NO154521C - Analogifremgangsmaate for fremstilling av nye, terapeutisk aktive piperidinderivater. - Google Patents

Analogifremgangsmaate for fremstilling av nye, terapeutisk aktive piperidinderivater.

Info

Publication number
NO154521C
NO154521C NO801014A NO801014A NO154521C NO 154521 C NO154521 C NO 154521C NO 801014 A NO801014 A NO 801014A NO 801014 A NO801014 A NO 801014A NO 154521 C NO154521 C NO 154521C
Authority
NO
Norway
Prior art keywords
preparation
therapeutically active
new therapeutically
analogy procedure
piperide
Prior art date
Application number
NO801014A
Other languages
English (en)
Norwegian (no)
Other versions
NO154521B (no
NO801014L (no
Inventor
Albert A Carr
Joseph E Dolfini
George J Wright
Original Assignee
Richardson Merrell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21845568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO154521(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc
Publication of NO801014L publication Critical patent/NO801014L/no
Publication of NO154521B publication Critical patent/NO154521B/no
Publication of NO154521C publication Critical patent/NO154521C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO801014A 1979-04-10 1980-04-09 Analogifremgangsmaate for fremstilling av nye, terapeutisk aktive piperidinderivater. NO154521C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/028,813 US4254129A (en) 1979-04-10 1979-04-10 Piperidine derivatives

Publications (3)

Publication Number Publication Date
NO801014L NO801014L (no) 1980-10-13
NO154521B NO154521B (no) 1986-06-30
NO154521C true NO154521C (no) 1986-10-08

Family

ID=21845568

Family Applications (2)

Application Number Title Priority Date Filing Date
NO801014A NO154521C (no) 1979-04-10 1980-04-09 Analogifremgangsmaate for fremstilling av nye, terapeutisk aktive piperidinderivater.
NO1998017C NO1998017I1 (no) 1979-04-10 1998-05-29 Fexofenadine

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO1998017C NO1998017I1 (no) 1979-04-10 1998-05-29 Fexofenadine

Country Status (19)

Country Link
US (1) US4254129A (de)
JP (1) JPS55141469A (de)
AT (1) AT376208B (de)
AU (1) AU531146B2 (de)
BE (1) BE882703A (de)
CA (1) CA1123438A (de)
CH (1) CH643245A5 (de)
DE (1) DE3007498A1 (de)
DK (1) DK153709C (de)
ES (1) ES8103735A1 (de)
FR (1) FR2453854A1 (de)
IL (1) IL59158A (de)
IT (1) IT1143960B (de)
NL (2) NL190580C (de)
NO (2) NO154521C (de)
NZ (1) NZ192653A (de)
PH (1) PH17023A (de)
SE (1) SE448726B (de)
ZA (1) ZA80332B (de)

