NO304523B1 - Vasoaktive cykliske polypeptider - Google Patents
Vasoaktive cykliske polypeptider Download PDFInfo
- Publication number
- NO304523B1 NO304523B1 NO923929A NO923929A NO304523B1 NO 304523 B1 NO304523 B1 NO 304523B1 NO 923929 A NO923929 A NO 923929A NO 923929 A NO923929 A NO 923929A NO 304523 B1 NO304523 B1 NO 304523B1
- Authority
- NO
- Norway
- Prior art keywords
- peptide
- lys
- boc
- mmol
- seq
- Prior art date
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- 108090000765 processed proteins & peptides Proteins 0.000 title claims description 313
- 102000004196 processed proteins & peptides Human genes 0.000 title description 28
- 229920001184 polypeptide Polymers 0.000 title description 5
- 125000004122 cyclic group Chemical group 0.000 title description 3
- 230000002227 vasoactive effect Effects 0.000 title description 3
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- 238000002360 preparation method Methods 0.000 claims description 51
- -1 methyl-cyclohexyl Chemical group 0.000 claims description 50
- 239000000463 material Substances 0.000 claims description 45
- 125000006239 protecting group Chemical group 0.000 claims description 32
- 102000001189 Cyclic Peptides Human genes 0.000 claims description 27
- 108010069514 Cyclic Peptides Proteins 0.000 claims description 27
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 14
- 101100129088 Caenorhabditis elegans lys-2 gene Proteins 0.000 claims description 12
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 9
- 229910052739 hydrogen Inorganic materials 0.000 claims description 8
- 239000001257 hydrogen Substances 0.000 claims description 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 8
- 229940124630 bronchodilator Drugs 0.000 claims description 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 7
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 6
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- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims description 3
- 125000001624 naphthyl group Chemical group 0.000 claims description 3
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/17—Vasoactive intestinal peptides; related peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/27—Cyclic peptide or cyclic protein
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77374791A | 1991-10-11 | 1991-10-11 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO923929D0 NO923929D0 (no) | 1992-10-09 |
| NO923929L NO923929L (no) | 1993-04-13 |
| NO304523B1 true NO304523B1 (no) | 1999-01-04 |
Family
ID=25099195
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO923929A NO304523B1 (no) | 1991-10-11 | 1992-10-09 | Vasoaktive cykliske polypeptider |
| NO975023A NO975023D0 (no) | 1991-10-11 | 1997-10-31 | Vasoaktive cykliske polypeptider |
| NO980377A NO980377D0 (no) | 1991-10-11 | 1998-01-28 | Vasoaktive cykliske peptider |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO975023A NO975023D0 (no) | 1991-10-11 | 1997-10-31 | Vasoaktive cykliske polypeptider |
| NO980377A NO980377D0 (no) | 1991-10-11 | 1998-01-28 | Vasoaktive cykliske peptider |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US5677419A (cs) |
| EP (1) | EP0536741B1 (cs) |
| JP (1) | JP2515473B2 (cs) |
| KR (1) | KR970001580B1 (cs) |
| CN (3) | CN1034943C (cs) |
| AT (1) | ATE132165T1 (cs) |
| AU (1) | AU656230B2 (cs) |
| BG (1) | BG61125B2 (cs) |
| BR (1) | BR9203959A (cs) |
| CA (1) | CA2080272C (cs) |
| CZ (1) | CZ281818B6 (cs) |
| DE (1) | DE69207138T2 (cs) |
| DK (1) | DK0536741T3 (cs) |
| ES (1) | ES2082317T3 (cs) |
| FI (2) | FI111646B (cs) |
| GR (1) | GR3019326T3 (cs) |
