ITMI20061132A1 - Composizioni topiche antimicrobiche comprendenti lattoferrina, acido ialuronico o suoi sali ed estratti vegetali - Google Patents
Composizioni topiche antimicrobiche comprendenti lattoferrina, acido ialuronico o suoi sali ed estratti vegetali Download PDFInfo
- Publication number
- ITMI20061132A1 ITMI20061132A1 IT001132A ITMI20061132A ITMI20061132A1 IT MI20061132 A1 ITMI20061132 A1 IT MI20061132A1 IT 001132 A IT001132 A IT 001132A IT MI20061132 A ITMI20061132 A IT MI20061132A IT MI20061132 A1 ITMI20061132 A1 IT MI20061132A1
- Authority
- IT
- Italy
- Prior art keywords
- hyaluronic acid
- salts
- lactoferrin
- extracts
- compositions
- Prior art date
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Description
Descrizione del brevetto per invenzione industriale avente per titolo:
“COMPOSIZIONI TOPICHE ANTIMICROBICHE COMPRENDENTI LATTOFERRINA, ACIDO IALURONICO O SUOI SALI ED ESTRATTI VEGETALI”
CAMPO DELL’INVENZIONE
La presente invenzione riguarda composizioni topiche antimicrobiche comprendenti lattoferrina, acido ialuronico ed estratti vegetali.
Più particolarmente, presente invenzione riguarda composizioni topiche antimicrobiche comprendenti lattoferrina; acido ialuronico o suoi sali ed estratti vegetali di Arnica montana, Sambucus nigra, Artemisia vulgaris ed eventualmente Piper betel.
TECNICA PRECEDENTE
La lattoferrina è una glicoproteina nota per la sua azione ad ampio spettro per una prima difesa delle superfici corporee, contro batteri, funghi, protozoi e virus. La sua proprietà di sequestrare ferro è alla base della sua azione batteriostatica. Oltre a questa proprietà, la lattoferrina ha azione battericida grazie alla sua capacità di legarsi alla porzione lipidica A dell’LPS, determinando un aumento della permeabilità batterica. La sua azione antibatterica si esplica inoltre interferendo con lo sviluppo del biofilm, dell’adesione e della colonizzazione batterica. Inoltre la lattoferrina è in grado di ridurre la colonizzazione batterica delle cellule e di portare in apoptosi le cellule infette. E’ stato recentemente proposto l’uso della lattoferrina come ingrediente attivo di composizioni per uso topico o mucosale per il trattamento di infezioni da HIV (US 5725864) in associazione con altri composti quali epigallocatechingallato (WO 2004/012622).
L’acido ialuronico è una proteina diffusa nei connettivi, che svolge azione immunomodulante, probabilmente anche tramite legame con il recettore TLR-4. L’acido ialuronico è inoltre in grado di determinare il rilascio di b-defensina-2 (BD2) a opera degli epiteli di rivestimento, sia delle mucose sia della cute. La BD-2 è una molecola appartenente alla famiglia delle defensine, peptidi di peso molecolare attorno ai 3 KD, con provata azione antibatterica e antimicrobica ad ampio spettro.
È noto che gli estratti di Arnica montana, Sambucus nigra, Artemisia vulgaris e Piper betel hanno azione antimicrobica e in alcuni casi anche antinfiammatoria.
L’arnica (Arnica montana) è nota per l’azione antiinfiammatoria, antimicrobica, antinevralgica, analgesica e antiflogistica, che la rendono utile nel trattamento di infiammazioni articolari, muscolari, distorsioni, ecchimosi, ematomi, vene varicose, traumi, flogosi delle mucose orali e faringee. I principi attivi sono contenuti nel rizoma e nei capolini, che contengono un olio essenziale contenenti alcoli triterpenici (arnicina, arnidiolo, faradiolo), lattoni sesquiterpenici, isoquercitina, astragalina, luteolina-7-glucoside, flavonoidi, acidi organici (acidi fenolici, acidi oleico, laurico e palmitico), timolo.
Il sambuco (Sambucus nigra) era usato in medicina popolare per la preparazione di gargarismi nella tonsillite e di impacchi nelle affezioni cutanee, grazie alle sue proprietà emollienti e lenitive. I principi attivi sono presenti in tutta la pianta, ma vengono utilizzate soprattutto le infiorescenze ben mature, sono ricche di flavonoidi (rutina e isoquercitina), olii essenziali, triterpeni, tannini, il glucoside cianogenetico sambuconigrina, l’alcaloide sambucina, acidi organici (valerianico e malico), mucillagini, resine, antiociani, colina. È importante evitare l’uso delle infiorescenze immature o della corteccia fresca, per evitare fenomeni di avvelenamento dovuti alla presenza di elevate quantità di glucoside cianogenetico sambuconigrina. L’azione è soprattutto astringente, decongestionante ed emolliente.
L’artemisia (Artemisia vulgaris) è utilizzata in medicina popolare come antispasmodico ed emmenagogo. La droga è costituita dalle parti aeree, soprattutto le sommità fiorite. I principi attivi sono un olio essenziale contente cineolo, thujone, linaloloe borneolo; un lattone sesquiterpenico (vulgarina) sostanza amara, rutina, curarine, tannini e resine.
Il betel (Piper betel) è un arbusto rampicante originario del sud-est asiatico. Le foglie pressate insieme, seccate, e spesso cucite a formare pacchetti insieme ad areca e calce (che libera i principi attivi), vengono masticate per la loro azione stimolante, antisettica, anticatarrale, rinfrescante dell’alito e sialogoga. I principi attivi sono costituiti da un olio contenente fenoli (chavibetolo e chavicolo), e un sesquiterpene biciclico, il cadinene.
DESCRIZIONE DELL’INVENZIONE
Si è ora trovato che l’associazione di lattoferrina, acido ialuronico o suoi sali ed estratti di Arnica montana, Sambucus nigra, Artemisia vulgaris ed eventualmente Piper betel è particolarmente efficace nel trattamento di tutte le infezioni microbiche a carico degli epiteli di rivestimento della superficie esterna del corpo (epidermide) e degli organi cavi (mucose), quali canale vaginale, cavità orale, superficie oculare, cavità intestinale e gastrica.
Pertanto, la presente invenzione ha per oggetto composizioni topiche ad attività antimicrobica, battericida e batteriostatica, comprendenti:
a) lattoferrina,
b) acido ialuronico o suoi sali e
c) estratti di Arnica montana, Sambucus nigra, Artemisia vulgaris ed eventualmente Piper betel.
Le composizioni della presente invenzione mostrano un effetto superiore a quello ottenuto dalla sommatoria degli effetti ottenuti in seguito alla somministrazione separata dei singoli componenti dell’associazione stessa. Apparentemente tale effetto superiore è dovuto a una sinergia d’azione tra i vari componenti, in particolare una sinergia di attività antimicrobica/batteriostatica/antibiotica tra i tre estratti vegetali e la lattoferrina, e una ulteriore sinergia d’azione tra tali componenti e l’attività immunostimolante dell’acido ialuronico, che è in grado di stimolare la produzione di antibiotici naturali a opera della pelle e delle mucose.
Secondo un aspetto preferito della presente invenzione, il contenuto in principi attivi delle composizioni in oggetto varierà entro i seguenti intervalli percentuali:
a) lattoferrina: da 2 a 0.10%;
b) acido ialuronico o suoi sali: da 2 a 0,10%;
c) estratti di Arnica montana, Sambucus nigra, Artemisia vulgaris ed eventualmente Piper betel: da 2 a 0,10%.
Le composizioni della presente invenzione potranno essere formulate in modo adatto alla somministrazione per via topica, saranno preparate secondo metodi convenzionali ben noti in tecnica farmaceutica, come quelli descritti in “Remington’s Pharmaceutical Handbook”, Mack Publishing Co., N.Y., USA, utilizzando eccipienti, diluenti, agenti di carica, antiagglomeranti accettabili per il loro uso finale. Esempi preferiti di formulazioni topiche dell’invenzione sono creme per uso topico, colluttori, dentifrici e creme per uso vaginale. Si riportano di seguito esempi di formulazione dell’invenzione.
