NO20004151L - Jerndekstranforbindelse for bruk som en komponent i en terapeutisk blanding for profylaske eller behandling av jernmangel, en fremgangsmÕte for fremstilling av jerndekstranforbindelsen og anvendelse av forbindelsen for fremstilling av en parenta - Google Patents
Jerndekstranforbindelse for bruk som en komponent i en terapeutisk blanding for profylaske eller behandling av jernmangel, en fremgangsmÕte for fremstilling av jerndekstranforbindelsen og anvendelse av forbindelsen for fremstilling av en parentaInfo
- Publication number
- NO20004151L NO20004151L NO20004151A NO20004151A NO20004151L NO 20004151 L NO20004151 L NO 20004151L NO 20004151 A NO20004151 A NO 20004151A NO 20004151 A NO20004151 A NO 20004151A NO 20004151 L NO20004151 L NO 20004151L
- Authority
- NO
- Norway
- Prior art keywords
- compound
- dextran
- daltons
- iron
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- -1 Iron dextran compound Chemical class 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 206010022971 Iron Deficiencies Diseases 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 229920002307 Dextran Polymers 0.000 abstract 4
- 239000012528 membrane Substances 0.000 abstract 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 2
- 238000000746 purification Methods 0.000 abstract 2
- 208000015710 Iron-Deficiency Anemia Diseases 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 229960004887 ferric hydroxide Drugs 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 229910052742 iron Inorganic materials 0.000 abstract 1
- IEECXTSVVFWGSE-UHFFFAOYSA-M iron(3+);oxygen(2-);hydroxide Chemical compound [OH-].[O-2].[Fe+3] IEECXTSVVFWGSE-UHFFFAOYSA-M 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Det er beskrevet en jerndekstranforbindelse for parental behandling av jemmangel-anemi innbefattende hydrogenert dekstran med en vektmidlere molekylmasse (Mw) mellom 700 og 1,400 Dalton, fortrinnsvis tilnærmet 1,000 Daltom, en antallsmidlere molekylmasse (Mn) på 400 til 1,400 Dalton og hvor 90 masse-% av dekstranet har en molekylmasse mindre enn 2,700 Dalton og Mw til den 10 masse-% fraksjonen av dekstranet med de høyeste molekylmassene er under 3,200 Dalton, hvilket hydrogenerte dekstran har blitt utsatt for rensing ved membranprosesser med en avskjæringsverdi mellom 340 og 800 Dalton, i stabil assosiasjon med jem(IH)oksyhydroksyd. Forbindelsen er fremstilt ved bruk av membranprosesser for å fjerne dekstraner med høyere molekylmasser enn tilnærmet 2,700 Dalton og membranprosesser for å fjerne sakkarider med molekylmasser under tilnærmet 340 Dalton fra det hydrogenerte dekstranet før utfelling av jern(III)hydroksyd i nærvær av dekstranet etterfulgt av varmebehandling og rensing.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK199800420A DK172860B1 (da) | 1998-03-25 | 1998-03-25 | Jerndextranforbindelse til anvendelse som komponent i et terapeutisk middel til forebyggelse af eller behandling af jernman |
| PCT/DK1999/000160 WO1999048533A1 (en) | 1998-03-25 | 1999-03-24 | An iron-dextran compound for use as a component in a therapeutical composition for prophylaxis or treatment of iron-deficiency, a process for producing said iron-dextran compound and use of said compound for the preparation of a parenterally administrable therapeutical composition |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20004151D0 NO20004151D0 (no) | 2000-08-18 |
| NO20004151L true NO20004151L (no) | 2000-08-18 |
| NO329591B1 NO329591B1 (no) | 2010-11-15 |
Family
ID=8093321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20004151A NO329591B1 (no) | 1998-03-25 | 2000-08-18 | Jerndekstranforbindelse for bruk som en komponent i en terapeutisk blanding for profylaske eller behandling av jernmangel, en fremgangsmate for fremstilling av jerndekstranforbindelsen og anvendelse av forbindelsen for fremstilling av en parental administrerbar terapeutisk blanding. |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6291440B1 (no) |
| EP (1) | EP1066056B2 (no) |
| JP (1) | JP4558198B2 (no) |
| KR (1) | KR100612071B1 (no) |
| CN (1) | CN1147322C (no) |
| AR (1) | AR015738A1 (no) |
| AT (1) | ATE220560T1 (no) |
| AU (1) | AU740432B2 (no) |
| BR (1) | BRPI9908914B8 (no) |
| CA (1) | CA2322633C (no) |
| CZ (1) | CZ300823B6 (no) |
| DE (1) | DE69902154T3 (no) |
| DK (2) | DK172860B1 (no) |
| EA (1) | EA003427B1 (no) |
| ES (1) | ES2180279T5 (no) |
| HU (1) | HU228483B1 (no) |
| ID (1) | ID26778A (no) |
| NO (1) | NO329591B1 (no) |
| NZ (1) | NZ505983A (no) |
| PL (1) | PL195582B1 (no) |
| PT (1) | PT1066056E (no) |
| SI (1) | SI1066056T2 (no) |
| SK (1) | SK284499B6 (no) |
| TR (1) | TR200002733T2 (no) |
| UA (1) | UA70939C2 (no) |
| WO (1) | WO1999048533A1 (no) |
| ZA (1) | ZA200004016B (no) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK173138B1 (da) | 1998-11-20 | 2000-02-07 | Pharmacosmos Holding As | Fremgangsmåde til fremstilling af en jerndextranforbindelse, jerndextranforbindelse fremstillet efter fremgangsmåden, farma |
| US7871597B2 (en) | 1999-04-09 | 2011-01-18 | Amag Pharmaceuticals, Inc. | Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents |
| PT1169062E (pt) * | 1999-04-09 | 2009-12-17 | Amag Pharmaceuticals Inc | Óxidos de ferro coloidais termoestáveis revestidos |
| KR20020003344A (ko) * | 2001-12-17 | 2002-01-12 | 유형선 | 철분 보급제 경구 투여 제제 조성물 |
| WO2003087164A1 (en) * | 2002-04-09 | 2003-10-23 | Pharmacosmos Holding A/S | Iron dextrin compounds for the treatment of iron deficiency anaemia |
| DE10249552A1 (de) | 2002-10-23 | 2004-05-13 | Vifor (International) Ag | Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel |
| US20060116349A1 (en) * | 2003-03-14 | 2006-06-01 | Luitpold Pharmaceuticals, Inc. | Methods and compositions for administration of iron for the treatment of restless leg syndrome |
| DE102004031181A1 (de) * | 2004-06-28 | 2006-01-19 | Vifor (International) Ag | Phosphatadsorbens |
| ITMO20050056A1 (it) * | 2005-03-15 | 2006-09-16 | Biofer Spa | Processo per la preparazione di complessi del ferro trivalente con zuccheri mono-, di- e polisaccaridi. |
| EP1757299A1 (de) | 2005-08-25 | 2007-02-28 | Vifor (International) Ag | Eisen(III)-Komplexverbindungen zur Behandlung von Eisenmangel-Zuständen bei Patienten mit chronisch-entzündlicher Darmerkrankung |
| PT1973549T (pt) | 2006-01-06 | 2016-10-25 | Luitpold Pharm Inc | Métodos e composições para administração de ferro |
| EP1947120A1 (de) * | 2007-01-19 | 2008-07-23 | Vifor (International) Ag | Eisen-Kohlenhydrat-Komplex-Verbindungen |
| EP1997833A1 (de) * | 2007-05-29 | 2008-12-03 | Vifor (International) Ag | Wasserlösliche Eisen-Kohlenhydratderivat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel |
| CN101585887B (zh) * | 2008-05-22 | 2011-12-14 | 中国科学院过程工程研究所 | 应用纳滤技术对右旋糖酐铁络合物水溶液进行脱盐和浓缩的方法 |
| CN109700828A (zh) | 2009-03-25 | 2019-05-03 | 法码科思莫斯控股有限公司 | 稳定的铁寡糖复合物 |
| CN101967205B (zh) * | 2010-10-12 | 2013-04-17 | 滨州学院 | 一种β-葡聚糖铁复合物及其制备方法 |
| EP2537866A1 (en) * | 2011-06-21 | 2012-12-26 | Serumwerk Bernburg AG | Hydroxyethyl starch derivatives, method for manufacturing the same and therapeutical uses thereof |
| PL398814A1 (pl) | 2012-04-16 | 2013-10-28 | Uniwersytet Jagiellonski | Zastosowanie pochodnych dekstranu do przeciwdzialania lub leczenia niedokrwistosci |
| EP3157516A4 (en) | 2014-06-22 | 2017-12-13 | Dexcel Pharma Technologies Ltd. | Pharmaceutical compositions comprising ferric citrate and methods for the production thereof |
| WO2016066172A1 (en) | 2014-10-27 | 2016-05-06 | Pharmacosmos Holding A/S | Treatment or prevention of anaemia in pregnant non-human mammals |
| ES3009466T3 (en) | 2017-09-11 | 2025-03-27 | Pharmacosmos Holding As | Iron complex compounds for therapeutic use |
| CN112203639A (zh) * | 2018-05-16 | 2021-01-08 | 法国诗华大药厂 | 兽医学组合物和其用于控制非人类哺乳动物的铁缺乏的用途 |
| CN109646454A (zh) * | 2018-12-29 | 2019-04-19 | 博瑞生物医药（苏州）股份有限公司 | 异麦芽糖酐铁1000的制备方法 |
| CN110183548B (zh) * | 2019-06-28 | 2021-05-18 | 瑞普（天津）生物药业有限公司 | 一种低分子葡聚糖铁的制备方法及其应用 |
| CA3226771A1 (en) | 2021-08-03 | 2023-02-09 | Pharmacosmos Holding A/S | Iron complex compounds for subcutaneous use in therapy of iron deficiency in companion animals |
| WO2026017901A1 (en) | 2024-07-18 | 2026-01-22 | Malian Biologicals Gmbh | Iron supplementation in neurodevelopmental or psychiatric disorder |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE24642E (en) | 1959-04-28 | Therapeutic preparations of iron | ||
| DK117730A (no) | ||||
| US2885393A (en) | 1956-02-24 | 1959-05-05 | R K Laros Company | Dextran-iron complex and process for making same |
| US3093545A (en) | 1960-08-29 | 1963-06-11 | Armour Pharma | Therapeutic iron-dextran preparations |
| US3234209A (en) * | 1963-09-13 | 1966-02-08 | Chemicals Inc | Process for making iron hydrogenated dextran |
| DE1293144B (de) * | 1964-11-04 | 1969-04-24 | Hausmann Ag Labor | Verfahren zur Herstellung von Komplexverbindungen des Eisens mit Sorbit, Gluconsaeure und einem Oligosaccharid |
| GB1183940A (en) | 1966-10-22 | 1970-03-11 | Fisons Pharmaceuticals Ltd | Ferric Hydroxide Complexes |
| GB1200902A (en) | 1967-05-13 | 1970-08-05 | Fisons Pharmaceuticals Ltd | Iron-dextran complexes |
| CH507993A (de) | 1967-07-13 | 1971-05-31 | Kutnowskie Zakl Farma | Verfahren zur Herstellung von Eisen(III)-komplexverbindungen mit hydriertem Dextran |
| DK129353B (da) | 1968-04-29 | 1974-09-30 | Fisons Pharmaceuticals Ltd | Analogifremgangsmåde til fremstilling af et ferrihydroxid-dextranderivatkompleks eller en opløsning deraf. |
| US3697502A (en) | 1969-11-03 | 1972-10-10 | Christensen Henry M | Method of making iron dextran-preparations |
| GB1562913A (en) * | 1976-06-16 | 1980-03-19 | Fisons Ltd | Fractionating fluid mixtures of dextrans |
| DE3422249A1 (de) * | 1984-06-15 | 1985-12-19 | Pfeifer & Langen, 5000 Köln | Wasserloesliches eisendextran und verfahren zu seiner herstellung |
| US4827945A (en) | 1986-07-03 | 1989-05-09 | Advanced Magnetics, Incorporated | Biologically degradable superparamagnetic materials for use in clinical applications |
| US5102652A (en) | 1986-07-03 | 1992-04-07 | Advanced Magnetics Inc. | Low molecular weight carbohydrates as additives to stabilize metal oxide compositions |
| IT1263831B (it) * | 1993-01-29 | 1996-09-04 | Paolo Chiesi | Complessi di inclusione multicomponente ad elevata solubilita' costituiti da un farmaco di tipo basico, un acido ed una ciclodestrina |
| RU2093577C1 (ru) * | 1993-11-04 | 1997-10-20 | Государственный институт кровезаменителей и медицинских препаратов | Способ получения декстрана |
| GB9402029D0 (en) * | 1994-02-03 | 1994-03-30 | Smithkline Beecham Plc | Novel formulation |
| US5624668A (en) * | 1995-09-29 | 1997-04-29 | Luitpold Pharmaceuticals, Inc. | Iron dextran formulations |
-
1998
- 1998-03-25 DK DK199800420A patent/DK172860B1/da not_active IP Right Cessation
-
1999
- 1999-03-24 PL PL99343164A patent/PL195582B1/pl unknown
- 1999-03-24 WO PCT/DK1999/000160 patent/WO1999048533A1/en not_active Ceased
- 1999-03-24 BR BRPI9908914 patent/BRPI9908914B8/pt not_active IP Right Cessation
- 1999-03-24 DK DK99908785T patent/DK1066056T4/da active
- 1999-03-24 ID IDW20001881A patent/ID26778A/id unknown
- 1999-03-24 HU HU0101189A patent/HU228483B1/hu unknown
- 1999-03-24 KR KR1020007010563A patent/KR100612071B1/ko not_active Expired - Lifetime
- 1999-03-24 AU AU28273/99A patent/AU740432B2/en not_active Ceased
- 1999-03-24 NZ NZ505983A patent/NZ505983A/xx not_active IP Right Cessation
- 1999-03-24 ES ES99908785T patent/ES2180279T5/es not_active Expired - Lifetime
- 1999-03-24 CA CA002322633A patent/CA2322633C/en not_active Expired - Fee Related
- 1999-03-24 CN CNB998042498A patent/CN1147322C/zh not_active Expired - Lifetime
- 1999-03-24 US US09/509,454 patent/US6291440B1/en not_active Expired - Lifetime
- 1999-03-24 SI SI9930103T patent/SI1066056T2/sl unknown
- 1999-03-24 PT PT99908785T patent/PT1066056E/pt unknown
- 1999-03-24 UA UA2000095459A patent/UA70939C2/uk unknown
- 1999-03-24 EP EP99908785A patent/EP1066056B2/en not_active Expired - Lifetime
- 1999-03-24 SK SK1409-2000A patent/SK284499B6/sk not_active IP Right Cessation
- 1999-03-24 CZ CZ20003535A patent/CZ300823B6/cs not_active IP Right Cessation
- 1999-03-24 TR TR2000/02733T patent/TR200002733T2/xx unknown
- 1999-03-24 JP JP2000537579A patent/JP4558198B2/ja not_active Expired - Lifetime
- 1999-03-24 AT AT99908785T patent/ATE220560T1/de active
- 1999-03-24 DE DE69902154T patent/DE69902154T3/de not_active Expired - Lifetime
- 1999-03-24 EA EA200000981A patent/EA003427B1/ru not_active IP Right Cessation
- 1999-03-24 AR ARP990101309A patent/AR015738A1/es active IP Right Grant
-
2000
- 2000-08-07 ZA ZA200004016A patent/ZA200004016B/xx unknown
- 2000-08-18 NO NO20004151A patent/NO329591B1/no not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |