NO2582728T3 - - Google Patents
Info
- Publication number
- NO2582728T3 NO2582728T3 NO11725095A NO11725095A NO2582728T3 NO 2582728 T3 NO2582728 T3 NO 2582728T3 NO 11725095 A NO11725095 A NO 11725095A NO 11725095 A NO11725095 A NO 11725095A NO 2582728 T3 NO2582728 T3 NO 2582728T3
- Authority
- NO
- Norway
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA201000529 | 2010-06-15 | ||
DKPA201100039 | 2011-01-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
NO2582728T3 true NO2582728T3 (zh) | 2018-01-20 |
Family
ID=44534293
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO11725095A NO2582728T3 (zh) | 2010-06-15 | 2011-06-15 |
Country Status (24)
Country | Link |
---|---|
US (5) | US9168314B2 (zh) |
EP (2) | EP3281956A3 (zh) |
JP (1) | JP6055404B2 (zh) |
KR (1) | KR101935058B1 (zh) |
CN (3) | CN103119065B (zh) |
AU (1) | AU2011267106B2 (zh) |
BR (1) | BR112012031727B1 (zh) |
CA (1) | CA2802782C (zh) |
CY (1) | CY1119616T1 (zh) |
DK (1) | DK2582728T3 (zh) |
EA (1) | EA034675B1 (zh) |
ES (1) | ES2647388T3 (zh) |
HR (1) | HRP20171789T1 (zh) |
HU (1) | HUE035599T2 (zh) |
LT (1) | LT2582728T (zh) |
ME (1) | ME02919B (zh) |
MX (1) | MX347893B (zh) |
NO (1) | NO2582728T3 (zh) |
NZ (1) | NZ604718A (zh) |
PL (1) | PL2582728T3 (zh) |
PT (1) | PT2582728T (zh) |
RS (1) | RS56599B1 (zh) |
SI (1) | SI2582728T1 (zh) |
WO (1) | WO2011157741A2 (zh) |
Families Citing this family (50)
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JP4966497B2 (ja) | 2002-11-15 | 2012-07-04 | ゲンマブ エー/エス | Cd25に対するヒトモノクローナル抗体 |
UA109633C2 (uk) | 2008-12-09 | 2015-09-25 | Антитіло людини проти тканинного фактора | |
AU2011267106B2 (en) * | 2010-06-15 | 2015-05-14 | Genmab A/S | Human antibody drug conjugates against tissue factor |
UA117901C2 (uk) | 2011-07-06 | 2018-10-25 | Ґенмаб Б.В. | Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування |
EP3632462A1 (en) | 2012-07-06 | 2020-04-08 | Genmab B.V. | Dimeric protein with triple mutations |
BR112015000167B1 (pt) | 2012-07-06 | 2021-11-23 | Genmab B.V. | Proteína dimérica, proteína, composição, kit de partes e seus usos, bem como método para aumentar a oligomerização em solução de uma proteína dimérica compreendendo um primeiro e segundo polipeptídeo, cada um compreendendo pelo menos as regiões ch2 e ch3 de uma cadeia pesada de igg1 humana e proteína dimérica variante |
AU2013372331A1 (en) | 2013-01-10 | 2015-07-23 | Genmab B.V. | Human IgG1 Fc region variants and uses thereof |
CN103342752B (zh) * | 2013-05-16 | 2014-07-09 | 太原博奥特生物技术有限公司 | 一种抗人组织因子单链抗体及其制备方法 |
US10617764B2 (en) | 2013-11-21 | 2020-04-14 | Genmab A/S | Lyophilized anti-tissue factor antibody-drug conjugates |
KR20160136279A (ko) * | 2014-02-03 | 2016-11-29 | 국립연구개발법인 고쿠리츠간켄큐센터 | 항-조직 인자 모노클로널 항체 |
UY36041A (es) * | 2014-03-21 | 2015-09-30 | Abbvie Inc | Anticuerpos y conjugados de anticuerpo y fármaco anti-egfr |
JP2017512801A (ja) * | 2014-04-08 | 2017-05-25 | シアトル ジェネティックス, インコーポレイテッド | Cd19抗体薬物コンジュゲートの最適な投薬 |
CA2929542A1 (en) * | 2015-05-13 | 2016-11-13 | Pfizer Inc. | Treatment with anti-efna4 antibody-drug conjugates |
KR20180021723A (ko) * | 2015-06-29 | 2018-03-05 | 다이이찌 산쿄 가부시키가이샤 | 항체-약물 콘주게이트의 선택적 제조 방법 |
BR112018001275A2 (pt) * | 2015-07-22 | 2018-09-18 | Iconic Therapeutics Inc | métodos para tratar transtornos associados à angiogênese e neovascularização |
WO2017028823A1 (zh) * | 2015-08-20 | 2017-02-23 | 复旦大学 | 靶向于组织因子的抗体、其制备方法和用途 |
EP3919081A1 (en) | 2015-09-11 | 2021-12-08 | Genmab A/S | Dosing regimens for anti-tf-antibody drug-conjugates |
AU2017225982B2 (en) | 2016-03-02 | 2023-10-05 | Eisai R&D Management Co., Ltd. | Eribulin-based antibody-drug conjugates and methods of use |
WO2017158436A1 (en) * | 2016-03-17 | 2017-09-21 | Oslo Universitetssykehus Hf | Fusion proteins targeting tumour associated macrophages for treating cancer |
JP2019509322A (ja) | 2016-03-22 | 2019-04-04 | バイオノミクス リミテッド | 抗lgr5モノクローナル抗体の投与 |
US10676537B2 (en) | 2016-08-22 | 2020-06-09 | Fudan University | Antibody targeted to tissue factor, preparation method therefor, and use thereof |
