ES2057746T3 - Monoamidas de dtpa, agentes farmaceuticos que contienen estos compuestos, su utilizacion y procedimientos para su preparacion. - Google Patents

Monoamidas de dtpa, agentes farmaceuticos que contienen estos compuestos, su utilizacion y procedimientos para su preparacion.

Info

Publication number
ES2057746T3
ES2057746T3 ES91250089T ES91250089T ES2057746T3 ES 2057746 T3 ES2057746 T3 ES 2057746T3 ES 91250089 T ES91250089 T ES 91250089T ES 91250089 T ES91250089 T ES 91250089T ES 2057746 T3 ES2057746 T3 ES 2057746T3
Authority
ES
Spain
Prior art keywords
group
hydrogen atom
radical
alkyl
denote
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91250089T
Other languages
English (en)
Inventor
Heinz Dr Gries
Erich Dr Klieger
Bernd Dr Raduchel
Heribert Dr Schmitt-Willich
Hanns-Joachim Dr Weinmann
Hubert Dr Vogler
Gabriele D Schuhmann-Giampieri
Jurgen Dr Conrad
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2057746T3 publication Critical patent/ES2057746T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02—Iron compounds
    • C07F15/025—Iron compounds without a metal-carbon linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

COMPUESTOS DE FORMULA GENERAL I EN LA QUE Z ELEVADO 1 Y Z (AL CUADRADO) REPRESENTAN RESPECTIVAMENTE UN ATOMO DE HIDROGENO O EL RESTO SUB K CIFRAS 0 Y 1, Y R ES UN ATOMO DE HIDROGENO, UN RESTO ALQUILO DE C SUB 1 2 HIDROGENO, UN RESTO ALQUILO DE C SUB 1 NCILO, R (AL CUADRADO) REPRESENTA UN GRUPO ALQUILO DE HASTA 20 ATOMOS DE C, SATURADO, INSATURADO, DE CADENA LINEAL O RAMIFICADA O CICLICO, SUSTITUIDO EVENTUALMENTE POR UN GRUPO CARBOXILO O SULFONILO ESTERIFICADO CON UN RESTO ALQUILO DE C SUB 1 UB 6 O CON UN RESTO BENCILO; UN GRUPO ARILO O UN GRUPO ARALQUILO. R ELEVADO 3 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO DE HASTA 20 ATOMOS DE C, SATURADO, INSATURADO, DE CADENA LINEAL O RAMIFICADA O CICLICO, SUSTITUIDO EVENTUALMENTE POR UN GRUPO CARBOXILO O SULFONILO ESTERIFICADO CON UN RESTO ALQUILO DE C SUB 1 UN GRUPO ARALQUILO, X REPRESENTA UN ATOMO DE HIDROGENO Y/O EL EQUIVALENTE DE UN ION METALICO DE UN ELEMENTO DE N CUADRADO) SEA UN ATOMO DE HIDROGENO, Y QUE -CUANDO N Y L SIGNIFICAN CADAUNO LA CIFRA 0 TE LA CIFRA 1, Y QUE ES DE DESEAR QUE EL RESTO DE LOS GRUPOS ACIDOS ESTE PRESENTE COMO ESTER O COMO AMIDA, ASI COMO EN FORMA DE SUS SALES CON BASES ORGANICAS Y/O INORGANICAS, AMINOACIDOS O AMIDAS DE AMINOACIDOS. ESTOS COMPUESTOS SON VALIOSAS SUSTANCIAS FARMACEUTICAS.
ES91250089T 1990-04-06 1991-04-05 Monoamidas de dtpa, agentes farmaceuticos que contienen estos compuestos, su utilizacion y procedimientos para su preparacion. Expired - Lifetime ES2057746T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4011684A DE4011684A1 (de) 1990-04-06 1990-04-06 Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
ES2057746T3 true ES2057746T3 (es) 1994-10-16

Family

ID=6404192

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91250089T Expired - Lifetime ES2057746T3 (es) 1990-04-06 1991-04-05 Monoamidas de dtpa, agentes farmaceuticos que contienen estos compuestos, su utilizacion y procedimientos para su preparacion.

Country Status (16)

Country Link
US (4) US5859214A (es)
EP (1) EP0450742B1 (es)
JP (1) JP2854159B2 (es)
AT (1) ATE108179T1 (es)
AU (1) AU644639B2 (es)
CA (1) CA2039846A1 (es)
DE (2) DE4011684A1 (es)
DK (1) DK0450742T3 (es)
ES (1) ES2057746T3 (es)
FI (1) FI911646A (es)
HU (1) HUT57180A (es)
IE (1) IE65923B1 (es)
NO (1) NO180582C (es)
NZ (1) NZ237711A (es)
PT (1) PT97263B (es)
ZA (1) ZA912550B (es)

