NO328313B1 - Fremgangsmate for fremstilling av et farmasoytisk preparat for oral anvendelse mot peptisk ulcus og anvendelse av sinkhyaluronatassosiat (-kompleks) med en molekylvekt i omradet fra 500 000 dalton til 1 200 000 dalton for fremstilling av farmasoytiske preparater for oral anvendelse mot peptisk ulcus - Google Patents
Fremgangsmate for fremstilling av et farmasoytisk preparat for oral anvendelse mot peptisk ulcus og anvendelse av sinkhyaluronatassosiat (-kompleks) med en molekylvekt i omradet fra 500 000 dalton til 1 200 000 dalton for fremstilling av farmasoytiske preparater for oral anvendelse mot peptisk ulcus Download PDFInfo
- Publication number
- NO328313B1 NO328313B1 NO19995229A NO995229A NO328313B1 NO 328313 B1 NO328313 B1 NO 328313B1 NO 19995229 A NO19995229 A NO 19995229A NO 995229 A NO995229 A NO 995229A NO 328313 B1 NO328313 B1 NO 328313B1
- Authority
- NO
- Norway
- Prior art keywords
- zinc
- zinc hyaluronate
- daltons
- gastric
- peptic ulcer
- Prior art date
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- 229940059329 chondroitin sulfate Drugs 0.000 description 1
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- 229910017052 cobalt Inorganic materials 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
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- 229960001596 famotidine Drugs 0.000 description 1
- XUFQPHANEAPEMJ-UHFFFAOYSA-N famotidine Chemical compound NC(N)=NC1=NC(CSCCC(N)=NS(N)(=O)=O)=CS1 XUFQPHANEAPEMJ-UHFFFAOYSA-N 0.000 description 1
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- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
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- 230000003179 granulation Effects 0.000 description 1
- 230000003394 haemopoietic effect Effects 0.000 description 1
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- 229960002897 heparin Drugs 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 231100000508 hormonal effect Toxicity 0.000 description 1
- 229940014041 hyaluronate Drugs 0.000 description 1
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- 238000001802 infusion Methods 0.000 description 1
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- 239000008101 lactose Substances 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
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- 230000009526 moderate injury Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
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- 210000000653 nervous system Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 229960000381 omeprazole Drugs 0.000 description 1
- 239000008203 oral pharmaceutical composition Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
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- 230000035755 proliferation Effects 0.000 description 1
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- 238000011160 research Methods 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 238000009097 single-agent therapy Methods 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- SDKPSXWGRWWLKR-UHFFFAOYSA-M sodium;9,10-dioxoanthracene-1-sulfonate Chemical compound [Na+].O=C1C2=CC=CC=C2C(=O)C2=C1C=CC=C2S(=O)(=O)[O-] SDKPSXWGRWWLKR-UHFFFAOYSA-M 0.000 description 1
- GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000002602 strong irritant Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 150000003445 sucroses Chemical class 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
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- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
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- 235000012222 talc Nutrition 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
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- 231100000419 toxicity Toxicity 0.000 description 1
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- 231100000027 toxicology Toxicity 0.000 description 1
