MX9700871A - Procedimiento para hacer compuestos antimicrobianos. - Google Patents

Procedimiento para hacer compuestos antimicrobianos.

Info

Publication number
MX9700871A
MX9700871A MX9700871A MX9700871A MX9700871A MX 9700871 A MX9700871 A MX 9700871A MX 9700871 A MX9700871 A MX 9700871A MX 9700871 A MX9700871 A MX 9700871A MX 9700871 A MX9700871 A MX 9700871A
Authority
MX
Mexico
Prior art keywords
making
salt
lactam
solvate
antimicrobial compounds
Prior art date
Application number
MX9700871A
Other languages
English (en)
Inventor
Jared Lynn Randall
Jane Ellen Godlewski
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of MX9700871A publication Critical patent/MX9700871A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/12—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals attached in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

La presente invencion provee un procedimiento para hacer compuesto que tiene una estructura de conformidad con la formula I, en donde a A1, A2, y A3 son independientemente carbono o nitrogeno y R1, R3, R4 y R6 son substituyentes de quinolona conocidos; y en donde uno de R1, R3 o R6 puede ser una porcion que contiene lactama; o una forma protegida, sal, sal farmacéuticamente aceptable,éster biohidrolizable, un solvato del mismo; el procedimiento comprendiendo hacer reaccionar uno o más compuestos de organosilicio con un compuesto que tiene una estructura de conformidad con la formula II, en donde A1, A2 y A3, R1, R3 R4 y R6 son como se describio antes, en donde uno de R1, R3 o R6 puede ser una porcion que contiene lactama; y X es un grupo residual; o una forma protegida, sal, éster biohidrolizable o solvato, del mismo. Los compuestos preparados de conformidad con los procedimientos de la invencion son en sí mismos utiles como antimicrobianos, o pueden usarse como intermediarios para hacer otros intermediarios que contienen quinolilona.
MX9700871A 1994-08-02 1995-08-01 Procedimiento para hacer compuestos antimicrobianos. MX9700871A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28496094A 1994-08-02 1994-08-02
PCT/US1995/009647 WO1996004247A1 (en) 1994-08-02 1995-08-01 Process for making antimicrobial compounds

Publications (1)

Publication Number Publication Date
MX9700871A true MX9700871A (es) 1997-05-31

Family

ID=23092187

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9700871A MX9700871A (es) 1994-08-02 1995-08-01 Procedimiento para hacer compuestos antimicrobianos.

Country Status (19)

Country Link
US (1) US5703231A (es)
EP (1) EP0775114B1 (es)
JP (1) JPH10504815A (es)
KR (1) KR100242355B1 (es)
CN (1) CN1158120A (es)
AT (1) ATE190972T1 (es)
AU (1) AU705818B2 (es)
BR (1) BR9508514A (es)
CA (1) CA2196538C (es)
DE (1) DE69515882T2 (es)
DK (1) DK0775114T3 (es)
ES (1) ES2143644T3 (es)
FI (1) FI970427A (es)
GR (1) GR3033001T3 (es)
MX (1) MX9700871A (es)
NO (1) NO311356B1 (es)
NZ (1) NZ290721A (es)
PT (1) PT775114E (es)
WO (1) WO1996004247A1 (es)

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CA2290712C (en) * 1995-09-22 2003-09-09 Wakunaga Pharmaceutical Co., Ltd. Novel pyridonecarboxylic acid derivatives or their salts, and antibacterial agents containing the same as their effective components
DE19926400A1 (de) 1999-06-10 2000-12-14 Bayer Ag Verbessertes Verfahren zur Herstellung von 2,6-Dichlor-5-fluor-nicotinsäure und grobteilige und besonders reine 2,6-Dichlor-5-fluor-nicotinsäure
CN1338455A (zh) * 2000-08-16 2002-03-06 大连绿源实业有限公司 新的喹诺酮羧酸的制备方法
ATE300522T1 (de) * 2000-12-14 2005-08-15 Procter & Gamble Cyclisierungsverfahrensschritt bei der herstellung von chinolonen und naphthyridinen
US6803469B2 (en) * 2002-08-05 2004-10-12 The Procter & Gamble Company Process for preparing quinolone antibiotic intermediates
KR100735587B1 (ko) 2002-08-05 2007-07-04 더 프록터 앤드 갬블 캄파니 퀴놀론계 항생제 중간체의 제조 방법
ES2255871B1 (es) * 2004-12-31 2007-08-16 Quimica Sintetica, S.A. Procedimiento para la obtencion de levofloxacino exento de sales.
EP1973587B1 (en) * 2005-12-12 2019-02-06 AllAccem, Inc. Methods and systems for preparing antimicrobial films and coatings
CN101020647B (zh) * 2007-02-14 2011-03-30 杭州师范学院 一种β-环丙胺基丙烯酸(酯)的合成方法
US8222239B2 (en) 2007-02-21 2012-07-17 Allaccem, Inc. Bridged polycyclic compound based compositions for the inhibition and amelioration of disease
US20080300258A1 (en) * 2007-05-30 2008-12-04 Souza Fabio Eduardo Silva Anhydrous ciprofloxacin hydrochloride
US8188068B2 (en) 2007-08-10 2012-05-29 Allaccem, Inc. Bridged polycyclic compound based compositions for coating oral surfaces in pets
US8153617B2 (en) 2007-08-10 2012-04-10 Allaccem, Inc. Bridged polycyclic compound based compositions for coating oral surfaces in humans
US8153618B2 (en) 2007-08-10 2012-04-10 Allaccem, Inc. Bridged polycyclic compound based compositions for topical applications for pets
CN105566217B (zh) * 2016-02-23 2019-03-01 青岛科技大学 一种氟罗沙星粗品的纯化方法
US11059788B2 (en) * 2017-06-12 2021-07-13 Virginia Commonwealth University Streamlined syntheses of fluoroquinolones
CN112552260A (zh) * 2019-09-26 2021-03-26 宜昌东阳光长江药业股份有限公司 左氧氟沙星及其中间体的制备方法
CN112552261A (zh) * 2019-09-26 2021-03-26 宜昌东阳光长江药业股份有限公司 左氧氟沙星及其中间体的制备方法
US11884658B1 (en) * 2023-09-26 2024-01-30 King Faisal University 1-cyclopropyl-6-fluoro-4-oxo-7-(4-((2-thioxobenzo[d]thiazol-3(2H)-yl)methyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid as an antimicrobial compound

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Also Published As

Publication number Publication date
EP0775114B1 (en) 2000-03-22
DK0775114T3 (da) 2000-07-10
BR9508514A (pt) 1997-12-23
NO311356B1 (no) 2001-11-19
KR100242355B1 (ko) 2000-03-02
US5703231A (en) 1997-12-30
DE69515882T2 (de) 2000-11-02
ES2143644T3 (es) 2000-05-16
CA2196538A1 (en) 1996-02-15
GR3033001T3 (en) 2000-07-31
ATE190972T1 (de) 2000-04-15
AU3153995A (en) 1996-03-04
CA2196538C (en) 2000-04-25
CN1158120A (zh) 1997-08-27
FI970427A (fi) 1997-03-26
KR970704694A (ko) 1997-09-06
NO970427D0 (no) 1997-01-31
DE69515882D1 (de) 2000-04-27
JPH10504815A (ja) 1998-05-12
EP0775114A1 (en) 1997-05-28
WO1996004247A1 (en) 1996-02-15
NZ290721A (en) 1999-03-29
FI970427A0 (fi) 1997-01-31
PT775114E (pt) 2000-09-29
NO970427L (no) 1997-03-26
AU705818B2 (en) 1999-06-03

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