Families Citing this family (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR240018A1 (es) * 1987-10-07 1990-01-31 Merrell Pharma Inc Procedimiento para preparar una composicion que comprende derivados de piperidinoalcanol.
US4929605A (en) * 1987-10-07 1990-05-29 Merrell Dow Pharmaceuticals Inc. Pharmaceutical composition for piperidinoalkanol derivatives
CN1053570C (zh) 1987-10-07 2000-06-21 默尔多药物公司 哌啶子基链烷醇的药用组合物-减充血剂复方的制备方法
US4908372A (en) * 1988-10-13 1990-03-13 Merrell Dow Pharmaceuticals Inc. Antihistaminic piperidinyl benzimidazoles
AR245888A1 (es) * 1989-01-23 1994-03-30 Merrell Pharma Inc Procedimiento para la preparacion de una composicion farmaceutica liquida de derivados de piperidinoalcanol.
DE3917241A1 (de) * 1989-05-26 1990-11-29 Schaper & Bruemmer Gmbh 4-(hydroxydiphenylmethyl)-1-piperidyl-phenylalkan-derivate
US5182097A (en) * 1991-02-14 1993-01-26 Virginia Commonwealth University Formulations for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
US5190029A (en) * 1991-02-14 1993-03-02 Virginia Commonwealth University Formulation for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
TW198008B (de) * 1991-04-08 1993-01-11 Green Cross Corp
HU211019B (en) * 1991-12-02 1995-09-28 Richter Gedeon Vegyeszet Process for producing new 1,2,3,6-tetrahydropyridine and piperidine derivatives substituted with n-(hydroxylalkyl) group and compositions comprising such compounds
FI943727A0 (fi) * 1992-02-13 1994-08-12 Merrell Dow Pharma Piperidinyylitiasyklisiä johdannaisia
MX9302076A (es) * 1992-04-10 1994-03-31 Merrell Dow Pharma Proceso novedoso para preparar derivados de piperidina.
US5631375A (en) * 1992-04-10 1997-05-20 Merrell Pharmaceuticals, Inc. Process for piperidine derivatives
AU679910B2 (en) 1992-05-11 1997-07-17 Merrell Pharmaceuticals Inc. Use of terfenadine derivatives as antihistaminics in a hepatically impaired patient
PT1214937E (pt) * 1992-08-03 2007-07-25 Sepracor Inc Carboxilato de terfenadina e o tratamento de irritação dérmica.
US5654433A (en) * 1993-01-26 1997-08-05 Merrell Pharmaceuticals Inc. Process for piperidine derivatives
US20020007068A1 (en) 1999-07-16 2002-01-17 D'ambra Thomas E. Piperidine derivatives and process for their production
DK0703902T3 (da) * 1993-06-24 1999-08-23 Albany Molecular Res Inc Fremgangsmåde til fremstilling af piperidinderivater
US6147216A (en) * 1993-06-25 2000-11-14 Merrell Pharmaceuticals Inc. Intermediates useful for the preparation of antihistaminic piperidine derivatives
DE69431954T2 (de) 1993-06-25 2003-11-06 Merrell Pharmaceuticals Inc., Cincinnati Neue zwischenprodukte für die herstellung von antihistaminschen 4-diphenylmethyl/diphenylmethoxypiperidin-derivaten
WO1995010278A1 (en) * 1993-10-15 1995-04-20 Hoechst Marion Roussel, Inc. Treatment of allergic disorders with terfenadine carboxylate
CN1060040C (zh) * 1993-10-25 2001-01-03 默里尔药物公司 稳定的丁苯哌丁醇与布洛芬的药物组合物
ATE194328T1 (de) * 1994-05-16 2000-07-15 Merrell Pharma Inc Verfahren und diastereomere salze nützlich bei der racemattrennung von racemischer 4-(4-(4- (hydroxydiphenylmethyl)-1-piperidinyl)-1- hydroxybutyl)-alpha,alpha-dimethylphenyl essigsäure sowie entsprechende diastereomere salze
CN101497581B (zh) * 1994-05-18 2012-07-11 安万特萨博Ⅱ有限公司 抗组胺哌啶衍生物,其多晶形物和假同晶物的无水和水合物形式的制备方法
ATE220667T1 (de) * 1994-05-18 2002-08-15 Aventis Pharma Inc Verfahren zur herstellung von wasserfreien und hydrat-formen von antihistaminischen piperinderivaten, polymerphe und pseudomorphe davon
US20030045722A1 (en) * 1994-05-18 2003-03-06 Henton Daniel R. Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof
KR100362620B1 (ko) 1994-08-25 2003-02-14 메렐 파마슈티칼스 인크. 알레르기성질환치료에유용한치환된피페리딘,이를포함하는약제학적조성물및이의제조방법
NZ302926A (en) * 1995-02-28 1998-10-28 Hoechst Marion Roussel Inc Composition for use as antihistamines comprising piperidinoalkanol derivatives and inert ingredients
HUP9801254A3 (en) * 1995-05-08 1998-09-28 Aventis Pharmaceuticals Inc Br Alpha-(substituted alkylphenyl)-4-(hydroxydiphenylmethyl)-1-piperidine butanol derivatives, their preparation and their use as anti-histamines, anti-allergy agents and bronchodilators
US5574045A (en) * 1995-06-06 1996-11-12 Hoechst Marion Roussel, Inc. Oral pharmaceutical composition of piperidinoalkanol compounds in solution form
US5906747A (en) * 1995-11-13 1999-05-25 Biosepra Inc. Separation of molecules from dilute solutions using composite chromatography media having high dynamic sorptive capacity at high flow rates
US6211199B1 (en) 1995-11-17 2001-04-03 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US6153754A (en) * 1995-12-21 2000-11-28 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US6201124B1 (en) 1995-12-21 2001-03-13 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US5932571A (en) * 1996-02-21 1999-08-03 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US5998439A (en) 1996-02-21 1999-12-07 Hoescht Marion Roussel, Inc. Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
