PT93753A - Processo para a preparacao de compostos azabiciclicos - Google Patents

Processo para a preparacao de compostos azabiciclicos

Info

Publication number
PT93753A
PT93753A PT93753A PT9375390A PT93753A PT 93753 A PT93753 A PT 93753A PT 93753 A PT93753 A PT 93753A PT 9375390 A PT9375390 A PT 9375390A PT 93753 A PT93753 A PT 93753A
Authority
PT
Portugal
Prior art keywords
group
preparation
alkyl
chem
integer
Prior art date
Application number
PT93753A
Other languages
English (en)
Other versions
PT93753B (pt
Inventor
Steven Dabbs
Barry Sidney Orlek
Steven Mark Bromidge
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898908365A external-priority patent/GB8908365D0/en
Priority claimed from GB898923299A external-priority patent/GB8923299D0/en
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of PT93753A publication Critical patent/PT93753A/pt
Publication of PT93753B publication Critical patent/PT93753B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PT93753A 1989-04-13 1990-04-12 Processo para a preparacao de compostos azabiciclicos PT93753B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898908365A GB8908365D0 (en) 1989-04-13 1989-04-13 Novel compounds
GB898923299A GB8923299D0 (en) 1989-10-16 1989-10-16 Novel compounds

Publications (2)

Publication Number Publication Date
PT93753A true PT93753A (pt) 1990-11-20
PT93753B PT93753B (pt) 1996-08-30

Family

ID=26295213

Family Applications (1)

Application Number Title Priority Date Filing Date
PT93753A PT93753B (pt) 1989-04-13 1990-04-12 Processo para a preparacao de compostos azabiciclicos

Country Status (12)

Country Link
US (1) USRE35593E (pt)
EP (1) EP0392803B1 (pt)
JP (3) JP2665818B2 (pt)
KR (1) KR0185378B1 (pt)
AT (1) ATE269330T1 (pt)
CA (1) CA2014379C (pt)
DE (1) DE69034146T2 (pt)
DK (1) DK0392803T3 (pt)
ES (1) ES2219636T3 (pt)
NZ (1) NZ233290A (pt)
PT (1) PT93753B (pt)
SG (1) SG48315A1 (pt)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5362739A (en) * 1990-08-24 1994-11-08 Beecham Group P.L.C. Azabicyclic compounds and pharmaceutical compositions containing them
GB9019095D0 (en) * 1990-09-01 1990-10-17 Beecham Group Plc Novel compounds
EP0552213A1 (en) * 1990-10-12 1993-07-28 Beecham Group Plc 1,2,5,6-tetrahydropyridine oxime derivatives
WO1992011261A1 (en) * 1990-12-21 1992-07-09 Merck Sharp & Dohme Limited 4-azatricyclo[2.2.1.02,6]heptanes and pharmaceutical compositions
MX9300875A (es) * 1992-02-20 1993-08-31 Smithkline Beecham Plc Procedimiento para la preparacion de compuestos azabiciclicos.
GB9409718D0 (en) * 1994-05-14 1994-07-06 Smithkline Beecham Plc Novel compounds
GB9409705D0 (en) * 1994-05-14 1994-07-06 Smithkline Beecham Plc Novel compounds
GB9421472D0 (en) * 1994-10-25 1994-12-07 Smithkline Beecham Plc Novel methods
AU751607B2 (en) * 1995-07-29 2002-08-22 Smithkline Beecham Plc Method of treatment of dementia
AR004178A1 (es) * 1995-07-29 1998-11-04 Smithkline Beecham Plc Procedimiento para la formulacion de un farmaco, una composicion farmaceutica obtenible mediante este procedimiento y el uso de la misma.
BR9708947A (pt) * 1996-05-13 1999-08-03 Zeneca Ltd Composto composição inseticida acaricida e nematicida método para combate e controle de pragas e processo para preparação de um composto
GB9615628D0 (en) * 1996-07-25 1996-09-04 Smithkline Beecham Plc Formulation
GB9619074D0 (en) * 1996-09-12 1996-10-23 Smithkline Beecham Plc Composition
US20010003588A1 (en) * 1996-09-12 2001-06-14 Smithkline Beecham Corporation Controlled release dosage form of [R-(Z)]-alpha-(methoxyimino)-alpha-(1-azabicyclo[2.2.2.]oct-3-yl)acetonitrile monohydrochloride
US6284771B1 (en) * 1997-04-11 2001-09-04 Eli Lilly And Company Method for treating schizophrenia
GB9815383D0 (en) * 1998-07-15 1998-09-16 Smithkline Beecham Plc Novel method of treatment
KR20030021641A (ko) * 2001-09-07 2003-03-15 안병로 투명비누 자가제조용 키트 및 상기 키트를 이용한투명비누 자가제조방법
WO2007025177A2 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
EP2377530A3 (en) 2005-10-21 2012-06-20 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
EP1942879A1 (en) 2005-10-31 2008-07-16 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
GB0607952D0 (en) * 2006-04-21 2006-05-31 Minster Res Ltd Novel treatment
GB0607946D0 (en) * 2006-04-21 2006-05-31 Minster Res The Ltd Mono and combination therapy
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
EP2021000A2 (en) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenesis by modulating angiotensin
BRPI0716604A2 (pt) 2006-09-08 2013-04-09 Braincells Inc combinaÇÕes contendo um derivado de 4-acilaminopiridina
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
KR102287645B1 (ko) 2018-12-18 2021-08-06 한화솔루션 주식회사 실리카계 촉매를 이용한 배위-음이온 개환 중합에 의한 폴리아마이드의 제조방법 및 이에 의해 제조된 폴리아마이드
WO2026013570A1 (en) * 2024-07-09 2026-01-15 Syremis Therapeutics Ltd. New salt forms of sabcomeline
WO2026013566A1 (en) * 2024-07-09 2026-01-15 Syremis Therapeutics Ltd. New salt forms of sabcomeline
WO2026013573A1 (en) * 2024-07-09 2026-01-15 Syremis Therapeutics Ltd. New salt forms of sabcomeline
WO2026013563A1 (en) * 2024-07-09 2026-01-15 Syremis Therapeutics Ltd. New salt forms of sabcomeline
WO2026018154A1 (en) 2024-07-16 2026-01-22 Syremis Therapeutics Ltd. Combinations of sabcomeline with non-cns penetrant muscarinic antagonists
WO2026018155A1 (en) 2024-07-16 2026-01-22 Syremis Therapeutics Ltd. Combinations of sabcomeline with long-acting non-cns penetrant muscarinic antagonists

