NO20070343L - N-(1 -(1 -benzyl-4-fenyl-1 H-imidazol-2-yl)-2,2-dimetylpropyl)benzamid derivater og relaterte forbindelser som kinesin spindelprotein (KSP) inhibitorer for behandling av kreft - Google Patents
N-(1 -(1 -benzyl-4-fenyl-1 H-imidazol-2-yl)-2,2-dimetylpropyl)benzamid derivater og relaterte forbindelser som kinesin spindelprotein (KSP) inhibitorer for behandling av kreftInfo
- Publication number
- NO20070343L NO20070343L NO20070343A NO20070343A NO20070343L NO 20070343 L NO20070343 L NO 20070343L NO 20070343 A NO20070343 A NO 20070343A NO 20070343 A NO20070343 A NO 20070343A NO 20070343 L NO20070343 L NO 20070343L
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- Prior art keywords
- group
- optionally substituted
- substituted
- hydrogen
- aryl
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/24—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07—ORGANIC CHEMISTRY
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Animal Behavior & Ethology (AREA)
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- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58092704P | 2004-06-18 | 2004-06-18 | |
PCT/US2005/022062 WO2006002236A1 (en) | 2004-06-18 | 2005-06-20 | N- (1- (1-benzyl -4-phenyl-1h-imidazol-2-yl) -2,2-dymethylpropyl) benzamide derivatives and related compounds as kinesin spindle protein (ksp) inhibitors for the treatment of cancer |
Publications (1)
Publication Number | Publication Date |
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NO20070343L true NO20070343L (no) | 2007-03-05 |
Family
ID=34980173
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20070343A NO20070343L (no) | 2004-06-18 | 2007-01-18 | N-(1 -(1 -benzyl-4-fenyl-1 H-imidazol-2-yl)-2,2-dimetylpropyl)benzamid derivater og relaterte forbindelser som kinesin spindelprotein (KSP) inhibitorer for behandling av kreft |
Country Status (21)
Country | Link |
---|---|
US (3) | US7576221B2 (es) |
EP (1) | EP1765789B1 (es) |
JP (2) | JP4836280B2 (es) |
KR (1) | KR101170925B1 (es) |
CN (1) | CN1993331A (es) |
AU (1) | AU2005258135B2 (es) |
BR (1) | BRPI0510929A (es) |
CA (1) | CA2571002A1 (es) |
EC (1) | ECSP077183A (es) |
ES (1) | ES2409345T3 (es) |
IL (1) | IL180147A0 (es) |
MA (1) | MA28739B1 (es) |
MX (1) | MXPA06014909A (es) |
NO (1) | NO20070343L (es) |
NZ (1) | NZ552510A (es) |
RU (1) | RU2427572C2 (es) |
SG (1) | SG153851A1 (es) |
TN (1) | TNSN06419A1 (es) |
TW (1) | TW200612958A (es) |
WO (1) | WO2006002236A1 (es) |
ZA (1) | ZA200700481B (es) |
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KR20070046176A (ko) | 2004-08-18 | 2007-05-02 | 아스트라제네카 아베 | 특정 융합 피리미돈의 거울상이성질체 및 이의 암 치료 및예방에 있어서의 용도 |
WO2007011647A2 (en) * | 2005-07-15 | 2007-01-25 | Kalypsys, Inc. | Inhibitors of mitotic kinesin ksp |
TW200800951A (en) * | 2005-08-09 | 2008-01-01 | Novartis Ag | Substituted imidazole compounds as KSP inhibitors |
US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
KR101464385B1 (ko) | 2006-04-19 | 2014-11-21 | 노파르티스 아게 | 6-o-치환된 벤즈옥사졸 및 벤조티아졸 화합물, 및 csf-1r 신호전달의 억제 방법 |
US8273738B2 (en) * | 2006-09-05 | 2012-09-25 | Kyowa Hakko Kirin Co., Ltd. | Imidazole derivatives |
