NO300263B1 - Fremgangsmåte for fremstilling av 2-alkyl-3,4,6-trifluorbenzoesyre - Google Patents

Fremgangsmåte for fremstilling av 2-alkyl-3,4,6-trifluorbenzoesyre Download PDF

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Publication number
NO300263B1
NO300263B1 NO942468A NO942468A NO300263B1 NO 300263 B1 NO300263 B1 NO 300263B1 NO 942468 A NO942468 A NO 942468A NO 942468 A NO942468 A NO 942468A NO 300263 B1 NO300263 B1 NO 300263B1
Authority
NO
Norway
Prior art keywords
alkyl
compound
preparation
trifluorobenzoic acid
formula
Prior art date
Application number
NO942468A
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English (en)
Other versions
NO942468L (no
NO942468D0 (no
Inventor
John Michael Domagala
Susan Elizabeth Hagen
John Steven Kiely
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of NO942468L publication Critical patent/NO942468L/no
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of NO942468D0 publication Critical patent/NO942468D0/no
Publication of NO300263B1 publication Critical patent/NO300263B1/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Claims (1)

  1. Fremgangsmåte for fremstilling av forbindelser med forme
    len
    hvor R er alkyl, karakterisert ved at man (a) omsetter en forbindelse med formelen
    ■med en base og trimetylsilylklorid, hvilket gir en forbindelse
    med formelen (b) omsetter denne forbindelse med en base og et alkylhalogenid, hvilket gir en forbindelse med formelen (c) fjerner SiMe3, og (d) hydrolyserer den resulterende forbindelse.
NO942468A 1988-01-25 1994-06-30 Fremgangsmåte for fremstilling av 2-alkyl-3,4,6-trifluorbenzoesyre NO300263B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14746288A 1988-01-25 1988-01-25
US07/280,924 US4920120A (en) 1988-01-25 1988-12-09 Antibacterial agents
PCT/US1989/000278 WO1989006649A2 (en) 1988-01-25 1989-01-23 Antibacterial agents

Publications (3)

Publication Number Publication Date
NO942468L NO942468L (no) 1990-07-24
NO942468D0 NO942468D0 (no) 1994-06-30
NO300263B1 true NO300263B1 (no) 1997-05-05

Family

ID=26844956

Family Applications (2)

Application Number Title Priority Date Filing Date
NO903286A NO178194C (no) 1988-01-25 1990-07-24 Analogifremgangsmåte for fremstilling av terapeutisk aktive naftyridin-derivater
NO942468A NO300263B1 (no) 1988-01-25 1994-06-30 Fremgangsmåte for fremstilling av 2-alkyl-3,4,6-trifluorbenzoesyre

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO903286A NO178194C (no) 1988-01-25 1990-07-24 Analogifremgangsmåte for fremstilling av terapeutisk aktive naftyridin-derivater

Country Status (16)

Country Link
US (1) US4920120A (no)
EP (2) EP0398967A1 (no)
JP (2) JP2815119B2 (no)
KR (3) KR0130931B1 (no)
AT (1) ATE109471T1 (no)
AU (4) AU624118B2 (no)
CA (1) CA1340492C (no)
DE (1) DE68917163T2 (no)
DK (2) DK173057B1 (no)
ES (1) ES2056963T3 (no)
FI (1) FI93360C (no)
IE (1) IE65350B1 (no)
NO (2) NO178194C (no)
NZ (1) NZ227680A (no)
PT (1) PT89520B (no)
WO (1) WO1989006649A2 (no)

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Also Published As

Publication number Publication date
DK174690D0 (da) 1990-07-20
JPH03502452A (ja) 1991-06-06
FI93360B (fi) 1994-12-15
AU3048389A (en) 1989-08-11
CA1340492C (en) 1999-04-13
AU659444B2 (en) 1995-05-18
KR0130931B1 (ko) 1998-04-16
NO903286L (no) 1990-07-24
PT89520B (pt) 1994-02-28
KR19980703084A (ko) 1998-09-05
US4920120A (en) 1990-04-24
JPH10291959A (ja) 1998-11-04
DK174690A (da) 1990-07-20
AU1388892A (en) 1992-07-09
KR0145958B1 (en) 1998-08-17
NO178194C (no) 1996-02-07
FI93360C (fi) 1995-03-27
AU674272B2 (en) 1996-12-12
PT89520A (pt) 1989-10-04
EP0326891B1 (en) 1994-08-03
DK173057B1 (da) 1999-12-13
NZ227680A (en) 1991-11-26
DK140996A (da) 1996-12-09
NO942468L (no) 1990-07-24
AU671575B2 (en) 1996-08-29
AU624118B2 (en) 1992-06-04
AU2722495A (en) 1995-10-05
NO903286D0 (no) 1990-07-24
EP0326891A2 (en) 1989-08-09
DE68917163T2 (de) 1994-12-01
ES2056963T3 (es) 1994-10-16
IE883900L (en) 1989-07-25
NO178194B (no) 1995-10-30
AU2722395A (en) 1995-10-19
EP0398967A1 (en) 1990-11-28
KR900700475A (ko) 1990-08-13
WO1989006649A2 (en) 1989-07-27
KR0182275B1 (ko) 1999-05-01
EP0326891A3 (en) 1990-04-25
WO1989006649A3 (en) 1989-12-28
JP2815119B2 (ja) 1998-10-27
FI903696A0 (fi) 1990-07-23
IE65350B1 (en) 1995-10-18
DE68917163D1 (de) 1994-09-08
ATE109471T1 (de) 1994-08-15
NO942468D0 (no) 1994-06-30
JP2986154B2 (ja) 1999-12-06

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