FI970427A0 - Menetelmä mikrobinvastaisten yhdisteiden valmistamiseksi - Google Patents

Menetelmä mikrobinvastaisten yhdisteiden valmistamiseksi

Info

Publication number
FI970427A0
FI970427A0 FI970427A FI970427A FI970427A0 FI 970427 A0 FI970427 A0 FI 970427A0 FI 970427 A FI970427 A FI 970427A FI 970427 A FI970427 A FI 970427A FI 970427 A0 FI970427 A0 FI 970427A0
Authority
FI
Finland
Prior art keywords
salt
lactam
solvate
antimicrobials
compound
Prior art date
Application number
FI970427A
Other languages
English (en)
Swedish (sv)
Other versions
FI970427A (fi
Inventor
Jared Lynn Randall
Jane Ellen Godlewski
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of FI970427A0 publication Critical patent/FI970427A0/fi
Publication of FI970427A publication Critical patent/FI970427A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/12—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals attached in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cephalosporin Compounds (AREA)
FI970427A 1994-08-02 1997-01-31 Menetelmä mikrobinvastaisten yhdisteiden valmistamiseksi FI970427A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28496094A 1994-08-02 1994-08-02
PCT/US1995/009647 WO1996004247A1 (en) 1994-08-02 1995-08-01 Process for making antimicrobial compounds

Publications (2)

Publication Number Publication Date
FI970427A0 true FI970427A0 (fi) 1997-01-31
FI970427A FI970427A (fi) 1997-03-26

Family

ID=23092187

Family Applications (1)

Application Number Title Priority Date Filing Date
FI970427A FI970427A (fi) 1994-08-02 1997-01-31 Menetelmä mikrobinvastaisten yhdisteiden valmistamiseksi

Country Status (19)

Country Link
US (1) US5703231A (fi)
EP (1) EP0775114B1 (fi)
JP (1) JPH10504815A (fi)
KR (1) KR100242355B1 (fi)
CN (1) CN1158120A (fi)
AT (1) ATE190972T1 (fi)
AU (1) AU705818B2 (fi)
BR (1) BR9508514A (fi)
CA (1) CA2196538C (fi)
DE (1) DE69515882T2 (fi)
DK (1) DK0775114T3 (fi)
ES (1) ES2143644T3 (fi)
FI (1) FI970427A (fi)
GR (1) GR3033001T3 (fi)
MX (1) MX9700871A (fi)
NO (1) NO311356B1 (fi)
NZ (1) NZ290721A (fi)
PT (1) PT775114E (fi)
WO (1) WO1996004247A1 (fi)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
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ES2183473T3 (es) * 1995-09-22 2003-03-16 Wakunaga Pharma Co Ltd Derivados de acido piridonacarboxilico como agentes antibacterianos.
DE19926400A1 (de) 1999-06-10 2000-12-14 Bayer Ag Verbessertes Verfahren zur Herstellung von 2,6-Dichlor-5-fluor-nicotinsäure und grobteilige und besonders reine 2,6-Dichlor-5-fluor-nicotinsäure
CN1338455A (zh) * 2000-08-16 2002-03-06 大连绿源实业有限公司 新的喹诺酮羧酸的制备方法
IL155677A0 (en) * 2000-12-14 2003-11-23 Procter & Gamble Cyclization process step in the making of quinolones and naphthyridines
KR100735587B1 (ko) 2002-08-05 2007-07-04 더 프록터 앤드 갬블 캄파니 퀴놀론계 항생제 중간체의 제조 방법
US6803469B2 (en) * 2002-08-05 2004-10-12 The Procter & Gamble Company Process for preparing quinolone antibiotic intermediates
ES2255871B1 (es) * 2004-12-31 2007-08-16 Quimica Sintetica, S.A. Procedimiento para la obtencion de levofloxacino exento de sales.
NZ569756A (en) 2005-12-12 2011-07-29 Allaccem Inc Methods and systems for preparing antimicrobial films and coatings utilising polycyclic bridged ammonium salts
CN101020647B (zh) * 2007-02-14 2011-03-30 杭州师范学院 一种β-环丙胺基丙烯酸(酯)的合成方法
NZ579785A (en) 2007-02-21 2012-06-29 Allaccem Inc Bridged polycyclic compound based compositions for the inhibition and amelioration of disease
US20080300258A1 (en) * 2007-05-30 2008-12-04 Souza Fabio Eduardo Silva Anhydrous ciprofloxacin hydrochloride
US8188068B2 (en) 2007-08-10 2012-05-29 Allaccem, Inc. Bridged polycyclic compound based compositions for coating oral surfaces in pets
US8153617B2 (en) 2007-08-10 2012-04-10 Allaccem, Inc. Bridged polycyclic compound based compositions for coating oral surfaces in humans
US8153618B2 (en) 2007-08-10 2012-04-10 Allaccem, Inc. Bridged polycyclic compound based compositions for topical applications for pets
CN105566217B (zh) * 2016-02-23 2019-03-01 青岛科技大学 一种氟罗沙星粗品的纯化方法
WO2018231747A2 (en) * 2017-06-12 2018-12-20 Virginia Commonwealth University Streamlined syntheses of fluoroquinolones
CN112552260A (zh) * 2019-09-26 2021-03-26 宜昌东阳光长江药业股份有限公司 左氧氟沙星及其中间体的制备方法
CN112552261A (zh) * 2019-09-26 2021-03-26 宜昌东阳光长江药业股份有限公司 左氧氟沙星及其中间体的制备方法
US11884658B1 (en) * 2023-09-26 2024-01-30 King Faisal University 1-cyclopropyl-6-fluoro-4-oxo-7-(4-((2-thioxobenzo[d]thiazol-3(2H)-yl)methyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid as an antimicrobial compound

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE279886C (fi) *
US4383946A (en) * 1980-03-27 1983-05-17 Merck & Co., Inc. Process for the preparation of 1-carbapenems and intermediates via silyl-substituted dithioacetals
NL8005041A (nl) * 1980-09-05 1982-04-01 Gist Brocades Nv Werkwijze voor de bereiding van thioethers, alsmede gesilyleerde thiolen voor toepassing bij deze werkwijze.
US4546176A (en) * 1982-12-14 1985-10-08 Eisai Co., Ltd. 7-Carboxymethoxyphenylacetamido-3-cephem derivatives and antibacterial preparations containing the same
EP0181521A1 (en) * 1984-10-19 1986-05-21 Otsuka Pharmaceutical Co., Ltd. Antimicrobial 1-substituted Phenyl-4-oxoquinoline-3-carboxylic acid compounds
US4755513A (en) * 1985-01-30 1988-07-05 Otsuka Pharmaceutical Company, Limited Antimicrobial 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds
DE3509769A1 (de) * 1985-03-19 1986-09-25 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von carbapenemzwischenprodukten
US4684648A (en) * 1985-05-10 1987-08-04 Otsuka Pharmaceutical Company Limited Antimicrobial 1-substituted phenyl-4-oxoquinoline-3-carboxylic acid compounds and compositions thereof
DE3542644A1 (de) * 1985-12-03 1987-06-04 Hoechst Ag Verfahren zur herstellung von cefodizim
JPS62215591A (ja) * 1986-03-14 1987-09-22 Dainippon Pharmaceut Co Ltd ピリドベンズオキサジン誘導体の製造法およびその中間体
EP0242789A3 (en) * 1986-04-25 1990-09-05 Dainippon Pharmaceutical Co., Ltd. Novel quinoline derivates and processes for preparation thereof
DE3724466A1 (de) * 1987-07-24 1989-02-02 Bayer Ag Verfahren zur herstellung von chinoloncarbonsaeuren
US4833270A (en) * 1987-12-21 1989-05-23 American Cyanamid Company Process for preparing 2-chloro-4,5-difluorobenzoic acid
US4920120A (en) * 1988-01-25 1990-04-24 Warner-Lambert Company Antibacterial agents
EP0342849A3 (en) * 1988-05-19 1990-03-14 Pfizer Inc. Intermediates for preparing 1,4-dihydro-4-oxo-quinoline-3-carboxylic acid esters
ES2148135T3 (es) * 1988-10-24 2000-10-16 Norwich Eaton Pharma Nuevos esteres antimicrobianos de quinolonil lactamas.
EP0366193A3 (en) * 1988-10-24 1992-01-08 Norwich Eaton Pharmaceuticals, Inc. Novel antimicrobial quinolonyl lactams
ES2014560A6 (es) * 1988-12-30 1990-07-16 Marga Investigacion Proceso para la preparacion de un nuevo reactivo organo-sililpolifosforico y su aplicacion al proceso de sontesis de 3-carboxi-quinolonas o azaquinolonas y sus sales.
ZA912279B (en) * 1990-04-09 1992-02-26 Hoffmann La Roche Carbapenem compounds
KR920004385A (ko) * 1990-08-09 1992-03-27 와꾸나가 기스께 신규 삼환화합물 또는 그의 염, 이의 제조방법 및 이를 함유하는 항균제
IT1248011B (it) * 1991-06-07 1995-01-05 Mediolanum Farmaceutici Spa Procedimento per la preparazione dell'acido 9-fluoro-10- (4-metil-1-piperazinil)-7-oxo-2,3-diidro-7h-pirido (1,2,3-de) (1,4)benzotiadin-6-carbossilico cloridrato.
BR9206590A (pt) * 1991-10-01 1995-04-25 Procter & Gamble Pharma Processo para a obtenção de quinolonil lactamas antimicrobianas
EG20543A (en) * 1992-10-30 1999-07-31 Procter & Gamble Process for preparing of novel antimicrobial -5- (n-heterosubstituted amino) quinolones

Also Published As

Publication number Publication date
GR3033001T3 (en) 2000-07-31
PT775114E (pt) 2000-09-29
NZ290721A (en) 1999-03-29
MX9700871A (es) 1997-05-31
CN1158120A (zh) 1997-08-27
NO970427L (no) 1997-03-26
DE69515882D1 (de) 2000-04-27
DE69515882T2 (de) 2000-11-02
KR100242355B1 (ko) 2000-03-02
KR970704694A (ko) 1997-09-06
CA2196538C (en) 2000-04-25
ATE190972T1 (de) 2000-04-15
JPH10504815A (ja) 1998-05-12
AU705818B2 (en) 1999-06-03
CA2196538A1 (en) 1996-02-15
NO970427D0 (no) 1997-01-31
DK0775114T3 (da) 2000-07-10
EP0775114B1 (en) 2000-03-22
US5703231A (en) 1997-12-30
NO311356B1 (no) 2001-11-19
BR9508514A (pt) 1997-12-23
EP0775114A1 (en) 1997-05-28
WO1996004247A1 (en) 1996-02-15
ES2143644T3 (es) 2000-05-16
FI970427A (fi) 1997-03-26
AU3153995A (en) 1996-03-04

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