AR015738A1 - "un compuesto de hierro-dextrano, una composicion, un proceso para producir dicho compuesto de hierro-dextrano, uso de dicho compuesto para la preparacion de una composicion terapeutica administrable parenteralmente para utilizar como un componente en una composicion terapeutica para la profilaxis o - Google Patents
"un compuesto de hierro-dextrano, una composicion, un proceso para producir dicho compuesto de hierro-dextrano, uso de dicho compuesto para la preparacion de una composicion terapeutica administrable parenteralmente para utilizar como un componente en una composicion terapeutica para la profilaxis oInfo
- Publication number
- AR015738A1 AR015738A1 ARP990101309A ARP990101309A AR015738A1 AR 015738 A1 AR015738 A1 AR 015738A1 AR P990101309 A ARP990101309 A AR P990101309A AR P990101309 A ARP990101309 A AR P990101309A AR 015738 A1 AR015738 A1 AR 015738A1
- Authority
- AR
- Argentina
- Prior art keywords
- daltons
- dextran
- compound
- weight
- molecular weights
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Un compuesto de hierro-dextrano para el tratamiento parenteral de la anemia por deficiencia de hierro que comprende un dextrano hidrogenado que tiene unpeso molecular promedio ponderal (Mw) entre 700 y 1400 Daltons, preferentemente aproximadamente 1.000 Dalton, un peso molecular promedio numérico (Mn) de 400 a1400 Daltons y en donde 90% en peso del dextrano tiene pesos moleculares de menos de 2700 Daltons y el Mw de la fraccion de 10% en peso del dextrano que tienelos pesos moleculares más elevados está por debajo de 3.200 Daltons, en asociacion estalbe con oxihidroxido férrico. El compuesto es producido utilizandoprocesos de membrana para eliminar los dextranos de pesos moleculares superiores a aproximadamente 2700 Daltons y procesos de membrana para remover lossacáridos de pesos moleculares inferiores a aproximadamente 340 Daltons de dextrano hidrogenado antes de precipitar hidroxido férrico en presencia de dichodextrano seguido por tratamiento térmico y purificacion. Además se describe el uso de un compuesto para la preparacion de una composicion terapéuticaparenteralmente administrable para la profilaxis o el tratamiento de la anemia por deficiencia de hierros en sujetos animales o humanos, que comprende undextrano hidrogenadoque tiene un peso molecular promedio ponderal (Mw) entre 700 y 1400 Daltons, preferentemente aproximadamente 1.000 Daltons, un pesomolecular promedio numérico (Mn) de 400 a 1.400 Daltons y en donde 90% en peso del dextrano tiene pesos moleculares demenos de 2.700 Daltons y el Mw de lafraccion de 10% en peso del dextrano que tiene los pesos moleculares más elevados está por debajo de 3.200 Daltons, habiendo sido sometido dicho dextranohidrogenado a purificacion mediante procesos de membrana quetienen un valor de corte entre 340 y 800 Daltons, en asociacion estable con oxihidroxido férrico.También comprende un proceso para producir un líquido para inyeccion que contiene un compuesto que se disuelve el compuesto como un polvo seco en medioacuoso,ajustando el pH, en caso de ser necesario, optativamente agregado estabilizador, y esteriliazando el líquido mediante filtracion antes de cargar en ampollas o
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK199800420A DK172860B1 (da) | 1998-03-25 | 1998-03-25 | Jerndextranforbindelse til anvendelse som komponent i et terapeutisk middel til forebyggelse af eller behandling af jernman |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR015738A1 true AR015738A1 (es) | 2001-05-16 |
Family
ID=8093321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990101309A AR015738A1 (es) | 1998-03-25 | 1999-03-24 | "un compuesto de hierro-dextrano, una composicion, un proceso para producir dicho compuesto de hierro-dextrano, uso de dicho compuesto para la preparacion de una composicion terapeutica administrable parenteralmente para utilizar como un componente en una composicion terapeutica para la profilaxis o |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6291440B1 (es) |
| EP (1) | EP1066056B2 (es) |
| JP (1) | JP4558198B2 (es) |
| KR (1) | KR100612071B1 (es) |
| CN (1) | CN1147322C (es) |
| AR (1) | AR015738A1 (es) |
| AT (1) | ATE220560T1 (es) |
| AU (1) | AU740432B2 (es) |
| BR (1) | BRPI9908914B8 (es) |
| CA (1) | CA2322633C (es) |
| CZ (1) | CZ300823B6 (es) |
| DE (1) | DE69902154T3 (es) |
| DK (2) | DK172860B1 (es) |
| EA (1) | EA003427B1 (es) |
| ES (1) | ES2180279T5 (es) |
| HK (1) | HK1033426A1 (es) |
| HU (1) | HU228483B1 (es) |
| ID (1) | ID26778A (es) |
| NO (1) | NO329591B1 (es) |
| NZ (1) | NZ505983A (es) |
| PL (1) | PL195582B1 (es) |
| PT (1) | PT1066056E (es) |
| SI (1) | SI1066056T2 (es) |
| SK (1) | SK284499B6 (es) |
| TR (1) | TR200002733T2 (es) |
| UA (1) | UA70939C2 (es) |
| WO (1) | WO1999048533A1 (es) |
| ZA (1) | ZA200004016B (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK173138B1 (da) * | 1998-11-20 | 2000-02-07 | Pharmacosmos Holding As | Fremgangsmåde til fremstilling af en jerndextranforbindelse, jerndextranforbindelse fremstillet efter fremgangsmåden, farma |
| DK1169062T3 (da) * | 1999-04-09 | 2010-01-25 | Amag Pharmaceuticals Inc | Varmestabile overtrukne kolloide jernoxider |
| US7871597B2 (en) | 1999-04-09 | 2011-01-18 | Amag Pharmaceuticals, Inc. | Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents |
| KR20020003344A (ko) * | 2001-12-17 | 2002-01-12 | 유형선 | 철분 보급제 경구 투여 제제 조성물 |
| CN1309741C (zh) * | 2002-04-09 | 2007-04-11 | 法玛科思莫斯控股有限公司 | 用于治疗缺铁性贫血的铁糊精化合物 |
| DE10249552A1 (de) | 2002-10-23 | 2004-05-13 | Vifor (International) Ag | Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel |
| US20060116349A1 (en) * | 2003-03-14 | 2006-06-01 | Luitpold Pharmaceuticals, Inc. | Methods and compositions for administration of iron for the treatment of restless leg syndrome |
| DE102004031181A1 (de) * | 2004-06-28 | 2006-01-19 | Vifor (International) Ag | Phosphatadsorbens |
| ITMO20050056A1 (it) * | 2005-03-15 | 2006-09-16 | Biofer Spa | Processo per la preparazione di complessi del ferro trivalente con zuccheri mono-, di- e polisaccaridi. |
| EP1757299A1 (de) | 2005-08-25 | 2007-02-28 | Vifor (International) Ag | Eisen(III)-Komplexverbindungen zur Behandlung von Eisenmangel-Zuständen bei Patienten mit chronisch-entzündlicher Darmerkrankung |
| CN101365458B (zh) | 2006-01-06 | 2012-09-05 | 卢特波尔德药品公司 | 用于铁给药的方法和组合物 |
| EP1947120A1 (de) * | 2007-01-19 | 2008-07-23 | Vifor (International) Ag | Eisen-Kohlenhydrat-Komplex-Verbindungen |
| EP1997833A1 (de) * | 2007-05-29 | 2008-12-03 | Vifor (International) Ag | Wasserlösliche Eisen-Kohlenhydratderivat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel |
| CN101585887B (zh) * | 2008-05-22 | 2011-12-14 | 中国科学院过程工程研究所 | 应用纳滤技术对右旋糖酐铁络合物水溶液进行脱盐和浓缩的方法 |
| NZ595597A (en) * | 2009-03-25 | 2013-05-31 | Pharmacosmos Holding As | A stable iron oligosaccharide compound |
| CN101967205B (zh) * | 2010-10-12 | 2013-04-17 | 滨州学院 | 一种β-葡聚糖铁复合物及其制备方法 |
| EP2537866A1 (en) * | 2011-06-21 | 2012-12-26 | Serumwerk Bernburg AG | Hydroxyethyl starch derivatives, method for manufacturing the same and therapeutical uses thereof |
| PL398814A1 (pl) | 2012-04-16 | 2013-10-28 | Uniwersytet Jagiellonski | Zastosowanie pochodnych dekstranu do przeciwdzialania lub leczenia niedokrwistosci |
| EP3157516A4 (en) | 2014-06-22 | 2017-12-13 | Dexcel Pharma Technologies Ltd. | Pharmaceutical compositions comprising ferric citrate and methods for the production thereof |
| ES2743223T3 (es) * | 2014-10-27 | 2020-02-18 | Pharmacosmos Holding As | Tratamiento o prevención de la anemia en mamíferos no humanos gestantes y crías |
| BR112020004357A2 (pt) * | 2017-09-11 | 2020-09-08 | Pharmacosmos Holding A/S | compostos de complexo de ferro para uso terapêutico |
| CN109646454A (zh) * | 2018-12-29 | 2019-04-19 | 博瑞生物医药（苏州）股份有限公司 | 异麦芽糖酐铁1000的制备方法 |
| CN110183548B (zh) * | 2019-06-28 | 2021-05-18 | 瑞普（天津）生物药业有限公司 | 一种低分子葡聚糖铁的制备方法及其应用 |
| JP2024529536A (ja) | 2021-08-03 | 2024-08-06 | ファーマコスモス ホールディング エー／エス | コンパニオンアニマルの鉄欠乏症の治療における皮下使用のための鉄錯体化合物 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK117730A (es) | ||||
| USRE24642E (en) | 1959-04-28 | Therapeutic preparations of iron | ||
| US2885393A (en) | 1956-02-24 | 1959-05-05 | R K Laros Company | Dextran-iron complex and process for making same |
| US3093545A (en) | 1960-08-29 | 1963-06-11 | Armour Pharma | Therapeutic iron-dextran preparations |
| US3234209A (en) * | 1963-09-13 | 1966-02-08 | Chemicals Inc | Process for making iron hydrogenated dextran |
| DE1293144B (de) * | 1964-11-04 | 1969-04-24 | Hausmann Ag Labor | Verfahren zur Herstellung von Komplexverbindungen des Eisens mit Sorbit, Gluconsaeure und einem Oligosaccharid |
| GB1183940A (en) | 1966-10-22 | 1970-03-11 | Fisons Pharmaceuticals Ltd | Ferric Hydroxide Complexes |
| GB1200902A (en) | 1967-05-13 | 1970-08-05 | Fisons Pharmaceuticals Ltd | Iron-dextran complexes |
| CH507993A (de) | 1967-07-13 | 1971-05-31 | Kutnowskie Zakl Farma | Verfahren zur Herstellung von Eisen(III)-komplexverbindungen mit hydriertem Dextran |
| DK129353B (da) | 1968-04-29 | 1974-09-30 | Fisons Pharmaceuticals Ltd | Analogifremgangsmåde til fremstilling af et ferrihydroxid-dextranderivatkompleks eller en opløsning deraf. |
| US3697502A (en) | 1969-11-03 | 1972-10-10 | Christensen Henry M | Method of making iron dextran-preparations |
| GB1562913A (en) * | 1976-06-16 | 1980-03-19 | Fisons Ltd | Fractionating fluid mixtures of dextrans |
| DE3422249A1 (de) * | 1984-06-15 | 1985-12-19 | Pfeifer & Langen, 5000 Köln | Wasserloesliches eisendextran und verfahren zu seiner herstellung |
| US5102652A (en) | 1986-07-03 | 1992-04-07 | Advanced Magnetics Inc. | Low molecular weight carbohydrates as additives to stabilize metal oxide compositions |
| US4827945A (en) | 1986-07-03 | 1989-05-09 | Advanced Magnetics, Incorporated | Biologically degradable superparamagnetic materials for use in clinical applications |
| IT1263831B (it) * | 1993-01-29 | 1996-09-04 | Paolo Chiesi | Complessi di inclusione multicomponente ad elevata solubilita' costituiti da un farmaco di tipo basico, un acido ed una ciclodestrina |
| RU2093577C1 (ru) * | 1993-11-04 | 1997-10-20 | Государственный институт кровезаменителей и медицинских препаратов | Способ получения декстрана |
| GB9402029D0 (en) * | 1994-02-03 | 1994-03-30 | Smithkline Beecham Plc | Novel formulation |
| US5624668A (en) * | 1995-09-29 | 1997-04-29 | Luitpold Pharmaceuticals, Inc. | Iron dextran formulations |
-
1998
- 1998-03-25 DK DK199800420A patent/DK172860B1/da not_active IP Right Cessation
-
1999
- 1999-03-24 KR KR1020007010563A patent/KR100612071B1/ko not_active IP Right Cessation
- 1999-03-24 AT AT99908785T patent/ATE220560T1/de active
- 1999-03-24 AR ARP990101309A patent/AR015738A1/es active IP Right Grant
- 1999-03-24 ES ES99908785T patent/ES2180279T5/es not_active Expired - Lifetime
- 1999-03-24 JP JP2000537579A patent/JP4558198B2/ja not_active Expired - Lifetime
- 1999-03-24 US US09/509,454 patent/US6291440B1/en not_active Expired - Lifetime
- 1999-03-24 CN CNB998042498A patent/CN1147322C/zh not_active Expired - Lifetime
- 1999-03-24 EA EA200000981A patent/EA003427B1/ru not_active IP Right Cessation
- 1999-03-24 DE DE69902154T patent/DE69902154T3/de not_active Expired - Lifetime
- 1999-03-24 TR TR2000/02733T patent/TR200002733T2/xx unknown
- 1999-03-24 PT PT99908785T patent/PT1066056E/pt unknown
- 1999-03-24 ID IDW20001881A patent/ID26778A/id unknown
- 1999-03-24 AU AU28273/99A patent/AU740432B2/en not_active Ceased
- 1999-03-24 CZ CZ20003535A patent/CZ300823B6/cs not_active IP Right Cessation
- 1999-03-24 BR BRPI9908914-9 patent/BRPI9908914B8/pt not_active IP Right Cessation
- 1999-03-24 CA CA002322633A patent/CA2322633C/en not_active Expired - Fee Related
- 1999-03-24 HU HU0101189A patent/HU228483B1/hu unknown
- 1999-03-24 UA UA2000095459A patent/UA70939C2/uk unknown
- 1999-03-24 PL PL99343164A patent/PL195582B1/pl unknown
- 1999-03-24 NZ NZ505983A patent/NZ505983A/xx not_active IP Right Cessation
- 1999-03-24 EP EP99908785A patent/EP1066056B2/en not_active Expired - Lifetime
- 1999-03-24 SK SK1409-2000A patent/SK284499B6/sk not_active IP Right Cessation
- 1999-03-24 SI SI9930103T patent/SI1066056T2/sl unknown
- 1999-03-24 WO PCT/DK1999/000160 patent/WO1999048533A1/en active IP Right Grant
- 1999-03-24 DK DK99908785T patent/DK1066056T4/da active
-
2000
- 2000-08-07 ZA ZA200004016A patent/ZA200004016B/xx unknown
- 2000-08-18 NO NO20004151A patent/NO329591B1/no not_active IP Right Cessation
-
2001
- 2001-06-13 HK HK01104034A patent/HK1033426A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR015738A1 (es) | "un compuesto de hierro-dextrano, una composicion, un proceso para producir dicho compuesto de hierro-dextrano, uso de dicho compuesto para la preparacion de una composicion terapeutica administrable parenteralmente para utilizar como un componente en una composicion terapeutica para la profilaxis o | |
| CY1123084T1 (el) | Θεραπεια των ασθενειων αποθηκευσης γλυκογονου τυπου ιι | |
| BR0108734A (pt) | Composições antimicrobiais ácidas para tratar alimento e superfìcies de contato do alimento e métodos para uso das mesmas | |
| SI2440239T1 (en) | Hemoglobin compositions | |
| IL153593A (en) | Pharmaceutical composition containing a soluble ctla4 mutant molecule | |
| EP1688425A3 (en) | Cyclic salen-metal compounds as scavengers for oxygen radicals and useful as antioxidants in the treatment and prevention of diseases | |
| TR200103476T2 (tr) | A-beta peptid bileşimleri ve bunları hazırlama yöntemleri | |
| RU2010117173A (ru) | Глазные композиции на основе полисахарида семян тамаринда и гиалуроновой кислоты | |
| BRPI0413967A (pt) | polìmero solúvel em água, processo para preparar um polìmero solúvel em água, composição e solução aquosa | |
| TR199901334A3 (tr) | Saç muamelesi için maddeler ve bu maddelerin bilesimleri. | |
| ATE487390T1 (de) | Proteinzusammensetzung zur behandlung eines physiologisch bedingten, klinisch unauffälligen proteinmehrbedarfs | |
| DE60039130D1 (de) | High Density Lipoprotein zur Bekämpfung von Organdysfunktion infolge eines hämorrhagischen Schocks | |
| GR1003490B (el) | Νεες φαρμακευτικες συνθεσεις που περιεχουν αλας παροξετινης | |
| DE60206245D1 (de) | Verwendung von r-ibuprofen methanesulfonamied und dessen salzen zur behandlung und verhinderung von abstossungreaktionen in transplartierten organen | |
| CA2526570A1 (en) | Aqueous solution of olanexidine, method of preparing the aqueous solution, and disinfectant | |
| GB9505082D0 (en) | Medicament | |
| BR0013645A (pt) | Medicamento contendo oligo ou/e polirribonucleotìdeos xenogênicos | |
| RU2000127989A (ru) | Препарат для санации животноводческих объектов - Мономал | |
| RU2003117876A (ru) | Фармацевтическая композиция для лечения воспалительных процессов в заднем отрезке глаза "делипос" | |
| BR0007491A (pt) | Uso de 3-isoxazolidinonas e ácidos hidroxilâmicospara o tratamento de infecções | |
| CHOI et al. | Effective Concentration of Mitomycin-C in Surgery for Primary Pterygium | |
| BG108775A (en) | REGENERATING COMPOSITION | |
| Mohy et al. | Clinical comparison between the coronally positioned flap augmented with connective tissue and cornally positioned flap in treatment of localized gingival recession | |
| Han et al. | Total Thyroidectomy in Graves' Disease | |
| RU99123233A (ru) | Способ лечения гнойных ран солевым раствором на основе высокомолекулярной фракции (вмф) отхода декстранового производства |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |