NO321912B1 - Anordning for spraytorking og fremgangsmater for bruk av samme - Google Patents
Anordning for spraytorking og fremgangsmater for bruk av samme Download PDFInfo
- Publication number
- NO321912B1 NO321912B1 NO20015351A NO20015351A NO321912B1 NO 321912 B1 NO321912 B1 NO 321912B1 NO 20015351 A NO20015351 A NO 20015351A NO 20015351 A NO20015351 A NO 20015351A NO 321912 B1 NO321912 B1 NO 321912B1
- Authority
- NO
- Norway
- Prior art keywords
- drying
- drying chamber
- sectional area
- cross
- pipe
- Prior art date
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D1/00—Evaporating
- B01D1/16—Evaporating by spraying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
- B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D1/00—Evaporating
- B01D1/16—Evaporating by spraying
- B01D1/18—Evaporating by spraying to obtain dry solids
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Drying Of Solid Materials (AREA)
- Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Glanulating (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/304,257 US6223455B1 (en) | 1999-05-03 | 1999-05-03 | Spray drying apparatus and methods of use |
PCT/US2000/011158 WO2000066256A1 (en) | 1999-05-03 | 2000-04-26 | Spray drying apparatus and methods of use |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20015351L NO20015351L (no) | 2001-01-02 |
NO20015351D0 NO20015351D0 (no) | 2001-11-01 |
NO321912B1 true NO321912B1 (no) | 2006-07-17 |
Family
ID=23175745
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20015351A NO321912B1 (no) | 1999-05-03 | 2001-11-01 | Anordning for spraytorking og fremgangsmater for bruk av samme |
Country Status (19)
Country | Link |
---|---|
US (2) | US6223455B1 (zh) |
EP (1) | EP1175257B9 (zh) |
JP (1) | JP5412022B2 (zh) |
KR (1) | KR100464065B1 (zh) |
AT (1) | ATE260707T1 (zh) |
AU (1) | AU769298B2 (zh) |
BR (1) | BR0011226B1 (zh) |
CA (1) | CA2372194C (zh) |
DE (1) | DE60008720T3 (zh) |
DK (1) | DK1175257T4 (zh) |
ES (1) | ES2216889T5 (zh) |
IL (1) | IL146265A0 (zh) |
MY (1) | MY125075A (zh) |
NO (1) | NO321912B1 (zh) |
NZ (1) | NZ515684A (zh) |
PT (1) | PT1175257E (zh) |
TW (1) | TW553770B (zh) |
WO (1) | WO2000066256A1 (zh) |
ZA (1) | ZA200109553B (zh) |
Families Citing this family (86)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6051256A (en) | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
US20030203036A1 (en) * | 2000-03-17 | 2003-10-30 | Gordon Marc S. | Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients |
DE10001256A1 (de) * | 2000-01-14 | 2001-07-19 | Bayer Ag | Kontinuierliches Verfahren und Vorrichtung zur Trocknung und Gelbildung von lösungsmittelhaltigen gelbildenden Polymeren |
GT200100039A (es) * | 2000-03-16 | 2001-12-31 | Pfizer | Inhibidor de la glucogeno fosforilasa. |
US7575761B2 (en) * | 2000-06-30 | 2009-08-18 | Novartis Pharma Ag | Spray drying process control of drying kinetics |
WO2002009669A2 (en) * | 2000-08-01 | 2002-02-07 | Inhale Therapeutic Systems, Inc. | Apparatus and process to produce particles having a narrow size distribution and particles made thereby |
