NO902925L - DERIVATIZED DTPA COMPLEXS, PROCEDURE FOR MANUFACTURING, AND USE THEREOF. - Google Patents
DERIVATIZED DTPA COMPLEXS, PROCEDURE FOR MANUFACTURING, AND USE THEREOF.Info
- Publication number
- NO902925L NO902925L NO90902925A NO902925A NO902925L NO 902925 L NO902925 L NO 902925L NO 90902925 A NO90902925 A NO 90902925A NO 902925 A NO902925 A NO 902925A NO 902925 L NO902925 L NO 902925L
- Authority
- NO
- Norway
- Prior art keywords
- represent
- hydrogen atom
- denote
- complexs
- procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
- C07F15/02—Iron compounds
- C07F15/025—Iron compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic System without C-Metal linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/94—Bismuth compounds
Abstract
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3922005A DE3922005A1 (en) | 1989-06-30 | 1989-06-30 | DERIVATIVED DTPA COMPLEXES, PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS, THEIR USE AND METHOD FOR THE PRODUCTION THEREOF |
Publications (4)
Publication Number | Publication Date |
---|---|
NO902925D0 NO902925D0 (en) | 1990-06-29 |
NO902925L true NO902925L (en) | 1991-01-02 |
NO179203B NO179203B (en) | 1996-05-20 |
NO179203C NO179203C (en) | 1996-08-28 |
Family
ID=6384290
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO902925A NO179203C (en) | 1989-06-30 | 1990-06-29 | Derivatized DPTA complexes and their use in NMR and X-ray diagnostics |
NO2005013C NO2005013I2 (en) | 1989-06-30 | 2005-05-23 | Derivatized DTPA complexes and their use in NMR and X-ray diagnostics |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO2005013C NO2005013I2 (en) | 1989-06-30 | 2005-05-23 | Derivatized DTPA complexes and their use in NMR and X-ray diagnostics |
Country Status (24)
Country | Link |
---|---|
EP (1) | EP0405704B1 (en) |
JP (1) | JP2603357B2 (en) |
KR (1) | KR100190808B1 (en) |
AT (1) | ATE115546T1 (en) |
AU (1) | AU637111B2 (en) |
CA (1) | CA2020142C (en) |
CZ (1) | CZ277926B6 (en) |
DD (1) | DD296276B5 (en) |
DE (3) | DE3922005A1 (en) |
DK (1) | DK0405704T3 (en) |
ES (1) | ES2066113T3 (en) |
FI (1) | FI102168B (en) |
HK (1) | HK1002810A1 (en) |
HU (1) | HU210208B (en) |
IE (1) | IE65676B1 (en) |
IL (1) | IL94818A (en) |
NL (1) | NL300182I2 (en) |
NO (2) | NO179203C (en) |
NZ (1) | NZ234295A (en) |
PT (1) | PT94541B (en) |
RU (1) | RU2086554C1 (en) |
TW (1) | TW219356B (en) |
UA (1) | UA27275C2 (en) |
ZA (1) | ZA905129B (en) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4011684A1 (en) | 1990-04-06 | 1991-10-10 | Schering Ag | DTPA MONOAMIDES, PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS, THEIR USE AND METHOD FOR THE PRODUCTION THEREOF |
DE4302287A1 (en) * | 1993-01-25 | 1994-07-28 | Schering Ag | Derivatized DTPA complexes, pharmaceutical compositions containing these compounds, their use and processes for their preparation |
DE4302289A1 (en) * | 1993-01-25 | 1994-07-28 | Schering Ag | Process for the preparation of C-substituted diethylenetriamines |
DE4341724A1 (en) * | 1993-12-03 | 1995-06-08 | Schering Ag | Pharmaceutical compositions containing haloaryl-substituted metal complexes, their use in diagnostics, and methods for producing the complexes and compositions |
US5582814A (en) * | 1994-04-15 | 1996-12-10 | Metasyn, Inc. | 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging |
US5672335A (en) * | 1994-11-30 | 1997-09-30 | Schering Aktiengesellschaft | Use of metal complexes as liver and gallbladder X-ray diagnostic agents |
CA2206558A1 (en) * | 1994-11-30 | 1996-06-06 | Schering Aktiengesellschaft | Use of metal complexes as x-ray diagnostic agents for the liver and gallbladder |
