NO342119B1 - Medikamentdispenser - Google Patents
Medikamentdispenser Download PDFInfo
- Publication number
- NO342119B1 NO342119B1 NO20080474A NO20080474A NO342119B1 NO 342119 B1 NO342119 B1 NO 342119B1 NO 20080474 A NO20080474 A NO 20080474A NO 20080474 A NO20080474 A NO 20080474A NO 342119 B1 NO342119 B1 NO 342119B1
- Authority
- NO
- Norway
- Prior art keywords
- drug
- cover
- dispenser
- medicine
- stated
- Prior art date
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- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
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Landscapes
- Health & Medical Sciences (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| GBGB0515584.1A GB0515584D0 (en) | 2005-07-28 | 2005-07-28 | Medicament dispenser |
| PCT/GB2006/002831 WO2007012871A1 (en) | 2005-07-28 | 2006-07-27 | Medicament dispenser |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20080474L NO20080474L (no) | 2008-04-24 |
| NO342119B1 true NO342119B1 (no) | 2018-03-26 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20080474A NO342119B1 (no) | 2005-07-28 | 2008-01-25 | Medikamentdispenser |
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| EP (1) | EP1907037B2 (enExample) |
| JP (2) | JP5107918B2 (enExample) |
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| NZ (1) | NZ565437A (enExample) |
| PL (1) | PL1907037T5 (enExample) |
| PT (1) | PT1907037T (enExample) |
| WO (1) | WO2007012871A1 (enExample) |
| ZA (1) | ZA200800693B (enExample) |
Families Citing this family (158)
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| GB0317374D0 (en) | 2003-07-24 | 2003-08-27 | Glaxo Group Ltd | Medicament dispenser |
| GB0418278D0 (en) | 2004-08-16 | 2004-09-15 | Glaxo Group Ltd | Medicament dispenser |
| GB0427856D0 (en) | 2004-12-20 | 2005-01-19 | Glaxo Group Ltd | Maniflod for use in medicament dispenser |
| GB0427858D0 (en) | 2004-12-20 | 2005-01-19 | Glaxo Group Ltd | Manifold for use in medicament dispenser |
| GB0515584D0 (en) | 2005-07-28 | 2005-09-07 | Glaxo Group Ltd | Medicament dispenser |
| AR058289A1 (es) | 2005-12-12 | 2008-01-30 | Glaxo Group Ltd | Colector para ser usado en dispensador de medicamento |
| AR058290A1 (es) * | 2005-12-12 | 2008-01-30 | Glaxo Group Ltd | Dispensador de medicamento |
| USD613848S1 (en) | 2006-02-16 | 2010-04-13 | Glaxo Group Limited | Inhalation device |
| USD623054S1 (en) * | 2006-04-28 | 2010-09-07 | Vectura Delivery Devices Limited | Dispenser |
| DK2046787T3 (da) | 2006-08-01 | 2011-07-18 | Glaxo Group Ltd | Pyrazolo[3,4-B]pyridin-forbindelser, og deres anvendelse som PDE4-inhibitorer |
| GB0622827D0 (en) | 2006-11-15 | 2006-12-27 | Glaxo Group Ltd | Sheet driver for use in a drug dispenser |
| GB0704928D0 (en) * | 2007-03-14 | 2007-04-25 | Cambridge Consultants | Dry powder inhalers |
| FR2924352B1 (fr) | 2007-12-03 | 2010-01-29 | Valois Sas | Dispositif de distribution de produit fluide. |
| WO2009079078A1 (en) | 2007-12-14 | 2009-06-25 | Labogroup S.A.S. | Delivering aerosolizable food products |
| CA2711907A1 (en) * | 2008-01-23 | 2009-07-30 | Astrazeneca Ab | A medicament -containing dispenser provided with a display for presenting indicia to a user |
| EP2082758A1 (en) * | 2008-01-24 | 2009-07-29 | Boehringer Ingelheim International GmbH | Inhaler |
| EP2082772A1 (en) * | 2008-01-24 | 2009-07-29 | Vectura Delivery Devices Limited | Inhaler |
| EP2082765A1 (en) * | 2008-01-24 | 2009-07-29 | Boehringer Ingelheim International GmbH | Inhaler |
| EP2082770A1 (en) * | 2008-01-24 | 2009-07-29 | Vectura Delivery Devices Limited | Inhaler |
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| EP2082771A1 (en) | 2008-01-24 | 2009-07-29 | Vectura Delivery Devices Limited | Inhaler |
| EP2285440B2 (en) | 2008-05-02 | 2018-10-24 | Boehringer Ingelheim International GmbH | Inhaler |