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- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
- 210000003954 umbilical cord Anatomy 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9700826A HU225991B1 (en) | 1997-04-29 | 1997-04-29 | Use of the zinc hyaluronate associate (complex) for the preparation of pharmaceutical compositions for oral use against peptic ulcer |
| PCT/HU1998/000044 WO1998048815A1 (en) | 1997-04-29 | 1998-04-28 | Use of zinc hyaluronate against peptic ulcer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO995229D0 NO995229D0 (no) | 1999-10-26 |
| NO995229L NO995229L (no) | 1999-12-22 |
| NO328313B1 true NO328313B1 (no) | 2010-01-25 |
Family
ID=89995068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19995229A NO328313B1 (no) | 1997-04-29 | 1999-10-26 | Fremgangsmate for fremstilling av et farmasoytisk preparat for oral anvendelse mot peptisk ulcus og anvendelse av sinkhyaluronatassosiat (-kompleks) med en molekylvekt i omradet fra 500 000 dalton til 1 200 000 dalton for fremstilling av farmasoytiske preparater for oral anvendelse mot peptisk ulcus |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6656921B1 (pt) |
| EP (1) | EP1017403B1 (pt) |
| JP (1) | JP2001522361A (pt) |
| KR (1) | KR100572190B1 (pt) |
| CN (1) | CN1126548C (pt) |
| AT (1) | ATE320814T1 (pt) |
| BG (1) | BG64458B1 (pt) |
| BR (1) | BR9809354A (pt) |
| CA (1) | CA2286756C (pt) |
| CZ (1) | CZ297317B6 (pt) |
| DE (1) | DE69833937T2 (pt) |
| DK (1) | DK1017403T3 (pt) |
| EA (1) | EA002134B1 (pt) |
| EE (1) | EE04953B1 (pt) |
| ES (1) | ES2259813T3 (pt) |
| HK (1) | HK1025250A1 (pt) |
| HU (1) | HU225991B1 (pt) |
| IL (1) | IL132214A0 (pt) |
| NO (1) | NO328313B1 (pt) |
| NZ (1) | NZ500978A (pt) |
| PL (1) | PL189526B1 (pt) |
| PT (1) | PT1017403E (pt) |
| SK (1) | SK284864B6 (pt) |
| TW (1) | TW501927B (pt) |
| UA (1) | UA62964C2 (pt) |
| WO (1) | WO1998048815A1 (pt) |
| ZA (1) | ZA983626B (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU225991B1 (en) | 1997-04-29 | 2008-02-28 | Richter Gedeon Nyrt | Use of the zinc hyaluronate associate (complex) for the preparation of pharmaceutical compositions for oral use against peptic ulcer |
| ITPD980168A1 (it) * | 1998-07-06 | 2000-01-06 | Fidia Advanced Biopolymers Srl | Composizioni biocompatibili e biodegradabili comprendenti acido ialuronico e suoi derivati per il trattamento delle ulcere dell'appara |
| HUP0303779A2 (en) * | 2003-11-20 | 2006-02-28 | Richter Gedeon Vegyeszet | Pharmaceutical compositions containing hyaluronan complex for the treatment of sclerosis multiplex |
| AU2006287321B2 (en) * | 2005-09-09 | 2011-09-29 | Bally Gaming, Inc. | Wagering game system with community gaming system |
| CN100355790C (zh) * | 2005-11-04 | 2007-12-19 | 山东福瑞达生物化工有限公司 | 一种透明质酸锌的制备方法 |
| CN1329414C (zh) * | 2005-12-02 | 2007-08-01 | 凌沛学 | 透明质酸铋钾及其制备方法和应用 |
| CN100348621C (zh) * | 2005-12-02 | 2007-11-14 | 凌沛学 | 透明质酸铋及其制备方法和应用 |
| CN101023961B (zh) * | 2006-02-23 | 2010-07-21 | 山东省生物药物研究院 | 一种含透明质酸钠和锌盐的药物组合物 |
| ITMI20061132A1 (it) * | 2006-06-13 | 2007-12-14 | Sinclair Pharmaceuticals Ltd | Composizioni topiche antimicrobiche comprendenti lattoferrina, acido ialuronico o suoi sali ed estratti vegetali |
| TWI516269B (zh) * | 2009-08-14 | 2016-01-11 | 禾伸堂生技股份有限公司 | 使用於炎症性腸疾病（ｉｂｄ）治療和預防之透明質酸混合物 |
| TWI383796B (zh) * | 2009-08-14 | 2013-02-01 | Holy Stone Healthcare Co Ltd | Use of hyaluronic acid mixture for the treatment and prevention of peptic ulcer and duodenal ulcer |
| HUP0900717A3 (en) | 2009-11-18 | 2012-02-28 | Richter Gedeon Nyrt | Pharmaceutical composition for urological use containing zinc hyaluronate |
| US20110166099A1 (en) * | 2010-01-04 | 2011-07-07 | Wu Tsung-Chung | Mixture of hyaluronic acid for treating and preventing peptic ulcer and duodenal ulcer |
| US8722644B2 (en) | 2010-01-04 | 2014-05-13 | Holy Stone Healthcare Co., Ltd. | Mixture of hyaluronic acid for treating and preventing peptic ulcer and duodenal ulcer |
