NO902925D0 - DERIVATIZED DTPA COMPLEXS, PROCEDURE FOR MANUFACTURING, AND USE THEREOF. - Google Patents

DERIVATIZED DTPA COMPLEXS, PROCEDURE FOR MANUFACTURING, AND USE THEREOF.

Info

Publication number
NO902925D0
NO902925D0 NO902925A NO902925A NO902925D0 NO 902925 D0 NO902925 D0 NO 902925D0 NO 902925 A NO902925 A NO 902925A NO 902925 A NO902925 A NO 902925A NO 902925 D0 NO902925 D0 NO 902925D0
Authority
NO
Norway
Prior art keywords
represent
hydrogen atom
denote
complexs
procedure
Prior art date
Application number
NO902925A
Other languages
Norwegian (no)
Other versions
NO902925L (en
NO179203C (en
NO179203B (en
Inventor
Heribert Schmitt-Willich
Johannes Platzek
Heinz Gries
Gabriele Schuhmann-Giampieri
Hubert Vogler
Hanns-Joachim Weinmann
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6384290&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO902925(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO902925D0 publication Critical patent/NO902925D0/en
Publication of NO902925L publication Critical patent/NO902925L/en
Publication of NO179203B publication Critical patent/NO179203B/en
Publication of NO179203C publication Critical patent/NO179203C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02—Iron compounds
    • C07F15/025—Iron compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/94—Bismuth compounds

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Compounds of the general formula <IMAGE> in which Z<1> and Z<2> each represent a hydrogen atom or the radical -(CH2)m-(C6H4)q-(O)k-(CH2)n(C6H4) l-(O)r-R, in which m and n denote the figures 0 - 20, k, l, q and r denote the figures 0 and 1 and R denotes a hydrogen atom, an unsubstituted or OR<1>-substituted C1-C6-alkyl radical or a CH2COOR<1> group where R<1> denotes a hydrogen atom, a C1-C6-alkyl radical or a benzyl group, X represents a hydrogen atom and/or a metal ion equivalent of an element of atomic number 21 - 29, 42, 44 or 57 - 83, with the proviso that at least two of the substituents X represent a metal ion equivalent in which one of the substituents Z<1> and Z<2> represents a hydrogen atom and the other does not represent a hydrogen atom, in which - if n and l each represent the figure 0 - k and r do not simultaneously each denote the figure 1, in which Z<1> or Z<2> do not represent -CH2-C6H4-O-CH2-COOCH2C6H5 or CH2-C6H4-O-(CH2)5-COOCH2C6H5 and in which -(O)r-R does not represent -OH, and their salts with inorganic and/or organic bases, amino acids or amino acid amides, are useful pharmaceutical agents.
NO902925A 1989-06-30 1990-06-29 Derivatized DPTA complexes and their use in NMR and X-ray diagnostics NO179203C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3922005A DE3922005A1 (en) 1989-06-30 1989-06-30 DERIVATIVED DTPA COMPLEXES, PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS, THEIR USE AND METHOD FOR THE PRODUCTION THEREOF

Publications (4)

Publication Number Publication Date
NO902925D0 true NO902925D0 (en) 1990-06-29
NO902925L NO902925L (en) 1991-01-02
NO179203B NO179203B (en) 1996-05-20
NO179203C NO179203C (en) 1996-08-28

Family

ID=6384290

Family Applications (2)

Application Number Title Priority Date Filing Date
NO902925A NO179203C (en) 1989-06-30 1990-06-29 Derivatized DPTA complexes and their use in NMR and X-ray diagnostics
NO2005013C NO2005013I2 (en) 1989-06-30 2005-05-23 Derivatized DTPA complexes and their use in NMR and X-ray diagnostics

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO2005013C NO2005013I2 (en) 1989-06-30 2005-05-23 Derivatized DTPA complexes and their use in NMR and X-ray diagnostics

Country Status (24)

