ATE18201T1 - Amide mit pharmakologischer wirkung, herstellung und diese verbindungen enthaltende mittel und verwendung. - Google Patents
Amide mit pharmakologischer wirkung, herstellung und diese verbindungen enthaltende mittel und verwendung.Info
- Publication number
- ATE18201T1 ATE18201T1 AT82108860T AT82108860T ATE18201T1 AT E18201 T1 ATE18201 T1 AT E18201T1 AT 82108860 T AT82108860 T AT 82108860T AT 82108860 T AT82108860 T AT 82108860T AT E18201 T1 ATE18201 T1 AT E18201T1
- Authority
- AT
- Austria
- Prior art keywords
- sup
- sub
- compounds
- alkyl
- carbon atoms
- Prior art date
Links
- -1 nitro, sulphonyl Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 108010092674 Enkephalins Proteins 0.000 abstract 1
- URLZCHNOLZSCCA-VABKMULXSA-N Leu-enkephalin Chemical class C([C@@H](C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 URLZCHNOLZSCCA-VABKMULXSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 102000003729 Neprilysin Human genes 0.000 abstract 1
- 108090000028 Neprilysin Proteins 0.000 abstract 1
- 150000001447 alkali salts Chemical class 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000002346 iodo group Chemical group I* 0.000 abstract 1
- 238000013160 medical therapy Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000004092 methylthiomethyl group Chemical group [H]C([H])([H])SC([H])([H])* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Glass Compositions (AREA)
- Manufacturing Cores, Coils, And Magnets (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8129053 | 1981-09-25 | ||
| EP82108860A EP0075896B1 (de) | 1981-09-25 | 1982-09-24 | Amide mit pharmakologischer Wirkung, Herstellung und diese Verbindungen enthaltende Mittel und Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE18201T1 true ATE18201T1 (de) | 1986-03-15 |
Family
ID=10524742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT82108860T ATE18201T1 (de) | 1981-09-25 | 1982-09-24 | Amide mit pharmakologischer wirkung, herstellung und diese verbindungen enthaltende mittel und verwendung. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4504492A (de) |
| EP (1) | EP0075896B1 (de) |
| JP (1) | JPS5877852A (de) |
| AT (1) | ATE18201T1 (de) |
| AU (1) | AU8866882A (de) |
| DE (1) | DE3269422D1 (de) |
| DK (1) | DK425382A (de) |
| GB (1) | GB2108118B (de) |
| NZ (1) | NZ201998A (de) |
| ZA (1) | ZA827000B (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5166212A (en) * | 1985-12-06 | 1992-11-24 | Ciba-Geigy Corporation | Certain n-substituted butyramide derivatives |
| EP0225292A3 (de) * | 1985-12-06 | 1988-11-30 | Ciba-Geigy Ag | Einige N-substituierte Buttersäureamidderivate |
| DK77487A (da) * | 1986-03-11 | 1987-09-12 | Hoffmann La Roche | Hydroxylaminderivater |
| FR2609289B1 (fr) * | 1987-01-06 | 1991-03-29 | Bellon Labor Sa Roger | Nouveaux composes a activite d'inhibiteurs de collagenase, procede pour les preparer et compositions pharmaceutiques contenant ces composes |
| CA1337400C (en) * | 1987-06-08 | 1995-10-24 | Norma G. Delaney | Inhibitors of neutral endopeptidase |
| US4931430A (en) * | 1987-12-14 | 1990-06-05 | E. R. Squibb & Sons, Inc. | Method for preventing or treating anxiety employing an ACE inhibitor |
| US5599951A (en) * | 1989-09-15 | 1997-02-04 | Societe Civile Bioprojet | Amino acid derivatives, the process for their preparation and their applications to therapy |