| FR2931137B1 (fr) * | 2008-05-13 | 2012-03-30 | Valois Sas | Dispositif de distribution de produit fluide |
| TR200803523A1 (tr) * | 2008-05-16 | 2009-12-21 | Bi̇lgi̇ç Mahmut | Şerit ambalaj içeren düzenek |
| CA2732826C (en) | 2008-09-26 | 2017-08-22 | Oriel Therapeutics, Inc. | Inhaler mechanisms with radially biased piercers and related methods |
| AU2009296535B2 (en) | 2008-09-26 | 2013-04-18 | Oriel Therapeutics, Inc. | Dry powder inhalers with dual piercing members and related devices and methods |
| ES2570128T3 (es) | 2008-09-26 | 2016-05-17 | Oriel Therapeutics Inc | Inhaladores con discos que tienen conductos de aire equipados con canales discretos de conductos de aire y discos y métodos relacionados |
| US9050427B2 (en) | 2008-09-30 | 2015-06-09 | Oriel Therapeutics, Inc. | Dry powder inhalers with multi-facet surface deagglomeration chambers and related devices and methods |
| BRPI0920671A2 (pt) * | 2008-10-08 | 2019-07-09 | Astrazeneca Ab | inalador com meio indicador audível |
| GB201020130D0 (en) * | 2010-11-26 | 2011-01-12 | Vectura Delivery Devices Ltd | Inhaler |
| US8763608B2 (en) | 2008-10-09 | 2014-07-01 | Vectura Delivery Devices Limited | Inhaler |
| JP2009143234A (ja) * | 2008-12-24 | 2009-07-02 | Nippon Mining & Metals Co Ltd | キャリア付金属箔 |
| JP2009143233A (ja) * | 2008-12-24 | 2009-07-02 | Nippon Mining & Metals Co Ltd | キャリア付金属箔 |
| ES2739352T3 (es) | 2009-02-26 | 2020-01-30 | Glaxo Group Ltd | Formulaciones farmacéuticas que comprenden 4-{(1R)-2-[(6-{2-[(2,6-diclorobencil)oxi]etoxi}hexil)amino]-1-hidroxietil}-2-(hidroximetil)fenol |
| ES2662769T3 (es) * | 2009-05-18 | 2018-04-09 | Adamis Pharmaceuticals Corporation | Contadores de dosis de inhalador de polvo seco |
| EA021160B1 (ru) | 2009-05-18 | 2015-04-30 | Нортон Хэлткэа Лимитед | Сухопорошковый ингалятор |
| PL2432530T3 (pl) * | 2009-05-18 | 2015-04-30 | Norton Healthcare Ltd | Inhalator do suchego proszku |
| EP2432533B1 (en) * | 2009-05-18 | 2015-07-01 | Norton Healthcare Limited | Dry-powder inhaler |
| GB0910537D0 (en) * | 2009-06-18 | 2009-07-29 | Ivax Pharmaceuticals Ireland | Inhaler |
| WO2011000669A1 (de) * | 2009-07-03 | 2011-01-06 | Boehringer Ingelheim International Gmbh | Verpackungen mit adsorbens für arzneimittel |
| TR200907238A2 (tr) | 2009-09-23 | 2011-04-21 | Bi̇lgi̇ç Mahmut | Tiotropyum içeren kombinasyonun blisterde taşınması. |
| TR200907236A2 (tr) * | 2009-09-23 | 2011-04-21 | Bi̇lgi̇ç Mahmut | Tiotropyum kuru toz formülasyonunun blister ambalajda taşınması. |
| TR200907913A2 (tr) | 2009-10-20 | 2011-05-23 | Bi̇lgi̇ç Mahmut | İnhalason yolu ile alınmak üzere kuru toz formunda farmasötik bileşim |
| TR200907915A2 (tr) | 2009-10-20 | 2011-05-23 | Bi̇lgi̇ç Mahmut | Kuru toz formunda farmasötik bileşim. |
| WO2011129788A1 (en) | 2010-04-13 | 2011-10-20 | Mahmut Bilgic | User-friendly dry powder inhaler |
| US9345848B2 (en) * | 2009-10-20 | 2016-05-24 | Sima Patent Ve Lisanslama Hizmetleri Ltd. Sti. | Dry powder inhaler |
| TR200907917A2 (tr) | 2009-10-20 | 2011-05-23 | Bi̇lgi̇ç Mahmut | Kuru toz inhaleri. |
| GB0921075D0 (en) | 2009-12-01 | 2010-01-13 | Glaxo Group Ltd | Novel combination of the therapeutic agents |
| KR101046545B1 (ko) | 2009-12-22 | 2011-07-05 | 제이엑스 닛코 닛세키 킨조쿠 가부시키가이샤 | 적층체의 제조 방법 및 적층체 |
| USD641076S1 (en) | 2010-03-26 | 2011-07-05 | Oriel Therapeutics, Inc. | Dry powder inhaler |
| EP2566551B1 (en) * | 2010-04-13 | 2016-03-30 | Sima Patent ve Lisanslama Hizmetleri Ltd.Sti. | Inhalation device |
| DK2558148T3 (en) * | 2010-04-13 | 2016-07-25 | Sima Patent Ve Lisanslama Hizmetleri Ltd Sti | BRUSH BUTTON dry powder inhaler |
| EP2566546B1 (en) * | 2010-04-13 | 2016-03-30 | Sima Patent ve Lisanslama Hizmetleri Ltd.Sti. | Dry powder inhaler mouthpiece button |
| GB201006759D0 (en) * | 2010-04-23 | 2010-06-09 | 3M Innovative Properties Co | An inhaler |