| ES2388281B1 (es) * | 2010-12-27 | 2013-10-01 | Laboratorios Viñas S.A. | Composición farmacéutica que comprende ácido hialurónico y un compuesto de zinc y pastilla con palito y procedimiento para preparación correspondientes |
| JP6095014B2 (ja) * | 2012-03-01 | 2017-03-15 | キユーピー株式会社 | 浮腫抑制用経口剤 |
| WO2015076294A1 (ja) * | 2013-11-22 | 2015-05-28 | キユーピー株式会社 | 薬剤の副作用である胃潰瘍の発症抑制方法、および胃潰瘍発症が抑制された経口薬剤組成物ならびにその製造方法 |
| CN104262499A (zh) * | 2014-09-03 | 2015-01-07 | 佐源集团有限公司 | 一种低聚果糖锌及含有低聚果糖锌的口服液 |
| CN108051553A (zh) * | 2017-12-29 | 2018-05-18 | 武汉轻工大学 | 一种仔猪肠道功能保护剂的筛选方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1229075B (it) * | 1985-04-05 | 1991-07-17 | Fidia Farmaceutici | Medicamenti per uso topico, ottenuti tramite l'impiego dell'acido ialuronico |
| AU600483B2 (en) * | 1986-03-14 | 1990-08-16 | Bio-Technology General Corporation | Heavy metal salts of hyaluronic acid |
| US6458774B1 (en) * | 1989-02-24 | 2002-10-01 | Richter Gedeon Vegyeszeti Gyar Rt. | Compositions containing hyaluronic acid associates and a process for preparing same |
| HU203372B (en) * | 1989-02-24 | 1991-07-29 | Richter Gedeon Vegyeszet | Process for producing hyaluronic associates and pharmaceutical compositions and cosmetics comprising such active ingredient |
| US5472950A (en) | 1989-02-24 | 1995-12-05 | Richter Gedeon Vegyeszeti Gyar Rt. | Compositions containing cobalt hyaluronic acid complex |
| JPH0648950A (ja) | 1992-07-30 | 1994-02-22 | Taito Kk | 抗潰瘍剤 |
| HU225991B1 (en) | 1997-04-29 | 2008-02-28 | Richter Gedeon Nyrt | Use of the zinc hyaluronate associate (complex) for the preparation of pharmaceutical compositions for oral use against peptic ulcer |
| HU225329B1 (en) * | 1996-09-12 | 2006-09-28 | Richter Gedeon Vegyeszet | Use of zinc or cobalt hyaluronate associate for the manufacture of pharmaceutical compositions of antimicrobial activity |
-
1997
- 1997-04-29 HU HU9700826A patent/HU225991B1/hu unknown
-
1998
- 1998-04-28 DE DE69833937T patent/DE69833937T2/de not_active Expired - Lifetime
- 1998-04-28 NZ NZ500978A patent/NZ500978A/en not_active IP Right Cessation
- 1998-04-28 ES ES98920684T patent/ES2259813T3/es not_active Expired - Lifetime
- 1998-04-28 EP EP98920684A patent/EP1017403B1/en not_active Expired - Lifetime
- 1998-04-28 IL IL13221498A patent/IL132214A0/xx not_active IP Right Cessation
- 1998-04-28 PT PT98920684T patent/PT1017403E/pt unknown
- 1998-04-28 BR BR9809354-1A patent/BR9809354A/pt not_active IP Right Cessation
- 1998-04-28 US US09/403,714 patent/US6656921B1/en not_active Expired - Lifetime
- 1998-04-28 DK DK98920684T patent/DK1017403T3/da active
- 1998-04-28 JP JP54638898A patent/JP2001522361A/ja active Pending
- 1998-04-28 PL PL98336482A patent/PL189526B1/pl unknown
- 1998-04-28 TW TW087106525A patent/TW501927B/zh not_active IP Right Cessation
- 1998-04-28 KR KR1019997010037A patent/KR100572190B1/ko not_active IP Right Cessation
- 1998-04-28 EE EEP199900470A patent/EE04953B1/xx unknown
- 1998-04-28 CN CN98804672A patent/CN1126548C/zh not_active Expired - Fee Related
- 1998-04-28 EA EA199900983A patent/EA002134B1/ru not_active IP Right Cessation
- 1998-04-28 SK SK1468-99A patent/SK284864B6/sk not_active IP Right Cessation
- 1998-04-28 WO PCT/HU1998/000044 patent/WO1998048815A1/en active IP Right Grant
- 1998-04-28 AT AT98920684T patent/ATE320814T1/de active
- 1998-04-28 UA UA99116468A patent/UA62964C2/uk unknown
- 1998-04-28 CZ CZ0382799A patent/CZ297317B6/cs not_active IP Right Cessation
- 1998-04-28 CA CA002286756A patent/CA2286756C/en not_active Expired - Fee Related
- 1998-04-29 ZA ZA983626A patent/ZA983626B/xx unknown
-
1999
- 1999-10-19 BG BG103822A patent/BG64458B1/bg unknown
- 1999-10-26 NO NO19995229A patent/NO328313B1/no not_active IP Right Cessation
-
2000
- 2000-07-20 HK HK00104494A patent/HK1025250A1/xx not_active IP Right Cessation
Also Published As
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