| HU (2) | HUT62606A (cs) |
| IL (3) | IL117252A (cs) |
| MX (1) | MX9205822A (cs) |
| NO (3) | NO304523B1 (cs) |
| NZ (1) | NZ244644A (cs) |
| RU (1) | RU2095368C1 (cs) |
| SK (1) | SK279399B6 (cs) |
| TW (1) | TW305846B (cs) |
| UY (2) | UY23488A1 (cs) |
| ZA (1) | ZA927724B (cs) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6872803B1 (en) | 1993-09-21 | 2005-03-29 | Kyowa Hakko Kogyo Co., Ltd. | Peptides |
| AU722895B2 (en) * | 1996-02-09 | 2000-08-10 | F. Hoffmann-La Roche Ag | Synthesis of VIP analog |
| WO1998002192A1 (en) | 1996-07-12 | 1998-01-22 | Immunomedics, Inc. | Radiometal-binding peptide analogues |
| WO1998002453A2 (en) * | 1996-07-15 | 1998-01-22 | Universite Libre De Bruxelles | Peptidic ligands having a higher selectivity for the vip1 receptor than for the vip2 receptor |
| US6972319B1 (en) | 1999-09-28 | 2005-12-06 | Bayer Pharmaceuticals Corporation | Pituitary adenylate cyclase activating peptide (PACAP)receptor 3 (R3) agonists and their pharmacological methods of use |
| EP1192182B1 (en) * | 1999-09-28 | 2008-06-04 | Bayer Corporation | Pituitary adenylate cyclase activating peptide (pacap) receptor 3 (r3) agonists and their pharmacological methods of use |
| EP1257576B1 (en) * | 2000-02-18 | 2004-09-15 | Dabur Research Foundation | Vasoactive intestinal peptide analogs |
| WO2001060863A1 (en) | 2000-02-18 | 2001-08-23 | Dabur Research Foundation | Radiolabeled vasoactive intestinal peptide analogs for diagnosis and radiotherapy |
| US6828304B1 (en) | 2000-07-31 | 2004-12-07 | Dabur Research Foundation | Peptides for treatment of cancer |
| US7507714B2 (en) * | 2000-09-27 | 2009-03-24 | Bayer Corporation | Pituitary adenylate cyclase activating peptide (PACAP) receptor 3 (R3) agonists and their pharmacological methods of use |
| CN101229363A (zh) | 2000-11-28 | 2008-07-30 | 蒙多生物技术许可股份公司 | 具有血管活性肠肽的生物学活性的用于治疗肺动脉和小动脉高压的化合物 |
| DE60326723D1 (de) | 2002-06-10 | 2009-04-30 | Mondobiotech Licensing Out Ag | Verwendung von zusammensetzungen mit der biologischen aktivität der vasoaktiven intestinalen peptide zur behandlung von sarcoidose |
| AU2005208911A1 (en) * | 2004-01-27 | 2005-08-11 | Bayer Healthcare Llc | Pituitary adenylate cyclase activating peptide (PACAP) receptor (VPAC2) agonists and their pharmacological methods of use |
| US20080085860A1 (en) * | 2004-08-18 | 2008-04-10 | Eli Lilly And Company | Selective Vpac2 Receptor Peptide Agonists |
| EP1781692A2 (en) * | 2004-08-18 | 2007-05-09 | Eli Lilly And Company | Selective vpac2 receptor peptide agonists |
| US20100048460A1 (en) * | 2006-02-28 | 2010-02-25 | Lianshan Zhang | Selective vpac2 receptor peptide agonists |
| JP2009542593A (ja) * | 2006-07-06 | 2009-12-03 | エフ．ホフマン−ラ ロシュ アーゲー | 血管作動性腸管ペプチドの類似体 |
| CN101906144B (zh) * | 2009-06-03 | 2013-06-19 | 首都医科大学 | 一根Arg-Gly-Asp-Val链通过Asp与两根脂肪醇链的偶联物、它们的合成及在医学中的应用 |
| PT2464370T (pt) | 2009-08-14 | 2017-05-17 | Phasebio Pharmaceuticals Inc | Péptidos vasoativos intestinais modificados |
| CA2797033C (en) * | 2010-04-22 | 2021-10-19 | Longevity Biotech, Inc. | Highly active polypeptides and methods of making and using the same |
| US9561262B2 (en) | 2011-06-06 | 2017-02-07 | Phasebio Pharmaceuticals, Inc. | Use of modified vasoactive intestinal peptides in the treatment of hypertension |
| EP2968469A4 (en) | 2013-03-15 | 2016-08-31 | Longevity Biotech Inc | PEPTIDES COMPRISING NON-ENDOGENIC AMINO ACIDS AND METHODS OF MAKING AND USING SAME |
| GB201421647D0 (en) * | 2014-12-05 | 2015-01-21 | Amcure Gmbh And Ruprecht-Karls-Universitat And Karlsruher Institut F�R Technologie | CD44v6-derived cyclic peptides for treating cancers and angiogenesis related diseases |
