EA200802210A1 - Замещенные пролинамиды, их получение и их применение в качестве лекарственных средств - Google Patents

Замещенные пролинамиды, их получение и их применение в качестве лекарственных средств

Info

Publication number
EA200802210A1
EA200802210A1 EA200802210A EA200802210A EA200802210A1 EA 200802210 A1 EA200802210 A1 EA 200802210A1 EA 200802210 A EA200802210 A EA 200802210A EA 200802210 A EA200802210 A EA 200802210A EA 200802210 A1 EA200802210 A1 EA 200802210A1
Authority
EA
Eurasian Patent Office
Prior art keywords
substituted
medicines
receiving
prolinamides
salts
Prior art date
Application number
EA200802210A
Other languages
English (en)
Inventor
Кай Герлах
Хеннинг Припке
Роланд Пфау
Вольфганг Винен
Аннетте Шулер-Метц
Георг Даманн
Герберт Нар
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA200802210A1 publication Critical patent/EA200802210A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

В заявке описаны новые, обладающие ценными свойствами замещенные пролинамиды общей формулы (I)в которой D, L, Е, G, J, M, R, R, Rи Rимеют указанные в описании изобретения значения, их таутомеры, их энантиомеры, их диастереомеры, их смеси и их соли, прежде всего их физиологически совместимые соли с неорганическими или органическими кислотами или основаниями.
EA200802210A 2006-05-16 2007-05-14 Замещенные пролинамиды, их получение и их применение в качестве лекарственных средств EA200802210A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06113977 2006-05-16
EP07102566 2007-02-16
PCT/EP2007/054631 WO2007131982A2 (de) 2006-05-16 2007-05-14 Substituierte prolinamide, deren herstellung und deren verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
EA200802210A1 true EA200802210A1 (ru) 2009-06-30

Family

ID=38646563

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200802210A EA200802210A1 (ru) 2006-05-16 2007-05-14 Замещенные пролинамиды, их получение и их применение в качестве лекарственных средств

Country Status (24)

Country Link
US (1) US7807693B2 (ru)
EP (1) EP2051975B1 (ru)
JP (1) JP5263686B2 (ru)
KR (1) KR101422456B1 (ru)
AR (1) AR060945A1 (ru)
AU (1) AU2007251614B2 (ru)
BR (1) BRPI0711648A2 (ru)
CA (1) CA2653753C (ru)
CL (1) CL2007001391A1 (ru)
DK (1) DK2051975T3 (ru)
EA (1) EA200802210A1 (ru)
EC (1) ECSP088824A (ru)
ES (1) ES2395538T3 (ru)
HK (1) HK1131140A1 (ru)
IL (1) IL195245A (ru)
MX (1) MX2008014499A (ru)
MY (1) MY146623A (ru)
NO (1) NO20084530L (ru)
NZ (1) NZ573573A (ru)
PE (1) PE20080702A1 (ru)
PL (1) PL2051975T3 (ru)
TW (1) TW200813047A (ru)
UY (1) UY30352A1 (ru)
WO (1) WO2007131982A2 (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2636050C2 (ru) * 2012-05-24 2017-11-20 Оно Фармасьютикал Ко., Лтд. Замещенные пирролидины в качестве ингибиторов фактора xia для лечения тромбоэмболических заболеваний

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EP1975165A1 (de) 2007-03-27 2008-10-01 Boehringer Ingelheim Pharma GmbH & Co. KG Substituierte Pyrrolidinamide, deren Herstellung und deren Verwendung als Arzneimittel
JP5524852B2 (ja) 2007-11-15 2014-06-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換アミド、それらの製造及び医薬品としての使用
US20110046130A1 (en) * 2008-03-31 2011-02-24 Evotec Ag Tetrahydronaphthyridines and aza derivatives thereof as histamine h3 receptor antagonists
JP6052527B2 (ja) 2013-02-21 2016-12-27 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ジヒドロプテリジノンｉ
JP6337750B2 (ja) * 2013-11-22 2018-06-06 小野薬品工業株式会社 化合物
WO2015116904A1 (en) 2014-02-03 2015-08-06 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ror-gamma
HUE060660T2 (hu) * 2014-03-07 2023-04-28 Biocryst Pharm Inc Szubsztituált pirazolok mint humán plazma kallikrein-gátlók
WO2016061160A1 (en) 2014-10-14 2016-04-21 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ror-gamma
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
US9845308B2 (en) 2014-11-05 2017-12-19 Vitae Pharmaceuticals, Inc. Isoindoline inhibitors of ROR-gamma
EP3078378B1 (en) 2015-04-08 2020-06-24 Vaiomer Use of factor xa inhibitors for regulating glycemia
ES2856931T3 (es) 2015-08-05 2021-09-28 Vitae Pharmaceuticals Llc Moduladores de ROR-gamma
RU2018121946A (ru) 2015-11-20 2019-12-23 Вайтаи Фармасьютиклз, Ллк Модуляторы ror-гамма
TW202220968A (zh) 2016-01-29 2022-06-01 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
US9481674B1 (en) 2016-06-10 2016-11-01 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
WO2019018975A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. INHIBITORS OF ROR GAMMA
MA49685A (fr) 2017-07-24 2021-04-14 Vitae Pharmaceuticals Llc INHIBITEURS DE ROR gamma
CN114646701B (zh) * 2022-03-01 2023-09-29 浙江国邦药业有限公司 一种l-脯氨酰胺中有关物质的hplc测试方法

