NO20070343L - N-(1 -(1 -benzyl-4-fenyl-1 H-imidazol-2-yl)-2,2-dimetylpropyl)benzamid derivater og relaterte forbindelser som kinesin spindelprotein (KSP) inhibitorer for behandling av kreft - Google Patents
N-(1 -(1 -benzyl-4-fenyl-1 H-imidazol-2-yl)-2,2-dimetylpropyl)benzamid derivater og relaterte forbindelser som kinesin spindelprotein (KSP) inhibitorer for behandling av kreftInfo
- Publication number
- NO20070343L NO20070343L NO20070343A NO20070343A NO20070343L NO 20070343 L NO20070343 L NO 20070343L NO 20070343 A NO20070343 A NO 20070343A NO 20070343 A NO20070343 A NO 20070343A NO 20070343 L NO20070343 L NO 20070343L
- Authority
- NO
- Norway
- Prior art keywords
- group
- optionally substituted
- substituted
- hydrogen
- aryl
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- LOUPRKONTZGTKE-WZBLMQSHSA-N Quinine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-WZBLMQSHSA-N 0.000 title 2
- 235000001258 Cinchona calisaya Nutrition 0.000 title 1
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- KTVLPYPWRBPIAZ-UHFFFAOYSA-N n-[1-(1-benzyl-4-phenylimidazol-2-yl)-2,2-dimethylpropyl]benzamide Chemical class N=1C(C=2C=CC=CC=2)=CN(CC=2C=CC=CC=2)C=1C(C(C)(C)C)NC(=O)C1=CC=CC=C1 KTVLPYPWRBPIAZ-UHFFFAOYSA-N 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 229960000948 quinine Drugs 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 4
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000004442 acylamino group Chemical group 0.000 abstract 2
- 125000000266 alpha-aminoacyl group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- -1 carboxyl ester Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000002460 imidazoles Chemical class 0.000 abstract 1
- 125000005415 substituted alkoxy group Chemical group 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/24—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58092704P | 2004-06-18 | 2004-06-18 | |
| PCT/US2005/022062 WO2006002236A1 (en) | 2004-06-18 | 2005-06-20 | N- (1- (1-benzyl -4-phenyl-1h-imidazol-2-yl) -2,2-dymethylpropyl) benzamide derivatives and related compounds as kinesin spindle protein (ksp) inhibitors for the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20070343L true NO20070343L (no) | 2007-03-05 |
Family
ID=34980173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20070343A NO20070343L (no) | 2004-06-18 | 2007-01-18 | N-(1 -(1 -benzyl-4-fenyl-1 H-imidazol-2-yl)-2,2-dimetylpropyl)benzamid derivater og relaterte forbindelser som kinesin spindelprotein (KSP) inhibitorer for behandling av kreft |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US7576221B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1765789B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP4836280B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101170925B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN1993331A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2005258135B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0510929A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2571002A1 (cg-RX-API-DMAC7.html) |
| EC (1) | ECSP077183A (cg-RX-API-DMAC7.html) |
| ES (1) | ES2409345T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL180147A0 (cg-RX-API-DMAC7.html) |
| MA (1) | MA28739B1 (cg-RX-API-DMAC7.html) |
| MX (1) | MXPA06014909A (cg-RX-API-DMAC7.html) |
| NO (1) | NO20070343L (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ552510A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2427572C2 (cg-RX-API-DMAC7.html) |
| SG (1) | SG153851A1 (cg-RX-API-DMAC7.html) |
| TN (1) | TNSN06419A1 (cg-RX-API-DMAC7.html) |
