NO301879B1 - Indol-derivater - Google Patents

Indol-derivater

Info

Publication number
NO301879B1
NO301879B1 NO943913A NO943913A NO301879B1 NO 301879 B1 NO301879 B1 NO 301879B1 NO 943913 A NO943913 A NO 943913A NO 943913 A NO943913 A NO 943913A NO 301879 B1 NO301879 B1 NO 301879B1
Authority
NO
Norway
Prior art keywords
indole derivatives
indole
derivatives
Prior art date
Application number
NO943913A
Other languages
English (en)
Norwegian (no)
Other versions
NO943913L (no
NO943913D0 (no
Inventor
Alfredo Cugola
Giovanni Gaviraghi
Simone Giacobbe
Original Assignee
Glaxo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Spa filed Critical Glaxo Spa
Publication of NO943913D0 publication Critical patent/NO943913D0/no
Publication of NO943913L publication Critical patent/NO943913L/no
Publication of NO301879B1 publication Critical patent/NO301879B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
NO943913A 1992-04-16 1994-10-14 Indol-derivater NO301879B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929208492A GB9208492D0 (en) 1992-04-16 1992-04-16 Heterocyclic compounds
PCT/EP1993/000938 WO1993021153A1 (en) 1992-04-16 1993-04-15 Indole-2-carboxylic acid derivatives

Publications (3)

Publication Number Publication Date
NO943913D0 NO943913D0 (no) 1994-10-14
NO943913L NO943913L (no) 1994-12-14
NO301879B1 true NO301879B1 (no) 1997-12-22

Family

ID=10714220

Family Applications (1)

Application Number Title Priority Date Filing Date
NO943913A NO301879B1 (no) 1992-04-16 1994-10-14 Indol-derivater

Country Status (41)