| ES2705494T3 (es) | 2010-08-31 | 2019-03-25 | Glaxosmithkline Ip Dev Ltd | Productos farmacológicos para la inhalación de polvo seco que presentan propiedades de control de la humedad y procedimientos de administración de los mismos |
| EP2611423B2 (en) | 2010-08-31 | 2022-09-21 | GlaxoSmithKline Intellectual Property Development Limited | Dry powder inhalation drug products exhibiting moisture control properties and methods of administering the same |
| BR112013007371A2 (pt) * | 2010-09-30 | 2016-07-12 | Novartis Ag | inalador. |
| WO2012084017A1 (de) * | 2010-12-21 | 2012-06-28 | Boehringer Ingelheim International Gmbh | Verpackungen mit adsorbens für arzneimittel |
| USD687946S1 (en) | 2011-04-20 | 2013-08-13 | 3M Innovative Properties Company | Inhaler |
| USD687947S1 (en) | 2011-04-20 | 2013-08-13 | 3M Innovative Properties Company | Inhaler |
| USD687945S1 (en) | 2011-04-20 | 2013-08-13 | 3M Innovative Properties Company | Inhaler |
| CA2838030A1 (en) | 2011-06-08 | 2012-12-13 | Glaxo Group Limited | Combination comprising umeclidinium and a corticosteroid |
| RU2013153202A (ru) | 2011-06-08 | 2015-07-20 | Глаксо Груп Лимитед | Композиции для ингалятора сухого порошка, содержащие умеклидиний |
| US9849255B2 (en) | 2011-11-25 | 2017-12-26 | Mahmut Bilgic | Inhalation device |
| KR101831217B1 (ko) | 2011-12-27 | 2018-02-22 | 벡투라 게엠베하 | 피드백 시스템을 가지는 흡입 장치 |
| ES2814336T3 (es) | 2012-04-13 | 2021-03-26 | Glaxosmithkline Ip Dev Ltd | Partículas de agregado |
| GB2502348A (en) * | 2012-05-25 | 2013-11-27 | Vectura Delivery Devices Ltd | Inhaler with blister piercing mechanism |
| JP5995339B2 (ja) | 2012-05-25 | 2016-09-21 | アーヴェン イラチュ サナイ ヴェ ティヂャレット エー． エス．Ａｒｖｅｎ Ｉｌａｃ Ｓａｎａｙｉ Ｖｅ Ｔｉｃａｒｅｔ Ａ．Ｓ． | 吸入装置のトリガー機構 |
| US20150096563A1 (en) * | 2012-05-25 | 2015-04-09 | Arven Ilac Sanayi Ve Ticaret A.S. | Inhaler comprising a inner body having an air channel |
| GB201222679D0 (en) | 2012-12-17 | 2013-01-30 | Glaxo Group Ltd | Pharmaceutical combination products |
| AU353859S (en) | 2013-04-11 | 2014-02-25 | Glaxo Group Ltd | Inhaler |
| JP5842019B2 (ja) * | 2014-02-28 | 2016-01-13 | 大和製罐株式会社 | 吸入器 |
| WO2015030242A1 (ja) * | 2013-09-02 | 2015-03-05 | 大和製罐株式会社 | 吸入器 |
| JP5842020B2 (ja) * | 2014-02-28 | 2016-01-13 | 大和製罐株式会社 | 吸入器 |
| TWD166977S (zh) * | 2013-09-26 | 2015-04-01 | 大和製罐股份有限公司 | 粉末醫藥品吸入器用吹嘴 |
| GB201321717D0 (en) * | 2013-12-09 | 2014-01-22 | Pharmachemie Bv | Inhalable Medicaments |
| US10987363B2 (en) | 2014-05-28 | 2021-04-27 | Glaxosmithkline Intellectual Property Development Limited | Fluticasone furoate in the treatment of COPD |
| CA2965759C (en) | 2014-10-31 | 2023-12-12 | Glaxosmithkline Intellectual Property Development Limited | Powdered polypeptides with decreased disulfide impurities comprising divalent cationic materials |
| AU2016205562A1 (en) | 2015-01-09 | 2017-06-15 | Adherium (Nz) Limited | Monitor for a medicament inhaler |
| GB201503720D0 (en) | 2015-03-05 | 2015-04-22 | Glaxosmithkline Ip No 2 Ltd | Chemical compound |
| AU2016231122A1 (en) | 2015-03-11 | 2017-09-07 | Glaxosmithkline Intellectual Property Development Limited | TSLP binding proteins |
| GB201504689D0 (en) | 2015-03-19 | 2015-05-06 | Glaxosmithkline Ip Dev Ltd | Chemical compounds |
| ES2910938T3 (es) | 2015-06-15 | 2022-05-17 | Glaxosmithkline Ip Dev Ltd | Reguladores de NRF2 |
| CN107709306A (zh) | 2015-06-15 | 2018-02-16 | 葛兰素史密斯克莱知识产权发展有限公司 | Nrf2调节剂 |
| PT3307739T (pt) | 2015-06-15 | 2021-01-04 | Glaxosmithkline Ip Dev Ltd | Reguladores de nrf2 |
| NZ739315A (en) * | 2015-07-20 | 2018-09-28 | Vectura Delivery Devices Ltd | Dry powder inhaler |
| USD777904S1 (en) * | 2015-08-12 | 2017-01-31 | Reciprocal Labs Corporation | Usage monitoring attachment for an inhaler |
| USD861852S1 (en) * | 2015-08-13 | 2019-10-01 | Adherium (Nz) Limited | Compliance monitor for a medicament inhaler |
