ECSP077183A - Derivados de la n-(1-bencil-4-fenil-1h-imidazol-2-il)-2,2-dimetilpropil)benzamida y los compuestos relacionados como inhibidores de la proteína de quiinesina del huso (ksp) para el tratamiento del cáncer - Google Patents

Derivados de la n-(1-bencil-4-fenil-1h-imidazol-2-il)-2,2-dimetilpropil)benzamida y los compuestos relacionados como inhibidores de la proteína de quiinesina del huso (ksp) para el tratamiento del cáncer

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Publication number
ECSP077183A
ECSP077183A EC2007007183A ECSP077183A ECSP077183A EC SP077183 A ECSP077183 A EC SP077183A EC 2007007183 A EC2007007183 A EC 2007007183A EC SP077183 A ECSP077183 A EC SP077183A EC SP077183 A ECSP077183 A EC SP077183A
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EC
Ecuador
Prior art keywords
group
substituted
optionally substituted
hydrogen
aryl
Prior art date
Application number
EC2007007183A
Other languages
English (en)
Inventor
Welbo Wang
Paul A Barsanti
Yi Xi
Rustum Boyce
Sabina Pecchi
Nathan Brammeier
Megan Phillips
Kris Mendenhall
Kelly Wayman
Liana Marie Lagniton
Ryan Constantine
Hong Yang
Elizabeth Mieuli
Savithri Ramurthy
Elisa Jazan
Anu Sharma
Jain Rama
Sharadha Sabramanian
Paul Renhowe
Kenneth Walter Bair
David Duhl
Annette Walter
Tinya Abrams
Kay Huh
Eric Martin
Mark Knapp
Vincent Le
Original Assignee
Chiron Corp
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34980173&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP077183(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of ECSP077183A publication Critical patent/ECSP077183A/es

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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
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    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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  • Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Esta invención se dirige a los compuestos substituidos del imidazol, los cuales, modulan la actividad de la KSP representado por la fórmula I: en donde: R1 se selecciona del grupo que consiste de acilamino, carboxilo, éster de carboxilo, arilo, y alquilo opcionalmente sustituido con hidroxi o halo; R2 se seleccionan del grupo que consiste de hidrógeno, alquilo, y arilo; R3 se seleccionan del grupo que consiste del hidrógeno y - X-A, en donde X se selecciona del grupo que consiste de -C(O) -, - C(S) -, - S(O) -, - S(O)2, y - S(O)2-N(R)-, donde R es hidrógeno o alquilo y A se selecciona del grupo que consiste de hidrógeno, alquilo opcionalmente substituido, del arilo alkoxy, opcionalmente substituido opcionalmente substituido, del éster carboxilo, carboxilo, del aminoacilo, del heteroarilo opcionalmente substituido, del cycloalquilo heterocíclico, y opcionalmente substituido opcionalmente substituido, en donde substituyen a los grupos opcionalmente substituidos con 1 a 4 sustitutos; R5 es seleccionado del grupo que consiste de L-A1, en donde L es seleccionado del grupo que consiste de -S(O)q- donde q es uno ó dos, y el alquenilo de C1 a C5 opcionalmente sustituido con hidroxi, halo, o acilamino; y A1 es seleccionado del grupo que consiste de arilo, arilo sustituido, heteroarilo, heteroarilo sustituido, heterocíclico, heterocíclico sustituido, cicloalquilo, y cicloalquilo sustituido; y uno de tanto R6 ó R7 es seleccionado del grupo que consiste de heterocíclico, arilo y heteroarilo, todos de los cuales pueden estar opcionalmente sustituidos con-(R8)m donde R8 es como se define aquí y m es un número entero de 1 a 3, y los otros de R6 ó R7 es seleccionado del grupo que consiste de hidrógeno, halo, y alquilo; ó R6 y R7 son ambos hidrógeno;
EC2007007183A 2004-06-18 2007-01-18 Derivados de la n-(1-bencil-4-fenil-1h-imidazol-2-il)-2,2-dimetilpropil)benzamida y los compuestos relacionados como inhibidores de la proteína de quiinesina del huso (ksp) para el tratamiento del cáncer ECSP077183A (es)

Applications Claiming Priority (1)

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US58092704P 2004-06-18 2004-06-18

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ECSP077183A true ECSP077183A (es) 2007-02-28

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EC2007007183A ECSP077183A (es) 2004-06-18 2007-01-18 Derivados de la n-(1-bencil-4-fenil-1h-imidazol-2-il)-2,2-dimetilpropil)benzamida y los compuestos relacionados como inhibidores de la proteína de quiinesina del huso (ksp) para el tratamiento del cáncer

Country Status (21)

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US (3) US7576221B2 (es)
EP (1) EP1765789B1 (es)
JP (2) JP4836280B2 (es)
KR (1) KR101170925B1 (es)
CN (1) CN1993331A (es)
AU (1) AU2005258135B2 (es)
BR (1) BRPI0510929A (es)
CA (1) CA2571002A1 (es)
EC (1) ECSP077183A (es)
ES (1) ES2409345T3 (es)
IL (1) IL180147A0 (es)
MA (1) MA28739B1 (es)
MX (1) MXPA06014909A (es)
NO (1) NO20070343L (es)
NZ (1) NZ552510A (es)
RU (1) RU2427572C2 (es)
SG (1) SG153851A1 (es)
TN (1) TNSN06419A1 (es)
TW (1) TW200612958A (es)
WO (1) WO2006002236A1 (es)
ZA (1) ZA200700481B (es)

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US20060009472A1 (en) 2006-01-12
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ZA200700481B (en) 2008-10-29
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US8318791B2 (en) 2012-11-27
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JP4836280B2 (ja) 2011-12-14
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AU2005258135A1 (en) 2006-01-05
US20090258016A1 (en) 2009-10-15
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US7576221B2 (en) 2009-08-18
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TW200612958A (en) 2006-05-01
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RU2007101612A (ru) 2008-08-10
EP1765789A1 (en) 2007-03-28
US20130017196A1 (en) 2013-01-17
US8735599B2 (en) 2014-05-27
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WO2006002236A1 (en) 2006-01-05
EP1765789B1 (en) 2013-02-27
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KR20070106961A (ko) 2007-11-06

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