AU2002342241B2 (en) * | 2001-11-01 | 2007-07-19 | Novartis Ag | Spray drying methods and compositions thereof |
US20030190472A1 (en) * | 2002-04-03 | 2003-10-09 | 3D Systems, Inc. | Thermoplastic polymer filled pastes |
KR20050011741A (ko) * | 2002-04-11 | 2005-01-29 | 메드이뮨 백신즈 인코포레이티드 | 분무 건조에 의한 생물학적 활성 물질의 보존 |
AU2003223718B2 (en) * | 2002-04-25 | 2007-08-16 | The Scripps Research Institute | Treatment and prevention of pulmonary conditions |
GB0216562D0 (en) | 2002-04-25 | 2002-08-28 | Bradford Particle Design Ltd | Particulate materials |
GB0219815D0 (en) * | 2002-08-24 | 2002-10-02 | Accentus Plc | Preparation of small crystals |
US9339459B2 (en) | 2003-04-24 | 2016-05-17 | Nektar Therapeutics | Particulate materials |
DE10234165B4 (de) * | 2002-07-26 | 2008-01-03 | Advanced Micro Devices, Inc., Sunnyvale | Verfahren zum Füllen eines Grabens, der in einem Substrat gebildet ist, mit einem isolierenden Material |
US20040121003A1 (en) * | 2002-12-19 | 2004-06-24 | Acusphere, Inc. | Methods for making pharmaceutical formulations comprising deagglomerated microparticles |
US6962006B2 (en) * | 2002-12-19 | 2005-11-08 | Acusphere, Inc. | Methods and apparatus for making particles using spray dryer and in-line jet mill |
MXPA05007154A (es) | 2002-12-30 | 2005-09-21 | Nektar Therapeutics | Atomizador prepeliculizacion. |
KR100760144B1 (ko) * | 2003-03-26 | 2007-09-18 | 현대중공업 주식회사 | 휘발성 첨가제를 이용한 초고압수 도장 전처리용 분사액조성물 |
GB0327723D0 (en) * | 2003-09-15 | 2003-12-31 | Vectura Ltd | Pharmaceutical compositions |
JP2005138051A (ja) * | 2003-11-07 | 2005-06-02 | Kurita Water Ind Ltd | 除去材の製造方法及び除去材 |
JP2007513180A (ja) * | 2003-12-04 | 2007-05-24 | ザ スクリプス リサーチ インスティテュート | 喘息の処置および予防 |
DE102004007526A1 (de) * | 2004-02-17 | 2005-09-01 | Oetjen, Georg-Wilhelm, Dr. | Verfahren und Einrichtung zur Gefriertrocknung von Produkten |
WO2005096744A2 (en) * | 2004-03-31 | 2005-10-20 | The Regents Of The University Of California | Oriented polymer fibers and methods for fabricating thereof |
GB0411502D0 (en) * | 2004-05-22 | 2004-06-23 | Britannia Pharmaceuticals Ltd | Pharmaceutical compositions |
JP4427643B2 (ja) * | 2004-08-27 | 2010-03-10 | 国立大学法人室蘭工業大学 | 活性化アルミニウム微粒子の乾燥及び保存方法 |
EP1807332A2 (en) * | 2004-10-08 | 2007-07-18 | E.I. Dupont De Nemours And Company | Dust suppression method and apparatus |
US7045110B1 (en) | 2004-11-17 | 2006-05-16 | Poly Systems Usa, Inc. | High yield co-production of anhydrous hydrogen bromide and sodium bisulfate |
GB0501835D0 (en) * | 2005-01-28 | 2005-03-09 | Unilever Plc | Improvements relating to spray dried compositions |
US20080227693A1 (en) * | 2005-08-29 | 2008-09-18 | Palatin Technologies, Inc. | Cyclic Peptide Isolation by Spray Drying |
GB0517688D0 (en) * | 2005-08-31 | 2005-10-05 | Cambridge Biostability Ltd | Improvements in the stabilisation of biological materials |
GB0523638D0 (en) | 2005-11-21 | 2005-12-28 | Cambridge Biostability Ltd | Pharmaceutical device for the administration of substances to patients |
