NO911345D0 - Dtpa-monoamider, preparater som inneholder forbindelsene,samt anvendelse og fremgangsmaate for fremstilling av forbindelsene. - Google Patents

Dtpa-monoamider, preparater som inneholder forbindelsene,samt anvendelse og fremgangsmaate for fremstilling av forbindelsene.

Info

Publication number
NO911345D0
NO911345D0 NO911345A NO911345A NO911345D0 NO 911345 D0 NO911345 D0 NO 911345D0 NO 911345 A NO911345 A NO 911345A NO 911345 A NO911345 A NO 911345A NO 911345 D0 NO911345 D0 NO 911345D0
Authority
NO
Norway
Prior art keywords
group
hydrogen atom
radical
compounds
alkyl
Prior art date
Application number
NO911345A
Other languages
English (en)
Other versions
NO911345L (no
NO180582B (no
NO180582C (no
Inventor
Heinz Gries
Erich Klieger
Bernd Raduechel
Heribert Schmitt-Willich
Hanns-Joachim Weinmann
Hubert Vogler
Gabriele Schuhmann-Giampieri
Juergen Conrad
Original Assignee
Schering Aktiengesellshcaft Be
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Aktiengesellshcaft Be filed Critical Schering Aktiengesellshcaft Be
Publication of NO911345D0 publication Critical patent/NO911345D0/no
Publication of NO911345L publication Critical patent/NO911345L/no
Publication of NO180582B publication Critical patent/NO180582B/no
Publication of NO180582C publication Critical patent/NO180582C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02—Iron compounds
    • C07F15/025—Iron compounds without a metal-carbon linkage

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO911345A 1990-04-06 1991-04-05 Dietylentriamineddiksyremonoamider (DTPA-monoamider), komplekser og komplekssalter derav, samt anvendelse av forbindelsene til fremstilling av midler for NMR-, röntgen-eller radiodiagnostikk NO180582C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4011684A DE4011684A1 (de) 1990-04-06 1990-04-06 Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung

Publications (4)

Publication Number Publication Date
NO911345D0 true NO911345D0 (no) 1991-04-05
NO911345L NO911345L (no) 1991-10-07
NO180582B NO180582B (no) 1997-02-03
NO180582C NO180582C (no) 1997-05-14

Family

ID=6404192

Family Applications (1)

Application Number Title Priority Date Filing Date
NO911345A NO180582C (no) 1990-04-06 1991-04-05 Dietylentriamineddiksyremonoamider (DTPA-monoamider), komplekser og komplekssalter derav, samt anvendelse av forbindelsene til fremstilling av midler for NMR-, röntgen-eller radiodiagnostikk

Country Status (16)

