NO20065864L - Femleddete heterosykler anvendelige som serinproteaseinhibitorer - Google Patents
Femleddete heterosykler anvendelige som serinproteaseinhibitorerInfo
- Publication number
- NO20065864L NO20065864L NO20065864A NO20065864A NO20065864L NO 20065864 L NO20065864 L NO 20065864L NO 20065864 A NO20065864 A NO 20065864A NO 20065864 A NO20065864 A NO 20065864A NO 20065864 L NO20065864 L NO 20065864L
- Authority
- NO
- Norway
- Prior art keywords
- factor
- formula
- compounds
- serine protease
- protease inhibitors
- Prior art date
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- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P9/06—Antiarrhythmics
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Foreliggende oppfinnelse tilveiebringer en metode for behandling av en trombotisk eller en inflammatorisk lidelse ved administrering til en pasient med behov for dette av en terapeutisk effektiv mengde av minst én forbindelse med formel (I) eller Formel (V): eller en stereoisomer eller farmasøytisk akseptabelt salt eller solvat derav, hvor variablene A, L, Z, R3, R4, R6, R11, X1, X2 og X3 er som definert her. Forbindelsene med formel (I) er anvendelige som selektive inhibitorer av serinprotease-enzymer i koaguleringskaskaden og/eller kontaktaktiveringsystemet; for eksempel trombin, faktor Xa, faktor Xla, faktor IXa, faktor Vlla og/eller plasmakallikrein. Spesielt angår den forbindelser som er selektive faktor Xla inhibitorer. Foreliggende oppfinnelse tilveiebringer også forbindelser innen omfanget av formel I og angår farmasøytiske preparater omfattende disse forbindelser.
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PCT/US2005/021212 WO2005123050A2 (en) | 2004-06-15 | 2005-06-14 | Five-membered heterocycles useful as serine protease inhibitors |
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NO20065864A NO20065864L (no) | 2004-06-15 | 2006-12-15 | Femleddete heterosykler anvendelige som serinproteaseinhibitorer |
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US (6) | US7453002B2 (no) |
EP (1) | EP1773786B1 (no) |
JP (1) | JP4791460B2 (no) |
KR (1) | KR20070024601A (no) |
AU (1) | AU2005254102A1 (no) |
BR (1) | BRPI0512084A (no) |
CA (1) | CA2570472A1 (no) |
ES (1) | ES2628279T3 (no) |
IL (1) | IL179844A0 (no) |
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NO (1) | NO20065864L (no) |
RU (1) | RU2007101073A (no) |
WO (1) | WO2005123050A2 (no) |
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US7453002B2 (en) * | 2004-06-15 | 2008-11-18 | Bristol-Myers Squibb Company | Five-membered heterocycles useful as serine protease inhibitors |
US7429604B2 (en) | 2004-06-15 | 2008-09-30 | Bristol Myers Squibb Company | Six-membered heterocycles useful as serine protease inhibitors |
CN101137412B (zh) | 2005-01-13 | 2012-11-07 | 布里斯托尔-迈尔斯·斯奎布公司 | 用作凝血因子XIa抑制剂的取代的二芳基化合物 |
BRPI0620010A2 (pt) | 2005-12-14 | 2011-11-22 | Bristol-Myers Squibb Company | compostos ánalogos de arilpropionamida, arilacrilamida, arilpropinamida, ou arilmetiluréia, processo para sua preparação, composição farmacêutica e uso dos mesmos |
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- 2005-06-14 CA CA002570472A patent/CA2570472A1/en not_active Abandoned
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- 2005-06-14 BR BRPI0512084-5A patent/BRPI0512084A/pt not_active IP Right Cessation
- 2005-06-14 AU AU2005254102A patent/AU2005254102A1/en not_active Abandoned
- 2005-06-14 WO PCT/US2005/021212 patent/WO2005123050A2/en active Application Filing
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- 2006-12-05 IL IL179844A patent/IL179844A0/en unknown
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Also Published As
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ES2628279T3 (es) | 2017-08-02 |
EP1773786B1 (en) | 2017-04-26 |
RU2007101073A (ru) | 2008-07-20 |
US20090036438A1 (en) | 2009-02-05 |
WO2005123050A3 (en) | 2007-01-04 |
JP2008502700A (ja) | 2008-01-31 |
US20150259297A1 (en) | 2015-09-17 |
US20140206706A1 (en) | 2014-07-24 |
MXPA06014642A (es) | 2007-02-12 |
US8101778B2 (en) | 2012-01-24 |
AU2005254102A1 (en) | 2005-12-29 |
BRPI0512084A (pt) | 2008-02-06 |
US9617224B2 (en) | 2017-04-11 |
EP1773786A2 (en) | 2007-04-18 |
US7453002B2 (en) | 2008-11-18 |
US20120088758A1 (en) | 2012-04-12 |
JP4791460B2 (ja) | 2011-10-12 |
US10112936B2 (en) | 2018-10-30 |
CA2570472A1 (en) | 2005-12-29 |
KR20070024601A (ko) | 2007-03-02 |
US9079860B2 (en) | 2015-07-14 |
US20050282805A1 (en) | 2005-12-22 |
US8716492B2 (en) | 2014-05-06 |
IL179844A0 (en) | 2007-07-04 |
WO2005123050A2 (en) | 2005-12-29 |
US20170166560A1 (en) | 2017-06-15 |
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