DK2051975T3 - Substituerede prolinamider, fremstilling deraf og anvendelse deraf som lægemiddel. - Google Patents

Substituerede prolinamider, fremstilling deraf og anvendelse deraf som lægemiddel.

Info

Publication number
DK2051975T3
DK2051975T3 DK07729083.1T DK07729083T DK2051975T3 DK 2051975 T3 DK2051975 T3 DK 2051975T3 DK 07729083 T DK07729083 T DK 07729083T DK 2051975 T3 DK2051975 T3 DK 2051975T3
Authority
DK
Denmark
Prior art keywords
drug
preparation
prolinamides
substituted
substituted prolinamides
Prior art date
Application number
DK07729083.1T
Other languages
English (en)
Inventor
Kai Gerlach
Henning Priepke
Roland Pfau
Wolfgang Wienen
Annette Schuler-Metz
Georg Dahmann
Herbert Nar
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Application granted granted Critical
Publication of DK2051975T3 publication Critical patent/DK2051975T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
DK07729083.1T 2006-05-16 2007-05-14 Substituerede prolinamider, fremstilling deraf og anvendelse deraf som lægemiddel. DK2051975T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06113977 2006-05-16
EP07102566 2007-02-16
PCT/EP2007/054631 WO2007131982A2 (de) 2006-05-16 2007-05-14 Substituierte prolinamide, deren herstellung und deren verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
DK2051975T3 true DK2051975T3 (da) 2012-10-15

Family

ID=38646563

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07729083.1T DK2051975T3 (da) 2006-05-16 2007-05-14 Substituerede prolinamider, fremstilling deraf og anvendelse deraf som lægemiddel.

Country Status (24)

