NO2005013I2 - Derivatiserte DTPA-komplekser samt anvendelse derav ved NMR-og rontgendiagnostikk - Google Patents
Derivatiserte DTPA-komplekser samt anvendelse derav ved NMR-og rontgendiagnostikkInfo
- Publication number
- NO2005013I2 NO2005013I2 NO2005013C NO2005013C NO2005013I2 NO 2005013 I2 NO2005013 I2 NO 2005013I2 NO 2005013 C NO2005013 C NO 2005013C NO 2005013 C NO2005013 C NO 2005013C NO 2005013 I2 NO2005013 I2 NO 2005013I2
- Authority
- NO
- Norway
- Prior art keywords
- represent
- hydrogen atom
- denote
- nmr
- ray diagnostics
- Prior art date
Links
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical class OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 229910021645 metal ion Inorganic materials 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
- C07F15/025—Iron compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/94—Bismuth compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3922005A DE3922005A1 (de) | 1989-06-30 | 1989-06-30 | Derivatisierte dtpa-komplexe, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO2005013I2 true NO2005013I2 (no) | 2006-06-19 |
Family
ID=6384290
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO902925A NO179203C (no) | 1989-06-30 | 1990-06-29 | Derivatiserte DPTA-komplekser samt anvendelse derav ved NMR- og röntgendiagnostikk |
| NO2005013C NO2005013I2 (no) | 1989-06-30 | 2005-05-23 | Derivatiserte DTPA-komplekser samt anvendelse derav ved NMR-og rontgendiagnostikk |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO902925A NO179203C (no) | 1989-06-30 | 1990-06-29 | Derivatiserte DPTA-komplekser samt anvendelse derav ved NMR- og röntgendiagnostikk |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0405704B1 (no) |
| JP (1) | JP2603357B2 (no) |
| KR (1) | KR100190808B1 (no) |
| AT (1) | ATE115546T1 (no) |
| AU (1) | AU637111B2 (no) |
| CA (1) | CA2020142C (no) |
| CZ (1) | CZ277926B6 (no) |
| DD (1) | DD296276B5 (no) |
| DE (3) | DE3922005A1 (no) |
| DK (1) | DK0405704T3 (no) |
| ES (1) | ES2066113T3 (no) |
| FI (1) | FI102168B1 (no) |
| HK (1) | HK1002810A1 (no) |
| HU (1) | HU210208B (no) |
| IE (1) | IE65676B1 (no) |
| IL (1) | IL94818A (no) |
| NL (1) | NL300182I2 (no) |
| NO (2) | NO179203C (no) |
| NZ (1) | NZ234295A (no) |
| PT (1) | PT94541B (no) |
| RU (1) | RU2086554C1 (no) |
| TW (1) | TW219356B (no) |
| UA (1) | UA27275C2 (no) |
| ZA (1) | ZA905129B (no) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4011684A1 (de) | 1990-04-06 | 1991-10-10 | Schering Ag | Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung |
| DE4302287A1 (de) * | 1993-01-25 | 1994-07-28 | Schering Ag | Derivatisierte DTPA-Komplexe, diese Verbindungen enthaltende pharmazeutische Mittel, ihre Verwendung und Verfahren zu deren Herstellung |
| DE4302289A1 (de) * | 1993-01-25 | 1994-07-28 | Schering Ag | Verfahren zur Herstellung C-substituierter Diethylentriamine |
| DE4341724A1 (de) * | 1993-12-03 | 1995-06-08 | Schering Ag | Halogenaryl-substituierte Metallkomplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik, sowie Verfahren zur Herstellung der Komplexe und Mittel |
| US5582814A (en) * | 1994-04-15 | 1996-12-10 | Metasyn, Inc. | 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging |
| CZ166797A3 (en) * | 1994-11-30 | 1997-11-12 | Schering Ag | Application of metal complexes as liver and gallbladder x-ray diagnostic agents |
| US5672335A (en) * | 1994-11-30 | 1997-09-30 | Schering Aktiengesellschaft | Use of metal complexes as liver and gallbladder X-ray diagnostic agents |
| TW319763B (no) | 1995-02-01 | 1997-11-11 | Epix Medical Inc | |
| CA2212162A1 (en) * | 1995-02-09 | 1996-08-15 | Schering Aktiengesellschaft | Liposomes that contain contrast media for the visualization of intravascular space |
| DE19507820A1 (de) * | 1995-02-21 | 1996-08-22 | Schering Ag | Neuartig substituierte DTPA-Derivate, deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik, sowie Verfahren zur Herstellung der Komplexe und Mittel |
| JP2759627B2 (ja) * | 1995-07-21 | 1998-05-28 | 東北大学長 | 非エステル結合性ｄｔｐａ誘導体およびその製造方法 |
| DE19641197C2 (de) * | 1996-09-24 | 1999-02-18 | Schering Ag | Ionenpaare und ihre Verwendung als Kontrastmittel |
| DE19646762B4 (de) * | 1996-11-04 | 2004-05-13 | Schering Ag | Verwendung von Metallverbindungen zur Herstellung von Mitteln zur Strahlentherapie von Tumoren |
| DE19712012A1 (de) * | 1997-03-13 | 1998-09-24 | Schering Ag | Verfahren zur Herstellung kristalliner 3,6,9-Triaza-3,6-9-tris(carboxymethyl)-4-(4- ethoxybenzyl)-undecandisäure |
| DE19744004C1 (de) * | 1997-09-26 | 1999-07-22 | Schering Ag | Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging |
| US6495118B1 (en) | 1997-09-26 | 2002-12-17 | Schering Aktiengesellschaft | Lipophilic metal complexes for necrosis and infarction imaging |
| US6534040B2 (en) * | 1999-12-23 | 2003-03-18 | Health Research, Inc. | Chlorin and bacteriochlorin-based aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals |
| FR2867473B1 (fr) | 2004-03-12 | 2006-06-23 | Guerbet Sa | Compose de porphyrines et utilisation a haut champ en irm |
| KR100749087B1 (ko) * | 2006-06-02 | 2007-08-14 | 경북대학교 산학협력단 | 신규한 ｄｔｐａ-비스-아미드 리간드들 및 이들이 결합된가돌리늄 착물 |
| SE533165C2 (sv) * | 2008-06-13 | 2010-07-13 | Chemseq Internat Ab | Kemikalie och förfarande för komplexbindning av metalljoner, som är minst tvåvärda |
| EP2338874A1 (en) * | 2009-12-16 | 2011-06-29 | Bracco Imaging S.p.A | Process for the preparation of chelated compounds |
| DE102010023890A1 (de) | 2010-06-11 | 2011-12-15 | Bayer Schering Pharma Aktiengesellschaft | Verfahren zur Herstellung kristalliner 3,6,9-Triaza-3,6,9-tris(carboxymethyl)-4-(ethoxybenzyl)-undecandinsäure und die Verwendung zur Herstellung von Primovist |
| WO2011154333A2 (de) | 2010-06-11 | 2011-12-15 | Bayer Pharma Aktiengesellschaft | Verfahren zur herstellung kristalliner 3,6,9-triaza-3,6,9-tris(carboxymethyl)-4-(4-ethoxybenzyl)-undecandisäure und die verwendung zur herstellung von primovist® |
| CN104761461A (zh) * | 2014-09-09 | 2015-07-08 | 山东富创医药科技有限公司 | 一种新的钆塞酸二钠中间体的制备方法 |
| WO2017208258A1 (en) * | 2016-05-30 | 2017-12-07 | Biophore India Pharmaceuticals Pvt. Ltd. | Novel process for the preparation of gadolinium complex of (4s)-4-(4-ethoxybenzyl)-3,6,9-tris(carboxylatomethyl)-3,6,9- triazaundecanedioic acid disodium (gadoxetate disodium) |
| JP6867639B2 (ja) * | 2016-10-11 | 2021-05-12 | 学校法人 聖マリアンナ医科大学 | 非イオン性ヨード造影剤の結合体 |
| EP4059925A1 (en) | 2021-03-15 | 2022-09-21 | Bayer Aktiengesellschaft | New contrast agent for use in magnetic resonance imaging |
| EP4335462A1 (en) | 2022-09-09 | 2024-03-13 | Bayer AG | Contrast agents for use in diagnostic computed tomography imaging |
| EP4335840A1 (en) | 2022-09-09 | 2024-03-13 | Bayer Aktiengesellschaft | New contrast agents for use in diagnostic imaging |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL194579C (nl) * | 1983-01-21 | 2002-08-05 | Schering Ag | Diagnostisch middel. |
| US4672028A (en) * | 1984-05-23 | 1987-06-09 | Icn Micromedic Systems, Inc. | Compositions and method for simultaneous multiple array of analytes using radioisotope chelate labels |
| US4824986A (en) * | 1985-04-26 | 1989-04-25 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Metal chelate protein conjugate |
| IL83966A (en) * | 1986-09-26 | 1992-03-29 | Schering Ag | Amides of aminopolycarboxylic acids and pharmaceutical compositions containing them |
| DE3710730A1 (de) * | 1987-03-31 | 1988-10-20 | Schering Ag | Substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel |
| DE3869251D1 (de) * | 1987-07-16 | 1992-04-23 | Nycomed As | Aminopolycarbonsaeure und ihre derivate. |
| AU617338B2 (en) * | 1987-07-16 | 1991-11-28 | Nycomed As | Aminopolycarboxylic acids and derivatives thereof |
| DE3728525A1 (de) * | 1987-08-24 | 1989-03-16 | Schering Ag | Mehrkernige substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel |
-
1989
- 1989-06-30 DE DE3922005A patent/DE3922005A1/de not_active Withdrawn
-
1990
- 1990-06-21 IL IL9481890A patent/IL94818A/en active IP Right Grant
- 1990-06-26 CZ CS903174A patent/CZ277926B6/cs not_active IP Right Cessation
- 1990-06-26 IE IE229990A patent/IE65676B1/en not_active IP Right Cessation
- 1990-06-27 KR KR1019900009529A patent/KR100190808B1/ko not_active IP Right Cessation
- 1990-06-27 AT AT90250165T patent/ATE115546T1/de active
- 1990-06-27 DE DE59007987T patent/DE59007987D1/de not_active Expired - Lifetime
- 1990-06-27 DE DE200412000051 patent/DE122004000051I2/de active Active
- 1990-06-27 ES ES90250165T patent/ES2066113T3/es not_active Expired - Lifetime
- 1990-06-27 DK DK90250165.9T patent/DK0405704T3/da active
- 1990-06-27 EP EP90250165A patent/EP0405704B1/de not_active Expired - Lifetime
- 1990-06-28 NZ NZ234295A patent/NZ234295A/xx unknown
- 1990-06-29 HU HU904040A patent/HU210208B/hu unknown
- 1990-06-29 NO NO902925A patent/NO179203C/no not_active IP Right Cessation
- 1990-06-29 PT PT94541A patent/PT94541B/pt not_active IP Right Cessation
- 1990-06-29 CA CA002020142A patent/CA2020142C/en not_active Expired - Lifetime
- 1990-06-29 ZA ZA905129A patent/ZA905129B/xx unknown
- 1990-06-29 DD DD34235090A patent/DD296276B5/de active IP Right Maintenance
- 1990-06-29 FI FI903295A patent/FI102168B1/fi active Protection Beyond IP Right Term
- 1990-06-29 JP JP2170372A patent/JP2603357B2/ja not_active Expired - Lifetime
- 1990-06-29 UA UA4830458A patent/UA27275C2/uk unknown
- 1990-06-29 RU SU904830458A patent/RU2086554C1/ru active Protection Beyond IP Right Term
- 1990-06-29 AU AU58024/90A patent/AU637111B2/en not_active Expired
- 1990-11-10 TW TW079109532A patent/TW219356B/zh active
-
1998
- 1998-03-10 HK HK98101936A patent/HK1002810A1/xx not_active IP Right Cessation
-
2005
- 2005-03-18 NL NL300182C patent/NL300182I2/nl unknown
- 2005-05-23 NO NO2005013C patent/NO2005013I2/no unknown
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