CN106938051B (zh) * | 2016-08-22 | 2019-10-11 | 复旦大学 | 靶向于组织因子的抗体-药物偶联物 |
CN110461868A (zh) | 2016-11-01 | 2019-11-15 | 根马布私人有限公司 | 多肽变体及其用途 |
EP3573995A1 (en) * | 2017-01-24 | 2019-12-04 | Pfizer Inc. | Calicheamicin derivatives and antibody drug conjugates thereof |
CA3053222A1 (en) | 2017-02-10 | 2018-08-16 | Genmab B.V. | Polypeptide variants and uses thereof |
CN113512111B (zh) * | 2017-03-10 | 2023-08-15 | 北京天广实生物技术股份有限公司 | 抗埃博拉病毒单克隆抗体、其制备方法及用途 |
BR112020008593A2 (pt) * | 2017-11-02 | 2020-10-20 | Genmab A/S | método de tratamento de câncer cervical em um indivíduo |
MX2020005473A (es) * | 2017-11-27 | 2020-08-27 | Purdue Pharma Lp | Anticuerpos humanizados que se dirigen al factor tisular humano. |
SG11202006400UA (en) * | 2018-01-04 | 2020-08-28 | Iconic Therapeutics Inc | Anti-tissue factor antibodies, antibody-drug conjugates, and related methods |
MA51666A (fr) | 2018-01-24 | 2020-12-02 | Genmab Bv | Variants polypeptidiques et leurs utilisations |
BR112020018092A2 (pt) * | 2018-03-07 | 2020-12-22 | Genmab A/S | Método para tratar câncer em um sujeito, estojo, uso de um conjugado anticorpo-fármaco que se liga ao fator tecidual, e, conjugado anticorpo-fármaco. |
AU2019240073A1 (en) * | 2018-03-21 | 2020-09-03 | Genmab A/S | Methods of treating cancer with a combination of a platinum-based agent and an anti-tissue factor antibody-drug conjugate |
AU2019264217A1 (en) | 2018-05-03 | 2020-12-17 | Genmab B.V. | Antibody variant combinations and uses thereof |
AU2019266205A1 (en) * | 2018-05-07 | 2020-10-22 | Genmab A/S | Methods of treating cancer with a combination of an anti-PD-1 antibody and an anti-tissue factor antibody-drug conjugate |
JP7460608B2 (ja) * | 2018-05-07 | 2024-04-02 | ジェンマブ エー/エス | 抗pd-1抗体と抗組織因子抗体-薬物コンジュゲートとの組み合わせを用いるがんの治療方法 |
AU2019321442A1 (en) * | 2018-08-16 | 2021-02-11 | Genmab A/S | Anti-tissue factor antibody-drug conjugates and their use in the treatment of cancer |
TW202034958A (zh) * | 2018-10-30 | 2020-10-01 | 丹麥商珍美寶股份有限公司 | 使用抗血管內皮生長因子(vegf)抗體與抗組織因子(tf)抗體-藥物共軛體之組合以治療癌症之方法 |
BR112021025720A2 (pt) * | 2019-07-03 | 2022-06-21 | Iconic Therapeutics Inc | Conjugados anticorpo-fármaco de fator antitecido e métodos relacionados |
EP4055046A1 (en) | 2019-11-06 | 2022-09-14 | Genmab B.V. | Antibody variant combinations and uses thereof |
MX2022005222A (es) | 2019-11-07 | 2022-06-08 | Genmab As | Metodos para tratar el cancer con una combinacion de un anticuerpo anti muerte programada 1 (pd-1) y un conjugado de anticuerpo anti factor tisular-farmaco. |
TW202131954A (zh) | 2019-11-07 | 2021-09-01 | 丹麥商珍美寶股份有限公司 | 利用鉑類劑與抗組織因子抗體-藥物共軛體之組合來治療癌症之方法 |
WO2021134045A1 (en) * | 2019-12-26 | 2021-07-01 | Ohio State Innovation Foundation | Methods and compositions for inhibition of dihydroorotate dehydrogenase in combination with an anti-cd38 therapeutic agent |
BR112022025105A2 (pt) | 2020-06-29 | 2023-01-17 | Genmab As | Método para o tratamento de câncer cervical em um indivíduo, conjugado anticorpo-fármaco, e, uso de um conjugado anticorpo-fármaco |
US20220089736A1 (en) * | 2020-09-11 | 2022-03-24 | Janssen Biotech, Inc. | Immune targeting molecules and uses thereof |
KR20230084508A (ko) | 2020-09-11 | 2023-06-13 | 얀센 바이오테크 인코포레이티드 | 베타 사슬 매개 면역을 조절하기 위한 방법 및 조성물 |
MX2023004941A (es) | 2020-11-08 | 2023-07-12 | Seagen Inc | Conjugado de anticuerpo y fármaco para terapia de combinación con inhibidor de células inmunitarias. |
CN113368232B (zh) * | 2021-06-02 | 2022-08-26 | 上海交通大学 | 多特异性抗原结合蛋白及其应用 |
CA3227357A1 (en) * | 2021-07-29 | 2023-02-02 | Eun Ji Shin | Hemocompatible mesenchymal stem cells, preparation method therefor and use thereof |
WO2023213960A1 (en) | 2022-05-06 | 2023-11-09 | Genmab A/S | Methods of treating cancer with anti-tissue factor antibody-drug conjugates |
WO2024083162A1 (en) * | 2022-10-19 | 2024-04-25 | Multitude Therapeutics Inc. | Antibodies, antibody-drug conjugates, preparations and uses thereof |
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