TW319763B (en) | 1995-02-01 | 1997-11-11 | Epix Medical Inc | |
DE19606326A1 (en) * | 1995-02-09 | 1996-08-22 | Schering Ag | Liposomal diagnostic formulation, esp. for blood pool imaging |
DE19507820A1 (en) * | 1995-02-21 | 1996-08-22 | Schering Ag | Novel substituted DTPA derivatives, their metal complexes, pharmaceutical compositions containing these complexes, their use in diagnostics, and methods for producing the complexes and compositions |
JP2759627B2 (en) * | 1995-07-21 | 1998-05-28 | 東北大学長 | Non-ester bondable DTPA derivative and method for producing the same |
DE19641197C2 (en) * | 1996-09-24 | 1999-02-18 | Schering Ag | Ion pairs and their use as contrast agents |
DE19646762B4 (en) * | 1996-11-04 | 2004-05-13 | Schering Ag | Use of metal compounds for the production of agents for radiotherapy of tumors |
DE19712012A1 (en) * | 1997-03-13 | 1998-09-24 | Schering Ag | Ethoxy:benzyl-di:ethylene tri:amine penta:acetic acid preparation |
US6495118B1 (en) | 1997-09-26 | 2002-12-17 | Schering Aktiengesellschaft | Lipophilic metal complexes for necrosis and infarction imaging |
DE19744004C1 (en) * | 1997-09-26 | 1999-07-22 | Schering Ag | Lipophilic metal complexes for necrosis and infarct imaging |
US6534040B2 (en) * | 1999-12-23 | 2003-03-18 | Health Research, Inc. | Chlorin and bacteriochlorin-based aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals |
FR2867473B1 (en) | 2004-03-12 | 2006-06-23 | Guerbet Sa | PORPHYRINE COMPOUND AND HIGH FIELD USE IN MRI |
KR100749087B1 (en) * | 2006-06-02 | 2007-08-14 | 경북대학교 산학협력단 | New dtpa-bis-amide ligands and gd-complexes thereof |
SE533165C2 (en) * | 2008-06-13 | 2010-07-13 | Chemseq Internat Ab | Chemical and process for the complex bonding of metal ions, which are at least divalent |
EP2338874A1 (en) * | 2009-12-16 | 2011-06-29 | Bracco Imaging S.p.A | Process for the preparation of chelated compounds |
PE20130458A1 (en) | 2010-06-11 | 2013-04-11 | Bayer Ip Gmbh | PROCEDURE FOR THE PREPARATION OF DIACIDE 3,6,9-TRIAZA-3,6,9-TRIS (CARBOXIMETHYL) -4- (4-ETOXYBENZYL) -UNDECANOIC CRYSTALLINE AND ITS USE IN THE PREPARATION OF GADOXETIC ACID |
DE102010023890A1 (en) | 2010-06-11 | 2011-12-15 | Bayer Schering Pharma Aktiengesellschaft | Preparing crystalline 3,6,9-triaza-3,6,9-tris(carboxymethyl)-4-(ethoxybenzyl)-undecanedioic acid comprises hydrolyzing 3,6,9-triaza-3,6,9-tris(tert-butoxy-carbonylmethyl)-4-(ethoxybenzyl)-undecanedioic acid-ditert-butylester and acidifying |
CN104761461A (en) * | 2014-09-09 | 2015-07-08 | 山东富创医药科技有限公司 | Preparation method of novel gadoxetate disodium intermediate |
WO2017208258A1 (en) * | 2016-05-30 | 2017-12-07 | Biophore India Pharmaceuticals Pvt. Ltd. | Novel process for the preparation of gadolinium complex of (4s)-4-(4-ethoxybenzyl)-3,6,9-tris(carboxylatomethyl)-3,6,9- triazaundecanedioic acid disodium (gadoxetate disodium) |
JP6867639B2 (en) * | 2016-10-11 | 2021-05-12 | 学校法人 聖マリアンナ医科大学 | Combined nonionic iodine contrast agent |
EP4059925A1 (en) | 2021-03-15 | 2022-09-21 | Bayer Aktiengesellschaft | New contrast agent for use in magnetic resonance imaging |
EP4335840A1 (en) | 2022-09-09 | 2024-03-13 | Bayer Aktiengesellschaft | New contrast agents for use in diagnostic imaging |
EP4335462A1 (en) | 2022-09-09 | 2024-03-13 | Bayer AG | Contrast agents for use in diagnostic computed tomography imaging |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL194579C (en) * | 1983-01-21 | 2002-08-05 | Schering Ag | Diagnostic. |
US4672028A (en) * | 1984-05-23 | 1987-06-09 | Icn Micromedic Systems, Inc. | Compositions and method for simultaneous multiple array of analytes using radioisotope chelate labels |