| FR2652087B1 (fr) * | 1989-09-15 | 1993-10-15 | Bioprojet Ste Civile | Derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques. |
| US5098889A (en) * | 1990-09-17 | 1992-03-24 | E. R. Squibb & Sons, Inc. | Method for preventing or inhibiting loss of cognitive function employing a combination of an ace inhibitor and a drug that acts at serotonin receptors |
| US5756825A (en) * | 1992-09-08 | 1998-05-26 | Safavy; Ahmad | Hydroxamic acid-based bifunctional chelating compounds |
| EP1140878A1 (de) | 1999-01-02 | 2001-10-10 | Aventis Pharma Deutschland GmbH | Neue malonsäure derivate, verfahren zu ihrer herstellung, ihre verwendung und pharmazeutische zusammensetzungen sie enthaltend ( inhibierung der factor xa aktivität ) |
| EP1127884A1 (de) | 2000-02-26 | 2001-08-29 | Aventis Pharma Deutschland GmbH | Neue Malonsäure Derivaie, Verfahren zu ihrer Herstellung, ihre Verwendung als Inhibitor der Faktor XA Aktivtät und pharmazeutische Zusammensetzungen diese enthaltend |
| JP2008514612A (ja) * | 2004-09-23 | 2008-05-08 | ミシャロウ、アレクサンダー | 対抗適応を誘発することにより神経伝達物質系を調節する方法 |
| US20080045610A1 (en) * | 2004-09-23 | 2008-02-21 | Alexander Michalow | Methods for regulating neurotransmitter systems by inducing counteradaptations |
| JP6599094B2 (ja) | 2014-11-13 | 2019-10-30 | 株式会社ミツトヨ | 光学装置 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4105789A (en) * | 1976-05-10 | 1978-08-08 | E. R. Squibb & Sons, Inc. | Carboxyalkylacylamino acids |
| US4228184A (en) * | 1976-05-10 | 1980-10-14 | E. R. Squibb & Sons, Inc. | Carboxyalkylacylamino acids |
| DE3162404D1 (en) * | 1980-04-11 | 1984-04-05 | Wellcome Found | Pharmaceutical amides, and preparation, formulations and use thereof |
| FR2480747A1 (fr) * | 1980-04-17 | 1981-10-23 | Roques Bernard | Derives d'acides amines et leur application therapeutique |
| DE3042482A1 (de) * | 1980-11-11 | 1982-06-24 | A. Nattermann & Cie GmbH, 5000 Köln | N-benzoyl- (omega) -anilinoalkancarbonsaeuren, -salze und -ester, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| ZA827002B (en) * | 1981-09-25 | 1984-05-30 | Wellcome Found | Pharmaceutical amides,and preparation,formulations and use thereof |
| FR2518088B1 (fr) * | 1981-12-16 | 1987-11-27 | Roques Bernard | Nouveaux derives d'aminoacides, et leur application therapeutique |
-
1982
- 1982-09-24 DK DK425382A patent/DK425382A/da not_active Application Discontinuation
- 1982-09-24 GB GB08227346A patent/GB2108118B/en not_active Expired
- 1982-09-24 NZ NZ201998A patent/NZ201998A/en unknown
- 1982-09-24 AT AT82108860T patent/ATE18201T1/de not_active IP Right Cessation
- 1982-09-24 DE DE8282108860T patent/DE3269422D1/de not_active Expired
- 1982-09-24 ZA ZA827000A patent/ZA827000B/xx unknown
- 1982-09-24 US US06/422,997 patent/US4504492A/en not_active Expired - Lifetime
- 1982-09-24 EP EP82108860A patent/EP0075896B1/de not_active Expired
- 1982-09-24 AU AU88668/82A patent/AU8866882A/en not_active Abandoned
- 1982-09-25 JP JP57167459A patent/JPS5877852A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5877852A (ja) | 1983-05-11 |
| GB2108118B (en) | 1985-09-11 |
| US4504492A (en) | 1985-03-12 |
| AU8866882A (en) | 1983-03-31 |
| DK425382A (da) | 1983-03-26 |
| EP0075896A3 (en) | 1983-07-20 |
| GB2108118A (en) | 1983-05-11 |
| DE3269422D1 (en) | 1986-04-03 |
| ZA827000B (en) | 1984-05-30 |
| NZ201998A (en) | 1985-11-08 |
| EP0075896A2 (de) | 1983-04-06 |
| EP0075896B1 (de) | 1986-02-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |