PT97263A - Processo para a preparacao de monoamidas de dtpa e de composicoes farmaceuticas que as contem - Google Patents

Processo para a preparacao de monoamidas de dtpa e de composicoes farmaceuticas que as contem

Info

Publication number
PT97263A
PT97263A PT97263A PT9726391A PT97263A PT 97263 A PT97263 A PT 97263A PT 97263 A PT97263 A PT 97263A PT 9726391 A PT9726391 A PT 9726391A PT 97263 A PT97263 A PT 97263A
Authority
PT
Portugal
Prior art keywords
group
hydrogen atom
radical
alkyl
denote
Prior art date
Application number
PT97263A
Other languages
English (en)
Other versions
PT97263B (pt
Inventor
Bernd Raduchel
Heribert Schmitt-Willich
Heinz Gries
Gabriele Schuhmann-Giampieri
Hubert Vogler
Jurgen Conrad
Hans-Joachim Weinmann
Erich Klieger
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of PT97263A publication Critical patent/PT97263A/pt
Publication of PT97263B publication Critical patent/PT97263B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02—Iron compounds
    • C07F15/025—Iron compounds without a metal-carbon linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT97263A 1990-04-06 1991-04-05 Processo para a preparacao de monoamidas de dtpa e de composicoes farmaceuticas que as contem PT97263B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4011684A DE4011684A1 (de) 1990-04-06 1990-04-06 Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung

Publications (2)

Publication Number Publication Date
PT97263A true PT97263A (pt) 1992-01-31
PT97263B PT97263B (pt) 1998-08-31

Family

ID=6404192

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97263A PT97263B (pt) 1990-04-06 1991-04-05 Processo para a preparacao de monoamidas de dtpa e de composicoes farmaceuticas que as contem

Country Status (16)

Country Link
US (4) US5859214A (pt)
EP (1) EP0450742B1 (pt)
JP (1) JP2854159B2 (pt)
AT (1) ATE108179T1 (pt)
AU (1) AU644639B2 (pt)
CA (1) CA2039846A1 (pt)
DE (2) DE4011684A1 (pt)
DK (1) DK0450742T3 (pt)
ES (1) ES2057746T3 (pt)
FI (1) FI911646A (pt)
HU (1) HUT57180A (pt)
IE (1) IE65923B1 (pt)
NO (1) NO180582C (pt)
NZ (1) NZ237711A (pt)
PT (1) PT97263B (pt)
ZA (1) ZA912550B (pt)

