NO20084302L - 2-(syklisk amino)-pyrimidonderivater som TPK1-inhibitorer - Google Patents
2-(syklisk amino)-pyrimidonderivater som TPK1-inhibitorerInfo
- Publication number
- NO20084302L NO20084302L NO20084302A NO20084302A NO20084302L NO 20084302 L NO20084302 L NO 20084302L NO 20084302 A NO20084302 A NO 20084302A NO 20084302 A NO20084302 A NO 20084302A NO 20084302 L NO20084302 L NO 20084302L
- Authority
- NO
- Norway
- Prior art keywords
- hydrogen
- cyclic amino
- pyrimidone derivatives
- integer
- tpk1
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Forbindelse representert ved formel en optisk aktiv isomer derav, eller et farmasøytisk akseptabelt salt derav, hvor R2 er hydrogen eller lignende; R3 er metyl eller lignende; R20 er halogen eller lignende; q er et helt tall fra 0 til 3; Z er nitrogen, CH eller lignende; R4 er hydrogen eller lignende; R5 er hydrogen eller lignende; R6 er substituert alkyloksy eller lignende; p er et helt tall fra 0 til 3; X representerer en binding, CH2, oksygenatom, NH eller lignende; hvilke som helst av R5 og R6, R5 og R4, R6 og R4, X og R5, X og R4, X og R6 og R6 og R6 kan være kombinert med hverandre og danne en ring. Forbindelsen anvendes til forebyggende og/eller terapeutisk behandling av en sykdom forårsaket av t-proteinkinase 1-hyperaktivitet, så som neurodegenerative sykdommer (f.eks. Alzheimers sykdom).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006110242 | 2006-03-15 | ||
PCT/JP2007/055787 WO2007119463A1 (en) | 2006-03-15 | 2007-03-14 | 2-(cyclic amino)-pyrimidone derivatives as tpk1 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20084302L true NO20084302L (no) | 2008-12-03 |
Family
ID=38110618
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20084302A NO20084302L (no) | 2006-03-15 | 2008-10-14 | 2-(syklisk amino)-pyrimidonderivater som TPK1-inhibitorer |
Country Status (16)
Country | Link |
---|---|
US (1) | US8569294B2 (no) |
EP (2) | EP2001863A1 (no) |
JP (2) | JP2009530229A (no) |
KR (1) | KR20080102430A (no) |
CN (1) | CN101400668A (no) |
AR (1) | AR059899A1 (no) |
AU (1) | AU2007239962A1 (no) |
BR (1) | BRPI0708914A2 (no) |
CA (1) | CA2644979A1 (no) |
EA (1) | EA200870358A1 (no) |
MX (1) | MX2008011780A (no) |
NO (1) | NO20084302L (no) |
NZ (1) | NZ571709A (no) |
TW (1) | TW200813015A (no) |
WO (1) | WO2007119463A1 (no) |
ZA (1) | ZA200808364B (no) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200813015A (en) * | 2006-03-15 | 2008-03-16 | Mitsubishi Pharma Corp | 2-(cyclic amino)-pyrimidone derivatives |
AR064660A1 (es) * | 2006-12-26 | 2009-04-15 | Mitsubishi Tanabe Pharma Corp | Derivados de pirimidinona 6-heterociclica 2-sustituida, medicamentos que los contienen y usos para prevenir y/o tratar enfermedades neurodegenerativas entre otras |
AU2008297817A1 (en) | 2007-09-14 | 2009-03-19 | Mitsubishi Tanabe Pharma Corporation | 6-pyrimidinyl-pyrimid-4-one derivative |
