NO20063446L - Tiazolderivater - Google Patents
TiazolderivaterInfo
- Publication number
- NO20063446L NO20063446L NO20063446A NO20063446A NO20063446L NO 20063446 L NO20063446 L NO 20063446L NO 20063446 A NO20063446 A NO 20063446A NO 20063446 A NO20063446 A NO 20063446A NO 20063446 L NO20063446 L NO 20063446L
- Authority
- NO
- Norway
- Prior art keywords
- substituted
- unsubstituted
- heterocyclic group
- lower alkyl
- aromatic heterocyclic
- Prior art date
Links
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 title 1
- 125000006848 alicyclic heterocyclic group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229940123702 Adenosine A2a receptor antagonist Drugs 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000002467 adenosine A2a receptor antagonist Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 150000007979 thiazole derivatives Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Det beskrives forbindelser med formel I der n er et helt tall fra 0 til 3; R1 er substituert eller usubstituert cykloalkyl, substituert eller usubstituert aryl, en substituert eller usubstituert alicyklisk heterocyklisk gruppe, eller en substituert eller usubstituert aromatisk heterocyklisk gruppe; R2 er halogen, substituert eller usubstituert lavere alkyl, substituert eller usubstituert aryl, en substituert eller usubstituert alicyklisk heterocyklisk gruppe, en substituert eller usubstituert aromatisk heterocyklisk gruppe, -COR8, eller lignende; R3 og R4 kan være like eller forskjellige og hver betyr et hydrogenatom, substituert eller usubstituert lavere alkyl, substituert eller usubstituert aralkyl, -COR12 eller lignende. For eksempel tilveiebringes det adenosin A2A reseptorantagonister som, som aktiv bestanddel, omfatter et tiazolderivat representert ved den generelle formel (I), eller et farmasøytisk akseptabelt salt derav, og lignende.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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JP2003432777 | 2003-12-26 | ||
PCT/JP2004/019778 WO2005063743A1 (ja) | 2003-12-26 | 2004-12-24 | チアゾール誘導体 |
Publications (2)
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NO20063446L true NO20063446L (no) | 2006-09-08 |
NO338017B1 NO338017B1 (no) | 2016-07-18 |
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NO20063446A NO338017B1 (no) | 2003-12-26 | 2006-07-26 | Tiazolderivater, farmasøytiske preparater inneholdende slike, og anvendelse derav |
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EP (2) | EP3002283B1 (no) |
JP (1) | JP4638355B2 (no) |
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CN (1) | CN1902196B (no) |
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BR (1) | BRPI0418082B8 (no) |
CA (1) | CA2551611C (no) |
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DK (2) | DK1700856T3 (no) |
EA (1) | EA013249B1 (no) |
ES (2) | ES2629414T3 (no) |
HK (1) | HK1091837A1 (no) |
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LT (1) | LT3002283T (no) |
NO (1) | NO338017B1 (no) |
PL (2) | PL3002283T3 (no) |
PT (2) | PT3002283T (no) |
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- 2004-12-24 EP EP04808128.5A patent/EP1700856B1/en active Active
- 2004-12-24 DK DK04808128.5T patent/DK1700856T3/en active
- 2004-12-24 DK DK15192381.0T patent/DK3002283T3/en active
- 2004-12-24 PL PL04808128T patent/PL1700856T3/pl unknown
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2006
- 2006-07-20 ZA ZA2006/06027A patent/ZA200606027B/en unknown
- 2006-07-26 NO NO20063446A patent/NO338017B1/no not_active IP Right Cessation
- 2006-12-08 HK HK06113527.9A patent/HK1091837A1/xx not_active IP Right Cessation
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2010
- 2010-04-26 US US12/766,986 patent/US7880013B2/en active Active
- 2010-12-06 US US12/960,937 patent/US8420827B2/en active Active
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2013
- 2013-03-14 US US13/826,654 patent/US8889718B2/en active Active
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2016
- 2016-01-15 CY CY20161100040T patent/CY1117132T1/el unknown
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2017
- 2017-08-30 CY CY20171100913T patent/CY1119261T1/el unknown
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