Country Link
US (1) US7807693B2 (da)
EP (1) EP2051975B1 (da)
JP (1) JP5263686B2 (da)
KR (1) KR101422456B1 (da)
AR (1) AR060945A1 (da)
AU (1) AU2007251614B2 (da)
BR (1) BRPI0711648A2 (da)
CA (1) CA2653753C (da)
CL (1) CL2007001391A1 (da)
DK (1) DK2051975T3 (da)
EA (1) EA200802210A1 (da)
EC (1) ECSP088824A (da)
ES (1) ES2395538T3 (da)
HK (1) HK1131140A1 (da)
IL (1) IL195245A (da)
MX (1) MX2008014499A (da)
MY (1) MY146623A (da)
NO (1) NO20084530L (da)
NZ (1) NZ573573A (da)
PE (1) PE20080702A1 (da)
PL (1) PL2051975T3 (da)
TW (1) TW200813047A (da)
UY (1) UY30352A1 (da)
WO (1) WO2007131982A2 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1975165A1 (de) 2007-03-27 2008-10-01 Boehringer Ingelheim Pharma GmbH & Co. KG Substituierte Pyrrolidinamide, deren Herstellung und deren Verwendung als Arzneimittel
WO2009063028A2 (en) 2007-11-15 2009-05-22 Boehringer Ingelheim International Gmbh Substituted amides, manufacturing and use thereof as medicaments
CA2719985A1 (en) * 2008-03-31 2009-10-08 Evotec Ag Tetrahydronaphthyridines and aza derivatives thereof as histamine h3 receptor antagonists
GB201209138D0 (en) * 2012-05-24 2012-07-04 Ono Pharmaceutical Co Compounds
WO2014127815A1 (en) 2013-02-21 2014-08-28 Boehringer Ingelheim International Gmbh Dihydropteridinones i
JP6337750B2 (ja) * 2013-11-22 2018-06-06 小野薬品工業株式会社 化合物
DK3102576T3 (da) 2014-02-03 2019-07-22 Vitae Pharmaceuticals Llc Dihydropyrrolopyridininhibitorer af ror-gamma
JP6574435B2 (ja) * 2014-03-07 2019-09-11 バイオクリスト ファーマスーティカルズ，インコーポレイテッドＢｉｏｃｒｙｓｔ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． ヒト血漿カリクレイン阻害剤
CA2963140A1 (en) 2014-10-14 2016-04-21 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ror-gamma
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
US9845308B2 (en) 2014-11-05 2017-12-19 Vitae Pharmaceuticals, Inc. Isoindoline inhibitors of ROR-gamma
EP3078378B1 (en) 2015-04-08 2020-06-24 Vaiomer Use of factor xa inhibitors for regulating glycemia
ES2856931T3 (es) 2015-08-05 2021-09-28 Vitae Pharmaceuticals Llc Moduladores de ROR-gamma
MX2018006223A (es) 2015-11-20 2018-12-19 Vitae Pharmaceuticals Inc Moduladores de ror-gamma.
TWI757266B (zh) 2016-01-29 2022-03-11 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
US9481674B1 (en) 2016-06-10 2016-11-01 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
US10913739B2 (en) 2017-07-24 2021-02-09 Vitae Pharmaceuticals, LLC (121374) Inhibitors of RORγ
WO2019018975A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. INHIBITORS OF ROR GAMMA
CN114646701B (zh) * 2022-03-01 2023-09-29 浙江国邦药业有限公司 一种l-脯氨酰胺中有关物质的hplc测试方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7030141B2 (en) * 2001-11-29 2006-04-18 Christopher Franklin Bigge Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade
JP3975254B2 (ja) * 2002-07-25 2007-09-12 日野自動車株式会社 チャイルドシート用アンカの取付構造
BRPI0408420A (pt) 2003-04-03 2006-03-21 Merck Patent Gmbh compostos de carbonila
DE10329457A1 (de) 2003-04-03 2005-01-20 Merck Patent Gmbh Ethinylprolinderivate
ATE337000T1 (de) 2003-06-18 2006-09-15 Merck Patent Gmbh Pyrrolidin-1,2-dicarbonsäure-1- (4-ethinyl- phenyl)-amidö-2- (phenyl)-amidö derivate als inhibitoren der koagulationsfaktoren xa und viia zur behandlung von thrombosen
ES2223277B1 (es) 2003-06-19 2006-03-01 Fernando Bouffard Fita Composicion anestesica para administracion topica.
DE10358814A1 (de) 2003-12-16 2005-07-21 Merck Patent Gmbh Prolinylarylacetamide
DE102004014945A1 (de) 2004-03-26 2005-10-13 Merck Patent Gmbh Prolinylderivate
US7453002B2 (en) * 2004-06-15 2008-11-18 Bristol-Myers Squibb Company Five-membered heterocycles useful as serine protease inhibitors
DE102004045796A1 (de) 2004-09-22 2006-03-23 Merck Patent Gmbh Arzneimittel enthaltend Carbonylverbindungen sowie deren Verwendung
US20090099231A1 (en) 2005-04-11 2009-04-16 John David Harling 3-Sulfonylamino-Pyrrolidine-2-One Derivatives as Factor Xa Inhibitors
CA2614401A1 (en) 2005-07-15 2007-01-25 F. Hoffmann-La Roche Ag Novel heteroaryl fused cyclic amines

Also Published As

Publication number Publication date
TW200813047A (en) 2008-03-16
AR060945A1 (es) 2008-07-23
JP5263686B2 (ja) 2013-08-14
JP2009537483A (ja) 2009-10-29
US20080139605A1 (en) 2008-06-12
EP2051975A2 (de) 2009-04-29
EA200802210A1 (ru) 2009-06-30
AU2007251614A1 (en) 2007-11-22
CA2653753A1 (en) 2007-11-22
BRPI0711648A2 (pt) 2011-11-29
US7807693B2 (en) 2010-10-05
HK1131140A1 (en) 2010-01-15
WO2007131982A3 (de) 2008-01-10
IL195245A0 (en) 2009-09-22
KR101422456B1 (ko) 2014-07-23
MX2008014499A (es) 2008-11-27
EP2051975B1 (de) 2012-09-12
PE20080702A1 (es) 2008-07-10
ES2395538T3 (es) 2013-02-13
PL2051975T3 (pl) 2013-01-31
UY30352A1 (es) 2008-01-02
IL195245A (en) 2012-09-24
KR20090017523A (ko) 2009-02-18
NZ573573A (en) 2011-10-28
WO2007131982A2 (de) 2007-11-22
NO20084530L (no) 2008-12-12
ECSP088824A (es) 2008-11-27
MY146623A (en) 2012-09-14
AU2007251614B2 (en) 2013-01-17
CL2007001391A1 (es) 2008-01-18
CA2653753C (en) 2013-09-24

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