Country Link
US (4) US5859214A (no)
EP (1) EP0450742B1 (no)
JP (1) JP2854159B2 (no)
AT (1) ATE108179T1 (no)
AU (1) AU644639B2 (no)
CA (1) CA2039846A1 (no)
DE (2) DE4011684A1 (no)
DK (1) DK0450742T3 (no)
ES (1) ES2057746T3 (no)
FI (1) FI911646A (no)
HU (1) HUT57180A (no)
IE (1) IE65923B1 (no)
NO (1) NO180582C (no)
NZ (1) NZ237711A (no)
PT (1) PT97263B (no)
ZA (1) ZA912550B (no)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4011684A1 (de) * 1990-04-06 1991-10-10 Schering Ag Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung
US6875864B2 (en) 1991-08-01 2005-04-05 Bracco International B.V. Aminocarboxylate ligands having substituted aromatic amide moieties
EP0603403B2 (en) * 1992-07-03 2001-06-27 Welfide Corporation Novel chelating agent, complex compound composed of said agent and metallic atom, and diagnostic agent containing said compound
WO1994008630A1 (en) * 1992-10-13 1994-04-28 Mallinckrodt Medical, Inc. Novel compositions for magnetic resonance imaging
WO1994008624A2 (en) * 1992-10-14 1994-04-28 Sterling Winthrop Inc. Therapeutic and diagnostic imaging compositions and methods
EP0664819B1 (en) * 1992-10-14 1997-08-06 Nycomed Imaging As Chelating polymers
US5817292A (en) * 1992-10-14 1998-10-06 Nycomed Imaging As MR imaging compositions and methods
DE4317588C2 (de) * 1993-05-24 1998-04-16 Schering Ag Fluorhaltige makrocyclische Metallkomplexe, Verfahren zu ihrer Herstellung, sowie ihre Verwendung
DE4318369C1 (de) * 1993-05-28 1995-02-09 Schering Ag Verwendung von makrocyclischen Metallkomplexen als Temperatursonden
EP0702677A1 (en) * 1994-04-08 1996-03-27 BRACCO International B.V. Aromatic amide compounds and metal chelates thereof
US5582814A (en) * 1994-04-15 1996-12-10 Metasyn, Inc. 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging
US5672335A (en) * 1994-11-30 1997-09-30 Schering Aktiengesellschaft Use of metal complexes as liver and gallbladder X-ray diagnostic agents
HUT77553A (hu) * 1994-11-30 1998-05-28 Schering Aktiengesellschaft Eljárás fémeket tartalmazó kelát komplexek alkalmazására a máj és az epe röntgendiagnosztikájában
TW319763B (no) 1995-02-01 1997-11-11 Epix Medical Inc
IL117200A0 (en) * 1995-02-21 1996-06-18 Schering Ag Diethylenetriamine-pentaacetic acid monoamide derivatives pharmaceutical compostions containing the same and processes for the preparation thereof
DE19507822B4 (de) * 1995-02-21 2006-07-20 Schering Ag Substituierte DTPA-Monoamide der zentralen Carbonsäure und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel
DE19507820A1 (de) 1995-02-21 1996-08-22 Schering Ag Neuartig substituierte DTPA-Derivate, deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik, sowie Verfahren zur Herstellung der Komplexe und Mittel
DE19507819A1 (de) * 1995-02-21 1996-08-22 Schering Ag DTPA-Monoamide der zentralen Carbonsäure und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel
DE19646762B4 (de) * 1996-11-04 2004-05-13 Schering Ag Verwendung von Metallverbindungen zur Herstellung von Mitteln zur Strahlentherapie von Tumoren
US6334995B1 (en) * 1998-03-24 2002-01-01 Council Of Scientific & Industrial Research Process for the preparation of technetium-99m diethylene triamine penta-acetic acid diester
GB9806530D0 (en) 1998-03-26 1998-05-27 Glaxo Group Ltd Inflammatory mediator
GB9823175D0 (en) * 1998-10-22 1998-12-16 Nycomed Imaging As Compound
EP1793866A1 (en) * 2004-08-26 2007-06-13 Mallinckrodt, Inc. Luminescent metal complexes for monitoring renal function
FI20065030L (fi) * 2006-01-17 2007-07-18 Wallac Oy Neutraaliset leimausreagenssit ja niistä johdetut konjugaatit
JP5563299B2 (ja) * 2006-08-17 2014-07-30 エピックス ファーマシューティカルズ，インコーポレイテッド リンパ系撮像方法
WO2009143618A1 (en) * 2008-05-28 2009-12-03 Sixtron Advanced Materials, Inc. Silicon carbide-based antireflective coating
CN102549438B (zh) 2009-09-24 2014-10-29 国家健康与医学研究院 Fkbp52-tau相互作用作为新颖治疗靶点用于治疗涉及tau机能失调的神经障碍
US20140296106A1 (en) 2011-05-16 2014-10-02 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for screening substances capable of modulating the replication of an influenza virus
US20150276760A1 (en) 2012-10-04 2015-10-01 INSERM (Institut National de la Sante Et de la Recherche Medicate) Method for Screening a Compound Capable of Inhibiting the Notch1 Transcriptional Activity
US20170051062A1 (en) 2014-02-18 2017-02-23 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and Pharmaceutical Compositions for the Treatment of Diseases Mediated by the NRP-1/OBR Complex Signaling Pathway
ES2796857T3 (es) 2014-04-17 2020-11-30 Inst Nat Sante Rech Med Polipéptidos y usos de los mismos para reducir la motilidad celular mediada por CD95
CA3057976A1 (en) * 2017-04-27 2018-11-01 The Regents Of The University Of California Modified mri contrast agents and uses thereof
US11008354B2 (en) * 2018-05-24 2021-05-18 The Texas A&M University System Chiral solvating agents
WO2020144324A1 (en) 2019-01-11 2020-07-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for screening inhibitors against chikungunya virus and for determining whether subjects are predisposed to infection by said virus
CN115043747B (zh) * 2022-08-15 2022-11-25 康瑞鑫(天津)药物研究院有限公司 卡洛酸三钠的析晶方法及制备的卡洛酸三钠晶体

