DK0450742T3 - DTPA-monoamider, farmaceutiske midler, der indeholder dem, deres anvendelse og fremgangsmåde til deres fremstilling - Google Patents

DTPA-monoamider, farmaceutiske midler, der indeholder dem, deres anvendelse og fremgangsmåde til deres fremstilling

Info

Publication number
DK0450742T3
DK0450742T3 DK91250089.9T DK91250089T DK0450742T3 DK 0450742 T3 DK0450742 T3 DK 0450742T3 DK 91250089 T DK91250089 T DK 91250089T DK 0450742 T3 DK0450742 T3 DK 0450742T3
Authority
DK
Denmark
Prior art keywords
group
hydrogen atom
radical
alkyl
denote
Prior art date
Application number
DK91250089.9T
Other languages
Danish (da)
English (en)
Inventor
Heribert Dr Schmitt-Willich
Hanns-Joachim Dr Weinmann
Heinz Dr Gries
Erich Dr Klieger
Bernd Dr Raduechel
Hubert Dr Vogler
Gabriele D Schuhmann-Giampieri
Juergen Dr Conrad
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK0450742T3 publication Critical patent/DK0450742T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/12Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02Iron compounds
    • C07F15/025Iron compounds without a metal-carbon linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK91250089.9T 1990-04-06 1991-04-05 DTPA-monoamider, farmaceutiske midler, der indeholder dem, deres anvendelse og fremgangsmåde til deres fremstilling DK0450742T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4011684A DE4011684A1 (de) 1990-04-06 1990-04-06 Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
DK0450742T3 true DK0450742T3 (da) 1994-11-07

Family

ID=6404192

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91250089.9T DK0450742T3 (da) 1990-04-06 1991-04-05 DTPA-monoamider, farmaceutiske midler, der indeholder dem, deres anvendelse og fremgangsmåde til deres fremstilling

Country Status (16)

Country Link
US (4) US5859214A (no)
EP (1) EP0450742B1 (no)
JP (1) JP2854159B2 (no)
AT (1) ATE108179T1 (no)
AU (1) AU644639B2 (no)
CA (1) CA2039846A1 (no)
DE (2) DE4011684A1 (no)
DK (1) DK0450742T3 (no)
ES (1) ES2057746T3 (no)
FI (1) FI911646A (no)
HU (1) HUT57180A (no)
IE (1) IE65923B1 (no)
NO (1) NO180582C (no)
NZ (1) NZ237711A (no)
PT (1) PT97263B (no)
ZA (1) ZA912550B (no)