Country Link
US (4) US5374648A (ro)
EP (1) EP0568136A1 (ro)
JP (2) JPH07505407A (ro)
KR (1) KR100264114B1 (ro)
CN (1) CN1042331C (ro)
AP (1) AP480A (ro)
AT (1) AT403917B (ro)
AU (1) AU666927B2 (ro)
BE (1) BE1006343A5 (ro)
BG (1) BG62136B1 (ro)
BR (1) BR1100323A (ro)
CA (3) CA2094073A1 (ro)
CH (1) CH685630A5 (ro)
CY (1) CY2038B1 (ro)
CZ (1) CZ285799B6 (ro)
DK (1) DK169890B1 (ro)
ES (1) ES2105924B1 (ro)
FI (1) FI106198B (ro)
FR (1) FR2690919B1 (ro)
GB (2) GB9208492D0 (ro)
GE (1) GEP19991704B (ro)
GR (1) GR1001619B (ro)
HK (1) HK95797A (ro)
HU (2) HU217964B (ro)
IL (1) IL105412A (ro)
IS (1) IS3994A (ro)
IT (1) IT1265325B1 (ro)
LU (1) LU88248A1 (ro)
MX (1) MX9302195A (ro)
MY (1) MY112232A (ro)
NO (1) NO301879B1 (ro)
NZ (1) NZ247413A (ro)
OA (1) OA10103A (ro)
PL (1) PL176451B1 (ro)
RO (1) RO113242B1 (ro)
RU (1) RU2129544C1 (ro)
SE (1) SE504336C2 (ro)
SK (1) SK281941B6 (ro)
TW (1) TW224457B (ro)
WO (1) WO1993021153A1 (ro)
ZA (1) ZA932642B (ro)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9304500D0 (en) * 1993-03-05 1993-04-21 Glaxo Spa Heterocyclic compounds
US5519048A (en) * 1993-05-27 1996-05-21 Merrell Pharmaceuticals Inc. 3-(indol-3-yl)-propenoic acid derivatives and pharmaceutical compositions thereof
JP3334805B2 (ja) * 1993-05-27 2002-10-15 メレルファーマスーティカルズ インコーポレイテッド ３−（インドール−３−イル）−プロペン酸誘導体類及びその製剤組成物
GB9319243D0 (en) * 1993-09-17 1993-11-03 Glaxo Spa Heterocyclic compounds
GB9321221D0 (en) * 1993-10-14 1993-12-01 Glaxo Spa Heterocyclic compounds
TW280819B (ro) * 1993-11-17 1996-07-11 Sumitomo Pharma
US5563157B1 (en) * 1994-10-31 1999-02-02 Hoecst Marion Roussel Inc Heterocycle substituted propenoic acid derivatives and pharmaceutical compositions thereof
GB9502695D0 (en) * 1995-02-11 1995-03-29 Glaxo Spa Pharmaceutical composition
GB9504361D0 (en) * 1995-03-04 1995-04-26 Glaxo Spa Heterocyclic compounds
US6030968A (en) * 1996-09-17 2000-02-29 The Regents Of The University Of California Positive AMPA receptor modulation to enhance brain neurotrophic factor expression
DE69734594T2 (de) * 1996-09-30 2006-07-06 Aventis Pharmaceuticals Inc. Nmda (n-methyl-d-aspartate) antagonists
US5922752A (en) * 1997-06-11 1999-07-13 Hoechst Marion Roussell, Inc. NMDA (n-methyl-d-aspartate) antagonists
ES2367294T3 (es) * 1998-03-26 2011-11-02 Astellas Pharma Inc. Preparación de liberación sostenida de un compuesto macrólido como tacrolimus.
US20030162825A1 (en) * 2001-11-09 2003-08-28 Sepracor Inc. D-amino acid oxidase inhibitors for learning and memory
CA2468544A1 (en) * 2001-12-10 2003-06-19 Amgen Inc. Vanilloid receptor ligands
PA8579701A1 (es) * 2002-08-23 2005-05-24 Pfizer Prod Inc Profarmaco inhibidor de beta-lactamasa
DE10306202A1 (de) * 2003-02-13 2004-08-26 Grünenthal GmbH Arzneimittel enthaltend substituierte 2-Aryl-Aminoessigsäure-Verbindungen und/oder substituierte 2-Heteroaryl-Aminoessigsäure-Verbindungen
WO2004108733A1 (en) * 2003-06-05 2004-12-16 Pfizer Products Inc. Beta-lactamase inhibitor prodrug
WO2005051919A1 (en) * 2003-11-26 2005-06-09 Pfizer Products Inc. Aminopyrazole derivatives as gsk-3 inhibitors
US7488747B2 (en) * 2003-12-29 2009-02-10 Sepracor Inc. Pyrrole and pyrazole DAAO inhibitors
US20060002999A1 (en) * 2004-06-17 2006-01-05 Forest Laboratories, Inc. Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane
AU2006264317B2 (en) 2005-07-06 2012-02-23 Sunovion Pharmaceuticals Inc. Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
ES2594156T3 (es) * 2006-01-06 2016-12-16 Sunovion Pharmaceuticals Inc. Cicloalquilaminas como inhibidores de la recaptación de monoaminas
CN101426372A (zh) * 2006-01-06 2009-05-06 塞普拉柯公司 基于四氢萘酮的单胺再摄取抑制剂
US8097760B2 (en) 2006-03-31 2012-01-17 Sunovion Pharmacuticals Inc. Preparation of chiral amides and amines
US7884124B2 (en) * 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US7579370B2 (en) * 2006-06-30 2009-08-25 Sepracor Inc. Fused heterocycles
US20080082066A1 (en) * 2006-10-02 2008-04-03 Weyerhaeuser Co. Crosslinked carboxyalkyl cellulose fibers having non-permanent and temporary crosslinks
EP1942104A1 (en) 2006-12-20 2008-07-09 sanofi-aventis Heteroarylcyclopropanecarboxamides and their use as pharmaceuticals
US7902252B2 (en) * 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
ZA200904686B (en) 2007-01-18 2010-09-29 Sepracor Inc Inhibitiors of D-amino acid oxidase
MX2009012685A (es) 2007-05-31 2009-12-14 Sepracor Inc Cicloalquilaminas sustituidas con fenilo como inhibidores de la reabsorcion de monoamina.
WO2009151498A2 (en) * 2008-03-28 2009-12-17 Forest Laboratories Holdings Limited Memantine formulations
US20100120740A1 (en) * 2008-08-07 2010-05-13 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
CN102348683A (zh) * 2009-03-10 2012-02-08 参天制药株式会社 含有4,6-二氯-1h-吲哚-2-羧酸衍生物或其盐作为有效成分的视神经损伤的预防或治疗剂
US20110034434A1 (en) * 2009-08-07 2011-02-10 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
US9737531B2 (en) 2012-07-12 2017-08-22 Glytech, Llc Composition and method for treatment of depression and psychosis in humans
CA2946153C (en) 2014-04-30 2022-06-14 Yufeng Jane Tseng Use of known compounds as d-amino acid oxidase inhibitors
EP3512840B1 (en) 2016-09-14 2024-03-06 Yufeng Jane Tseng Novel substituted benzimidazole derivatives as d-amino acid oxidase (daao) inhibitors
RU2020100230A (ru) 2017-06-12 2021-07-13 Глитек Ллс. Лечение депрессии антагонистами nmda и антагонистами d2/5-ht2a или селективными антагонистами 5-нт2a
CN112707874A (zh) * 2020-12-29 2021-04-27 广东中科药物研究有限公司 一种抗病毒化合物及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3010971A (en) * 1960-08-04 1961-11-28 Smith Kline French Lab Cyclopropylamine derivatives and processes for their preparation
DK500285A (da) * 1984-11-02 1986-05-03 Glaxo Group Ltd Cephalosporinantibiotika
US4960786A (en) * 1989-04-24 1990-10-02 Merrell Dow Pharmaceuticals Inc. Excitatory amino acid antagonists
JPH0347123A (ja) * 1989-05-05 1991-02-28 G D Searle & Co インドール―２―カルボキシレート化合物類を含有するｃｎｓ疾患治療用組成物
EP0539503B1 (en) * 1990-07-16 1996-04-03 Merrell Dow Pharmaceuticals Inc. Excitatory amino acid antagonists
US5284862A (en) * 1991-03-18 1994-02-08 Warner-Lambert Company Derivatives of 2-carboxyindoles having pharmaceutical activity
US5145845A (en) * 1991-05-14 1992-09-08 Warner-Lambert Co. Substituted 2-carboxylindoles having pharmaceutical activity