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US6875864B2 (en) 1991-08-01 2005-04-05 Bracco International B.V. Aminocarboxylate ligands having substituted aromatic amide moieties
DK0603403T4 (da) * 1992-07-03 2002-12-16 Welfide Corp Nyt chelaterende middel, kompleksforbindelse mellem dette middel og et metalatom og diagnostisk middel indeholdende denne forbindelse
AU5360994A (en) * 1992-10-13 1994-05-09 Mallinckrodt Medical, Inc. Novel compositions for magnetic resonance imaging
US5817292A (en) * 1992-10-14 1998-10-06 Nycomed Imaging As MR imaging compositions and methods
CA2146990A1 (en) * 1992-10-14 1994-04-28 Robert A. Snow Chelating polymers
EP0664713B1 (en) * 1992-10-14 2000-01-19 Nycomed Imaging As Therapeutic and diagnostic imaging compositions and methods
DE4317588C2 (de) * 1993-05-24 1998-04-16 Schering Ag Fluorhaltige makrocyclische Metallkomplexe, Verfahren zu ihrer Herstellung, sowie ihre Verwendung
DE4318369C1 (de) * 1993-05-28 1995-02-09 Schering Ag Verwendung von makrocyclischen Metallkomplexen als Temperatursonden
WO1995027705A1 (en) * 1994-04-08 1995-10-19 Bracco International B.V. Aromatic amide compounds and metal chelates thereof
US5582814A (en) * 1994-04-15 1996-12-10 Metasyn, Inc. 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging
US5672335A (en) * 1994-11-30 1997-09-30 Schering Aktiengesellschaft Use of metal complexes as liver and gallbladder X-ray diagnostic agents
CA2206558A1 (en) * 1994-11-30 1996-06-06 Schering Aktiengesellschaft Use of metal complexes as x-ray diagnostic agents for the liver and gallbladder
TW319763B (pt) 1995-02-01 1997-11-11 Epix Medical Inc
DE19507820A1 (de) 1995-02-21 1996-08-22 Schering Ag Neuartig substituierte DTPA-Derivate, deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik, sowie Verfahren zur Herstellung der Komplexe und Mittel
DE19507822B4 (de) * 1995-02-21 2006-07-20 Schering Ag Substituierte DTPA-Monoamide der zentralen Carbonsäure und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel
IL117200A0 (en) * 1995-02-21 1996-06-18 Schering Ag Diethylenetriamine-pentaacetic acid monoamide derivatives pharmaceutical compostions containing the same and processes for the preparation thereof
DE19507819A1 (de) * 1995-02-21 1996-08-22 Schering Ag DTPA-Monoamide der zentralen Carbonsäure und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel
DE19646762B4 (de) * 1996-11-04 2004-05-13 Schering Ag Verwendung von Metallverbindungen zur Herstellung von Mitteln zur Strahlentherapie von Tumoren
US6334995B1 (en) * 1998-03-24 2002-01-01 Council Of Scientific & Industrial Research Process for the preparation of technetium-99m diethylene triamine penta-acetic acid diester
GB9806530D0 (en) 1998-03-26 1998-05-27 Glaxo Group Ltd Inflammatory mediator
GB9823175D0 (en) * 1998-10-22 1998-12-16 Nycomed Imaging As Compound
JP2008510806A (ja) * 2004-08-26 2008-04-10 マリンクロッド・インコーポレイテッド 腎機能監視用の発光金属錯体
FI20065030L (fi) * 2006-01-17 2007-07-18 Wallac Oy Neutraaliset leimausreagenssit ja niistä johdetut konjugaatit
KR101336505B1 (ko) * 2006-08-17 2013-12-05 에픽스 파마슈티칼스, 인코포레이티드 림프계의 영상화 방법
US20110146787A1 (en) * 2008-05-28 2011-06-23 Sebastien Allen Silicon carbide-based antireflective coating
EP2480891B1 (en) 2009-09-24 2016-11-23 INSERM - Institut National de la Santé et de la Recherche Médicale Fkbp52-tau interaction as a novel therapeutical target for treating the neurological disorders involving tau dysfunction
US20140296106A1 (en) 2011-05-16 2014-10-02 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for screening substances capable of modulating the replication of an influenza virus
US20150276760A1 (en) 2012-10-04 2015-10-01 INSERM (Institut National de la Sante Et de la Recherche Medicate) Method for Screening a Compound Capable of Inhibiting the Notch1 Transcriptional Activity
EP3108255B1 (en) 2014-02-18 2020-08-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of diseases mediated by the nrp-1/obr complex signaling pathway
WO2015158810A1 (en) 2014-04-17 2015-10-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Polypeptides and uses thereof for reducing cd95-mediated cell motility
US20200046859A1 (en) * 2017-04-27 2020-02-13 The Regents Of The University Of California Modified mri contrast agents and uses thereof
US11008354B2 (en) * 2018-05-24 2021-05-18 The Texas A&M University System Chiral solvating agents
ES2942917T3 (es) 2019-01-11 2023-06-07 Inst Nat Sante Rech Med Métodos para cribar inhibidores contra el virus de chikungunya y para determinar si los sujetos tienen predisposición a infección por dicho virus
CN115043747B (zh) * 2022-08-15 2022-11-25 康瑞鑫(天津)药物研究院有限公司 卡洛酸三钠的析晶方法及制备的卡洛酸三钠晶体

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Also Published As

Publication number Publication date
IE65923B1 (en) 1995-11-29
AU644639B2 (en) 1993-12-16
FI911646A0 (fi) 1991-04-05
AU7418691A (en) 1991-10-10
US6287538B1 (en) 2001-09-11
ATE108179T1 (de) 1994-07-15
US5859214A (en) 1999-01-12
NO180582C (no) 1997-05-14
JP2854159B2 (ja) 1999-02-03
JPH0665174A (ja) 1994-03-08
HU911126D0 (en) 1991-10-28
DK0450742T3 (da) 1994-11-07
DE4011684A1 (de) 1991-10-10
ES2057746T3 (es) 1994-10-16
NO180582B (no) 1997-02-03
US20030202943A1 (en) 2003-10-30
EP0450742B1 (de) 1994-07-06
ZA912550B (en) 1992-01-29
NZ237711A (en) 1993-12-23
DE59102092D1 (de) 1994-08-18
CA2039846A1 (en) 1991-10-07
IE911155A1 (en) 1991-10-09
US7074387B2 (en) 2006-07-11
FI911646A (fi) 1991-10-07
US6565830B1 (en) 2003-05-20
PT97263B (pt) 1998-08-31
NO911345D0 (no) 1991-04-05
NO911345L (no) 1991-10-07
EP0450742A1 (de) 1991-10-09
HUT57180A (en) 1991-11-28

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Effective date: 19910911

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Effective date: 19980506

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