| TW (1) | TW200612958A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2006002236A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA200700481B (cg-RX-API-DMAC7.html) |
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|---|---|---|---|---|
| US7576221B2 (en) * | 2004-06-18 | 2009-08-18 | Novartis Vaccines And Diagnostics, Inc. | Substituted imidazole derivatives |
| CA2575188A1 (en) | 2004-08-18 | 2006-02-23 | Astrazeneca Ab | Enantiomers of selected fused pyrimidones and uses in the treatment and preventi on of cancer |
| WO2007011647A2 (en) * | 2005-07-15 | 2007-01-25 | Kalypsys, Inc. | Inhibitors of mitotic kinesin ksp |
| TW200800951A (en) * | 2005-08-09 | 2008-01-01 | Novartis Ag | Substituted imidazole compounds as KSP inhibitors |
| US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| PT2010528T (pt) | 2006-04-19 | 2017-12-21 | Novartis Ag | Compostos benzotiazole e benzoxazole 6-o-substituídos e métodos de inibição da sinalização csf-1r |
| CN101511796B (zh) * | 2006-09-05 | 2012-05-09 | 协和发酵麒麟株式会社 | 咪唑衍生物 |
| US20100120717A1 (en) | 2006-10-09 | 2010-05-13 | Brown Jason W | Kinase inhibitors |
| UA97256C2 (ru) | 2006-11-13 | 2012-01-25 | Новартис Аг | Замещенные пиразолы и триазолы как ингибиторы кбв (кинезин-белок веретена) |
| JP2010515687A (ja) * | 2007-01-05 | 2010-05-13 | ノバルティス アーゲー | キネシンスピンドルタンパク質阻害剤（ｅｇ−５）としてのイミダゾール誘導体 |
| US8252832B2 (en) * | 2007-12-14 | 2012-08-28 | Novartis Ag | Kinesin inhibitors as cancer therapeutics |
| JP2012515749A (ja) | 2009-01-26 | 2012-07-12 | ノバルティス アーゲー | キネシン阻害化合物の塩及び多形体 |
| US8546434B2 (en) * | 2010-04-15 | 2013-10-01 | Novartis Ag | Triazole compounds as KSP inhibitors |
| JP2013525290A (ja) * | 2010-04-15 | 2013-06-20 | ノバルティス アーゲー | Ｋｓｐ阻害剤としてのオキサゾールおよびチアゾール化合物 |
| DE102010025663A1 (de) | 2010-06-30 | 2012-01-05 | Karl-Heinz Glüsenkamp | Neue beta-Aminoaldehyd-Derivate, Verfahren zu ihrer Herstellung und ihre chemische Verwendung als reaktive Intermediate |
| US8809372B2 (en) | 2011-09-30 | 2014-08-19 | Asana Biosciences, Llc | Pyridine derivatives |
| US9498540B2 (en) | 2013-03-15 | 2016-11-22 | Novartis Ag | Cell proliferation inhibitors and conjugates thereof |
| EP2968591A1 (en) * | 2013-03-15 | 2016-01-20 | Novartis AG | Cell proliferation inhibitors and conjugates thereof |
| PL3086814T3 (pl) * | 2013-12-23 | 2020-12-28 | Bayer Pharma Aktiengesellschaft | Koniugaty środka wiążącego (ADC) z inhibitorami KSP |
| WO2016020791A1 (en) | 2014-08-05 | 2016-02-11 | Novartis Ag | Ckit antibody drug conjugates |
| CA2970565A1 (en) | 2014-12-15 | 2016-06-23 | Bayer Pharma Aktiengesellschaft | Antibody-drug conjugates (adcs) of ksp inhibitors with aglycosylated anti-tweakr antibodies |
| IS2977B (is) | 2015-02-23 | 2017-07-15 | Actavis Group Ptc Ehf. | Aðferð til framleiðslu á milliefnum sem eru nytsamleg við nýsmíði á elúxadólíni |
| SG10201908685QA (en) * | 2015-06-22 | 2019-10-30 | Bayer Pharma AG | Antibody drug conjugates (adcs) and antibody prodrug conjugates (apdcs) with enzymatically cleavable groups |
| WO2016207104A1 (de) | 2015-06-23 | 2016-12-29 | Bayer Pharma Aktiengesellschaft | Antikörper-wirkstoff-konjugate (adcs) von ksp-inhibitoren mit anti-b7h3-antikörpern |
| JP2018528161A (ja) | 2015-06-23 | 2018-09-27 | バイエル ファーマ アクチエンゲゼルシャフト | Ｋｓｐ阻害剤との部位特異的均一複合体 |
| JP2018525334A (ja) | 2015-06-23 | 2018-09-06 | バイエル ファーマ アクチエンゲゼルシャフト | キネシンスピンドルタンパク質（ｋｓｐ）阻害剤の抗ｔｗｅａｋｒ抗体との抗体薬物複合体 |
| CN109310781B (zh) | 2016-06-15 | 2024-06-18 | 拜耳制药股份公司 | 具有ksp抑制剂和抗-cd123-抗体的特异性抗体-药物-缀合物(adc) |
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| PE20191235A1 (es) * | 2016-12-21 | 2019-09-11 | Bayer Pharma AG | Conjugados de ligando-farmaco (adcs) con grupos escindibles enzimaticamente |
