DE602005022897D1 - Piperidinylamino-thienoä2,3-dü-pyrimidinverbindungen - Google Patents
Piperidinylamino-thienoä2,3-dü-pyrimidinverbindungenInfo
- Publication number
- DE602005022897D1 DE602005022897D1 DE602005022897T DE602005022897T DE602005022897D1 DE 602005022897 D1 DE602005022897 D1 DE 602005022897D1 DE 602005022897 T DE602005022897 T DE 602005022897T DE 602005022897 T DE602005022897 T DE 602005022897T DE 602005022897 D1 DE602005022897 D1 DE 602005022897D1
- Authority
- DE
- Germany
- Prior art keywords
- thienoä2
- piperidinylamino
- pyrimidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/947,995 US20050222175A1 (en) | 2004-03-31 | 2004-09-23 | New piperidinylamino-thieno[2,3-D] pyrimidine compounds |
US11/075,565 US7612078B2 (en) | 2003-03-31 | 2005-03-08 | Piperidinylamino-thieno[2,3-D] pyrimidine compounds |
PCT/US2005/034862 WO2006034511A1 (en) | 2004-09-23 | 2005-09-23 | Piperidinylamino-thieno[2,3-d] pyrimidine compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602005022897D1 true DE602005022897D1 (de) | 2010-09-23 |
Family
ID=35528225
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602005022897T Active DE602005022897D1 (de) | 2004-09-23 | 2005-09-23 | Piperidinylamino-thienoä2,3-dü-pyrimidinverbindungen |
Country Status (21)
Country | Link |
---|---|
US (2) | US7612078B2 (de) |
EP (1) | EP1797099B1 (de) |
JP (1) | JP2008514643A (de) |
KR (1) | KR20070057970A (de) |
CN (1) | CN101048412A (de) |
AR (1) | AR054982A1 (de) |
AT (1) | ATE477257T1 (de) |
AU (1) | AU2005287898A1 (de) |
BR (1) | BRPI0515530A (de) |
CA (1) | CA2581175A1 (de) |
DE (1) | DE602005022897D1 (de) |
DK (1) | DK1797099T3 (de) |
HR (1) | HRP20100607T1 (de) |
IL (1) | IL182099A0 (de) |
MX (1) | MX2007003026A (de) |
NO (1) | NO20072037L (de) |
NZ (1) | NZ553886A (de) |
PL (1) | PL1797099T3 (de) |
PT (1) | PT1797099E (de) |
TW (1) | TW200628472A (de) |
WO (1) | WO2006034511A1 (de) |
Families Citing this family (36)
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US20050222175A1 (en) * | 2004-03-31 | 2005-10-06 | Dhanoa Dale S | New piperidinylamino-thieno[2,3-D] pyrimidine compounds |
US7488736B2 (en) * | 2004-05-17 | 2009-02-10 | Epix Delaware, Inc. | Thienopyridinone compounds and methods of treatment |
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US7576211B2 (en) * | 2004-09-30 | 2009-08-18 | Epix Delaware, Inc. | Synthesis of thienopyridinone compounds and related intermediates |
US7598265B2 (en) * | 2004-09-30 | 2009-10-06 | Epix Delaware, Inc. | Compositions and methods for treating CNS disorders |
US7576080B2 (en) * | 2004-12-23 | 2009-08-18 | Memory Pharmaceuticals Corporation | Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors |
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US20070099877A1 (en) * | 2005-11-02 | 2007-05-03 | Cytovia, Inc. | N-aryl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof |
US20070213305A1 (en) * | 2005-11-02 | 2007-09-13 | Cytovia, Inc. | N-alkyl-N-aryl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof |
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US8618116B2 (en) * | 2009-08-03 | 2013-12-31 | Daljit Singh Dhanoa | Deuterium-enriched pyrimidine compounds and derivatives |
CA2808432C (en) | 2010-07-23 | 2019-06-04 | President And Fellows Of Harvard College | Tricyclic proteasome activity enhancing compounds with thieno[2,3-d]pyrimidine core |
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US10246464B2 (en) | 2014-09-09 | 2019-04-02 | The Regents Of The University Of Michigan | Thienopyrimidine and thienopyridine compounds and methods of use thereof |
CN104592248A (zh) * | 2014-12-31 | 2015-05-06 | 芜湖杨燕制药有限公司 | 一种4-氯-6-取代噻吩并[2,3-d]嘧啶化合物的制备方法 |
EP3302057A4 (de) | 2015-06-04 | 2018-11-21 | Kura Oncology, Inc. | Verfahren und zusammensetzungen zur hemmung der interaktion von menin mit mll-proteinen |