Country Link
EP (1) EP0405704B1 (en)
JP (1) JP2603357B2 (en)
KR (1) KR100190808B1 (en)
AT (1) ATE115546T1 (en)
AU (1) AU637111B2 (en)
CA (1) CA2020142C (en)
CZ (1) CZ277926B6 (en)
DD (1) DD296276B5 (en)
DE (3) DE3922005A1 (en)
DK (1) DK0405704T3 (en)
ES (1) ES2066113T3 (en)
FI (1) FI102168B (en)
HK (1) HK1002810A1 (en)
HU (1) HU210208B (en)
IE (1) IE65676B1 (en)
IL (1) IL94818A (en)
NL (1) NL300182I2 (en)
NO (2) NO179203C (en)
NZ (1) NZ234295A (en)
PT (1) PT94541B (en)
RU (1) RU2086554C1 (en)
TW (1) TW219356B (en)
UA (1) UA27275C2 (en)
ZA (1) ZA905129B (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4011684A1 (en) * 1990-04-06 1991-10-10 Schering Ag DTPA MONOAMIDES, PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS, THEIR USE AND METHOD FOR THE PRODUCTION THEREOF
DE4302289A1 (en) * 1993-01-25 1994-07-28 Schering Ag Process for the preparation of C-substituted diethylenetriamines
DE4302287A1 (en) * 1993-01-25 1994-07-28 Schering Ag Derivatized DTPA complexes, pharmaceutical compositions containing these compounds, their use and processes for their preparation
DE4341724A1 (en) * 1993-12-03 1995-06-08 Schering Ag Pharmaceutical compositions containing haloaryl-substituted metal complexes, their use in diagnostics, and methods for producing the complexes and compositions
US5582814A (en) * 1994-04-15 1996-12-10 Metasyn, Inc. 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging
WO1996016678A1 (en) * 1994-11-30 1996-06-06 Schering Aktiengesellschaft Use of chelate compounds as diagnostic agents in the x-ray examination of liver and bile ducts
US5672335A (en) * 1994-11-30 1997-09-30 Schering Aktiengesellschaft Use of metal complexes as liver and gallbladder X-ray diagnostic agents
TW319763B (en) 1995-02-01 1997-11-11 Epix Medical Inc
AU4789096A (en) * 1995-02-09 1996-08-27 Schering Aktiengesellschaft Liposomes containing contrast media for blood pool imaging
DE19507820A1 (en) * 1995-02-21 1996-08-22 Schering Ag Novel substituted DTPA derivatives, their metal complexes, pharmaceutical compositions containing these complexes, their use in diagnostics, and methods for producing the complexes and compositions
JP2759627B2 (en) * 1995-07-21 1998-05-28 東北大学長 Non-ester bondable DTPA derivative and method for producing the same
DE19641197C2 (en) * 1996-09-24 1999-02-18 Schering Ag Ion pairs and their use as contrast agents
DE19646762B4 (en) * 1996-11-04 2004-05-13 Schering Ag Use of metal compounds for the production of agents for radiotherapy of tumors
DE19712012A1 (en) * 1997-03-13 1998-09-24 Schering Ag Ethoxy:benzyl-di:ethylene tri:amine penta:acetic acid preparation
US6495118B1 (en) 1997-09-26 2002-12-17 Schering Aktiengesellschaft Lipophilic metal complexes for necrosis and infarction imaging
DE19744004C1 (en) * 1997-09-26 1999-07-22 Schering Ag Lipophilic metal complexes for necrosis and infarct imaging
US6534040B2 (en) * 1999-12-23 2003-03-18 Health Research, Inc. Chlorin and bacteriochlorin-based aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals
FR2867473B1 (en) 2004-03-12 2006-06-23 Guerbet Sa PORPHYRINE COMPOUND AND HIGH FIELD USE IN MRI
KR100749087B1 (en) * 2006-06-02 2007-08-14 경북대학교 산학협력단 New dtpa-bis-amide ligands and gd-complexes thereof
SE533165C2 (en) * 2008-06-13 2010-07-13 Chemseq Internat Ab Chemical and process for the complex bonding of metal ions, which are at least divalent
EP2338874A1 (en) * 2009-12-16 2011-06-29 Bracco Imaging S.p.A Process for the preparation of chelated compounds
JP2013531643A (en) 2010-06-11 2013-08-08 バイエル・インテレクチユアル・プロパテイー・ゲー・エム・ベー・ハー Process for preparing crystalline 3,6,9-triaza-3,6,9-tris (carboxymethyl) -4- (4-ethoxybenzyl) undecanedioic acid and for producing Primovist (R) the method of
DE102010023890A1 (en) 2010-06-11 2011-12-15 Bayer Schering Pharma Aktiengesellschaft Preparing crystalline 3,6,9-triaza-3,6,9-tris(carboxymethyl)-4-(ethoxybenzyl)-undecanedioic acid comprises hydrolyzing 3,6,9-triaza-3,6,9-tris(tert-butoxy-carbonylmethyl)-4-(ethoxybenzyl)-undecanedioic acid-ditert-butylester and acidifying
CN104761461A (en) * 2014-09-09 2015-07-08 山东富创医药科技有限公司 Preparation method of novel gadoxetate disodium intermediate
ES2973718T3 (en) * 2016-05-30 2024-06-24 Biophore India Pharmaceuticals Pvt Ltd New process for the preparation of disodium (4s)-4-(4-ethoxybenzyl)-3,6,9-tris(carboxymethyl)-3,6,9-triazaundecanedioic acid gadolinium complex (disodium gadoxetate)
JP6867639B2 (en) * 2016-10-11 2021-05-12 学校法人 聖マリアンナ医科大学 Combined nonionic iodine contrast agent
EP4059925A1 (en) 2021-03-15 2022-09-21 Bayer Aktiengesellschaft New contrast agent for use in magnetic resonance imaging
EP4335840A1 (en) 2022-09-09 2024-03-13 Bayer Aktiengesellschaft New contrast agents for use in diagnostic imaging
EP4335462A1 (en) 2022-09-09 2024-03-13 Bayer AG Contrast agents for use in diagnostic computed tomography imaging