| UY36851A (es) | 2015-08-16 | 2017-03-31 | Glaxosmithkline Ip Dev Ltd | Compuestos para uso en aplicaciones antibacterianas |
| US10364256B2 (en) | 2015-10-06 | 2019-07-30 | Glaxosmithkline Intellectual Property Development Limited | Biaryl pyrazoles as NRF2 regulators |
| JP2018529744A (ja) | 2015-10-06 | 2018-10-11 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | Ｎｒｆ２レギュレーターとしてのアリールシクロヘキシルピラゾール |
| BR112018009899A8 (pt) | 2015-11-18 | 2019-02-26 | Glaxosmithkline Ip No 2 Ltd | composição, inalador, forma de dosagem única, métodos para fabricar partículas, para melhorar as exacerbações induzidas por infecção respiratória de um distúrbio respiratório, para prevenir as exacerbações induzidas por infecção respiratória de um distúrbio respiratório, para reduzir a incidência das exacerbações induzidas por infecção respiratória de um distúrbio respiratório, para reduzir a gravidade das exacerbações induzidas por infecção respiratória de um distúrbio respiratório, para prevenir uma infecção respiratória viral e para fabricar uma partícula de inalação de pó seco de ribavirina controlada na forma polimorfa cristalina, partículas fabricadas, método de tratamento, pluralidade de partículas, e, recipiente de dose. |
| JP7057285B2 (ja) * | 2016-01-19 | 2022-04-19 | ノバルティス アーゲー | 複数投与吸入器 |
| CA169756S (en) | 2016-02-08 | 2017-09-01 | Nicoventures Holdings Ltd | Electronic cigarette |
| GB201605100D0 (en) | 2016-03-24 | 2016-05-11 | Nicoventures Holdings Ltd | Vapour provision system |
| GB201605102D0 (en) | 2016-03-24 | 2016-05-11 | Nicoventures Holdings Ltd | Mechanical connector for electronic vapour provision system |
| GB201605101D0 (en) | 2016-03-24 | 2016-05-11 | Nicoventures Holdings Ltd | Electronic vapour provision system |
| GB201605105D0 (en) | 2016-03-24 | 2016-05-11 | Nicoventures Holdings Ltd | Vapour provision apparatus |
| JP7043417B2 (ja) * | 2016-04-26 | 2022-03-29 | エルテーエス ローマン テラピー－ジステーメ アーゲー | 有効成分を含んだまたは有効成分を担持したストリップを分配する（ｄｉｓｐｅｎｓｅ）デバイスおよび方法 |
| WO2017206689A1 (zh) * | 2016-05-30 | 2017-12-07 | 深圳市塔吉瑞生物医药有限公司 | 一种取代的黄嘌呤及其药物组合物 |
| EP3472566A1 (en) | 2016-06-17 | 2019-04-24 | Thin Film Electronics ASA | Wireless mechanism for detecting an open or closed container, and methods of making and using the same |
| RU2741664C2 (ru) | 2016-07-22 | 2021-01-28 | Никовенчерс Трейдинг Лимитед | Футляр для устройства предоставления пара |
| MY193988A (en) * | 2016-08-10 | 2022-11-04 | Halliburton Energy Services Inc | Soluble plug usable downhole |
| GB201614939D0 (en) | 2016-09-02 | 2016-10-19 | Glaxosmithkline Ip Dev Ltd | Crystalline hydrate |
| GB201614934D0 (en) | 2016-09-02 | 2016-10-19 | Glaxosmithkline Intellectual Property (No 2) Ltd | Chemical compounds |
| GB201614940D0 (en) | 2016-09-02 | 2016-10-19 | Glaxosmithkline Intellectual Property (No 2) Ltd | Chemical compounds |
| JP7106528B2 (ja) | 2016-09-20 | 2022-07-26 | グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッド | Ｔｒｐｖ４拮抗薬 |
| TW201825458A (zh) | 2016-09-20 | 2018-07-16 | 英商葛蘭素史克智慧財產（第二）有限公司 | Ｔｒｐｖ４拮抗劑 |
| US10590077B2 (en) | 2016-09-20 | 2020-03-17 | Glaxosmithkline Intellectual Property Development Limited | TRPV4 antagonists |
| USD818112S1 (en) * | 2016-10-19 | 2018-05-15 | Reciprocal Labs Corporation | Usage monitoring attachment for a dry powder inhaler |
| WO2018087243A1 (en) * | 2016-11-09 | 2018-05-17 | Arven Ilac Sanayi Ve Ticaret A.S. | Inhaler device comprising a fixable lid assembly |
| US20190307975A1 (en) | 2016-11-21 | 2019-10-10 | Lupin Inc. | Medicament dispenser |
| KR20190088404A (ko) | 2016-12-06 | 2019-07-26 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | 3-(2,3-디히드로-1h-인덴-5-일)프로판산 유도체 및 nrf2 조절제로서의 그의 용도 |
| US10426698B2 (en) * | 2016-12-08 | 2019-10-01 | Breeden Brothers, LLC | Pill container with cap |
| EP3551621A1 (en) | 2016-12-12 | 2019-10-16 | GlaxoSmithKline Intellectual Property Development Limited | N-aryl pyrazoles as nrf2 regulators |