ESEMPIO 1 - Crema uso topico
Lattoferrina 0,50% Sodio ialuronato 0,50% Arnica montana 0,50% Artemisia vulgaris 0,50% Sambucus nigra 0,50% Piper betel 0,50% Etilesil palmitato 10,00% Cetearil alcol - PEG-20 Stearato 9,00% Olus 5,00% Cetearil alcol 2,00% Glicerina 2,00% Dimethicone 1,00% Fenossietanolo 0,70% Imidazolidinil Urea 0,30% Propilparaben 0,15% Metilparaben 0,15% Disodio EDTA 0,10% Acqua deionizzata 62,60% Totale 100,00% ESEMPIO 2 - Collutorio
Lattoferrina 0,50% Sodio ialuronato 0,50% Arnica montana 0,50% Artemisia vulgaris 0,50% Sambucus nigra 0,50% Piper betel 0,50% Potassio sorbato 0,30% Sodio benzoato 0,30% Idrossietilcellulosa 0,30% Disodio EDTA 0,10% Benzalconio cloruro 0,10% PEG-40 Hydrogenated Castor Oil 0,10% Saccarina sodica 0,05% Aroma 0,03% Acqua deionizzata 91,72% Totale 100,00% ESEMPIO 3 - Dentifricio
Lattoferrina 0,50% Sodio ialuronato 0,50% Arnica montana 0,50% Artemisia vulgaris 0,50% Sambucus nigra 0,50% Piper betel 0,50% Sorbitolo 50,00% Silice idrata 8,00% Sodio lauroil sarcosinato 3,50% Carbossimetil cellulosa 1,50% Potassio Sorbato 0,30% Sodio Benzoato 0,30% PEG-40 Hydrogenated Castor Oil 0,16% Saccarina sodica 0,10% Aroma 0,50% Acqua deionizzata 29,09% Totale 100,00% ESEMPIO 4 - Crema vaginale
Lattoferrina 0,50% Sodio ialuronato 0,50% Arnica montana 0,50% Artemisia vulgaris 0,50% Sambucus nigra 0,50% Piper betel 0,50% Paraffina liquida 10,00% Cetearil Alcol - PEG-20 Stearato 9,00% Olus 5,00% Cetearil Alcol 2,00% Glicerina 2,00% Dimethicone 1,00% Fenossietanolo 0,70% Imidazolidinil Urea 0,30% Propilparaben 0,15% Metilparaben 0,15% Disodio EDTA 0,10% Acido lattico 0,10% Acqua deionizzata 62,60% Totale 100,00%
Claims (4)
- RIVENDICAZIONI 1. Composizioni oggetto composizioni topiche ad attività antimicrobica, battericida e batteriostatica, comprendenti: a) lattoferrina, b) acido ialuronico o suoi sali e c) estratti di Arnica montana, Sambucus nigra, Artemisia vulgaris ed eventualmente Piper betel.
- 2. Composizioni secondo la rivendicazione 1, contenenti i principi attivi entro i seguenti intervalli percentuali: a) lattoferrina: da 2 a 0.10%; b) acido ialuronico o suoi sali: da 2 a 0.10%; c) estratti di Arnica montana, Sambucus nigra, Artemisia vulgaris e Piper betel: da 2 a 0.10%.
- 3. Composizioni secondo le rivendicazioni 1 - 2, sotto forma di creme per uso topico, colluttori, dentifrici e creme per uso vaginale.
- 4. Uso di: a) lattoferrina, b) acido ialuronico o suoi sali e c) estratti di Arnica montana, Sambucus nigra, Artemisia vulgaris ed eventualmente Piper betel per la preparazione di composizioni topiche ad attività antimicrobica, battericida e batteriostatica.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT001132A ITMI20061132A1 (it) | 2006-06-13 | 2006-06-13 | Composizioni topiche antimicrobiche comprendenti lattoferrina, acido ialuronico o suoi sali ed estratti vegetali |
US12/304,204 US20100003311A1 (en) | 2006-06-13 | 2007-06-13 | Antimicrobial Composition |
PCT/GB2007/002197 WO2007144613A1 (en) | 2006-06-13 | 2007-06-13 | Antimicrobial composition |
EP07733203A EP2040715A1 (en) | 2006-06-13 | 2007-06-13 | Antimicrobial composition |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT001132A ITMI20061132A1 (it) | 2006-06-13 | 2006-06-13 | Composizioni topiche antimicrobiche comprendenti lattoferrina, acido ialuronico o suoi sali ed estratti vegetali |
Publications (1)
Publication Number | Publication Date |
---|---|
ITMI20061132A1 true ITMI20061132A1 (it) | 2007-12-14 |
Family
ID=38477376
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT001132A ITMI20061132A1 (it) | 2006-06-13 | 2006-06-13 | Composizioni topiche antimicrobiche comprendenti lattoferrina, acido ialuronico o suoi sali ed estratti vegetali |
Country Status (4)
Country | Link |
---|---|
US (1) | US20100003311A1 (it) |
EP (1) | EP2040715A1 (it) |
IT (1) | ITMI20061132A1 (it) |
WO (1) | WO2007144613A1 (it) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008145149A1 (en) * | 2007-05-28 | 2008-12-04 | Vincenzo Massimo Lombardo | Antiphlogistic and analgesic composition for topical use in a region of an animal locomotive system |
ES2540747T3 (es) * | 2008-07-22 | 2015-07-13 | Izun Pharmaceuticals Corporation | Combinación antiinflamatoria tópica |
ITMI20091075A1 (it) * | 2009-06-17 | 2010-12-17 | Valetudo Srl | Composizioni farmaceutiche e cosmetiche comprendenti lactoferrina ciclopirox acido etidronico |
ITFI20110156A1 (it) * | 2011-07-29 | 2013-01-30 | Inlinea S R L | Composizioni per l'igiene intima, secchezza ed arrossamento genitali e perianale |
CN103222944B (zh) * | 2011-09-27 | 2014-11-26 | 沈志荣 | 一种含植物提取物的瞬透生肌水组合物的制备方法 |
JP6038167B2 (ja) * | 2011-10-31 | 2016-12-07 | ケーン バイオテク インコーポレーテッド | 口腔疾患を予防及び治療する組成物及び方法 |
JP6348776B2 (ja) * | 2013-06-04 | 2018-06-27 | キッコーマンバイオケミファ株式会社 | 肌質改善経口組成物、食品および経口医薬品 |
MY176273A (en) * | 2015-06-25 | 2020-07-27 | Fri Batu Maung | Compositions containing piper betle extract for prevention and treatment of bacterial diseases in aquatic animals |
CN106619319B (zh) * | 2017-02-08 | 2019-09-20 | 广东科玮生物技术股份有限公司 | 一种含抗菌肽的止痒沐浴露及其制备方法 |
GB201713362D0 (en) * | 2017-08-21 | 2017-10-04 | Givaudan Sa | Improvements in or relating to organic compounds |
IT202000003733A1 (it) * | 2020-02-24 | 2021-08-24 | Terminter S R L | Diluizione colloidale per uso topico ed orale |
WO2022157314A1 (en) * | 2021-01-22 | 2022-07-28 | Dsm Ip Assets B.V. | Hyaluronic acid for use on the skin |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4784991A (en) * | 1986-03-14 | 1988-11-15 | Bio-Technology General Corp. | Heavy metal salts of hyaluronic acid and their use as antimicrobial agents |
HU225991B1 (en) * | 1997-04-29 | 2008-02-28 | Richter Gedeon Nyrt | Use of the zinc hyaluronate associate (complex) for the preparation of pharmaceutical compositions for oral use against peptic ulcer |
HU225329B1 (en) * | 1996-09-12 | 2006-09-28 | Richter Gedeon Vegyeszet | Use of zinc or cobalt hyaluronate associate for the manufacture of pharmaceutical compositions of antimicrobial activity |
KR20010057585A (ko) * | 1999-12-24 | 2001-07-04 | 고바야시 레이지로 | 피부외용제 |
US6828308B2 (en) * | 2000-07-28 | 2004-12-07 | Sinclair Pharmaceuticals, Ltd. | Compositions and methods for the treatment or prevention of inflammation |
ITMI20030195A1 (it) * | 2003-02-06 | 2004-08-07 | Bsd Bioscience Dev Snc Di O Mini C E Zucc | Formulazioni topiche contenenti principi attivi naturali adatte alla prevenzione e cura dei processi infiammatori delle mucose |
ES2296279T3 (es) * | 2006-02-10 | 2008-04-16 | Lombardo, Vincenzo Massimo | Compuesto antiflogistico y analgesico para uso topico sobre una zona del sistema locomotor animal. |
-
2006
- 2006-06-13 IT IT001132A patent/ITMI20061132A1/it unknown
-
2007
- 2007-06-13 EP EP07733203A patent/EP2040715A1/en not_active Withdrawn
- 2007-06-13 WO PCT/GB2007/002197 patent/WO2007144613A1/en active Application Filing
- 2007-06-13 US US12/304,204 patent/US20100003311A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP2040715A1 (en) | 2009-04-01 |
US20100003311A1 (en) | 2010-01-07 |
WO2007144613A1 (en) | 2007-12-21 |
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