US4824986A (en) * | 1985-04-26 | 1989-04-25 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Metal chelate protein conjugate |
IL83966A (en) * | 1986-09-26 | 1992-03-29 | Schering Ag | Amides of aminopolycarboxylic acids and pharmaceutical compositions containing them |
DE3710730A1 (en) * | 1987-03-31 | 1988-10-20 | Schering Ag | SUBSTITUTED COMPLEX ILLUMINATORS, COMPLEX AND COMPLEX SALTS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM |
EP0466200B1 (en) * | 1987-07-16 | 1996-04-24 | Nycomed Imaging As | Aminocarboxylic acids and derivatives thereof |
AU617338B2 (en) * | 1987-07-16 | 1991-11-28 | Nycomed As | Aminopolycarboxylic acids and derivatives thereof |
DE3728525A1 (en) * | 1987-08-24 | 1989-03-16 | Schering Ag | MULTI-CORE SUBSTITUTED COMPLEX ILLUMINATORS, COMPLEX AND COMPLEX SALTS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM |
-
1989
- 1989-06-30 DE DE3922005A patent/DE3922005A1/en not_active Withdrawn
-
1990
- 1990-06-21 IL IL9481890A patent/IL94818A/en active IP Right Grant
- 1990-06-26 IE IE229990A patent/IE65676B1/en not_active IP Right Cessation
- 1990-06-26 CZ CS903174A patent/CZ277926B6/en not_active IP Right Cessation
- 1990-06-27 KR KR1019900009529A patent/KR100190808B1/en not_active IP Right Cessation
- 1990-06-27 EP EP90250165A patent/EP0405704B1/en not_active Expired - Lifetime
- 1990-06-27 DK DK90250165.9T patent/DK0405704T3/en active
- 1990-06-27 DE DE59007987T patent/DE59007987D1/en not_active Expired - Lifetime
- 1990-06-27 ES ES90250165T patent/ES2066113T3/en not_active Expired - Lifetime
- 1990-06-27 DE DE200412000051 patent/DE122004000051I2/en active Active
- 1990-06-27 AT AT90250165T patent/ATE115546T1/en active
- 1990-06-28 NZ NZ234295A patent/NZ234295A/en unknown
- 1990-06-29 AU AU58024/90A patent/AU637111B2/en not_active Expired
- 1990-06-29 HU HU904040A patent/HU210208B/en unknown
- 1990-06-29 FI FI903295A patent/FI102168B/en active Protection Beyond IP Right Term
- 1990-06-29 PT PT94541A patent/PT94541B/en not_active IP Right Cessation
- 1990-06-29 UA UA4830458A patent/UA27275C2/en unknown
- 1990-06-29 NO NO902925A patent/NO179203C/en not_active IP Right Cessation
- 1990-06-29 CA CA002020142A patent/CA2020142C/en not_active Expired - Lifetime
- 1990-06-29 RU SU904830458A patent/RU2086554C1/en active Protection Beyond IP Right Term
- 1990-06-29 DD DD34235090A patent/DD296276B5/en active IP Right Maintenance
- 1990-06-29 JP JP2170372A patent/JP2603357B2/en not_active Expired - Lifetime
- 1990-06-29 ZA ZA905129A patent/ZA905129B/en unknown
- 1990-11-10 TW TW079109532A patent/TW219356B/zh active
-
1998
- 1998-03-10 HK HK98101936A patent/HK1002810A1/en not_active IP Right Cessation
-
2005
- 2005-03-18 NL NL300182C patent/NL300182I2/en unknown
- 2005-05-23 NO NO2005013C patent/NO2005013I2/en unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
SPCF | Filing of supplementary protection certificate |
Free format text: PRODUCT NAME: PRIMOVIST; NAT. REG. NO/DATE: 04-2770,04-2771 20041123; FIRST REG. NO/DATE: SE , 18929,18930 20040326 Spc suppl protection certif: 2005013 Filing date: 20050523 |
|
SPCG | Granted supplementary protection certificate |
Free format text: PRODUCT NAME: DINATRUMGADOKSETINSYRE(DINATRIUMGD-EOB-DTPA); NAT. REG. NO/DATE: 04-2770,04-2771 20041123; FIRST REG. NO/DATE: SE , 18929,18930 20040326 Spc suppl protection certif: 2005013 Filing date: 20050523 Extension date: 20150629 |
|
MK1K | Patent expired | ||
SPCX | Expiry of an spc |
Free format text: PRODUCT NAME: DINATRUMGADOKSETINSYRE(DINATRIUMGD-EOB-DTPA); NAT. REG. NO/DATE: 04-2770,04-2771 20041123; FIRST REG. NO/DATE: SE , 18929,18930 20040326 Spc suppl protection certif: 2005013 Effective date: 20150629 |