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU563225B2 (en) * 1982-04-14 1987-07-02 Alizyme Therapeutics Limited I-aza bicyclic compounds
FR2531955A1 (fr) * 1982-08-17 1984-02-24 Pharmuka Lab Nouveau procede de preparation de derives de la quinuclidine substitues en position 3
IL81610A (en) * 1986-02-27 1990-12-23 Roussel Uclaf Derivatives of 1,2,5,6-tetrahydropyridin-3-carboxaldehyde oxime,their preparation and pharmaceutical compositions containing them
ES2061502T3 (es) * 1986-06-27 1994-12-16 Beecham Group Plc Nuevos n-heterociclos biciclicos puenteados.
GB8615785D0 (en) * 1986-06-27 1986-08-06 Beecham Group Plc Compounds
US4710508A (en) * 1986-12-08 1987-12-01 Warner-Lambert Company O-substituted tetrahydropyridine oxime cholinergic agents
US4786648A (en) * 1986-12-08 1988-11-22 Warner-Lambert Company O-substituted tetrahydropyridine oxime cholinergic agents
US4798841A (en) * 1987-03-31 1989-01-17 Warner-Lambert Company Tetrahydropyridine oxime cholinergic agents and method of treatment
AU614513B2 (en) * 1987-04-15 1991-09-05 Beecham Group Plc 1-azabicyclic compounds
IT1203971B (it) * 1987-04-24 1989-02-23 Roussel Maestretti Spa Derivati di 1,2,5,6-tetraidropiridina, loro procedimento di preparazione e loro applicazione come medicamenti
IT1222526B (it) * 1987-08-21 1990-09-05 Roussel Maestretti Spa Derivati dell' ossima della 1,2,5,6-tetraidropiridin-3-carbossaldeide,loro procedimento di preparazione e loro impiego come sostanze medicinali
IT1222529B (it) * 1987-08-21 1990-09-05 Roussel Maestretti Spa Derivati dell' ossima della 1,2,5,6-tetraidropirdin-3-carbossaldeide,loro procedimento di preparazione e loro impiego come sostanze medicinali
IE63906B1 (en) * 1987-11-13 1995-06-14 Novo Nordisk As Azabicyclic compounds and their preparation and use
DE3738521C1 (de) * 1987-11-13 1988-12-01 Delta Getriebe Gmbh Planetengetriebe
IT1233446B (it) * 1987-12-30 1992-04-01 Roussel Maestretti Spa Derivati della 3 piperidinocarbaldeide ossima, loro procedimento di preparazione e loro applicazione come farmaci
AU3301689A (en) * 1988-04-15 1989-10-26 Beecham Group Plc 1-azabicyclo-alkyl derivatives
IT1227436B (it) * 1988-10-28 1991-04-11 Roussel Maestretti Spa Derivati di 1-azabicicloalcani, loro procedimento di preparazione e loro applicazione come farmaci
US4937239A (en) * 1989-02-13 1990-06-26 Warner-Lambert Company Azabicycloalkane oxime & azabicycloalkene oxime muscarinic agents
EP0402056A3 (en) * 1989-06-06 1991-09-04 Beecham Group p.l.c. Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
USRE35593E (en) 1997-08-19
CA2014379A1 (en) 1990-10-13
DE69034146T2 (de) 2005-07-14
CA2014379C (en) 2000-02-08
DE69034146D1 (de) 2004-07-22
AU5315990A (en) 1990-10-18
ES2219636T3 (es) 2004-12-01
HK1012365A1 (en) 1999-07-30
ATE269330T1 (de) 2004-07-15
SG48315A1 (en) 1998-04-17
JPH09188678A (ja) 1997-07-22
JP2913467B2 (ja) 1999-06-28
KR900016211A (ko) 1990-11-12
EP0392803B1 (en) 2004-06-16
PT93753B (pt) 1996-08-30
EP0392803A1 (en) 1990-10-17
JP2665818B2 (ja) 1997-10-22
DK0392803T3 (da) 2004-10-18
KR0185378B1 (ko) 1999-05-01
JP2913466B2 (ja) 1999-06-28
JPH09188679A (ja) 1997-07-22
NZ233290A (en) 1992-06-25
AU619969B2 (en) 1992-02-06
JPH037285A (ja) 1991-01-14

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19960528

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20110530