US20100120717A1 (en) | 2006-10-09 | 2010-05-13 | Brown Jason W | Kinase inhibitors |
US8129358B2 (en) * | 2006-11-13 | 2012-03-06 | Novartis Ag | Substituted pyrazole and triazole compounds as KSP inhibitors |
KR20090097210A (ko) * | 2007-01-05 | 2009-09-15 | 노파르티스 아게 | 키네신 방추체 단백질 (eg-5) 억제제로서의 이미다졸 유도체 |
US8252832B2 (en) | 2007-12-14 | 2012-08-28 | Novartis Ag | Kinesin inhibitors as cancer therapeutics |
JP2012515749A (ja) | 2009-01-26 | 2012-07-12 | ノバルティス アーゲー | キネシン阻害化合物の塩及び多形体 |
EA201201404A1 (ru) | 2010-04-15 | 2013-04-30 | Новартис Аг | Триазолы как ингибиторы кбв (кинезин-белок веретена) |
CN103153970A (zh) * | 2010-04-15 | 2013-06-12 | 诺瓦提斯公司 | 作为ksp抑制剂的*唑和噻唑化合物 |
DE102010025663A1 (de) | 2010-06-30 | 2012-01-05 | Karl-Heinz Glüsenkamp | Neue beta-Aminoaldehyd-Derivate, Verfahren zu ihrer Herstellung und ihre chemische Verwendung als reaktive Intermediate |
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JP2016516035A (ja) * | 2013-03-15 | 2016-06-02 | ノバルティス アーゲー | 細胞増殖阻害剤およびそれらのコンジュゲート |
BR112016014830A2 (pt) * | 2013-12-23 | 2017-09-19 | Bayer Pharma AG | Conjugados de fármaco de anticorpo (adcs) com inibidores de ksp |
US10786578B2 (en) | 2014-08-05 | 2020-09-29 | Novartis Ag | CKIT antibody drug conjugates |
EP3233127A1 (de) * | 2014-12-15 | 2017-10-25 | Bayer Pharma Aktiengesellschaft | Antikörper-wirkstoff-konjugate (adcs) von ksp-inhibitoren mit aglycosylierten anti-tweakrantikörpern |
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CN108025084A (zh) * | 2015-06-22 | 2018-05-11 | 拜耳医药股份有限公司 | 具有酶可裂解基团的抗体药物缀合物(adc)和抗体前药缀合物(apdc) |
JP2018528161A (ja) | 2015-06-23 | 2018-09-27 | バイエル ファーマ アクチエンゲゼルシャフト | Ksp阻害剤との部位特異的均一複合体 |
WO2016207104A1 (de) | 2015-06-23 | 2016-12-29 | Bayer Pharma Aktiengesellschaft | Antikörper-wirkstoff-konjugate (adcs) von ksp-inhibitoren mit anti-b7h3-antikörpern |
EP3313521A1 (de) | 2015-06-23 | 2018-05-02 | Bayer Pharma Aktiengesellschaft | Antikörper-wirkstoff-konjugate (adcs) von ksp-inhibitoren mit anti-tweakr-antikörpern |
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TW200612958A (en) | 2006-05-01 |
US8735599B2 (en) | 2014-05-27 |
US20060009472A1 (en) | 2006-01-12 |
NZ552510A (en) | 2010-12-24 |
EP1765789A1 (en) | 2007-03-28 |
EP1765789B1 (en) | 2013-02-27 |
MXPA06014909A (es) | 2007-02-28 |
TNSN06419A1 (en) | 2008-02-22 |
KR20070106961A (ko) | 2007-11-06 |
AU2005258135B2 (en) | 2011-09-22 |
US7576221B2 (en) | 2009-08-18 |
ES2409345T3 (es) | 2013-06-26 |
SG153851A1 (en) | 2009-07-29 |
US8318791B2 (en) | 2012-11-27 |
JP2008503501A (ja) | 2008-02-07 |
US20130017196A1 (en) | 2013-01-17 |
AU2005258135A1 (en) | 2006-01-05 |
IL180147A0 (en) | 2007-06-03 |
ZA200700481B (en) | 2008-10-29 |
US20090258016A1 (en) | 2009-10-15 |
RU2007101612A (ru) | 2008-08-10 |
CN1993331A (zh) | 2007-07-04 |
ECSP077183A (es) | 2007-02-28 |
CA2571002A1 (en) | 2006-01-05 |
BRPI0510929A (pt) | 2007-07-17 |
WO2006002236A1 (en) | 2006-01-05 |
MA28739B1 (fr) | 2007-07-02 |
JP2011256197A (ja) | 2011-12-22 |
JP4836280B2 (ja) | 2011-12-14 |
KR101170925B1 (ko) | 2012-08-07 |
RU2427572C2 (ru) | 2011-08-27 |
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