TWI703150B (zh) * | 2015-06-04 | 2020-09-01 | 美商庫拉腫瘤技術股份有限公司 | 用於抑制menin及mll蛋白之交互作用的方法及組合物 |
EP3429591B1 (de) | 2016-03-16 | 2023-03-15 | Kura Oncology, Inc. | Substituierte thieno[2,3-d]pyrimidinderivate als inhibitoren von menin-mll und verfahren zur verwendung |
BR112018068702A2 (pt) | 2016-03-16 | 2019-01-15 | Kura Oncology Inc | inibidores bicíclicos em ponte de menin-mll e métodos de uso |
US10611778B2 (en) * | 2016-09-14 | 2020-04-07 | Janssen Pharmaceutica Nv | Fused bicyclic inhibitors of menin-MLL interaction |
AU2017326487B2 (en) | 2016-09-14 | 2021-08-05 | Janssen Pharmaceutica Nv | Spiro bicyclic inhibitors of menin-MLL interaction |
CA3044739A1 (en) | 2016-12-15 | 2018-06-21 | Janssen Pharmaceutica Nv | Azepane inhibitors of menin-mll interaction |
WO2018175746A1 (en) | 2017-03-24 | 2018-09-27 | Kura Oncology, Inc. | Methods for treating hematological malignancies and ewing's sarcoma |
WO2018226976A1 (en) | 2017-06-08 | 2018-12-13 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with mll proteins |
TW201920170A (zh) | 2017-09-20 | 2019-06-01 | 美商庫拉腫瘤技術股份有限公司 | 經取代之menin-mll 抑制劑及使用方法 |
US11396517B1 (en) | 2017-12-20 | 2022-07-26 | Janssen Pharmaceutica Nv | Exo-aza spiro inhibitors of menin-MLL interaction |
CN110075109B (zh) * | 2019-03-28 | 2021-07-27 | 中国人民解放军军事科学院军事医学研究院 | 一种促进干细胞因子合成和分泌的化合物及其用途 |
CN114560843B (zh) * | 2022-04-02 | 2023-04-18 | 河南维诺生物科技有限公司 | 一种作为荧光探针的化合物及其合成方法和应用 |
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2005
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- 2005-09-23 DE DE602005022897T patent/DE602005022897D1/de active Active
- 2005-09-23 DK DK05800014.2T patent/DK1797099T3/da active
- 2005-09-23 TW TW094133175A patent/TW200628472A/zh unknown
- 2005-09-23 PL PL05800014T patent/PL1797099T3/pl unknown
- 2005-09-23 EP EP05800014A patent/EP1797099B1/de active Active
- 2005-09-23 JP JP2007533765A patent/JP2008514643A/ja active Pending
- 2005-09-23 NZ NZ553886A patent/NZ553886A/en unknown
- 2005-09-23 AU AU2005287898A patent/AU2005287898A1/en not_active Abandoned
- 2005-09-23 CN CNA2005800360646A patent/CN101048412A/zh active Pending
- 2005-09-23 KR KR1020077009078A patent/KR20070057970A/ko not_active Application Discontinuation
- 2005-09-23 AT AT05800014T patent/ATE477257T1/de active
- 2005-09-23 BR BRPI0515530-4A patent/BRPI0515530A/pt not_active IP Right Cessation
- 2005-09-23 MX MX2007003026A patent/MX2007003026A/es unknown
- 2005-09-23 PT PT05800014T patent/PT1797099E/pt unknown
- 2005-09-23 WO PCT/US2005/034862 patent/WO2006034511A1/en active Application Filing
- 2005-09-23 CA CA002581175A patent/CA2581175A1/en not_active Abandoned
- 2005-09-26 AR ARP050103996A patent/AR054982A1/es unknown
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2009
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Also Published As
Publication number | Publication date |
---|---|
US7612078B2 (en) | 2009-11-03 |
BRPI0515530A (pt) | 2008-07-29 |
NZ553886A (en) | 2010-11-26 |
AR054982A1 (es) | 2007-08-01 |
US20050222176A1 (en) | 2005-10-06 |
EP1797099A1 (de) | 2007-06-20 |
ATE477257T1 (de) | 2010-08-15 |
TW200628472A (en) | 2006-08-16 |
DK1797099T3 (da) | 2010-11-29 |
CA2581175A1 (en) | 2006-03-30 |
MX2007003026A (es) | 2007-12-04 |
US20100113485A1 (en) | 2010-05-06 |
NO20072037L (no) | 2007-06-21 |
HRP20100607T1 (hr) | 2011-03-31 |
WO2006034511A1 (en) | 2006-03-30 |
CN101048412A (zh) | 2007-10-03 |
JP2008514643A (ja) | 2008-05-08 |
AU2005287898A1 (en) | 2006-03-30 |
EP1797099B1 (de) | 2010-08-11 |
KR20070057970A (ko) | 2007-06-07 |
IL182099A0 (en) | 2007-07-24 |
PL1797099T3 (pl) | 2011-07-29 |
PT1797099E (pt) | 2010-11-18 |
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