| SG11202012608VA (en) | 2018-06-18 | 2021-02-25 | Bayer Ag | Binder/active agent conjugates directed against cxcr5, having enzymatically cleavable linkers and improved activity profile |
| US11236069B2 (en) | 2018-12-20 | 2022-02-01 | Amgen Inc. | KIF18A inhibitors |
| CN119241504A (zh) | 2021-08-26 | 2025-01-03 | 沃拉斯查疗法公司 | Kif18a的螺吲哚啉抑制剂 |
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- 2005-06-20 US US11/158,574 patent/US7576221B2/en not_active Expired - Fee Related
- 2005-06-20 ES ES05760871T patent/ES2409345T3/es not_active Expired - Lifetime
- 2005-06-20 CA CA002571002A patent/CA2571002A1/en not_active Abandoned
- 2005-06-20 TW TW094120475A patent/TW200612958A/zh unknown
- 2005-06-20 JP JP2007516842A patent/JP4836280B2/ja not_active Expired - Fee Related
- 2005-06-20 BR BRPI0510929-9A patent/BRPI0510929A/pt not_active IP Right Cessation
- 2005-06-20 RU RU2007101612/04A patent/RU2427572C2/ru not_active IP Right Cessation
- 2005-06-20 NZ NZ552510A patent/NZ552510A/en not_active IP Right Cessation
- 2005-06-20 EP EP05760871A patent/EP1765789B1/en not_active Expired - Lifetime
- 2005-06-20 SG SG200904294-6A patent/SG153851A1/en unknown
- 2005-06-20 KR KR1020077000979A patent/KR101170925B1/ko not_active Expired - Fee Related
- 2005-06-20 MX MXPA06014909A patent/MXPA06014909A/es active IP Right Grant
- 2005-06-20 WO PCT/US2005/022062 patent/WO2006002236A1/en not_active Ceased
- 2005-06-20 AU AU2005258135A patent/AU2005258135B2/en not_active Ceased
- 2005-06-20 CN CNA2005800262037A patent/CN1993331A/zh active Pending
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- 2006-12-18 TN TNP2006000419A patent/TNSN06419A1/en unknown
- 2006-12-18 IL IL180147A patent/IL180147A0/en unknown
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2007
- 2007-01-16 ZA ZA200700481A patent/ZA200700481B/xx unknown
- 2007-01-17 MA MA29617A patent/MA28739B1/fr unknown
- 2007-01-18 EC EC2007007183A patent/ECSP077183A/es unknown
- 2007-01-18 NO NO20070343A patent/NO20070343L/no not_active Application Discontinuation
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- 2009-06-05 US US12/455,798 patent/US8318791B2/en not_active Expired - Fee Related
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- 2011-08-18 JP JP2011179247A patent/JP2011256197A/ja not_active Withdrawn
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Also Published As
| Publication number | Publication date |
|---|---|
| ZA200700481B (en) | 2008-10-29 |
| JP2011256197A (ja) | 2011-12-22 |
| US20130017196A1 (en) | 2013-01-17 |
| JP2008503501A (ja) | 2008-02-07 |
| TNSN06419A1 (en) | 2008-02-22 |
| RU2427572C2 (ru) | 2011-08-27 |
| NZ552510A (en) | 2010-12-24 |
| SG153851A1 (en) | 2009-07-29 |
| EP1765789A1 (en) | 2007-03-28 |
| CN1993331A (zh) | 2007-07-04 |
| ES2409345T3 (es) | 2013-06-26 |
| AU2005258135A1 (en) | 2006-01-05 |
| TW200612958A (en) | 2006-05-01 |
| IL180147A0 (en) | 2007-06-03 |
| US8735599B2 (en) | 2014-05-27 |
| BRPI0510929A (pt) | 2007-07-17 |
| AU2005258135B2 (en) | 2011-09-22 |
| KR20070106961A (ko) | 2007-11-06 |
| EP1765789B1 (en) | 2013-02-27 |
| US7576221B2 (en) | 2009-08-18 |
| CA2571002A1 (en) | 2006-01-05 |
| US20060009472A1 (en) | 2006-01-12 |
| RU2007101612A (ru) | 2008-08-10 |
| WO2006002236A1 (en) | 2006-01-05 |
| JP4836280B2 (ja) | 2011-12-14 |
| ECSP077183A (es) | 2007-02-28 |
| KR101170925B1 (ko) | 2012-08-07 |
| MXPA06014909A (es) | 2007-02-28 |
| US20090258016A1 (en) | 2009-10-15 |
| US8318791B2 (en) | 2012-11-27 |
| MA28739B1 (fr) | 2007-07-02 |
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