EP2078717A1 (en) * | 2008-01-11 | 2009-07-15 | sanofi-aventis | 6-Pyrimidinyl-pyrimid-2-one derivative |
CN101538222B (zh) * | 2008-03-18 | 2012-12-26 | 上海医药工业研究院 | N-(2-苯基)乙基-2-[(2,2-二甲氧乙基)氨基]乙酰胺卤酸盐的制备方法 |
CN102300462B (zh) * | 2008-12-03 | 2015-01-28 | 普雷西迪奥制药公司 | Hcv ns5a的抑制剂 |
AR076014A1 (es) * | 2009-04-02 | 2011-05-11 | Sanofi Aventis | Derivados de 3- (1,4) oxazepan -4-pirimidona |
US9006232B2 (en) | 2009-08-13 | 2015-04-14 | Mitsubishi Tanabe Pharma Corporation | Pyrimidone derivatives |
US8940738B2 (en) | 2009-08-13 | 2015-01-27 | Mitsubishi Tanabe Pharma Corporation | Pyrimidone compounds |
EP2479165B1 (en) | 2009-09-16 | 2017-10-25 | Astellas Pharma Inc. | Glycine compound |
EP2683700B1 (de) | 2011-03-08 | 2015-02-18 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
US8710050B2 (en) | 2011-03-08 | 2014-04-29 | Sanofi | Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
US8901114B2 (en) | 2011-03-08 | 2014-12-02 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
EP2683705B1 (de) | 2011-03-08 | 2015-04-22 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
CN103232356B (zh) * | 2013-05-15 | 2017-02-15 | 天津金族科技有限公司 | 一种制备3‑苯基‑4‑氨基丁酸盐酸盐的工艺 |
EP3119774A1 (en) * | 2014-03-17 | 2017-01-25 | reMynd NV | Oxadiazole compounds |
WO2016030306A1 (en) * | 2014-08-27 | 2016-03-03 | F. Hoffmann-La Roche Ag | Substituted pyrazino[2,1-a]isoquinoline derivatives for the treatment of cns disorders |
CN104193695B (zh) * | 2014-09-03 | 2016-06-22 | 哈尔滨工业大学 | 一种吗啡啉类化合物的合成方法 |
WO2016179059A1 (en) * | 2015-05-05 | 2016-11-10 | Merck Sharp & Dohme Corp. | Heteroaryl-pyrimidinone compounds as pde2 inhibitors |
EP3319968A1 (en) | 2015-07-06 | 2018-05-16 | Rodin Therapeutics, Inc. | Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase |
RS62639B1 (sr) | 2015-07-06 | 2021-12-31 | Alkermes Inc | Hetero-halo inhibitori histonskih deacetilaza |
CA3049443A1 (en) | 2017-01-11 | 2018-07-19 | Rodin Therapeutics, Inc. | Bicyclic inhibitors of histone deacetylase |
US11225475B2 (en) | 2017-08-07 | 2022-01-18 | Alkermes, Inc. | Substituted pyridines as inhibitors of histone deacetylase |
CN107602457A (zh) * | 2017-10-10 | 2018-01-19 | 重庆奥舍生物化工有限公司 | 一锅法合成6‑甲基‑2‑氨基‑异烟酸的方法 |
KR101957063B1 (ko) | 2017-12-27 | 2019-03-11 | 주식회사 비케이에스 | 유압브레이커의 스텝씰 |
BR112020018444A2 (pt) * | 2018-03-14 | 2020-12-29 | Fochon Pharmaceuticals, Ltd. | Compostos de (2-azabiciclo[3,1,0]hexan-2-il)pirazolo[1,5-a]pirimidina substituída e imidazo[1,2-b]piridazina como inibidores de trk cinases |
US11878018B1 (en) * | 2018-12-20 | 2024-01-23 | Unm Rainforest Innovations | Phosphorylation of Syntaxin 17 by TBK1 controls autophagy initiation |
WO2020210785A1 (en) * | 2019-04-12 | 2020-10-15 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | D3 receptor agonist compounds; methods of preparation; intermediates thereof; and methods of use thereof |
CN113912622B (zh) * | 2020-07-10 | 2023-12-01 | 上海纽思克生物科技有限公司 | 三环嘧啶酮类化合物、其制备方法、其组合物和用途 |
CN111978242B (zh) * | 2020-08-21 | 2023-09-26 | 上海科利生物医药有限公司 | 一种(r)-3-氨基哌啶二盐酸盐的制备方法及应用 |
