NO20084583L - Makrosykliske kinase-inhibitorer - Google Patents

Makrosykliske kinase-inhibitorer

Info

Publication number
NO20084583L
NO20084583L NO20084583A NO20084583A NO20084583L NO 20084583 L NO20084583 L NO 20084583L NO 20084583 A NO20084583 A NO 20084583A NO 20084583 A NO20084583 A NO 20084583A NO 20084583 L NO20084583 L NO 20084583L
Authority
NO
Norway
Prior art keywords
kinase inhibitors
macrocyclic kinase
macrocyclic
useful
compound
Prior art date
Application number
NO20084583A
Other languages
English (en)
Inventor
Hong Fu
Yue Chen
Daniel V Santi
Original Assignee
Kosan Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kosan Biosciences Inc filed Critical Kosan Biosciences Inc
Publication of NO20084583L publication Critical patent/NO20084583L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

En forbindelse som har en struktur i henhold til formel (I) (I) hvor R1, R2, R3, R4 og R5 er som definert her, er anvendelige som kinase-inhibitorer
NO20084583A 2006-05-11 2008-11-03 Makrosykliske kinase-inhibitorer NO20084583L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US79978606P 2006-05-11 2006-05-11
US81726006P 2006-06-28 2006-06-28
US11/729,327 US7601852B2 (en) 2006-05-11 2007-03-27 Macrocyclic kinase inhibitors
PCT/US2007/008591 WO2007133352A2 (en) 2006-05-11 2007-04-05 Macrocyclic kinase inhibitors

Publications (1)

Publication Number Publication Date
NO20084583L true NO20084583L (no) 2008-12-04

Family

ID=38685942

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20084583A NO20084583L (no) 2006-05-11 2008-11-03 Makrosykliske kinase-inhibitorer

Country Status (6)

Country Link
US (1) US7601852B2 (no)
EP (1) EP2015745A4 (no)
JP (1) JP2009536946A (no)
CN (1) CN101489547B (no)
NO (1) NO20084583L (no)
WO (1) WO2007133352A2 (no)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8546404B2 (en) * 2005-12-13 2013-10-01 Merck Sharp & Dohme Compounds that are ERK inhibitors
US7807672B2 (en) * 2006-02-16 2010-10-05 Schering Corporation Compounds that are ERK inhibitors
WO2009073513A1 (en) * 2007-11-30 2009-06-11 Schering Corporation Braf biomarkers
ES2556353T3 (es) * 2008-02-21 2016-01-15 Merck Sharp & Dohme Corp. Compuestos que son inhibidores de las ERK
MX339811B (es) 2009-09-16 2016-06-08 Celgene Avilomics Res Inc * Conjugados e inhibidores de cinasa de proteina.
WO2011036299A1 (en) * 2009-09-28 2011-03-31 Universite De Strasbourg Irreversible inhibitors useful for the treatment of kinase-related pathologies
CN102812167A (zh) 2009-12-30 2012-12-05 阿维拉制药公司 蛋白的配体-介导的共价修饰
US9428845B1 (en) 2010-12-28 2016-08-30 Warp Drive Bio, Inc. Identifying new therapeutic agents
CN103173529B (zh) 2011-12-23 2015-04-29 上海吉凯基因化学技术有限公司 人nlk基因相关的用途及其相关药物
GB201212690D0 (en) * 2012-07-16 2012-08-29 Cancer Res Inst Royal Materials and methods for treating pten mutated or deficient cancer
CN104342440A (zh) * 2013-07-30 2015-02-11 上海交通大学医学院附属新华医院 CDKL1基因及其siRNA和应用
US10533016B2 (en) 2015-01-09 2020-01-14 Revolution Medicines, Inc. Compounds that participate in cooperative binding and uses thereof
EP4242304A3 (en) 2015-10-01 2024-02-07 Revolution Medicines, Inc. Methods and reagents for analyzing protein-protein interfaces
CN108379583B (zh) * 2018-03-27 2021-08-17 北京大学 一种肿瘤转移药物治疗的靶标及其应用
CA3123869A1 (en) * 2018-12-21 2020-06-25 Revolution Medicines, Inc. Compounds that participate in cooperative binding and uses thereof
TW202132315A (zh) 2019-11-04 2021-09-01 美商銳新醫藥公司 Ras 抑制劑
JP2022553859A (ja) 2019-11-04 2022-12-26 レボリューション メディシンズ インコーポレイテッド Ｒａｓ阻害剤
BR112022008565A2 (pt) 2019-11-04 2022-08-09 Revolution Medicines Inc Composto, composição farmacêutica, conjugado, métodos para tratar câncer e um distúrbio relativo à proteína ras
EP4214209A1 (en) 2020-09-15 2023-07-26 Revolution Medicines, Inc. Indole derivatives as ras inhibitors in the treatment of cancer

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9225396D0 (en) 1992-12-04 1993-01-27 Sandoz Ltd Improvements in or relating to organic compounds
JPH0840893A (ja) 1993-08-31 1996-02-13 Takeda Chem Ind Ltd インターロイキン−１産生抑制剤
US5795910A (en) 1994-10-28 1998-08-18 Cor Therapeutics, Inc. Method and compositions for inhibiting protein kinases
GB2323845A (en) * 1997-03-31 1998-10-07 Merck & Co Inc MEK inhibiting lactones
CA2356622A1 (en) 1998-12-24 2000-07-06 Novation Pharmaceuticals Inc. Compounds which affect mrna stability and uses therefor
JP2001294527A (ja) 2000-04-14 2001-10-23 Ajinomoto Co Inc Ｔｈ２反応に特異的な免疫寛容誘導剤
JP2004292315A (ja) 2000-12-14 2004-10-21 Chugai Pharmaceut Co Ltd Ｔａｋ１阻害剤
JP2004292314A (ja) 2000-12-14 2004-10-21 Chugai Pharmaceut Co Ltd ケラチノサイト増殖抑制剤
AU2002356922A1 (en) 2001-11-09 2003-05-26 Conforma Therapeutics Corporation Hsp90-inhibiting zearalanol compounds and methods of producing and using same
US7915306B2 (en) 2002-03-08 2011-03-29 Eisai Co., Ltd. Macrocyclic compounds useful as pharmaceuticals
JP4575667B2 (ja) * 2002-03-08 2010-11-04 エーザイ・アール・アンド・ディー・マネジメント株式会社 医薬として有用な大環状化合物
CN1652743A (zh) 2002-04-17 2005-08-10 大正制药株式会社 毛发生长补剂
WO2004004644A2 (en) 2002-07-05 2004-01-15 Beth Israel Deaconess Medical Center Combination of mtor inhibitor and a tyrosine kinase inhibitor for the treatment of neoplasms
WO2006036941A2 (en) * 2004-09-27 2006-04-06 Kosan Biosciences Incorporated Specific kinase inhibitors
WO2006034537A1 (en) * 2004-09-29 2006-04-06 Inventors Express Pty Ltd Drink carrier

Also Published As

Publication number Publication date
WO2007133352A3 (en) 2008-03-13
CN101489547B (zh) 2012-08-08
JP2009536946A (ja) 2009-10-22
US20070265333A1 (en) 2007-11-15
CN101489547A (zh) 2009-07-22
EP2015745A2 (en) 2009-01-21
WO2007133352A2 (en) 2007-11-22
EP2015745A4 (en) 2011-03-09
US7601852B2 (en) 2009-10-13

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application