NO20072632L - Oksadiazolderivater som DGAT-inhibitorer - Google Patents
Oksadiazolderivater som DGAT-inhibitorerInfo
- Publication number
- NO20072632L NO20072632L NO20072632A NO20072632A NO20072632L NO 20072632 L NO20072632 L NO 20072632L NO 20072632 A NO20072632 A NO 20072632A NO 20072632 A NO20072632 A NO 20072632A NO 20072632 L NO20072632 L NO 20072632L
- Authority
- NO
- Norway
- Prior art keywords
- optionally substituted
- oxadiazole derivatives
- dgat inhibitors
- compounds
- dgat
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
- C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Gynecology & Obstetrics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- AIDS & HIV (AREA)
- Emergency Medicine (AREA)
- Communicable Diseases (AREA)
Abstract
Det er beskrevet forbindelser med formel (I) og salter og prodrug-forbindelser derav: hvor for eksempel R1 er eventuelt substituert aryl eller heteroaryl; Y er en bindingsgruppe valgt fra, for eksempel en direkte binding og en (substituert) alkylkjede; R2 er en eventuelt substituert aryl, en eventuelt substituert cykloalkyl eller en eventuelt substituert heterocyklisk gruppe. Prosesser for å lage slike forbindelser og anvendelse av dem som DGAT-inhibitorer, for eksempel ved behandling av fedme, er også beskrevet.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0427328A GB0427328D0 (en) | 2004-12-14 | 2004-12-14 | Chemical compounds |
GB0507403A GB0507403D0 (en) | 2005-04-13 | 2005-04-13 | Chemical compounds |
GB0520383A GB0520383D0 (en) | 2005-10-07 | 2005-10-07 | Chemical compounds |
PCT/GB2005/004726 WO2006064189A1 (en) | 2004-12-14 | 2005-12-09 | Oxadiazole derivatives as dgat inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20072632L true NO20072632L (no) | 2007-08-31 |
Family
ID=35999598
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20072632A NO20072632L (no) | 2004-12-14 | 2007-05-24 | Oksadiazolderivater som DGAT-inhibitorer |
Country Status (15)
Country | Link |
---|---|
US (2) | US7795283B2 (no) |
EP (1) | EP1833806A1 (no) |
JP (1) | JP2008523133A (no) |
KR (1) | KR20070087096A (no) |
AR (1) | AR051842A1 (no) |
AU (2) | AU2005315430B2 (no) |
BR (1) | BRPI0519058A2 (no) |
CA (1) | CA2588162A1 (no) |
IL (1) | IL183279A0 (no) |
MX (1) | MX2007007101A (no) |
NO (1) | NO20072632L (no) |
NZ (2) | NZ555683A (no) |
SA (1) | SA05260407B1 (no) |
TW (1) | TW200633991A (no) |
WO (1) | WO2006064189A1 (no) |
Families Citing this family (63)
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WO2008011131A2 (en) * | 2006-07-21 | 2008-01-24 | Takeda Pharmaceutical Company Limited | Amide compounds |
US20040185559A1 (en) * | 2003-03-21 | 2004-09-23 | Isis Pharmaceuticals Inc. | Modulation of diacylglycerol acyltransferase 1 expression |
NZ555683A (en) * | 2004-12-14 | 2010-09-30 | Astrazeneca Ab | Oxadiazole derivatives as dgat inhibitors |
EP1874317A4 (en) * | 2005-04-19 | 2011-10-26 | Bayer Healthcare Llc | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES IN THE TREATMENT OF OBESITY |
AR058562A1 (es) * | 2005-12-22 | 2008-02-13 | Astrazeneca Ab | Derivados de pirimido [4,5 b] (1,4) oxazinas , procedimientos de obtencion y su uso como inhibidores de acetil coa y dgat 1 |
ES2356097T3 (es) * | 2006-05-30 | 2011-04-04 | Astrazeneca Ab | Ácidos 5-fenilamino-1,3,4-oxadiazol-2-ilcarbonilamino-4-fenoxi-ciclohexancarboxílico sustituidos como inhibidores de la acetil coenzima a diacilglicerol aciltransferasa. |
WO2007138304A1 (en) * | 2006-05-30 | 2007-12-06 | Astrazeneca Ab | 1, 3, 4 -oxadiazole derivatives as dgat1 inhibitors |
EP2035397A1 (en) * | 2006-06-06 | 2009-03-18 | Astra Zeneca AB | Chemical compounds |
WO2007141517A1 (en) * | 2006-06-08 | 2007-12-13 | Astrazeneca Ab | Benzimidazoles and their use for the treatemnt of diabetes |
GB0611507D0 (en) * | 2006-06-10 | 2006-07-19 | Astrazeneca Ab | Chemical compounds |
GB0611552D0 (en) * | 2006-06-12 | 2006-07-19 | Astrazeneca Ab | Chemical compounds |
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ATE554085T1 (de) * | 2006-11-30 | 2012-05-15 | Probiodrug Ag | Neue inhibitoren von glutaminylcyclase |
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ES2535083T3 (es) | 2007-12-20 | 2015-05-05 | Astrazeneca Ab | Compuestos de carbamoilo como inhibidores 190 de DGAT1 |
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EP2683701B1 (de) | 2011-03-08 | 2014-12-24 | Sanofi | Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
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CN108658889B (zh) * | 2018-05-11 | 2021-12-17 | 贵州医科大学 | 一种含萘环的1,2,4-噁二唑-芳基哌嗪型化合物及其制法和用途 |
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JP7335849B2 (ja) * | 2019-07-17 | 2023-08-30 | 信越化学工業株式会社 | ジメチルシクロブタン環を有するジエステル化合物及びその製造方法、並びにそれから誘導されるジメチルシクロブタン化合物の製造方法 |
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- 2005-12-09 NZ NZ555683A patent/NZ555683A/en not_active IP Right Cessation
- 2005-12-09 CA CA002588162A patent/CA2588162A1/en not_active Abandoned
- 2005-12-09 AU AU2005315430A patent/AU2005315430B2/en not_active Ceased
- 2005-12-09 US US11/792,922 patent/US7795283B2/en not_active Expired - Fee Related
- 2005-12-09 KR KR1020077016200A patent/KR20070087096A/ko not_active Application Discontinuation
- 2005-12-09 BR BRPI0519058-4A patent/BRPI0519058A2/pt not_active IP Right Cessation
- 2005-12-09 NZ NZ587106A patent/NZ587106A/en not_active IP Right Cessation
- 2005-12-09 EP EP05818139A patent/EP1833806A1/en not_active Withdrawn
- 2005-12-09 JP JP2007546161A patent/JP2008523133A/ja not_active Withdrawn
- 2005-12-09 MX MX2007007101A patent/MX2007007101A/es active IP Right Grant
- 2005-12-09 WO PCT/GB2005/004726 patent/WO2006064189A1/en active Application Filing
- 2005-12-13 AR ARP050105216A patent/AR051842A1/es not_active Application Discontinuation
- 2005-12-14 SA SA5260407A patent/SA05260407B1/ar unknown
- 2005-12-14 TW TW094144264A patent/TW200633991A/zh unknown
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2007
- 2007-05-17 IL IL183279A patent/IL183279A0/en unknown
- 2007-05-24 NO NO20072632A patent/NO20072632L/no not_active Application Discontinuation
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- 2010-07-28 AU AU2010206031A patent/AU2010206031A1/en not_active Abandoned
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Also Published As
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AR051842A1 (es) | 2007-02-14 |
IL183279A0 (en) | 2007-09-20 |
SA05260407B1 (ar) | 2009-11-15 |
TW200633991A (en) | 2006-10-01 |
AU2010206031A1 (en) | 2010-08-19 |
US20080096874A1 (en) | 2008-04-24 |
US7795283B2 (en) | 2010-09-14 |
AU2005315430B2 (en) | 2010-05-27 |
WO2006064189A1 (en) | 2006-06-22 |
KR20070087096A (ko) | 2007-08-27 |
CA2588162A1 (en) | 2006-06-22 |
BRPI0519058A2 (pt) | 2008-12-23 |
NZ555683A (en) | 2010-09-30 |
US20100317653A1 (en) | 2010-12-16 |
NZ587106A (en) | 2012-03-30 |
AU2005315430A1 (en) | 2006-06-22 |
MX2007007101A (es) | 2007-08-21 |
EP1833806A1 (en) | 2007-09-19 |
JP2008523133A (ja) | 2008-07-03 |
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