Also Published As

Publication number Publication date
SE9301241D0 (sv) 1993-04-15
HU9402975D0 (en) 1995-02-28
AU666927B2 (en) 1996-02-29
BG62136B1 (bg) 1999-03-31
JPH07505407A (ja) 1995-06-15
BE1006343A5 (fr) 1994-07-26
SK281941B6 (sk) 2001-09-11
CN1085212A (zh) 1994-04-13
IL105412A (en) 1998-02-22
ITRM930236A0 (it) 1993-04-15
FI944800A (fi) 1994-10-12
GB9208492D0 (en) 1992-06-03
SE504336C2 (sv) 1997-01-13
EP0568136A1 (en) 1993-11-03
AP480A (en) 1996-03-22
HU217964B (hu) 2000-05-28
HU211826A9 (en) 1995-12-28
NO943913L (no) 1994-12-14
FI106198B (fi) 2000-12-15
GB2266091A (en) 1993-10-20
IT1265325B1 (it) 1996-10-31
CA2094073A1 (en) 1993-10-17
RO113242B1 (ro) 1998-05-29
TW224457B (ro) 1994-06-01
MY112232A (en) 2001-05-31
BR1100323A (pt) 2000-06-27
US5374649A (en) 1994-12-20
WO1993021153A1 (en) 1993-10-28
CZ254394A3 (en) 1995-07-12
BG99111A (bg) 1995-05-31
ZA932642B (en) 1994-01-10
NZ247413A (en) 1995-12-21
CN1042331C (zh) 1999-03-03
CA2094075A1 (en) 1993-10-17
GB2266091B (en) 1995-08-09
FI944800A0 (fi) 1994-10-12
RU2129544C1 (ru) 1999-04-27
DK43193D0 (da) 1993-04-15
CY2038B1 (en) 1998-04-30
CZ285799B6 (cs) 1999-11-17
IL105412A0 (en) 1993-08-18
HUT70526A (en) 1995-10-30
US5510367A (en) 1996-04-23
US5374648A (en) 1994-12-20
ATA75293A (de) 1997-11-15
FR2690919A1 (fr) 1993-11-12
JPH0649027A (ja) 1994-02-22
DK43193A (da) 1993-10-17
GB9307808D0 (en) 1993-06-02
GEP19991704B (en) 1999-08-05
PL176451B1 (pl) 1999-05-31
MX9302195A (es) 1994-03-31
AT403917B (de) 1998-06-25
IS3994A (is) 1993-10-17
FR2690919B1 (fr) 1995-05-05
LU88248A1 (fr) 1994-03-01
AU3692393A (en) 1993-10-21
GR1001619B (el) 1994-07-29
CH685630A5 (fr) 1995-08-31
ITRM930236A1 (it) 1994-10-15
CA2094076A1 (en) 1993-10-17
ES2105924B1 (es) 1998-07-01
HK95797A (en) 1997-08-08
DK169890B1 (da) 1995-03-27
ES2105924A1 (es) 1997-10-16
US5373018A (en) 1994-12-13
SK124194A3 (en) 1995-05-10
OA10103A (en) 1996-12-18
NO943913D0 (no) 1994-10-14
AP9300524A0 (en) 1993-04-30
RU94045915A (ru) 1996-09-10
SE9301241L (sv) 1993-10-17
KR100264114B1 (ko) 2000-11-01

Similar Documents

Publication Publication Date Title
NO943913D0 (no) Indol-derivater
FI944969A (fi) Indolijohdannaisia
DE69325658T2 (de) Substituierte thiazolidindion derivate
FI944805A (fi) Indolijohdannaisia 5-HT1-kaltaisina agonisteina
NO961475L (no) Indol-derivater
NO932146D0 (no) Benzimidazolderivater
DE69330497T2 (de) Chinazolin-derivate
DK0411150T3 (da) Indolderivater
DE69212058D1 (de) Indol-Derivate
DE59308714D1 (de) Cyclobutan-benzol-derivate
FI940310A0 (fi) Indoleja
NO930520D0 (no) Bifenyl-substituerte kinolinderivater
FI950486A (fi) Amidijohdannaiset
NO952288D0 (no) Benzazepinon-derivater
DE69313890T2 (de) 5-Aminoflavon-Derivate
DK647289A (da) Annellerede indol-derivater
DK0725061T3 (da) Substituerede indolderivater
NO932638D0 (no) 21-klor-pregnanderivat
BR9306706A (pt) Derivados do triazolil-butano
DE59605373D1 (de) Substituierte Indol-Derivate
NO951241D0 (no) Forbedret indolbiosyntese
NO940360D0 (no) Heterocykliske derivater

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees

Free format text: LAPSED IN OCTOBER 2002