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ES2140469T3 (es) * 1992-10-14 2000-03-01 Nycomed Imaging As Composiciones y metodos terapeuticos y de diagnostico por obtencion de imagenes.
US5817292A (en) * 1992-10-14 1998-10-06 Nycomed Imaging As MR imaging compositions and methods
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DE4318369C1 (de) * 1993-05-28 1995-02-09 Schering Ag Verwendung von makrocyclischen Metallkomplexen als Temperatursonden
EP0702677A1 (en) * 1994-04-08 1996-03-27 BRACCO International B.V. Aromatic amide compounds and metal chelates thereof
US5582814A (en) * 1994-04-15 1996-12-10 Metasyn, Inc. 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging
US5672335A (en) * 1994-11-30 1997-09-30 Schering Aktiengesellschaft Use of metal complexes as liver and gallbladder X-ray diagnostic agents
AU4173896A (en) * 1994-11-30 1996-06-19 Schering Aktiengesellschaft Use of chelate compounds as diagnostic agents in the x-ray examination of liver and bile ducts
TW319763B (no) 1995-02-01 1997-11-11 Epix Medical Inc
DE19507820A1 (de) * 1995-02-21 1996-08-22 Schering Ag Neuartig substituierte DTPA-Derivate, deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik, sowie Verfahren zur Herstellung der Komplexe und Mittel
DE19507822B4 (de) * 1995-02-21 2006-07-20 Schering Ag Substituierte DTPA-Monoamide der zentralen Carbonsäure und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel
DE19507819A1 (de) * 1995-02-21 1996-08-22 Schering Ag DTPA-Monoamide der zentralen Carbonsäure und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel
IL117200A0 (en) * 1995-02-21 1996-06-18 Schering Ag Diethylenetriamine-pentaacetic acid monoamide derivatives pharmaceutical compostions containing the same and processes for the preparation thereof
DE19646762B4 (de) * 1996-11-04 2004-05-13 Schering Ag Verwendung von Metallverbindungen zur Herstellung von Mitteln zur Strahlentherapie von Tumoren
EP0953360B1 (en) * 1998-03-24 2004-05-26 Council of Scientific and Industrial Research Technetium-99m radiolabelled diethylene triamine pentaacetic acid diester and process for the preparation of technetium-99m diethylene triamine penta-acetic acid diester
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GB9823175D0 (en) * 1998-10-22 1998-12-16 Nycomed Imaging As Compound
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FI20065030L (fi) * 2006-01-17 2007-07-18 Wallac Oy Neutraaliset leimausreagenssit ja niistä johdetut konjugaatit
CA2660717A1 (en) * 2006-08-17 2008-02-21 Epix Pharmaceuticals, Inc. Methods for lymph system imaging
WO2009143618A1 (en) * 2008-05-28 2009-12-03 Sixtron Advanced Materials, Inc. Silicon carbide-based antireflective coating
JP5681719B2 (ja) 2009-09-24 2015-03-11 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル タウ機能不全を伴う神経障害を処置するための新規な治療ターゲットとしてのfkbp52−タウ相互作用
US20140296106A1 (en) 2011-05-16 2014-10-02 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for screening substances capable of modulating the replication of an influenza virus
WO2014053871A1 (en) 2012-10-04 2014-04-10 INSERM (Institut National de la Santé et de la Recherche Médicale) A method for screening a compound capable of inhibiting the notch1 transcriptional activity
WO2015124588A1 (en) 2014-02-18 2015-08-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of diseases mediated by the nrp-1/obr complex signaling pathway
US10189887B2 (en) 2014-04-17 2019-01-29 Inserm (Institut National De La Sante Et De La Recherche Medicale) Polypeptides and uses thereof for reducing CD95-mediated cell motility
CN110582306A (zh) * 2017-04-27 2019-12-17 加利福尼亚大学董事会 修饰的mri造影剂及其用途
US11008354B2 (en) * 2018-05-24 2021-05-18 The Texas A&M University System Chiral solvating agents
ES2942917T3 (es) 2019-01-11 2023-06-07 Inst Nat Sante Rech Med Métodos para cribar inhibidores contra el virus de chikungunya y para determinar si los sujetos tienen predisposición a infección por dicho virus
CN115043747B (zh) * 2022-08-15 2022-11-25 康瑞鑫(天津)药物研究院有限公司 卡洛酸三钠的析晶方法及制备的卡洛酸三钠晶体

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Also Published As

Publication number Publication date
AU644639B2 (en) 1993-12-16
NO911345L (no) 1991-10-07
ZA912550B (en) 1992-01-29
US7074387B2 (en) 2006-07-11
HU911126D0 (en) 1991-10-28
NO911345D0 (no) 1991-04-05
PT97263A (pt) 1992-01-31
FI911646A0 (fi) 1991-04-05
EP0450742A1 (de) 1991-10-09
ATE108179T1 (de) 1994-07-15
IE65923B1 (en) 1995-11-29
US20030202943A1 (en) 2003-10-30
CA2039846A1 (en) 1991-10-07
IE911155A1 (en) 1991-10-09
NZ237711A (en) 1993-12-23
US6565830B1 (en) 2003-05-20
AU7418691A (en) 1991-10-10
ES2057746T3 (es) 1994-10-16
US6287538B1 (en) 2001-09-11
NO180582C (no) 1997-05-14
FI911646A (fi) 1991-10-07
NO180582B (no) 1997-02-03
US5859214A (en) 1999-01-12
DE4011684A1 (de) 1991-10-10
JPH0665174A (ja) 1994-03-08
PT97263B (pt) 1998-08-31
HUT57180A (en) 1991-11-28
DE59102092D1 (de) 1994-08-18
EP0450742B1 (de) 1994-07-06
JP2854159B2 (ja) 1999-02-03

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