| JP2020500919A (ja) | 2016-12-12 | 2020-01-16 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | Ｎｒｆ２レギュレーターとしての３−カルボン酸ピロール |
| WO2018109647A1 (en) | 2016-12-14 | 2018-06-21 | Glaxosmithkline Intellectual Property Development Limited | Bisaryl amides as nrf2 regulators |
| JP2020502123A (ja) | 2016-12-14 | 2020-01-23 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | Ｎｒｆ２アクチベーターとしてのビスアリール複素環 |
| ES2848699T3 (es) | 2016-12-14 | 2021-08-11 | Glaxosmithkline Ip Dev Ltd | Compuestos de 3-oxo-1,4-diazepinilo como activadores de NRF2 |
| JP7110197B2 (ja) | 2016-12-15 | 2022-08-01 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド | Ｎｒｆ２アクチベーター |
| ES2908941T3 (es) | 2016-12-15 | 2022-05-04 | Glaxosmithkline Ip Dev Ltd | Triazoles unidos a éter como reguladores de NRF2 |
| CN108622469B (zh) * | 2017-03-24 | 2023-08-15 | 李和伟 | 一种独立包装的履带式给药器 |
| CN110662557A (zh) | 2017-03-31 | 2020-01-07 | 葛兰素史克知识产权开发有限公司 | 免疫原性组合物、用途和治疗方法 |
| US10441511B2 (en) * | 2017-07-10 | 2019-10-15 | Joseph Hamilton | Systems, devices, and/or methods for managing medicament dispenser |
| JP7275129B2 (ja) | 2017-07-25 | 2023-05-17 | アドヒアリアム（エヌ・ズィー）リミテッド | アドヒアランスを監視する方法および装置 |
| JP1600828S (enExample) * | 2017-08-24 | 2018-04-02 | ||
| JP1600829S (enExample) * | 2017-08-24 | 2018-04-02 | ||
| JP1600827S (enExample) * | 2017-08-24 | 2018-04-02 | ||
| WO2019116231A1 (en) | 2017-12-11 | 2019-06-20 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 activator for the treatment of acute lung injury, acute respiratory distress syndrome and multiple organ dysfunction syndrome |
| WO2019116230A1 (en) | 2017-12-11 | 2019-06-20 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 activator for the treatment of acute lung injury, acute respiratory distress syndrome and multiple organ dysfunction syndrome |
| GB201720989D0 (en) | 2017-12-15 | 2018-01-31 | Glaxosmithkline Ip Dev Ltd | Chemical compounds |
| BR112020014431A2 (pt) | 2018-01-17 | 2020-12-01 | Glaxosmithkline Intellectual Property Development Limited | inibidores de pl4kiiibeta |
| US20210085897A1 (en) * | 2018-04-06 | 2021-03-25 | Lupin Inc. | Medicament dispenser |
| WO2019224667A1 (en) | 2018-05-23 | 2019-11-28 | Glaxosmithkline Intellectual Property Development Limited | Indanes as nrf2 activators |
| GB201812671D0 (en) | 2018-08-03 | 2018-09-19 | Coalesce Product Dev Ltd | An inhaler device |
| AU2019339644B2 (en) * | 2018-09-10 | 2021-11-11 | Cipla Limited | Single blister-strip based dispenser |
| CN109875896B (zh) * | 2019-04-19 | 2021-05-28 | 浙江大学宁波理工学院 | 一种自动配药装置 |
| GB201908536D0 (en) | 2019-06-13 | 2019-07-31 | Glaxosmithkline Ip Dev Ltd | Compounds |
| US12427270B2 (en) | 2019-11-18 | 2025-09-30 | Vectura Delivery Devices Limited | Inhaler for use with a compliance monitor |
| CA195576S (en) * | 2019-11-18 | 2022-03-08 | Vectura Delivery Devices Ltd | Inhaler |
| USD1065507S1 (en) * | 2020-02-18 | 2025-03-04 | Alfred Von Schuckmann | Inhaler |
| EP4126139A1 (en) * | 2020-03-25 | 2023-02-08 | Lupin Inc. | Multi-carrier medicament dispensers |
| EP4487892A3 (en) | 2020-06-15 | 2025-01-29 | Norton (Waterford) Limited | Blister pack and inhaler comprising the same |
| JP6901180B1 (ja) | 2020-11-19 | 2021-07-14 | ニップファーマ株式会社 | 薬剤吸入器及びカウンタ機構 |
| WO2022175425A1 (en) | 2021-02-22 | 2022-08-25 | Glaxosmithkline Intellectual Property Development Limited | Inhaled mtor kinase inhibitors for use in the treatment or the prevention of a respiratory rna virus infection |
| WO2022175423A1 (en) | 2021-02-22 | 2022-08-25 | Glaxosmithkline Biologicals Sa | Immunogenic composition, use and methods |
| WO2022179967A1 (en) | 2021-02-23 | 2022-09-01 | Glaxosmithkline Intellectual Property (No.2) Limited | Vadadustat for treating covid-19 in a hospitalized subject |
| GB202111658D0 (en) | 2021-08-13 | 2021-09-29 | Norton Waterford Ltd | Dry powder medicament inhaler |