| CA2976038A1 (en) | 2015-02-09 | 2016-08-18 | Phasebio Pharmaceuticals, Inc. | Methods and compositions for treating muscle disease and disorders |
| CA3036768A1 (en) | 2016-09-30 | 2018-04-05 | Fujifilm Corporation | Cyclic peptide, affinity chromatography support, labeled antibody, antibody drug conjugate, and pharmaceutical preparation |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8427651D0 (en) * | 1984-11-01 | 1984-12-05 | Beecham Group Plc | Compounds |
| US4835252A (en) * | 1987-02-26 | 1989-05-30 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Vasoactive intestinal peptide analogs |
| GB8729802D0 (en) * | 1987-12-22 | 1988-02-03 | Beecham Group Plc | Novel compounds |
| US5084442A (en) * | 1988-09-06 | 1992-01-28 | Hoffmann-La Roche Inc. | Cyclic growth hormone releasing factor analogs and method for the manufacture thereof |
| US5141924A (en) * | 1989-06-30 | 1992-08-25 | Hoffmann-La Roche, Inc. | Synthetic vasoactive intestinal peptide analogs |
-
1992
- 1992-10-06 AU AU26228/92A patent/AU656230B2/en not_active Ceased
- 1992-10-07 NZ NZ244644A patent/NZ244644A/en unknown
- 1992-10-07 ZA ZA927724A patent/ZA927724B/xx unknown
- 1992-10-08 TW TW081107995A patent/TW305846B/zh active
- 1992-10-08 DK DK92117185.6T patent/DK0536741T3/da active
- 1992-10-08 EP EP92117185A patent/EP0536741B1/en not_active Expired - Lifetime
- 1992-10-08 DE DE69207138T patent/DE69207138T2/de not_active Expired - Lifetime
- 1992-10-08 ES ES92117185T patent/ES2082317T3/es not_active Expired - Lifetime
- 1992-10-08 AT AT92117185T patent/ATE132165T1/de not_active IP Right Cessation
- 1992-10-08 RU SU925053217A patent/RU2095368C1/ru active
- 1992-10-09 IL IL11725292A patent/IL117252A/xx not_active IP Right Cessation
- 1992-10-09 CZ CS923086A patent/CZ281818B6/cs not_active IP Right Cessation
- 1992-10-09 JP JP4297835A patent/JP2515473B2/ja not_active Expired - Fee Related
- 1992-10-09 CA CA002080272A patent/CA2080272C/en not_active Expired - Fee Related
- 1992-10-09 NO NO923929A patent/NO304523B1/no not_active IP Right Cessation
- 1992-10-09 HU HU9203194A patent/HUT62606A/hu unknown
- 1992-10-09 SK SK3086-92A patent/SK279399B6/sk unknown
- 1992-10-09 IL IL103396A patent/IL103396A/xx not_active IP Right Cessation
- 1992-10-09 FI FI924580A patent/FI111646B/fi active
- 1992-10-09 UY UY23488A patent/UY23488A1/es not_active IP Right Cessation
- 1992-10-09 MX MX9205822A patent/MX9205822A/es not_active IP Right Cessation
- 1992-10-10 KR KR1019920018660A patent/KR970001580B1/ko not_active IP Right Cessation
- 1992-10-10 CN CN92113069A patent/CN1034943C/zh not_active Expired - Fee Related
- 1992-10-13 BR BR929203959A patent/BR9203959A/pt not_active Application Discontinuation
-
1994
- 1994-02-28 BG BG098608A patent/BG61125B2/bg unknown
- 1994-09-19 US US08/308,729 patent/US5677419A/en not_active Expired - Lifetime
-
1995
- 1995-06-21 HU HU95P/P00297P patent/HU211534A9/hu unknown
-
1996
- 1996-02-23 IL IL11725296A patent/IL117252A0/xx unknown
- 1996-03-15 GR GR960400712T patent/GR3019326T3/el unknown
- 1996-08-15 CN CNB961115238A patent/CN1198841C/zh not_active Expired - Fee Related
- 1996-08-15 CN CNB961118075A patent/CN1225473C/zh not_active Expired - Fee Related
-
1997
- 1997-10-31 NO NO975023A patent/NO975023D0/no not_active Application Discontinuation
-
1998
- 1998-01-28 NO NO980377A patent/NO980377D0/no unknown
- 1998-07-06 UY UY25084A patent/UY25084A1/es unknown
-
2000
- 2000-09-15 FI FI20002041A patent/FI20002041A/fi unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |
Free format text: LAPSED IN APRIL 2002 |