Family Cites Families (28)
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JPS4935634B1 (no) * | 1970-12-30 | 1974-09-25 | ||
JPS5124008B2 (no) | 1972-08-10 | 1976-07-21 | ||
US5140029A (en) | 1989-01-09 | 1992-08-18 | Janssen Pharmaceutica N.V. | 2-aminopyrimidinone derivatives |
US5256659A (en) | 1989-01-09 | 1993-10-26 | Janssen Pharmaceutica N.V. | 2-aminopyrimidinone derivatives |
GB8900382D0 (en) | 1989-01-09 | 1989-03-08 | Janssen Pharmaceutica Nv | 2-aminopyrimidinone derivatives |
CA2116460A1 (en) | 1993-03-02 | 1994-09-03 | Mitsubishi Chemical Corporation | Preventive or therapeutic agents for alzheimer's disease, a screening method of alzheimer's disease and tau-protein kinase i originated from human being |
US6410729B1 (en) * | 1996-12-05 | 2002-06-25 | Amgen Inc. | Substituted pyrimidine compounds and methods of use |
AR023052A1 (es) | 1998-09-25 | 2002-09-04 | Mitsuharu Yoshimura Milton | Derivados de pirimidona |
WO2001070728A1 (en) * | 2000-03-23 | 2001-09-27 | Sanofi-Synthelabo | 2-[nitrogen-heterocyclic]pyrimidone derivatives |
EP1136482A1 (en) | 2000-03-23 | 2001-09-26 | Sanofi-Synthelabo | 2-Amino-3-(alkyl)-pyrimidone derivatives as GSK3beta inhibitors |
EP1136493A1 (en) * | 2000-03-23 | 2001-09-26 | Sanofi-Synthelabo | 2-(Thienopyridinyl)pyrimidone, 2-(furopyridinyl)pyrimidone 2-(isoquinolinyl)pyrimidone, 2-(pyridoindolyl)pyrimidone and 2-(benzofuropyridinyl)pyrimidone derivatives |
JP4368682B2 (ja) * | 2001-09-21 | 2009-11-18 | 田辺三菱製薬株式会社 | 3−置換−4−ピリミドン誘導体 |
WO2003037888A1 (en) * | 2001-09-21 | 2003-05-08 | Mitsubishi Pharma Corporation | 3-substituted-4-pyrimidone derivatives |
ZA200505258B (en) * | 2002-12-16 | 2006-09-27 | Mitsubishi Pharma Corp | 3-Substituted-4-pyrimidone derivatives |
EP1454910A1 (en) * | 2003-03-07 | 2004-09-08 | Sanofi-Synthelabo | Substituted pyrimidinyl-2-(diaza-bicyclo-alkyl)-pyrimidone derivatives |
BRPI0408186A (pt) | 2003-03-07 | 2006-04-04 | Sanofi Aventis | derivados de 2-(diaza-biciclo-alquil)-pirimidona substituìdos |
TWI357408B (en) * | 2003-03-26 | 2012-02-01 | Mitsubishi Tanabe Pharma Corp | 3-substituted-4-pyrimidone derivatives |
US7582631B2 (en) | 2004-01-14 | 2009-09-01 | Amgen Inc. | Substituted heterocyclic compounds and methods of use |
AR050865A1 (es) * | 2004-09-09 | 2006-11-29 | Sanofi Aventis | Derivados de 2- morfolino-4-pirimidona |
ZA200703383B (en) * | 2004-09-29 | 2009-05-27 | Mitsubishi Pharma Corp | 6-(pyridinyl)-4-pyrimidone derivates as tau protein kinase 1 inhibitors |
TW200740779A (en) * | 2005-07-22 | 2007-11-01 | Mitsubishi Pharma Corp | Intermediate compound for synthesizing pharmaceutical agent and production method thereof |
TW200813015A (en) * | 2006-03-15 | 2008-03-16 | Mitsubishi Pharma Corp | 2-(cyclic amino)-pyrimidone derivatives |
AR064660A1 (es) * | 2006-12-26 | 2009-04-15 | Mitsubishi Tanabe Pharma Corp | Derivados de pirimidinona 6-heterociclica 2-sustituida, medicamentos que los contienen y usos para prevenir y/o tratar enfermedades neurodegenerativas entre otras |
CA2698818A1 (en) * | 2007-09-14 | 2009-03-19 | Sanofi-Aventis | 3-methyl-2- ( (2s) -2- (4- (3-methyl-1, 2, 4-oxadiazol-5-yl) phenyl) morpholino) -6- (pyrimidin-4-yl) pyrimidin-4 (3h) -one as tau protein kinase inhibitor |
AU2008297817A1 (en) * | 2007-09-14 | 2009-03-19 | Mitsubishi Tanabe Pharma Corporation | 6-pyrimidinyl-pyrimid-4-one derivative |
EP2078717A1 (en) | 2008-01-11 | 2009-07-15 | sanofi-aventis | 6-Pyrimidinyl-pyrimid-2-one derivative |
TW201043618A (en) * | 2009-03-10 | 2010-12-16 | Sanofi Aventis | Intermediate compound for synthesizing pharmaceutical agent and production method thereof |
US8940738B2 (en) * | 2009-08-13 | 2015-01-27 | Mitsubishi Tanabe Pharma Corporation | Pyrimidone compounds |
-
2007
- 2007-03-13 TW TW096108629A patent/TW200813015A/zh unknown
- 2007-03-14 BR BRPI0708914-7A patent/BRPI0708914A2/pt not_active IP Right Cessation
- 2007-03-14 EP EP07739230A patent/EP2001863A1/en not_active Withdrawn
- 2007-03-14 CN CNA2007800089225A patent/CN101400668A/zh active Pending
- 2007-03-14 ZA ZA200808364A patent/ZA200808364B/xx unknown
- 2007-03-14 MX MX2008011780A patent/MX2008011780A/es not_active Application Discontinuation
- 2007-03-14 NZ NZ571709A patent/NZ571709A/en not_active IP Right Cessation
- 2007-03-14 JP JP2008543334A patent/JP2009530229A/ja active Pending
- 2007-03-14 WO PCT/JP2007/055787 patent/WO2007119463A1/en active Application Filing
- 2007-03-14 KR KR1020087024983A patent/KR20080102430A/ko not_active Application Discontinuation
- 2007-03-14 AU AU2007239962A patent/AU2007239962A1/en not_active Abandoned
- 2007-03-14 CA CA002644979A patent/CA2644979A1/en not_active Abandoned
- 2007-03-14 US US12/282,396 patent/US8569294B2/en not_active Expired - Fee Related
- 2007-03-14 AR ARP070101040A patent/AR059899A1/es not_active Application Discontinuation
- 2007-03-14 EA EA200870358A patent/EA200870358A1/ru unknown
- 2007-03-14 EP EP11189865A patent/EP2423207A3/en not_active Withdrawn
-
2008
- 2008-10-14 NO NO20084302A patent/NO20084302L/no not_active Application Discontinuation
-
2014
- 2014-12-05 JP JP2014246688A patent/JP2015078216A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
NZ571709A (en) | 2011-11-25 |
BRPI0708914A2 (pt) | 2011-07-12 |
AR059899A1 (es) | 2008-05-07 |
US20090233918A1 (en) | 2009-09-17 |
EP2001863A1 (en) | 2008-12-17 |
EP2423207A2 (en) | 2012-02-29 |
TW200813015A (en) | 2008-03-16 |
EP2423207A3 (en) | 2012-06-13 |
CN101400668A (zh) | 2009-04-01 |
JP2009530229A (ja) | 2009-08-27 |
JP2015078216A (ja) | 2015-04-23 |
AU2007239962A1 (en) | 2007-10-25 |
WO2007119463A1 (en) | 2007-10-25 |
CA2644979A1 (en) | 2007-10-25 |
EA200870358A1 (ru) | 2009-02-27 |
MX2008011780A (es) | 2008-12-03 |
ZA200808364B (en) | 2010-02-24 |
US8569294B2 (en) | 2013-10-29 |
KR20080102430A (ko) | 2008-11-25 |
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