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DE4011684A1 (de) * 1990-04-06 1991-10-10 Schering Ag Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung
US6875864B2 (en) 1991-08-01 2005-04-05 Bracco International B.V. Aminocarboxylate ligands having substituted aromatic amide moieties
EP0603403B2 (en) * 1992-07-03 2001-06-27 Welfide Corporation Novel chelating agent, complex compound composed of said agent and metallic atom, and diagnostic agent containing said compound
WO1994008630A1 (en) * 1992-10-13 1994-04-28 Mallinckrodt Medical, Inc. Novel compositions for magnetic resonance imaging
WO1994008624A2 (en) * 1992-10-14 1994-04-28 Sterling Winthrop Inc. Therapeutic and diagnostic imaging compositions and methods
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US5817292A (en) * 1992-10-14 1998-10-06 Nycomed Imaging As MR imaging compositions and methods
DE4317588C2 (de) * 1993-05-24 1998-04-16 Schering Ag Fluorhaltige makrocyclische Metallkomplexe, Verfahren zu ihrer Herstellung, sowie ihre Verwendung
DE4318369C1 (de) * 1993-05-28 1995-02-09 Schering Ag Verwendung von makrocyclischen Metallkomplexen als Temperatursonden
EP0702677A1 (en) * 1994-04-08 1996-03-27 BRACCO International B.V. Aromatic amide compounds and metal chelates thereof
US5582814A (en) * 1994-04-15 1996-12-10 Metasyn, Inc. 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging
US5672335A (en) * 1994-11-30 1997-09-30 Schering Aktiengesellschaft Use of metal complexes as liver and gallbladder X-ray diagnostic agents
HUT77553A (hu) * 1994-11-30 1998-05-28 Schering Aktiengesellschaft Eljárás fémeket tartalmazó kelát komplexek alkalmazására a máj és az epe röntgendiagnosztikájában
TW319763B (es) 1995-02-01 1997-11-11 Epix Medical Inc
IL117200A0 (en) * 1995-02-21 1996-06-18 Schering Ag Diethylenetriamine-pentaacetic acid monoamide derivatives pharmaceutical compostions containing the same and processes for the preparation thereof
DE19507822B4 (de) * 1995-02-21 2006-07-20 Schering Ag Substituierte DTPA-Monoamide der zentralen Carbonsäure und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel
DE19507820A1 (de) 1995-02-21 1996-08-22 Schering Ag Neuartig substituierte DTPA-Derivate, deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik, sowie Verfahren zur Herstellung der Komplexe und Mittel
DE19507819A1 (de) * 1995-02-21 1996-08-22 Schering Ag DTPA-Monoamide der zentralen Carbonsäure und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel
DE19646762B4 (de) * 1996-11-04 2004-05-13 Schering Ag Verwendung von Metallverbindungen zur Herstellung von Mitteln zur Strahlentherapie von Tumoren
US6334995B1 (en) * 1998-03-24 2002-01-01 Council Of Scientific & Industrial Research Process for the preparation of technetium-99m diethylene triamine penta-acetic acid diester
GB9806530D0 (en) 1998-03-26 1998-05-27 Glaxo Group Ltd Inflammatory mediator
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FI20065030L (fi) * 2006-01-17 2007-07-18 Wallac Oy Neutraaliset leimausreagenssit ja niistä johdetut konjugaatit
JP5563299B2 (ja) * 2006-08-17 2014-07-30 エピックス ファーマシューティカルズ，インコーポレイテッド リンパ系撮像方法
WO2009143618A1 (en) * 2008-05-28 2009-12-03 Sixtron Advanced Materials, Inc. Silicon carbide-based antireflective coating
CN102549438B (zh) 2009-09-24 2014-10-29 国家健康与医学研究院 Fkbp52-tau相互作用作为新颖治疗靶点用于治疗涉及tau机能失调的神经障碍
US20140296106A1 (en) 2011-05-16 2014-10-02 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for screening substances capable of modulating the replication of an influenza virus
US20150276760A1 (en) 2012-10-04 2015-10-01 INSERM (Institut National de la Sante Et de la Recherche Medicate) Method for Screening a Compound Capable of Inhibiting the Notch1 Transcriptional Activity
US20170051062A1 (en) 2014-02-18 2017-02-23 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and Pharmaceutical Compositions for the Treatment of Diseases Mediated by the NRP-1/OBR Complex Signaling Pathway
ES2796857T3 (es) 2014-04-17 2020-11-30 Inst Nat Sante Rech Med Polipéptidos y usos de los mismos para reducir la motilidad celular mediada por CD95
CA3057976A1 (en) * 2017-04-27 2018-11-01 The Regents Of The University Of California Modified mri contrast agents and uses thereof
US11008354B2 (en) * 2018-05-24 2021-05-18 The Texas A&M University System Chiral solvating agents
WO2020144324A1 (en) 2019-01-11 2020-07-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for screening inhibitors against chikungunya virus and for determining whether subjects are predisposed to infection by said virus
CN115043747B (zh) * 2022-08-15 2022-11-25 康瑞鑫(天津)药物研究院有限公司 卡洛酸三钠的析晶方法及制备的卡洛酸三钠晶体

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Also Published As

Publication number Publication date
AU7418691A (en) 1991-10-10
EP0450742B1 (de) 1994-07-06
ATE108179T1 (de) 1994-07-15
CA2039846A1 (en) 1991-10-07
NO911345L (no) 1991-10-07
DE4011684A1 (de) 1991-10-10
DK0450742T3 (da) 1994-11-07
FI911646A0 (fi) 1991-04-05
NO180582B (no) 1997-02-03
IE911155A1 (en) 1991-10-09
AU644639B2 (en) 1993-12-16
US6565830B1 (en) 2003-05-20
DE59102092D1 (de) 1994-08-18
ZA912550B (en) 1992-01-29
NO911345D0 (no) 1991-04-05
PT97263A (pt) 1992-01-31
US6287538B1 (en) 2001-09-11
US7074387B2 (en) 2006-07-11
HUT57180A (en) 1991-11-28
JP2854159B2 (ja) 1999-02-03
JPH0665174A (ja) 1994-03-08
PT97263B (pt) 1998-08-31
NO180582C (no) 1997-05-14
US5859214A (en) 1999-01-12
EP0450742A1 (de) 1991-10-09
FI911646A (fi) 1991-10-07
IE65923B1 (en) 1995-11-29
NZ237711A (en) 1993-12-23
HU911126D0 (en) 1991-10-28
US20030202943A1 (en) 2003-10-30

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