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US7030141B2 (en) 2001-11-29 2006-04-18 Christopher Franklin Bigge Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade
JP3975254B2 (ja) * 2002-07-25 2007-09-12 日野自動車株式会社 チャイルドシート用アンカの取付構造
DE10329457A1 (de) * 2003-04-03 2005-01-20 Merck Patent Gmbh Ethinylprolinderivate
KR20050118708A (ko) 2003-04-03 2005-12-19 메르크 파텐트 게엠베하 혈전-색전 질환의 치료에서 응고 인자 ｘａ의 저해제로서사용하기 위한피롤리디노-１,２-디카르복시-１-(페닐아미드)-２-(４-(３-옥소-모르폴리노-４-일)-페닐아미드) 유도체 및 관련화합물
WO2004110433A1 (de) * 2003-06-18 2004-12-23 Merck Patent Gmbh Pyrrolidin-1, 2- dicarbonsäure- 1- [(4- ethinyl- phenyl) - amid]- 2- [(phenyl)- amid] derivative als inhibitoren der koagulationsfaktoren xa und viia zur behandlung von thrombosen
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DE10358814A1 (de) * 2003-12-16 2005-07-21 Merck Patent Gmbh Prolinylarylacetamide
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US7453002B2 (en) * 2004-06-15 2008-11-18 Bristol-Myers Squibb Company Five-membered heterocycles useful as serine protease inhibitors
DE102004045796A1 (de) 2004-09-22 2006-03-23 Merck Patent Gmbh Arzneimittel enthaltend Carbonylverbindungen sowie deren Verwendung
WO2006108709A1 (en) 2005-04-11 2006-10-19 Glaxo Group Limited 3-sulfonylamino-pyrrolidine-2-one derivatives as factor xa inhibitors
BRPI0613045A2 (pt) * 2005-07-15 2010-12-14 Hoffmann La Roche aminas cÍclicas fundidas a heteroarila

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2636050C2 (ru) * 2012-05-24 2017-11-20 Оно Фармасьютикал Ко., Лтд. Замещенные пирролидины в качестве ингибиторов фактора xia для лечения тромбоэмболических заболеваний

Also Published As

Publication number Publication date
AU2007251614A1 (en) 2007-11-22
IL195245A (en) 2012-09-24
US7807693B2 (en) 2010-10-05
JP5263686B2 (ja) 2013-08-14
AR060945A1 (es) 2008-07-23
MY146623A (en) 2012-09-14
US20080139605A1 (en) 2008-06-12
EP2051975A2 (de) 2009-04-29
EP2051975B1 (de) 2012-09-12
DK2051975T3 (da) 2012-10-15
NZ573573A (en) 2011-10-28
CA2653753C (en) 2013-09-24
UY30352A1 (es) 2008-01-02
TW200813047A (en) 2008-03-16
KR20090017523A (ko) 2009-02-18
HK1131140A1 (en) 2010-01-15
NO20084530L (no) 2008-12-12
ECSP088824A (es) 2008-11-27
CA2653753A1 (en) 2007-11-22
MX2008014499A (es) 2008-11-27
KR101422456B1 (ko) 2014-07-23
IL195245A0 (en) 2009-09-22
JP2009537483A (ja) 2009-10-29
CL2007001391A1 (es) 2008-01-18
ES2395538T3 (es) 2013-02-13
PL2051975T3 (pl) 2013-01-31
WO2007131982A2 (de) 2007-11-22
PE20080702A1 (es) 2008-07-10
BRPI0711648A2 (pt) 2011-11-29
AU2007251614B2 (en) 2013-01-17
WO2007131982A3 (de) 2008-01-10

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