| FI4188491T3 (fi) * | 2021-08-13 | 2024-06-07 | Norton Waterford Ltd | Kuivajauhelääkeinhalaattori |
| WO2023052477A1 (en) * | 2021-09-29 | 2023-04-06 | Norton (Waterford) Limited | Dry powder medicament inhaler |
| ES3030527T3 (en) | 2021-09-29 | 2025-06-30 | Norton Waterford Ltd | Dry powder medicament inhaler |
| EP4221792B1 (en) * | 2021-09-29 | 2025-05-14 | Norton (Waterford) Limited | Dry powder medicament inhaler |
| CN117942463A (zh) * | 2022-10-20 | 2024-04-30 | 传思生物公司 | 药物分配器 |
| GB2625118A (en) | 2022-12-07 | 2024-06-12 | Merxin Ltd | Drive mechanism |
| CN116492551B (zh) * | 2023-06-07 | 2025-12-09 | 艾特美(苏州)医药科技有限公司 | 准纳器 |
| CN118304523B (zh) * | 2024-04-28 | 2025-04-04 | 苏州新劢德医疗器械科技有限公司 | 一种盖自动回弹结构及药物分配装置 |
| CN118304522B (zh) * | 2024-04-28 | 2024-10-29 | 苏州新劢德医疗器械科技有限公司 | 一种棘轮组件及药物分配装置 |
| CN118304524B (zh) * | 2024-04-28 | 2024-10-18 | 苏州新劢德医疗器械科技有限公司 | 一种片驱动器及药物分配装置 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003090825A1 (en) * | 2002-04-26 | 2003-11-06 | Glaxo Group Limited | Medicament dispenser |
| WO2005014089A1 (en) * | 2003-07-24 | 2005-02-17 | Glaxo Group Limited | Medicament dispenser |
| WO2005037353A1 (en) * | 2003-10-17 | 2005-04-28 | Vectura Limited | Inhaler |
Family Cites Families (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3269389A (en) | 1963-03-11 | 1966-08-30 | Bernard L Meurer | Compartmental dispensing container for nose and throat preparations |
| DE1461280A1 (de) | 1963-07-11 | 1969-02-27 | Zimmermann & Co | Mehrschichtblaetter aus Papier od.dgl.mit Hohlraeumen zur Aufnahme von vorzugsweise pulverfoermigen Stoffen und Verfahren zur Herstellung solcher Mehrschichtblaetter |
| GB1387954A (en) | 1973-05-08 | 1975-03-19 | Miles Lab | Insufflator |
| US4570769A (en) | 1981-11-26 | 1986-02-18 | Kabushiki Kaisha Sankyo Seiki Seisakusho | Ratchet mechanism |
| JPS5891932A (ja) | 1981-11-26 | 1983-06-01 | Sankyo Seiki Mfg Co Ltd | ラチエツト機構 |
| AT396872B (de) | 1985-07-30 | 1993-12-27 | Glaxo Group Ltd | Gerät zur verabreichung von medikamenten in pulverform |
| JPS62204756A (ja) | 1986-03-04 | 1987-09-09 | 大研医工株式会社 | 薬剤揮散方法および装置 |
| GB8713353D0 (en) | 1987-06-08 | 1987-07-15 | Scient Generics Ltd | Magnetic article surveillance systems |
| US4860419A (en) | 1987-08-17 | 1989-08-29 | General Motors Corporation | Split bearing assemblies, method for making |
| GB8909891D0 (en) | 1989-04-28 | 1989-06-14 | Riker Laboratories Inc | Device |
| US5007419A (en) | 1989-09-25 | 1991-04-16 | Allan Weinstein | Inhaler device |
| US5002048A (en) | 1989-12-12 | 1991-03-26 | Makiej Jr Walter J | Inhalation device utilizing two or more aerosol containers |
| GB9004781D0 (en) | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
| MY105368A (en) | 1990-03-02 | 1994-09-30 | Glaxo Group Ltd | Inhalation device. |
| GB9016789D0 (en) | 1990-07-31 | 1990-09-12 | Lilly Industries Ltd | Medicament administering devices |
| NL9002706A (nl) | 1990-12-10 | 1992-07-01 | Pharmachemie Bv | Inrichting ten gebruike bij het inhaleren van in staafvormige capsules verpakte poedervormige stoffen. |
| US5621316A (en) | 1991-01-04 | 1997-04-15 | Scientific Generics Limited | Apparatus for measuring the positions of plural movable members each associated with a respective magnetorestrictive element |
| AU650953B2 (en) | 1991-03-21 | 1994-07-07 | Novartis Ag | Inhaler |
| IT225480Y1 (it) | 1991-07-05 | 1996-11-18 | Zhermack S R L | Attrezzatura componibile particolarmente per il dosaggio di prodotti f luidi e/o pastosi multicomponenti |
| US5469843A (en) * | 1991-11-12 | 1995-11-28 | Minnesota Mining And Manufacturing Company | Inhalation device |
| IL108780A (en) | 1993-02-27 | 1999-06-20 | Fisons Plc | Inhalation device |
| DE59305345D1 (de) | 1993-03-15 | 1997-03-13 | Wilhelm A Keller | Zusammensteckbare Mehrfachkartusche |
