MA28739B1 - Derives de n-(1-(1-benzyl-4-phenyl-1h-imidazol-2-yl)-2,2-dymethylpropyl) benzamide et composes associes comme inhibiteurs de la proteine kinesine fuseau (ksp) pour le traitement du cancer - Google Patents

Derives de n-(1-(1-benzyl-4-phenyl-1h-imidazol-2-yl)-2,2-dymethylpropyl) benzamide et composes associes comme inhibiteurs de la proteine kinesine fuseau (ksp) pour le traitement du cancer

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Publication number
MA28739B1
MA28739B1 MA29617A MA29617A MA28739B1 MA 28739 B1 MA28739 B1 MA 28739B1 MA 29617 A MA29617 A MA 29617A MA 29617 A MA29617 A MA 29617A MA 28739 B1 MA28739 B1 MA 28739B1
Authority
MA
Morocco
Prior art keywords
dymethylpropyl
ksp
imidazol
fungal
inhibitors
Prior art date
Application number
MA29617A
Other languages
English (en)
Inventor
Weibo Wang
Paul A Barsanti
Yi Xi
Rustum S Boyce
Sabina Pecchi
Nathan Brammeier
Megan Phillips
Kris Mendenhall
Kelly Wayman
Liana Marie Lagniton
Ryan Constantine
Hong Yang
Elizabeth Mieuli
Savithri Ramurthy
Elisa Jazan
Anu Sharma
Jain Rama
Sharadha Sabramanian
Paul Renhowe
Kenneth Walter Bair
David Duhl
Annette Walter
Tinya Abrams
Kay Huh
Eric Martin
Mark Knapp
Vincent Le
Original Assignee
David Duhl
Annette Walter
Tinya Abrams
Kay Huh
Eric Martin
Mark Knapp
Vincent Le
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34980173&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA28739(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by David Duhl, Annette Walter, Tinya Abrams, Kay Huh, Eric Martin, Mark Knapp, Vincent Le filed Critical David Duhl
Publication of MA28739B1 publication Critical patent/MA28739B1/fr

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    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D233/20Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
MA29617A 2004-06-18 2007-01-17 Derives de n-(1-(1-benzyl-4-phenyl-1h-imidazol-2-yl)-2,2-dymethylpropyl) benzamide et composes associes comme inhibiteurs de la proteine kinesine fuseau (ksp) pour le traitement du cancer MA28739B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58092704P 2004-06-18 2004-06-18

Publications (1)

Publication Number Publication Date
MA28739B1 true MA28739B1 (fr) 2007-07-02

Family

ID=34980173

Family Applications (1)

Application Number Title Priority Date Filing Date
MA29617A MA28739B1 (fr) 2004-06-18 2007-01-17 Derives de n-(1-(1-benzyl-4-phenyl-1h-imidazol-2-yl)-2,2-dymethylpropyl) benzamide et composes associes comme inhibiteurs de la proteine kinesine fuseau (ksp) pour le traitement du cancer

Country Status (21)

Country Link
US (3) US7576221B2 (fr)
EP (1) EP1765789B1 (fr)
JP (2) JP4836280B2 (fr)
KR (1) KR101170925B1 (fr)
CN (1) CN1993331A (fr)
AU (1) AU2005258135B2 (fr)
BR (1) BRPI0510929A (fr)
CA (1) CA2571002A1 (fr)
EC (1) ECSP077183A (fr)
ES (1) ES2409345T3 (fr)
IL (1) IL180147A0 (fr)
MA (1) MA28739B1 (fr)
MX (1) MXPA06014909A (fr)
NO (1) NO20070343L (fr)
NZ (1) NZ552510A (fr)
RU (1) RU2427572C2 (fr)
SG (1) SG153851A1 (fr)
TN (1) TNSN06419A1 (fr)
TW (1) TW200612958A (fr)
WO (1) WO2006002236A1 (fr)
ZA (1) ZA200700481B (fr)

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JP6971858B2 (ja) 2015-06-22 2021-11-24 バイエル ファーマ アクチエンゲゼルシャフト 酵素開裂性基を有する抗体薬物複合体(adc)および抗体プロドラッグ複合体(apdc)
CA2990394A1 (fr) 2015-06-23 2016-12-29 Bayer Pharma Aktiengesellschaft Conjugues anticorps-principe actif (adc) d'inhibiteurs de ksp avec des anticorps anti-tweakr
WO2016207104A1 (fr) 2015-06-23 2016-12-29 Bayer Pharma Aktiengesellschaft Conjugués anticorps-principe actif (adc) d'inhibiteurs de ksp avec des anticorps anti-b7h3
MX2017017138A (es) * 2015-06-23 2018-04-30 Bayer Pharma AG Conjugados homogeneos especificos de sitio con inhibidores de ksp.
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JP7066714B2 (ja) 2016-12-21 2022-05-13 バイエル・ファルマ・アクティエンゲゼルシャフト 酵素的に切断可能な基を有する抗体薬物コンジュゲート(adc)
EP3558387B1 (fr) 2016-12-21 2021-10-20 Bayer Pharma Aktiengesellschaft Conjugués anticorps-principe actif (adc) spécifiques renfermant des inhibiteurs de ksp
WO2019243159A1 (fr) 2018-06-18 2019-12-26 Bayer Aktiengesellschaft Conjugués liant-principe actif inhibant cxcr5 comprenant des éléments de liaison pouvant être fragmentés de manière enzymatique et présentant un profil d'action amélioré
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US7576221B2 (en) 2009-08-18
RU2427572C2 (ru) 2011-08-27
JP2008503501A (ja) 2008-02-07
CN1993331A (zh) 2007-07-04
EP1765789A1 (fr) 2007-03-28
IL180147A0 (en) 2007-06-03
TNSN06419A1 (en) 2008-02-22
TW200612958A (en) 2006-05-01
JP4836280B2 (ja) 2011-12-14
SG153851A1 (en) 2009-07-29
ECSP077183A (es) 2007-02-28
KR101170925B1 (ko) 2012-08-07
JP2011256197A (ja) 2011-12-22
MXPA06014909A (es) 2007-02-28
BRPI0510929A (pt) 2007-07-17
KR20070106961A (ko) 2007-11-06
CA2571002A1 (fr) 2006-01-05
ES2409345T3 (es) 2013-06-26
US8318791B2 (en) 2012-11-27
RU2007101612A (ru) 2008-08-10
US20090258016A1 (en) 2009-10-15
US20130017196A1 (en) 2013-01-17
NO20070343L (no) 2007-03-05
US20060009472A1 (en) 2006-01-12
ZA200700481B (en) 2008-10-29
AU2005258135A1 (en) 2006-01-05
US8735599B2 (en) 2014-05-27
EP1765789B1 (fr) 2013-02-27
WO2006002236A1 (fr) 2006-01-05
NZ552510A (en) 2010-12-24
AU2005258135B2 (en) 2011-09-22

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