NO305598B1 - Fluoralkoksysubstituerte benzamider og deres anvendelse - Google Patents
Fluoralkoksysubstituerte benzamider og deres anvendelseInfo
- Publication number
- NO305598B1 NO305598B1 NO19955211A NO955211A NO305598B1 NO 305598 B1 NO305598 B1 NO 305598B1 NO 19955211 A NO19955211 A NO 19955211A NO 955211 A NO955211 A NO 955211A NO 305598 B1 NO305598 B1 NO 305598B1
- Authority
- NO
- Norway
- Prior art keywords
- stands
- alkoxy
- halogen
- hydrogen
- alkyl
- Prior art date
Links
- 229940054066 benzamide antipsychotics Drugs 0.000 title 1
- 150000003936 benzamides Chemical class 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 abstract 7
- 150000002367 halogens Chemical class 0.000 abstract 7
- 125000000229 (C1-C4)alkoxy group Chemical class 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 150000002431 hydrogen Chemical class 0.000 abstract 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
- -1 cyano, carboxyl Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH199693 | 1993-07-02 | ||
| PCT/EP1994/002169 WO1995001338A1 (de) | 1993-07-02 | 1994-07-02 | Fluoralkoxy substituierte benzamide und ihre verwendung als zyklisch-nukleotid phosphodiesterase-inhibitoren |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO955211L NO955211L (no) | 1995-12-21 |
| NO955211D0 NO955211D0 (no) | 1995-12-21 |
| NO305598B1 true NO305598B1 (no) | 1999-06-28 |
Family
ID=4223466
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19955211A NO305598B1 (no) | 1993-07-02 | 1995-12-21 | Fluoralkoksysubstituerte benzamider og deres anvendelse |
| NO2010018C NO2010018I1 (no) | 1993-07-02 | 2010-09-30 | Roflumilast, roflumilast-N-oksid og saltene av disse forbindelsene |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO2010018C NO2010018I1 (no) | 1993-07-02 | 2010-09-30 | Roflumilast, roflumilast-N-oksid og saltene av disse forbindelsene |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5712298A (cs) |
| EP (1) | EP0706513B1 (cs) |
| JP (1) | JP3093271B2 (cs) |
| KR (1) | KR100331255B1 (cs) |
| CN (1) | CN1046939C (cs) |
| AT (1) | ATE217612T1 (cs) |
| AU (1) | AU687087B2 (cs) |
| CA (1) | CA2165192C (cs) |
| CY (2) | CY2389B1 (cs) |
| CZ (1) | CZ290266B6 (cs) |
| DE (2) | DE59410119D1 (cs) |
| DK (1) | DK0706513T3 (cs) |
| ES (1) | ES2176252T3 (cs) |
| FI (1) | FI112864B (cs) |
| FR (1) | FR10C0052I2 (cs) |
| HU (1) | HU220041B (cs) |
| LU (1) | LU91709I2 (cs) |
| LV (1) | LV13074B (cs) |
| NO (2) | NO305598B1 (cs) |
| NZ (1) | NZ271316A (cs) |
| PL (1) | PL178314B1 (cs) |
| PT (1) | PT706513E (cs) |
| RU (1) | RU2137754C1 (cs) |
| SG (1) | SG143011A1 (cs) |
| SI (1) | SI0706513T1 (cs) |
| SK (1) | SK283263B6 (cs) |
| WO (1) | WO1995001338A1 (cs) |
Families Citing this family (202)
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| US5874437A (en) * | 1996-11-01 | 1999-02-23 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
| US5958926A (en) | 1996-11-01 | 1999-09-28 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
| USRE37234E1 (en) * | 1996-11-01 | 2001-06-19 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses |
| JP2001504457A (ja) * | 1996-11-01 | 2001-04-03 | ニトロメド インコーポレーテッド | ニトロソ化およびニトロシル化ホスホジエステラーゼ阻害剤化合物、組成物及びその使用法 |
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| TR199901772T2 (cs) * | 1997-02-17 | 1999-09-21 | Byk Gulden Lomberg Chemische Fabrik Gmbh | |
| US6472425B1 (en) | 1997-10-31 | 2002-10-29 | Nitromed, Inc. | Methods for treating female sexual dysfunctions |
| US6118017A (en) * | 1998-04-14 | 2000-09-12 | Smithkline Beecham Corporation | Substituted-(3-cyclopentyloxy-4-methoxyphenyl)-3-phenylcyanocyclobutan-1-one |
| JP2002538207A (ja) * | 1999-03-10 | 2002-11-12 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | 多発性硬化症治療のための３−シクロプロピルメトキシ−４−ジフルオロメトキシ−ｎ−（３，５−ジクロロピリド−４−イル）ベンズアミド |
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| EP1188438A1 (en) * | 2000-09-15 | 2002-03-20 | Warner-Lambert Company | Pharmaceutical composition for preventing or treating a disease associated with an excess of Il-12 production |
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| US20100310477A1 (en) * | 2000-11-28 | 2010-12-09 | Boehringer Ingelheim Pharma Gmbh & Co. Kg. | Pharmaceutical compositions based on anticholingerics and additional active ingredients |
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| MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| TWI347845B (en) * | 2002-03-06 | 2011-09-01 | Nycomed Gmbh | Pharmaceutical compositions,combinations,and kits for the treatment of respiratory diseases and use of the same |
| RU2227797C2 (ru) * | 2002-03-29 | 2004-04-27 | Пермская государственная фармацевтическая академия | 4-метил-2-пиридиламид тетрахлорфталевой кислоты, проявляющий гипертензивную активность |
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| TW200426138A (en) * | 2002-12-10 | 2004-12-01 | Hoffmann La Roche | Novel arylene-carboxylic acid (2-amino-phenyl)-amide derivatives, their manufacture and use as pharmaceutical agents |
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| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
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| US20070117861A1 (en) * | 2003-11-12 | 2007-05-24 | University Of South Carolina | Treatment or prevention of cardiovascular and respiratory disorders with novel substituted cyclic-amp specific phosphodiesterase inhibitors |
| ATE542546T1 (de) * | 2003-11-20 | 2012-02-15 | Astellas Pharma Inc | Pde 4 inhibitoren zur behandlung der interstitiellen cystitis |
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- 1994-07-02 RU RU96102569A patent/RU2137754C1/ru active Protection Beyond IP Right Term
- 1994-07-02 KR KR1019950705937A patent/KR100331255B1/ko not_active Expired - Lifetime
- 1994-07-02 EP EP94924713A patent/EP0706513B1/de not_active Expired - Lifetime
- 1994-07-02 DK DK94924713T patent/DK0706513T3/da active
-
1995
- 1995-12-21 NO NO19955211A patent/NO305598B1/no not_active IP Right Cessation
- 1995-12-29 FI FI956333A patent/FI112864B/fi not_active IP Right Cessation
-
2003
- 2003-05-13 LV LVP-03-48A patent/LV13074B/lv unknown
- 2003-11-11 CY CY0300082A patent/CY2389B1/xx unknown
-
2010
- 2010-07-21 LU LU91709C patent/LU91709I2/fr unknown
- 2010-09-29 CY CY2010015C patent/CY2010015I1/el unknown
- 2010-09-30 NO NO2010018C patent/NO2010018I1/no unknown
- 2010-12-06 FR FR10C0052C patent/FR10C0052I2/fr active Active
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