| ZA941881B (en) | 1993-04-02 | 1995-09-18 | Lilly Co Eli | Manifold medication injection apparatus and method |
| US5437267A (en) | 1993-08-03 | 1995-08-01 | Weinstein; Allan | Device for delivering aerosol to the nasal membranes and method of use |
| GB9324391D0 (en) * | 1993-11-26 | 1994-01-12 | Minnesota Mining & Mfg | Device for transmission of one-way torque |
| US5664557A (en) | 1994-03-10 | 1997-09-09 | Respiratory Delivery Systems, Inc. | Releasably engageable coupling for an inhaler |
| GB9409852D0 (en) * | 1994-05-17 | 1994-07-06 | Cambridge Consultants | Device for administering single doses of a medicament |
| CA2124410A1 (en) | 1994-05-26 | 1995-11-27 | Jean-Paul Praud | Device for the simultaneous delivery of beta 2 agonists and oxygen to a patient |
| FR2721106B1 (fr) * | 1994-06-10 | 1996-09-13 | Step | Compteur de doses pour inhalateurs. |
| US5998428A (en) | 1995-05-31 | 1999-12-07 | Smithkline Beecham Corporation | Compounds and methods for treating PDE IV-related diseases |
| KR19980702911A (ko) | 1995-03-10 | 1998-09-05 | 테릴 케이. 퀄리 | 에어로졸 밸브 |
| GB9506909D0 (en) | 1995-04-04 | 1995-05-24 | Scient Generics Ltd | Spatial magnetic interrogation system |
| US5622166A (en) | 1995-04-24 | 1997-04-22 | Dura Pharmaceuticals, Inc. | Dry powder inhaler delivery system |
| US5921237A (en) | 1995-04-24 | 1999-07-13 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
| EP0751077A1 (en) | 1995-06-28 | 1997-01-02 | GUALA S.p.A. | Dispenser for the simultaneous delivery of at least two paste-like products |
| US6182655B1 (en) | 1995-12-07 | 2001-02-06 | Jago Research Ag | Inhaler for multiple dosed administration of a pharmacological dry powder |
| NZ332669A (en) | 1996-04-29 | 1999-02-25 | Dura Pharma Inc | A dry power inhalation system which is flow rate independent |
| US6082588A (en) | 1997-01-10 | 2000-07-04 | Lever Brothers Company, Division Of Conopco, Inc. | Dual compartment package and pumps |
| SE9700424D0 (sv) | 1997-02-07 | 1997-02-07 | Astra Ab | Powder inhaler |
| US5830490A (en) | 1997-04-04 | 1998-11-03 | Weinstein; Robert E. | Method and device for organizing and coordinating the combined use of topical aerosols and oral medications for the treatment of disorders |
| WO1998051257A1 (en) | 1997-05-09 | 1998-11-19 | Paolo Vargiu | A multi-container device for the pocket transport of anti-allergic medicine |
| US5941241A (en) | 1997-05-12 | 1999-08-24 | Weinstein; Robert E. | Method and device for organizing and coordinating the combined use of topical aerosols for the treatment of respiratory disorders |
| GB2327408A (en) | 1997-07-22 | 1999-01-27 | Bespak Plc | Dual compartment dispensing apparatus |
| WO1999039991A1 (en) | 1998-02-06 | 1999-08-12 | Roche Diagnostics Gmbh | Metered dispenser |
| AU8179498A (en) | 1998-06-29 | 2000-01-17 | Allan M. Weinstein | A device for organizing the combined use of topical aerosols and oral medication |
| US6315112B1 (en) | 1998-12-18 | 2001-11-13 | Smithkline Beecham Corporation | Method and package for storing a pressurized container containing a drug |
| GB9902493D0 (en) | 1999-02-05 | 1999-03-24 | Glaxo Group Ltd | Inhalation device |
| AR035987A1 (es) | 1999-03-01 | 2004-08-04 | Smithkline Beecham Corp | Uso de un compuesto inhibidor de la pde 4 para la manufactura de un medicamento y el medicamento para tratar asma inducida por ejercicio |
| FI107126B (fi) | 1999-04-23 | 2001-06-15 | Orion Yhtymae Oyj | Jauheinhalaattori yhdistelmälääkkeelle |
| FI108518B (fi) | 1999-04-23 | 2002-02-15 | Orion Yhtymae Oyj | Jauheinhalaattori yhdistelmälääkkeelle |
| GB9920839D0 (en) | 1999-09-04 | 1999-11-10 | Innovata Biomed Ltd | Inhaler |
| EP1224601A1 (en) | 1999-10-01 | 2002-07-24 | Glaxo Group Limited | Remote patient assessment system |
| EP1220698B1 (en) | 1999-10-12 | 2004-07-21 | SHL Medical AB | Inhaler |
