335840A1 (en) | 2022-09-09 | 2024-03-13 | Bayer Aktiengesellschaft | New contrast agents for use in diagnostic imaging |
| EP4335462A1 (en) | 2022-09-09 | 2024-03-13 | Bayer AG | Contrast agents for use in diagnostic computed tomography imaging |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL194579C (nl) * | 1983-01-21 | 2002-08-05 | Schering Ag | Diagnostisch middel. |
| US4672028A (en) * | 1984-05-23 | 1987-06-09 | Icn Micromedic Systems, Inc. | Compositions and method for simultaneous multiple array of analytes using radioisotope chelate labels |
| US4824986A (en) * | 1985-04-26 | 1989-04-25 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Metal chelate protein conjugate |
| IL83966A (en) * | 1986-09-26 | 1992-03-29 | Schering Ag | Amides of aminopolycarboxylic acids and pharmaceutical compositions containing them |
| DE3710730A1 (de) * | 1987-03-31 | 1988-10-20 | Schering Ag | Substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel |
| EP0299795B1 (en) * | 1987-07-16 | 1992-03-18 | Nycomed As | Aminopolycarboxylic acids and derivatives thereof |
| AU617338B2 (en) * | 1987-07-16 | 1991-11-28 | Nycomed As | Aminopolycarboxylic acids and derivatives thereof |
| DE3728525A1 (de) * | 1987-08-24 | 1989-03-16 | Schering Ag | Mehrkernige substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel |
-
1989
- 1989-06-30 DE DE3922005A patent/DE3922005A1/de not_active Withdrawn
-
1990
- 1990-06-21 IL IL9481890A patent/IL94818A/en active IP Right Grant
- 1990-06-26 CZ CS903174A patent/CZ277926B6/cs not_active IP Right Cessation
- 1990-06-26 IE IE229990A patent/IE65676B1/en not_active IP Right Cessation
- 1990-06-27 DE DE59007987T patent/DE59007987D1/de not_active Expired - Lifetime
- 1990-06-27 AT AT90250165T patent/ATE115546T1/de active
- 1990-06-27 EP EP90250165A patent/EP0405704B1/de not_active Expired - Lifetime
- 1990-06-27 DK DK90250165.9T patent/DK0405704T3/da active
- 1990-06-27 ES ES90250165T patent/ES2066113T3/es not_active Expired - Lifetime
- 1990-06-27 KR KR1019900009529A patent/KR100190808B1/ko not_active IP Right Cessation
- 1990-06-27 DE DE200412000051 patent/DE122004000051I2/de active Active
- 1990-06-28 NZ NZ234295A patent/NZ234295A/xx unknown
- 1990-06-29 AU AU58024/90A patent/AU637111B2/en not_active Expired
- 1990-06-29 FI FI903295A patent/FI102168B/fi active Protection Beyond IP Right Term
- 1990-06-29 HU HU904040A patent/HU210208B/hu unknown
- 1990-06-29 UA UA4830458A patent/UA27275C2/uk unknown
- 1990-06-29 NO NO902925A patent/NO179203C/no not_active IP Right Cessation
- 1990-06-29 DD DD34235090A patent/DD296276B5/de active IP Right Maintenance
- 1990-06-29 ZA ZA905129A patent/ZA905129B/xx unknown
- 1990-06-29 CA CA002020142A patent/CA2020142C/en not_active Expired - Lifetime
- 1990-06-29 JP JP2170372A patent/JP2603357B2/ja not_active Expired - Lifetime
- 1990-06-29 PT PT94541A patent/PT94541B/pt not_active IP Right Cessation
- 1990-06-29 RU SU904830458A patent/RU2086554C1/ru active Protection Beyond IP Right Term
- 1990-11-10 TW TW079109532A patent/TW219356B/zh active
-
1998
- 1998-03-10 HK HK98101936A patent/HK1002810A1/xx not_active IP Right Cessation
-
2005
- 2005-03-18 NL NL300182C patent/NL300182I2/nl unknown
- 2005-05-23 NO NO2005013C patent/NO2005013I2/no unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO902925D0 (no) | Derivatiserte dtpa-komplekser, fremgangsmaate for fremstilling, samt anvendelse derav. | |
| NO911345D0 (no) | Dtpa-monoamider, preparater som inneholder forbindelsene,samt anvendelse og fremgangsmaate for fremstilling av forbindelsene. | |
| ATE124405T1 (de) | 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel. | |
| ES2073006T3 (es) | Secuestrantes asociados a polimeros de cascada, sus complejos y conjugados, proceso para su obtencion y preparados farmaceuticos que los contienen. | |
| MA19308A1 (fr) | Compositions herbicides a base de n-(3,4 dichlorophenyl) -n'metoxy-n'methyluree et de 2,6 -dimitro-n,n-dipropyl-4 trifluoromethylaniline. | |
| BE887316A (fr) | Composition antigingivite non colorante a base d'acide trans-4-(aminomethyl)cyclohexane-1-carboxylique | |
| SE8202651L (sv) | Slagverktyg | |
| HUT49846A (en) | Process for producing n-(3',4'-dimethoxycinnamoyl)-anthranilic acid (tranilast) | |
| Mlynarczyk et al. | Studies on acute toxicity of some new fungicides and insecticides designed for use in building industry. Part I. Intragastric acute toxicity. | |
| IT8585575A0 (it) | Macchina per l'invasamento di mezze pesche o simili tutte orientate nello stesso senso. | |
| IT8903484A0 (it) | Macchina per chiodare e graffare inpiu' punti contemporaneamente | |
| TH692A (th) | ซัลโฟนามีดที่ใช้ในการเกษตร | |
| BR8902385A (pt) | Politioureias,processo para a preparacao das mesmas |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SPCF | Filing of supplementary protection certificate |
Free format text: PRODUCT NAME: PRIMOVIST; NAT. REG. NO/DATE: 04-2770,04-2771 20041123; FIRST REG. NO/DATE: SE , 18929,18930 20040326 Spc suppl protection certif: 2005013 Filing date: 20050523 |
|
| SPCG | Granted supplementary protection certificate |
Free format text: PRODUCT NAME: DINATRUMGADOKSETINSYRE(DINATRIUMGD-EOB-DTPA); NAT. REG. NO/DATE: 04-2770,04-2771 20041123; FIRST REG. NO/DATE: SE , 18929,18930 20040326 Spc suppl protection certif: 2005013 Filing date: 20050523 Extension date: 20150629 |
|
| MK1K | Patent expired | ||
| SPCX | Expiry of an spc |
Free format text: PRODUCT NAME: DINATRUMGADOKSETINSYRE(DINATRIUMGD-EOB-DTPA); NAT. REG. NO/DATE: 04-2770,04-2771 20041123; FIRST REG. NO/DATE: SE , 18929,18930 20040326 Spc suppl protection certif: 2005013 Effective date: 20150629 |