EP1978933A2 (en) * | 2005-12-15 | 2008-10-15 | Acusphere, Inc. | Processes for making particle-based pharmaceutical formulations for oral administration |
EP1973523A2 (en) * | 2005-12-15 | 2008-10-01 | Acusphere, Inc. | Processes for making particle-based pharmaceutical formulations for pulmonary or nasal administration |
BRPI0708957A2 (pt) * | 2006-03-20 | 2011-06-28 | Vertex Pharma | composições farmacêuticas |
EP1870649A1 (en) | 2006-06-20 | 2007-12-26 | Octapharma AG | Lyophilisation targetting defined residual moisture by limited desorption energy levels |
EP2107934B1 (en) * | 2006-12-07 | 2019-11-20 | FrieslandCampina Nederland B.V. | Method and apparatus for spray drying |
MX2009006806A (es) * | 2006-12-22 | 2009-08-27 | Vertex Pharma | Secado por rocio fluidizado. |
WO2008122288A1 (en) * | 2007-04-10 | 2008-10-16 | Anhydro A/S | Process gas filtration |
SI2197429T1 (sl) * | 2007-09-03 | 2016-09-30 | Nanotherapeutics, Inc. | Sestavki iz delcev za vnos slabo topnih zdravil |
US8448880B2 (en) | 2007-09-18 | 2013-05-28 | Flow International Corporation | Apparatus and process for formation of laterally directed fluid jets |
WO2009111564A1 (en) * | 2008-03-04 | 2009-09-11 | Cleveland State University | Method and system for particle settling velocity measurement |
US8176655B2 (en) * | 2008-12-16 | 2012-05-15 | Spx Flow Technology Danmark A/S | Vapor atmosphere spray dryer |
WO2010111132A2 (en) * | 2009-03-27 | 2010-09-30 | Bend Research, Inc. | Spray-drying process |
CA2757961C (en) | 2009-04-09 | 2020-02-04 | Entegrion, Inc. | Spray-dried blood products and methods of making same |
US8407912B2 (en) * | 2010-09-16 | 2013-04-02 | Velico Medical, Inc. | Spray dried human plasma |
WO2011035062A2 (en) | 2009-09-16 | 2011-03-24 | Velico Medical, Inc. | Spray dried human plasma |
EP2496634B1 (en) | 2009-11-04 | 2016-10-05 | Research Foundation Of The City University Of New York | Method for making polyamide particles |
KR101164913B1 (ko) | 2010-01-05 | 2012-07-19 | 금호석유화학 주식회사 | 탄소나노튜브 합성용 촉매 제조 시스템 및 그 방법 |
FR2955927B1 (fr) * | 2010-02-01 | 2012-04-06 | Alcatel Lucent | Dispositif et procede de pilotage d'une operation de deshydratation durant un traitement de lyophilisation |
WO2011139749A2 (en) | 2010-04-27 | 2011-11-10 | University Of Maine System Board Of Trustees | Method for drying cellulose nanofibrils |
WO2012058575A2 (en) | 2010-10-29 | 2012-05-03 | Velico Medical, Inc. | System and method for spray drying a liquid |
US20140083628A1 (en) | 2012-09-27 | 2014-03-27 | Velico Medical, Inc. | Spray drier assembly for automated spray drying |
ES2645769T3 (es) | 2011-01-05 | 2017-12-07 | Hospira, Inc. | Secado por pulverización de la vancomicina |
CN102288015A (zh) * | 2011-07-26 | 2011-12-21 | 中国林业科学研究院林产化学工业研究所 | 常压低温喷雾干燥装置及干燥方法 |
JP5893882B2 (ja) * | 2011-09-28 | 2016-03-23 | 東京エレクトロン株式会社 | パーティクル捕集装置及びパーティクルの捕集方法 |