| GB9928265D0 (en) | 1999-12-01 | 2000-01-26 | Innovata Biomed Ltd | Inhaler |
| CO5270018A1 (es) | 1999-12-11 | 2003-04-30 | Glaxo Group Ltd | Distribuidor de medicamento |
| DE19961300A1 (de) | 1999-12-18 | 2001-06-21 | Asta Medica Ag | Vorratssystem für Arzneimittel in Pulverform und damit ausgestatteter Inhalator |
| GB9930602D0 (en) | 1999-12-24 | 2000-02-16 | Glaxo Group Ltd | Inhalation device |
| PL201275B1 (pl) | 2000-03-10 | 2009-03-31 | Univ North Carolina | Inhalator suchego proszku |
| GB0015034D0 (en) | 2000-06-21 | 2000-08-09 | Glaxo Group Ltd | Inhalation device |
| GB0015801D0 (en) | 2000-06-28 | 2000-08-16 | Innovata Biomed Ltd | Cover |
| US6543443B1 (en) | 2000-07-12 | 2003-04-08 | Aerogen, Inc. | Methods and devices for nebulizing fluids |
| GB0019715D0 (en) | 2000-08-10 | 2000-09-27 | Pa Consulting Services | Device for delivering physiologically active agent in powdered form |
| SE517229C2 (sv) | 2000-09-25 | 2002-05-14 | Microdrug Ag | Kontinuerlig inhalator för torrt pulver |
| FR2818963B1 (fr) | 2001-01-04 | 2003-04-11 | Valois Sa | Dispositif de distribution de produit fluide du type combidose |
| WO2003024514A1 (en) | 2001-09-19 | 2003-03-27 | Advent Pharmaceuticals Pty Ltd | An inhaler |
| GB0201677D0 (en) | 2002-01-25 | 2002-03-13 | Glaxo Group Ltd | Medicament dispenser |
| AU2003220125B2 (en) | 2002-03-20 | 2006-06-15 | Mannkind Corporation | Inhalation apparatus |
| CN1668354A (zh) | 2002-05-10 | 2005-09-14 | 奥里尔治疗公司 | 干粉吸入器、相关泡状体装置以及分配干粉物质和制造泡状体包装的相关方法 |
| US6889690B2 (en) | 2002-05-10 | 2005-05-10 | Oriel Therapeutics, Inc. | Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages |
| GB0217196D0 (en) | 2002-07-25 | 2002-09-04 | Glaxo Group Ltd | Medicament dispenser |
| DE60239639D1 (de) | 2002-07-31 | 2011-05-12 | Chiesi Farma Spa | Pulverinhalator |
| US6941947B2 (en) | 2002-12-18 | 2005-09-13 | Quadrant Technologies Limited | Unit dose dry powder inhaler |
| GB0303870D0 (en) | 2003-02-20 | 2003-03-26 | Norton Healthcare Ltd | Pre-metered dose magazine for breath-actuated dry powder inhaler |
| KR101105909B1 (ko) | 2004-02-16 | 2012-01-17 | 글락소 그룹 리미티드 | 약품 분배기에 사용되는 카운터 |
| GB0418278D0 (en) * | 2004-08-16 | 2004-09-15 | Glaxo Group Ltd | Medicament dispenser |
| GB0515584D0 (en) | 2005-07-28 | 2005-09-07 | Glaxo Group Ltd | Medicament dispenser |
-
2005
- 2005-07-28 GB GBGB0515584.1A patent/GB0515584D0/en not_active Ceased
-
2006
- 2006-07-27 AU AU2006273856A patent/AU2006273856B2/en active Active
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- 2006-07-27 BR BRPI0614568A patent/BRPI0614568B8/pt active IP Right Grant
- 2006-07-27 WO PCT/GB2006/002831 patent/WO2007012871A1/en not_active Ceased
- 2006-07-27 CA CA002616193A patent/CA2616193A1/en not_active Abandoned
- 2006-07-27 US US11/996,762 patent/US8746242B2/en active Active
- 2006-07-27 MX MX2008001250A patent/MX2008001250A/es active IP Right Grant
- 2006-07-27 KR KR1020087004439A patent/KR101496791B1/ko active Active
- 2006-07-27 NZ NZ565437A patent/NZ565437A/en unknown
- 2006-07-27 EP EP06765149.7A patent/EP1907037B2/en active Active
- 2006-07-27 PL PL06765149.7T patent/PL1907037T5/pl unknown
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- 2006-07-27 JP JP2008523458A patent/JP5107918B2/ja active Active
- 2006-07-27 DK DK06765149.7T patent/DK1907037T4/da active
- 2006-07-27 ES ES06765149T patent/ES2745602T5/es active Active
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003090825A1 (en) * | 2002-04-26 | 2003-11-06 | Glaxo Group Limited | Medicament dispenser |
| WO2005014089A1 (en) * | 2003-07-24 | 2005-02-17 | Glaxo Group Limited | Medicament dispenser |
| WO2005037353A1 (en) * | 2003-10-17 | 2005-04-28 | Vectura Limited | Inhaler |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CHAD | Change of the owner's name or address (par. 44 patent law, par. patentforskriften) |
Owner name: GLAXO GROUP LTD, GB |