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4352751A (en) * 1979-09-10 1982-10-05 Analytical Radiation Corporation Species-linked diamine triacetic acids and their chelates
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4957939A (en) * 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
DE3324235A1 (de) * 1983-07-01 1985-01-10 Schering AG, 1000 Berlin und 4709 Bergkamen Neue komplexbildner, komplexe und komplexsalze
US4687659A (en) * 1984-11-13 1987-08-18 Salutar, Inc. Diamide-DTPA-paramagnetic contrast agents for MR imaging
US4859451A (en) * 1984-10-04 1989-08-22 Salutar, Inc. Paramagnetic contrast agents for MR imaging
US5087439A (en) * 1984-11-13 1992-02-11 Salutar, Inc. Paramagnetic metal-diethylenetriamine-pentaacetic acid partial amide complexes for magnetic resonance imaging
US4826673A (en) * 1985-01-09 1989-05-02 Mallinckrodt, Inc. Methods and compositions for enhancing magnetic resonance imaging
GB8610551D0 (en) * 1986-04-30 1986-06-04 Hoffmann La Roche Polypeptide & protein derivatives
US5219553A (en) * 1986-08-04 1993-06-15 Salutar, Inc. Composition of a n-carboxymethylated tetraazacyclododecane chelating agent, a paramagnetic metal and excess calcium ions for MRI
AU608759B2 (en) * 1986-08-04 1991-04-18 Amersham Health Salutar Inc NMR imaging with paramagnetic polyvalents metal salts of poly-(acid-alkylene-amido)-alkanes
US5039512A (en) * 1986-08-04 1991-08-13 Salutar, Inc. NMR imaging with paramagnetic polyvalent metal salts of poly-(acid-alkylene-amino)-alkanes
IL83966A (en) * 1986-09-26 1992-03-29 Schering Ag Amides of aminopolycarboxylic acids and pharmaceutical compositions containing them
DE3640708C2 (de) * 1986-11-28 1995-05-18 Schering Ag Verbesserte metallhaltige Pharmazeutika
US5693309A (en) 1987-03-31 1997-12-02 Schering Aktiengesellschaft Substituted complexing agents, complexes, and complex salts, processes for their production, and pharmaceuticals containing same
DE3710730A1 (de) * 1987-03-31 1988-10-20 Schering Ag Substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
US4994259A (en) * 1987-05-08 1991-02-19 Salutar, Inc. Improvement in the method of NMR imaging employing a manganese II chelates of N,N'-bis[pyridoxal-alkylene (or cycloalkylene) (or arylene)]-N,N'-diacetic acid derivatives
ATE137228T1 (de) * 1987-07-16 1996-05-15 Nycomed Imaging As Aminocarbonsäure und derivate
US5399340A (en) * 1987-09-24 1995-03-21 Schering Aktiengesellschaft Use of amide complex compounds
US5137711A (en) * 1988-07-19 1992-08-11 Mallickrodt Medical, Inc. Paramagnetic dtpa and edta alkoxyalkylamide complexes as mri agents
DE68908185T2 (de) 1988-09-27 1993-11-25 Nycomed Salutar Inc Chelat-zusammensetzung.
US5198426A (en) 1988-12-30 1993-03-30 Warner-Lambert Company Renin inhibitors containing c-terminal dihydroxy amides
GB8900719D0 (en) * 1989-01-13 1989-03-08 Nycomed As Compounds
US5011925A (en) * 1989-03-09 1991-04-30 Mallinckrodt, Inc. Morpholinoamido EDTA derivatives
US5384108A (en) * 1989-04-24 1995-01-24 Mallinckrodt Medical, Inc. Magnetic resonance imaging agents
DE3922005A1 (de) * 1989-06-30 1991-01-10 Schering Ag Derivatisierte dtpa-komplexe, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung
US6039931A (en) 1989-06-30 2000-03-21 Schering Aktiengesellschaft Derivatized DTPA complexes, pharmaceutical agents containing these compounds, their use, and processes for their production
US5087440A (en) * 1989-07-31 1992-02-11 Salutar, Inc. Heterocyclic derivatives of DTPA used for magnetic resonance imaging
GB8923843D0 (en) * 1989-10-23 1989-12-13 Salutar Inc Compounds
US5843399A (en) * 1990-04-06 1998-12-01 Schering Aktiengesellschaft DTPA monoamides for MRI
DE4011684A1 (de) * 1990-04-06 1991-10-10 Schering Ag Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung
US5077037A (en) * 1990-08-03 1991-12-31 Mallinckrodt Medical, Inc. Novel compositions for magnetic resonance imaging
JP3215457B2 (ja) 1991-08-05 2001-10-09 株式会社ブリヂストン 氷雪上性能の改善されたゴム製品およびその製造方法
EP0603403B2 (en) * 1992-07-03 2001-06-27 Welfide Corporation Novel chelating agent, complex compound composed of said agent and metallic atom, and diagnostic agent containing said compound
US5330743A (en) * 1992-11-12 1994-07-19 Magnetic Research, Inc. Aminosaccharide contrast agents for magnetic resonance images

Also Published As

Publication number Publication date
AU7418691A (en) 1991-10-10
EP0450742B1 (de) 1994-07-06
ATE108179T1 (de) 1994-07-15
CA2039846A1 (en) 1991-10-07
NO911345L (no) 1991-10-07
DE4011684A1 (de) 1991-10-10
DK0450742T3 (da) 1994-11-07
FI911646A0 (fi) 1991-04-05
NO180582B (no) 1997-02-03
IE911155A1 (en) 1991-10-09
AU644639B2 (en) 1993-12-16
US6565830B1 (en) 2003-05-20
DE59102092D1 (de) 1994-08-18
ZA912550B (en) 1992-01-29
PT97263A (pt) 1992-01-31
US6287538B1 (en) 2001-09-11
ES2057746T3 (es) 1994-10-16
US7074387B2 (en) 2006-07-11
HUT57180A (en) 1991-11-28
JP2854159B2 (ja) 1999-02-03
JPH0665174A (ja) 1994-03-08
PT97263B (pt) 1998-08-31
NO180582C (no) 1997-05-14
US5859214A (en) 1999-01-12
EP0450742A1 (de) 1991-10-09
FI911646A (fi) 1991-10-07
IE65923B1 (en) 1995-11-29
NZ237711A (en) 1993-12-23
HU911126D0 (en) 1991-10-28
US20030202943A1 (en) 2003-10-30

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