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL194579C (en) * 1983-01-21 2002-08-05 Schering Ag Diagnostic.
US4672028A (en) * 1984-05-23 1987-06-09 Icn Micromedic Systems, Inc. Compositions and method for simultaneous multiple array of analytes using radioisotope chelate labels
US4824986A (en) * 1985-04-26 1989-04-25 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Metal chelate protein conjugate
IL83966A (en) * 1986-09-26 1992-03-29 Schering Ag Amides of aminopolycarboxylic acids and pharmaceutical compositions containing them
DE3710730A1 (en) * 1987-03-31 1988-10-20 Schering Ag SUBSTITUTED COMPLEX ILLUMINATORS, COMPLEX AND COMPLEX SALTS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM
US5198208A (en) * 1987-07-16 1993-03-30 Nycomed Imaging As Aminopolycarboxylic acids and derivatives thereof
AU617338B2 (en) * 1987-07-16 1991-11-28 Nycomed As Aminopolycarboxylic acids and derivatives thereof
DE3728525A1 (en) * 1987-08-24 1989-03-16 Schering Ag MULTI-CORE SUBSTITUTED COMPLEX ILLUMINATORS, COMPLEX AND COMPLEX SALTS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM

Also Published As

Publication number Publication date
JPH03215457A (en) 1991-09-20
EP0405704B1 (en) 1994-12-14
NZ234295A (en) 1993-02-25
RU2086554C1 (en) 1997-08-10
DE122004000051I1 (en) 2005-04-21
EP0405704A2 (en) 1991-01-02
HK1002810A1 (en) 1998-09-18
DE59007987D1 (en) 1995-02-02
FI102168B1 (en) 1998-10-30
CA2020142A1 (en) 1990-12-31
NO902925L (en) 1991-01-02
PT94541B (en) 1997-02-28
CS9003174A2 (en) 1991-11-12
DE3922005A1 (en) 1991-01-10
IL94818A (en) 1996-05-14
NO179203C (en) 1996-08-28
DK0405704T3 (en) 1995-02-20
EP0405704A3 (en) 1991-03-27
NO2005013I2 (en) 2006-06-19
HUT54622A (en) 1991-03-28
DD296276B5 (en) 1995-11-02
FI102168B (en) 1998-10-30
TW219356B (en) 1994-01-21
FI903295A0 (en) 1990-06-29
NL300182I1 (en) 2005-06-01
IL94818A0 (en) 1991-04-15
CA2020142C (en) 2001-04-17
NL300182I2 (en) 2005-08-01
IE65676B1 (en) 1995-11-15
ES2066113T3 (en) 1995-03-01
IE902299A1 (en) 1991-01-16
PT94541A (en) 1991-02-08
ATE115546T1 (en) 1994-12-15
UA27275C2 (en) 2000-09-15
AU637111B2 (en) 1993-05-20
CZ277926B6 (en) 1993-06-16
ZA905129B (en) 1991-04-24
KR910000134A (en) 1991-01-29
JP2603357B2 (en) 1997-04-23
HU210208B (en) 1995-02-28
KR100190808B1 (en) 1999-06-01
NO179203B (en) 1996-05-20
DE122004000051I2 (en) 2011-12-29
AU5802490A (en) 1991-01-03
HU904040D0 (en) 1990-12-28
IE902299L (en) 1990-12-30

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Legal Events

Date Code Title Description
SPCF Filing of supplementary protection certificate

Free format text: PRODUCT NAME: PRIMOVIST; NAT. REG. NO/DATE: 04-2770,04-2771 20041123; FIRST REG. NO/DATE: SE , 18929,18930 20040326

Spc suppl protection certif: 2005013

Filing date: 20050523

SPCG Granted supplementary protection certificate

Free format text: PRODUCT NAME: DINATRUMGADOKSETINSYRE(DINATRIUMGD-EOB-DTPA); NAT. REG. NO/DATE: 04-2770,04-2771 20041123; FIRST REG. NO/DATE: SE , 18929,18930 20040326

Spc suppl protection certif: 2005013

Filing date: 20050523

Extension date: 20150629

MK1K Patent expired
SPCX Expiry of an spc

Free format text: PRODUCT NAME: DINATRUMGADOKSETINSYRE(DINATRIUMGD-EOB-DTPA); NAT. REG. NO/DATE: 04-2770,04-2771 20041123; FIRST REG. NO/DATE: SE , 18929,18930 20040326

Spc suppl protection certif: 2005013

Effective date: 20150629