US20130089638A1 (en) | 2011-10-11 | 2013-04-11 | Mead Johnson Nutrition Company | Compositions Comprising Maltotriose And Methods Of Using Same To Inhibit Damage Caused By Dehydration Processes |
SG10202103003RA (en) * | 2011-11-18 | 2021-05-28 | Regeneron Pharma | Polymer protein microparticles |
US20130172271A1 (en) * | 2012-01-04 | 2013-07-04 | Cynthia Fragale | Pharmaceutical Spray Drying |
US20150011380A1 (en) * | 2012-02-22 | 2015-01-08 | Mitsubishi Heavy Industries, Ltd. | Catalyst for carbon nanotube production |
RU2497792C1 (ru) * | 2012-04-23 | 2013-11-10 | Федеральное казенное предприятие "Государственный научно-исследовательский институт химических продуктов" (ФКП "ГосНИИХП") | Способ предварительной сушки сферического пороха |
JP5827178B2 (ja) * | 2012-06-05 | 2015-12-02 | 北越紀州製紙株式会社 | セルロース多孔質体及びその製造方法 |
CN104043104B (zh) | 2013-03-15 | 2018-07-10 | 浙江创新生物有限公司 | 含盐酸万古霉素的喷雾干粉及其工业化制备方法 |
RU2529763C1 (ru) * | 2013-08-01 | 2014-09-27 | Иван Егорович Тимофеев | Способ сушки дисперсного материала во взвешенно-транспортируемом слое и установка для его осуществления |
JP6238401B2 (ja) * | 2013-10-28 | 2017-11-29 | 日本化薬株式会社 | 生理活性ペプチド徐放性微粒子及びその製造方法 |
PT107567B (pt) * | 2014-03-31 | 2019-02-13 | Hovione Farm S A | Secador por atomização com atomizador múltiplo, método para o aumento de escala de pós para inalação secos por dispositivo de atomização múltiplo e uso de vários atomizadores num secador por atomização |
WO2015166777A1 (ja) * | 2014-04-28 | 2015-11-05 | 日本ゼオン株式会社 | 電気化学素子電極用複合粒子の製造方法 |
US9561184B2 (en) | 2014-09-19 | 2017-02-07 | Velico Medical, Inc. | Methods and systems for multi-stage drying of plasma |
EP3628398B1 (en) | 2015-01-28 | 2021-08-04 | Fona Technologies, Inc. | Method for preparing an encapsulated product and encapsulated product |
US10571272B2 (en) | 2016-01-05 | 2020-02-25 | Blackberry Limited | Mobile transceiver with adaptive monitoring and reporting |
JP7073037B2 (ja) * | 2016-03-11 | 2022-05-23 | 株式会社リコー | 粒子製造装置、及び粒子製造方法 |
US10967345B2 (en) | 2016-04-18 | 2021-04-06 | Premex S.A.S. | Multiple modular system for the formation of particles in powder and microcapsule form for different processes |
US20170296993A1 (en) * | 2016-04-18 | 2017-10-19 | Premex S.A. | Multiple modular system for the formation of particles in powder and microcapsule form for different processes |
ES2674808B1 (es) * | 2016-12-30 | 2019-04-11 | Bioinicia S L | Instalacion y procedimiento de encapsulado industrial de sustanciastermolabiles |
IT201700035338A1 (it) * | 2017-03-30 | 2018-09-30 | Bio On Spa | Composizione cosmetica comprendente un poliestere biodegradabile e una fase oleosa. |
CN106931767A (zh) * | 2017-04-28 | 2017-07-07 | 南通永大管业股份有限公司 | 多功能管式烘干装置 |
US10648730B1 (en) * | 2017-05-08 | 2020-05-12 | Cenorin, Llc | Medical implement drying apparatus |
KR101945104B1 (ko) * | 2017-05-16 | 2019-02-08 | 한국지질자원연구원 | 자외선 차단용 점토광물-금속산화물 복합체 분말, 이의 제조방법 및 상기 복합체 분말을 포함하는 자외선 차단용 조성물 |
JP6616053B1 (ja) * | 2018-06-08 | 2019-12-04 | 株式会社アルバック | 凍結真空乾燥装置及び凍結真空乾燥方法 |
WO2019235036A1 (ja) | 2018-06-08 | 2019-12-12 | 株式会社アルバック | 凍結真空乾燥装置及び凍結真空乾燥方法 |
US11617965B2 (en) | 2018-12-21 | 2023-04-04 | Novo Nordisk A/S | Process of spray drying of GLP-1 peptide |
CN110694532B (zh) * | 2019-09-16 | 2022-03-01 | 陕西中医药大学 | 一种药理学实验用的混合加热装置 |
AU2021333925A1 (en) * | 2020-08-31 | 2023-03-30 | Spraying Systems Co. | Electrostatic spray dryer apparatus and method |
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US11975274B2 (en) | 2022-09-15 | 2024-05-07 | Velico Medical, Inc. | Blood plasma product |
US11841189B1 (en) | 2022-09-15 | 2023-12-12 | Velico Medical, Inc. | Disposable for a spray drying system |
US11998861B2 (en) | 2022-09-15 | 2024-06-04 | Velico Medical, Inc. | Usability of a disposable for a spray drying plasma system |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL280499A (zh) * | ||||
GB634467A (en) * | 1947-08-07 | 1950-03-22 | Calder And Mersey Extract Comp | Improvements relating to the formation of powders by drying |
BE543857A (zh) * | 1954-12-23 | |||
US2912768A (en) * | 1955-11-08 | 1959-11-17 | Cherry Burrell Corp | Cyclone discharge chamber |
FR2257326B1 (zh) * | 1973-06-19 | 1976-05-28 | Rhone Progil | |
DE2352894B2 (de) † | 1973-10-22 | 1981-04-16 | Aktieselskabet Niro Atomizer, Soeborg | Verfahren zur Herstellung von Pulver aus Milch oder ähnlichen Flüssigkeiten |
US3908632A (en) * | 1974-06-24 | 1975-09-30 | Universal Oil Prod Co | Solar heat absorbing system |
US4187617A (en) * | 1978-12-18 | 1980-02-12 | Becker James J Jr | Spray dryer |
US4441822A (en) * | 1980-09-03 | 1984-04-10 | Foster Wheeler Energy Corporation | Apparatus for mixing and distributing solid particulate material |
JPS58154702A (ja) * | 1982-03-09 | 1983-09-14 | Mitsui Petrochem Ind Ltd | 撹拌流動層型気相重合装置のガス分散板 |
JPH0615001B2 (ja) * | 1984-09-04 | 1994-03-02 | 株式会社クメタ製作所 | 噴霧乾燥装置 |
JPS6387582A (ja) * | 1986-09-30 | 1988-04-18 | 日本フア−ネス工業株式会社 | 直接接触乾燥プラントの固形物付着防止方法 |
FR2652153B1 (fr) * | 1989-07-06 | 1995-01-27 | Francois Laurenty | Procede et tour de sechage de produits en grains. |
US5096537A (en) * | 1990-06-28 | 1992-03-17 | Henningsen Foods, Inc. | Tower spray dryer with hot and cool air supply |
KR100259989B1 (ko) | 1991-10-01 | 2000-08-01 | 모리다 가쓰라 | 서방성 마이크로캡슐 제제 및 그의 제조법 |
JPH0790307A (ja) * | 1993-09-22 | 1995-04-04 | Hokkaido Sumiden Seimitsu Kk | 粉末の製造方法及び装置 |
US5581903A (en) * | 1994-11-22 | 1996-12-10 | Botich; Leon A. | Apparatus for heating purge gas and transmitting microwave energy for desiccant regeneration |
US5611344A (en) | 1996-03-05 | 1997-03-18 | Acusphere, Inc. | Microencapsulated fluorinated gases for use as imaging agents |
NZ331460A (en) * | 1996-03-05 | 1998-12-23 | Acusphere Inc | Microencapsulated fluorinated gases for use as imaging agents |
KR0177309B1 (ko) * | 1996-04-10 | 1999-03-20 | 성재갑 | 분무 건조에 의한 서방성 미세입자의 제조방법 |
US5647142A (en) * | 1996-05-13 | 1997-07-15 | Niro A/S | Apparatus and process for drying a moist material dispersed or dispersible in a stream of drying gas |
US5855913A (en) | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
JP3585654B2 (ja) * | 1996-07-11 | 2004-11-04 | 株式会社パウダリングジャパン | 2段乾燥式スプレードライヤー装置 |
BR9812693A (pt) * | 1997-09-29 | 2000-08-22 | Inhale Therapeutic Syst | Uso de um agente bioativo, processo para formar uma microestrutura perfurada, microestrutura perfurada, processo para aumentar a dispersibilidade de um pó, pó de microestrutura perfurada, pó tendo dispersibilidade aumentada, sistema de inalação para a administração pulmonar de um agente bioativo a um paciente, e, processo para a liberação pulmonar de um ou mais agentes bioativos |
-
1999
- 1999-05-03 US US09/304,257 patent/US6223455B1/en not_active Expired - Lifetime
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2000
- 2000-04-26 BR BRPI0011226-7A patent/BR0011226B1/pt not_active IP Right Cessation
- 2000-04-26 ES ES00928391T patent/ES2216889T5/es not_active Expired - Lifetime
- 2000-04-26 IL IL14626500A patent/IL146265A0/xx not_active IP Right Cessation
- 2000-04-26 WO PCT/US2000/011158 patent/WO2000066256A1/en active IP Right Grant
- 2000-04-26 AT AT00928391T patent/ATE260707T1/de active
- 2000-04-26 DK DK00928391T patent/DK1175257T4/da active
- 2000-04-26 NZ NZ515684A patent/NZ515684A/en not_active IP Right Cessation
- 2000-04-26 DE DE60008720T patent/DE60008720T3/de not_active Expired - Lifetime
- 2000-04-26 JP JP2000615133A patent/JP5412022B2/ja not_active Expired - Fee Related
- 2000-04-26 EP EP00928391A patent/EP1175257B9/en not_active Expired - Lifetime
- 2000-04-26 KR KR10-2001-7013974A patent/KR100464065B1/ko not_active IP Right Cessation
- 2000-04-26 PT PT00928391T patent/PT1175257E/pt unknown
- 2000-04-26 CA CA002372194A patent/CA2372194C/en not_active Expired - Lifetime
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2001
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- 2001-11-20 ZA ZA200109553A patent/ZA200109553B/en unknown
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ES2216889T5 (es) | 2009-03-01 |
NO20015351D0 (no) | 2001-11-01 |
US6223455B1 (en) | 2001-05-01 |
DK1175257T4 (da) | 2008-10-27 |
TW553770B (en) | 2003-09-21 |
DE60008720D1 (de) | 2004-04-08 |
DE60008720T2 (de) | 2005-03-24 |
NZ515684A (en) | 2003-05-30 |
KR20010110808A (ko) | 2001-12-13 |
EP1175257B2 (en) | 2008-09-10 |
US6308434B1 (en) | 2001-10-30 |
ATE260707T1 (de) | 2004-03-15 |
BR0011226B1 (pt) | 2011-11-01 |
EP1175257B9 (en) | 2009-08-12 |
DK1175257T3 (da) | 2004-07-05 |
PT1175257E (pt) | 2004-07-30 |
NO20015351L (no) | 2001-01-02 |
ZA200109553B (en) | 2003-06-06 |
KR100464065B1 (ko) | 2005-01-03 |
DE60008720T3 (de) | 2009-04-30 |
IL146265A0 (en) | 2002-07-25 |
US20010027614A1 (en) | 2001-10-11 |
WO2000066256A1 (en) | 2000-11-09 |
EP1175257B1 (en) | 2004-03-03 |
BR0011226A (pt) | 2002-05-07 |
JP2002542926A (ja) | 2002-12-17 |
JP5412022B2 (ja) | 2014-02-12 |
ES2216889T3 (es) | 2004-11-01 |
AU4664000A (en) | 2000-11-17 |
MY125075A (en) | 2006-07-31 |
EP1175257A1 (en) | 2002-01-30 |
CA2372194A1 (en) | 2000-11-09 |
AU769298B2 (en) | 2004-01-22 |
CA2372194C (en) | 2005-01-18 |
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