US5922737A (en) * 1996-02-21 1999-07-13 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
US5925761A (en) * 1997-02-04 1999-07-20 Sepracor Inc. Synthesis of terfenadine and derivatives
DK0864653T3 (da) * 1997-03-11 2004-07-12 Aventis Pharma Inc Fremgangsmåde til fremstilling af 4-(4-(4-(hydroxydiphenyl)-1-piperidinyl)-1-hydroxybutyl)-alfa,alfa-dimethylphenyleddikesyre og phosphorylerede derivater deraf
CA2301267C (en) * 1997-08-14 2004-07-13 Hoechst Marion Roussel, Inc. Method of enhancing bioavailability of fexofenadine and its derivatives
US6451815B1 (en) 1997-08-14 2002-09-17 Aventis Pharmaceuticals Inc. Method of enhancing bioavailability of fexofenadine and its derivatives
CN1159012C (zh) * 1997-08-26 2004-07-28 阿旺蒂斯制药公司 用于组合哌啶子基烷醇-减充血剂的药物组合物
ES2200260T3 (es) * 1997-12-17 2004-03-01 Aventis Pharma Deutschland Gmbh Procedimiento para la alquilacion de derivados de alquil-o bencilciano en presencia de trialquilaminas o trialquifosfinas.
CN1283115A (zh) * 1997-12-23 2001-02-07 先灵公司 用于治疗呼吸道和皮肤病的含有至少一种白三烯拮抗剂和至少一种抗组胺药的组合物
US6194431B1 (en) * 1998-04-14 2001-02-27 Paul D. Rubin Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors
PT1091938E (pt) * 1998-07-02 2010-12-20 Aventisub Ii Inc Derivados de piperidina anti-histamínicos e intermediários para a sua preparação
US6689898B2 (en) 1998-07-02 2004-02-10 Aventis Pharmaceuticals Inc. Antihistaminic piperidine derivatives and intermediates for the preparation thereof
AU2007200674C1 (en) * 1998-07-02 2011-02-24 Aventisub Llc Novel antihistaminic piperidine derivatives and intermediates for the preparation thereof
US6683094B2 (en) 1998-07-02 2004-01-27 Aventis Pharmaceuticals Inc. Antihistaminic piperidine derivatives and intermediates for the preparation thereof
GB9822170D0 (en) * 1998-10-13 1998-12-02 Danbioyst Uk Ltd Novel formulations of fexofenadine
IN191492B (de) * 1999-05-25 2003-12-06 Ranbaxy Lab Ltd
US6613906B1 (en) * 2000-06-06 2003-09-02 Geneva Pharmaceuticals, Inc. Crystal modification
US6613907B2 (en) 2000-11-08 2003-09-02 Amr Technology, Inc. Process for the production of piperidine derivatives with microorganisms
CH695216A5 (de) * 2001-02-23 2006-01-31 Cilag Ag Verfahren zur Herstellung eines nicht hydratisierten Salzes eines Piperidinderivats und eine so erhältliche neue kristalline Form eines solchen Salzes.
SK13822003A3 (sk) * 2001-04-09 2004-09-08 Teva Pharmaceutical Industries Ltd. Polymorfné formy chloridu fexofenadínu
US20030021849A1 (en) * 2001-04-09 2003-01-30 Ben-Zion Dolitzky Polymorphs of fexofenadine hydrochloride
EE200400010A (et) * 2001-06-18 2004-02-16 Dr. Reddy's Laboratories Ltd. 4-[4-[4-(hüdroksüdifenüülmetüül)-1-piperidinüül]-1-hüdroksübutüül]-a,a-dimetüülben seenäädikhappe ja selle hüdrokloriidi uued kristalsed vormid
US7700779B2 (en) * 2001-06-18 2010-04-20 Dr. Reddy's Laboratories Limited Crystalline forms of fexofenadine and its hydrochloride
US20030158227A1 (en) * 2001-11-08 2003-08-21 Barnaba Krochmal Polymorphs of fexofenadine base
WO2003039482A2 (en) * 2001-11-08 2003-05-15 Teva Pharmaceutical Industries Ltd. Polymorphs of fexofenadine base
US6723348B2 (en) * 2001-11-16 2004-04-20 Ethypharm Orodispersible tablets containing fexofenadine
EP1490090A4 (de) 2002-02-22 2006-09-20 New River Pharmaceuticals Inc Wirkstoff-abgabesystem und verfahren zum schutz und zur verabreichung von wirkstoffen
JP2005532356A (ja) * 2002-06-10 2005-10-27 テバ ファーマシューティカル インダストリーズ リミティド 塩酸フェキソフェナジンの多型体ｘｖｉ
CN1741981A (zh) * 2002-12-16 2006-03-01 兰贝克赛实验室有限公司 非索那汀的制备方法
CN1756743A (zh) * 2003-01-31 2006-04-05 兰贝克赛实验室有限公司 制备弗克芬得的方法
US20050026890A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an antihistamine for treatment of asthma or chronic obstructive pulmonary disease
US20050065183A1 (en) * 2003-07-31 2005-03-24 Indranil Nandi Fexofenadine composition and process for preparing
GB0319935D0 (en) * 2003-08-26 2003-09-24 Cipla Ltd Polymorphs
TW200517114A (en) 2003-10-15 2005-06-01 Combinatorx Inc Methods and reagents for the treatment of immunoinflammatory disorders
WO2005102999A2 (en) * 2004-04-26 2005-11-03 Teva Pharmaceutical Industries Ltd. Crystalline forms of fexofenadine hydrochloride and processes for their preparation
WO2006008567A1 (en) * 2004-06-18 2006-01-26 Wockhardt Limited Pharmaceutical compositions for piperidinoalkanol compounds
ITMI20041568A1 (it) * 2004-07-30 2004-10-30 Dipharma Spa "polimorfi di fexofenadina base"
US7498443B2 (en) * 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of carebastine
US7498345B2 (en) * 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US20060148851A1 (en) * 2004-09-28 2006-07-06 Shlomit Wizel Fexofenadine crystal form and processes for its preparation thereof
EP2486942B1 (de) * 2004-11-24 2018-10-10 Meda Pharmaceuticals Inc. Zusammensetzungen mit azelastin und anwendungsverfahren
US8758816B2 (en) * 2004-11-24 2014-06-24 Meda Pharmaceuticals Inc. Compositions comprising azelastine and methods of use thereof
US20070020330A1 (en) 2004-11-24 2007-01-25 Medpointe Healthcare Inc. Compositions comprising azelastine and methods of use thereof
JP2008120684A (ja) * 2005-03-07 2008-05-29 Kumamoto Univ 抗アレルギー薬
US20080274196A1 (en) * 2005-08-05 2008-11-06 Lipin Limited Oral Pharmaceutical Suspension Compositions Of Fexofenadine
US20070088065A1 (en) * 2005-10-14 2007-04-19 Jie Du Metaxalone products, method of manufacture, and method of use
US20080292584A1 (en) * 2005-10-14 2008-11-27 Mutual Pharmaceutical Company, Inc. Metaxalone products, method of manufacture, and method of use
RU2283649C1 (ru) * 2005-10-27 2006-09-20 Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") Фармацевтическая композиция для лечения аллергических заболеваний
WO2007049303A2 (en) * 2005-10-28 2007-05-03 Ind-Swift Laboratories Limited An improved process for the preparation of highly pure fexofenadine
EP1956906A4 (de) 2005-11-09 2009-12-30 Combinatorx Inc Verfahren, zusammensetzungen und kits für die behandlung von medizinischen beschwerden
DOP2006000274A (es) * 2005-12-14 2007-10-15 Sanofi Aventis Us Llc Formulación de suspensión de fexofenadina
CN100443470C (zh) * 2006-07-21 2008-12-17 杭州保灵有限公司 一种依巴斯汀的制备方法
ITMI20061492A1 (it) * 2006-07-27 2008-01-28 Archimica Srl Processo per la preparazione di fexofenadina.
ITMI20061491A1 (it) * 2006-07-27 2008-01-28 Archimica Srl Processo per la preparazione di fexofenadina.
US20080161324A1 (en) * 2006-09-14 2008-07-03 Johansen Lisa M Compositions and methods for treatment of viral diseases
NZ580495A (en) 2007-04-13 2011-05-27 Southern Res Inst Use of anti-angiogenic agents and methods of use, particulary amiodarone for inhibiting or reducing angiogenesis
ITMI20070987A1 (it) * 2007-05-16 2008-11-17 Dipharma Francis Srl Procedimento per la preparazione di composti chetonici
US20090076080A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched fexofenadine
EP2105134A1 (de) 2008-03-24 2009-09-30 Ranbaxy Laboratories Limited Stabiles und amorphes Fexofenadin-Hydrochlorid
CA2724607A1 (en) * 2008-05-30 2009-12-31 Fairfield Clinical Trials, Llc Method and composition for skin inflammation and discoloration
US20100092479A1 (en) * 2008-08-18 2010-04-15 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
CN101585805B (zh) * 2009-06-06 2011-07-06 浙江大学宁波理工学院 一种抗过敏药物非索非那定盐酸盐的制备方法
EP2289867A3 (de) 2009-08-19 2012-04-25 Jubilant Organosys Limited Verfahren zur Herstellung von 4-(4-Halogen-1-oxybutyl)-alpha,alpha-dimethylbenzolessigsäure oder Alkylestern davon
CN101671292B (zh) * 2009-10-10 2011-09-07 浙江大学宁波理工学院 盐酸非索非那定的合成方法
US20110130711A1 (en) * 2009-11-19 2011-06-02 Follica, Inc. Hair growth treatment
EP2371817A1 (de) * 2010-04-01 2011-10-05 Arevipharma GmbH Verfahren zur Herstellung von 1-[4-(1,1-Dimethylethyl)phenyl]-4-[4-(diphenylmethoxy)-1-piperidinyl]-1-butanon und Säureadditionssalze daraus
US9216955B2 (en) 2010-06-15 2015-12-22 Chemelectiva S.R.L. Polymorphic form of Fexofenadine hydrochloride, intermediates and process for its preparation
KR20140030267A (ko) 2011-05-23 2014-03-11 사노피 Ｎ­알킬 그룹을 함유하는 중수소화된 화합물의 제조방법
TW201318624A (zh) 2011-09-29 2013-05-16 Shionogi & Co 包含ｐｇｄ２拮抗劑及組織胺拮抗劑之過敏性鼻炎治療用醫藥
EP2578570A1 (de) 2011-10-07 2013-04-10 Almirall, S.A. Neues Verfahren zur Herstellung von 5-(2-{[6-(2,2-Difluor-2-phenylethoxy)hexyl]amino}-1(R)-hydroxyethyl)-8-hydroxychinolin-2(1H)-on mittels neuen Synthesezwischenstoffen
EP2641900A1 (de) 2012-03-20 2013-09-25 Almirall, S.A. Neuartige polymorphe Kristallformen von 5-(2-{[6-(2,2-difluor-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxychinolin-2(1H)-on, Heminapadisylat als Agonist des beta2-adrenergen Rezeptors
CN102659667B (zh) * 2012-04-20 2013-08-14 浙江启明药业有限公司 一种非索非那定关键中间体的合成方法
CN103333100B (zh) * 2013-06-06 2016-04-06 池州东升药业有限公司 一种盐酸非索非那定的合成工艺
ITMI20131652A1 (it) 2013-10-07 2015-04-08 Dipharma Francis Srl Procedimento per la purificazione di derivati dell'acido 2-fenil-2-metil-propanoico
CN104557671B (zh) * 2013-10-10 2018-04-13 池州东升药业有限公司 一种非索非那定及中间体的合成方法
EP2949321A1 (de) 2014-05-26 2015-12-02 Sanovel Ilac Sanayi ve Ticaret A.S. Mehrschichtige formulierungen aus fexofenadin und montelukast
WO2016116555A1 (en) 2015-01-22 2016-07-28 Sanofi-Aventis Deutschland Gmbh Process for the production of 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl-propanenitrile
CN109071438B (zh) 2015-10-22 2023-02-21 赛诺菲-安万特德国有限公司 用于制备非索非那定和其中使用的中间体的方法
GB2629127A (en) 2022-08-31 2024-10-23 Novumgen Ltd An orodispersible tablet of fexofenadine and its process of preparation
KR20250133597A (ko) 2023-01-20 2025-09-08 오펠라 헬스케어 그룹 에스에이에스 파라벤 프리 펙소페나딘 제제

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1242169A (en) * 1969-04-09 1971-08-11 Ucb Sa Piperidine derivatives
BE794598A (fr) * 1972-01-28 1973-05-16 Richardson Merrell Inc Nouveaux derives olefiniques de piperidines substituees en 4 et leur procede de preparation
BE794596A (fr) * 1972-01-28 1973-05-16 Richardson Merrell Inc Piperidinoalcanone-oximes substituees et leur procede de preparation
US3878217A (en) * 1972-01-28 1975-04-15 Richardson Merrell Inc Alpha-aryl-4-substituted piperidinoalkanol derivatives
US3806526A (en) * 1972-01-28 1974-04-23 Richardson Merrell Inc 1-aroylalkyl-4-diphenylmethyl piperidines
US3965257A (en) * 1972-01-28 1976-06-22 Richardson-Merrell Inc. Compositions and methods for the treatment of the symptoms of histamine induced allergic reactions
ZA728544B (en) * 1972-01-28 1974-02-27 Richardson Merrell Inc Alpha-aryl-4-substituted piperidinoalkanol derivatives
US3941795A (en) * 1974-02-08 1976-03-02 Richardson-Merrell Inc. α-ARYL-4-SUBSTITUTED PIPERIDINOALKANOL DERIVATIVES
US3931197A (en) * 1974-02-08 1976-01-06 Richardson-Merrell Inc. Substituted piperidine derivatives
US3946022A (en) * 1974-03-04 1976-03-23 Richardson-Merrell Inc. Piperidine derivatives
US3956296A (en) * 1974-12-11 1976-05-11 A. H. Robins Company, Incorporated 1-Substituted-4-benzylpiperidines
US3922276A (en) * 1974-12-11 1975-11-25 Robins Co Inc A H 1-Substituted-4-benzylidenepiperidines

Also Published As

Publication number Publication date
SE8002634L (sv) 1980-10-11
NO1998017I1 (no) 1998-05-29
FR2453854B1 (de) 1983-06-24
ZA80332B (en) 1981-01-28
AU531146B2 (en) 1983-08-11
AU5501680A (en) 1980-10-16
NL980013I1 (nl) 1998-06-02
CA1123438A (en) 1982-05-11
DK132980A (da) 1980-10-11
NZ192653A (en) 1982-03-16
DK153709C (da) 1988-12-27
BE882703A (fr) 1980-07-31
SE448726B (sv) 1987-03-16
NL8000754A (nl) 1980-10-14
ES489934A0 (es) 1981-03-16
PH17023A (en) 1984-05-11
NL190580B (nl) 1993-12-01
ATA144880A (de) 1984-03-15
DE3007498A1 (de) 1980-10-23
ES8103735A1 (es) 1981-03-16
DE3007498C2 (de) 1989-09-07
US4254129A (en) 1981-03-03
NO154521B (no) 1986-06-30
NO801014L (no) 1980-10-13
IT1143960B (it) 1986-10-29
FR2453854A1 (fr) 1980-11-07
CH643245A5 (de) 1984-05-30
DK153709B (da) 1988-08-22
JPS55141469A (en) 1980-11-05
JPH0132823B2 (de) 1989-07-10
IL59158A0 (en) 1980-05-30
IT8048245A0 (it) 1980-03-24
IL59158A (en) 1984-04-30
AT376208B (de) 1984-10-25
NL190580C (nl) 1994-05-02
NL980013I2 (nl) 1998-10-01

Similar Documents

Publication Publication Date Title
NO154521C (no) Analogifremgangsmaate for fremstilling av nye, terapeutisk aktive piperidinderivater.
NO154964C (no) Analogifremgangsmaate ved fremstilling av nye, terapeutisk aktive piperidinderivater.
NO151085C (no) Analogifremgangsmaate ved fremstilling av nye, terapeutisk aktive peptidylargininaldehydderivater
NO153136C (no) Analogifremgangsmaate ved fremstilling av nye terapeutisk aktive naftyridinderivater.
NO154883C (no) Analogifremgangsmaate ved fremstilling av nye, terapeutisk aktive 2-acylaminomethyl-1,4-benzodiazepiner.
NO152841C (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive nye 4-aroylimidazol-2-oner.
NO152899C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive glycerolderivater.
NO152215C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 4,5-diaryl-2-nitroimidazoler
NO149102C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive trans-4-fenyl-1,2,3,4-tetrahydro-1-naftalenamin-derivater
NO871879D0 (no) Fremgangsmaate for fremstilling av nye, terapeutisk aktive heterocykliske forbindelser.
NO144455C (no) Fremgangsmaate ved fremstilling av terapeutisk aktive nye piperidinderivater.
NO145379C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive n2-arylsulfonyl-l-argininamider.
NO156787C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive kinolonderivater.
NO153496C (no) Analogifremgangsmaate for fremstilling av fysiologisk aktive indolizin-derivater.
NO150884C (no) Analogifremgangsmaate for fremstilling av nye, terapeutisk aktive imidazotiazolderivater
NO148926C (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive, nye merkaptoimidazolderivater
NO823520L (no) Fremgangsmaate ved fremstilling av nye, terapeutisk aktive carbohydrater.
NO800857L (no) Fremgangsmaate for fremstilling av nye antisekretorisk aktive forbindelser.
NO154268C (no) Analogifremgangsmaate ved fremstilling av nye terapeutisk aktive 6alfa-flour-9a-klor-prednisolon-17,21-diestere.
NO145198C (no) