NO330394B1 - Piperidinoylpiperidiner som 5-HTIF-agonister - Google Patents
Piperidinoylpiperidiner som 5-HTIF-agonister Download PDFInfo
- Publication number
- NO330394B1 NO330394B1 NO20044654A NO20044654A NO330394B1 NO 330394 B1 NO330394 B1 NO 330394B1 NO 20044654 A NO20044654 A NO 20044654A NO 20044654 A NO20044654 A NO 20044654A NO 330394 B1 NO330394 B1 NO 330394B1
- Authority
- NO
- Norway
- Prior art keywords
- compound
- methyl
- alkyl
- substituted
- benzamide
- Prior art date
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- 239000000556 agonist Substances 0.000 title description 9
- SNOJOKOVTYPHMC-UHFFFAOYSA-N di(piperidin-1-yl)methanone Chemical class C1CCCCN1C(=O)N1CCCCC1 SNOJOKOVTYPHMC-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 147
- 239000001257 hydrogen Substances 0.000 claims abstract description 33
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 33
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- 206010027599 migraine Diseases 0.000 claims abstract description 23
- 239000002253 acid Substances 0.000 claims abstract description 21
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 14
- 241000124008 Mammalia Species 0.000 claims abstract description 13
- -1 1-methyl-4-piperidinyl Chemical group 0.000 claims description 62
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 22
- 238000011282 treatment Methods 0.000 claims description 19
- 125000000217 alkyl group Chemical group 0.000 claims description 12
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- 239000000825 pharmaceutical preparation Substances 0.000 claims description 6
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- 239000008177 pharmaceutical agent Substances 0.000 claims description 4
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 3
- 239000003085 diluting agent Substances 0.000 claims description 3
- YBTPRLDGGGYWIP-UHFFFAOYSA-N 2,4,6-trifluoro-n-[6-(1-methylpiperidine-4-carbonyl)pyridin-2-yl]benzamide;hydrochloride Chemical compound Cl.C1CN(C)CCC1C(=O)C1=CC=CC(NC(=O)C=2C(=CC(F)=CC=2F)F)=N1 YBTPRLDGGGYWIP-UHFFFAOYSA-N 0.000 claims description 2
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Classifications
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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- Life Sciences & Earth Sciences (AREA)
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Applications Claiming Priority (2)
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| US36908802P | 2002-03-29 | 2002-03-29 | |
| PCT/US2003/008455 WO2003084949A1 (en) | 2002-03-29 | 2003-03-27 | Pyridinoylpiperidines as 5-ht1f agonists |
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| NO20044654L NO20044654L (no) | 2004-10-28 |
| NO330394B1 true NO330394B1 (no) | 2011-04-04 |
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| NO20044654A NO330394B1 (no) | 2002-03-29 | 2004-10-28 | Piperidinoylpiperidiner som 5-HTIF-agonister |
Country Status (32)
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| AT (1) | ATE341543T1 (es) |
| AU (1) | AU2003224719B2 (es) |
| BR (1) | BRPI0308495B8 (es) |
| CA (2) | CA2478229C (es) |
| CR (1) | CR7496A (es) |
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| IL (1) | IL163928A0 (es) |
| MX (1) | MXPA04009497A (es) |
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| UA (1) | UA77504C2 (es) |
| WO (1) | WO2003084949A1 (es) |
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2004
- 2004-09-22 ZA ZA200407666A patent/ZA200407666B/xx unknown
- 2004-09-24 HR HRP20040883 patent/HRP20040883B1/xx not_active IP Right Cessation
- 2004-09-24 CR CR7496A patent/CR7496A/es unknown
- 2004-09-27 EC EC2004005317A patent/ECSP045317A/es unknown
- 2004-10-28 NO NO20044654A patent/NO330394B1/no not_active IP Right Cessation
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2005
- 2005-06-13 HK HK05104936A patent/HK1073464A1/xx not_active IP Right Cessation
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2007
- 2007-01-03 CY CY20071100004T patent/CY1105899T1/el unknown
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2008
- 2008-07-22 US US12/220,225 patent/US8044207B2/en active Active
- 2008-08-07 US US12/221,919 patent/US20090209563A1/en not_active Abandoned
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2010
- 2010-03-01 JP JP2010044032A patent/JP2010159272A/ja active Pending
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2012
- 2012-02-01 US US13/363,895 patent/US8748459B2/en not_active Expired - Lifetime
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2014
- 2014-06-05 US US14/296,911 patent/US20150376178A1/en not_active Abandoned
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2016
- 2016-04-06 US US15/091,776 patent/US20170044136A1/en not_active Abandoned
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| Date | Code | Title | Description |
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| MK1K | Patent expired |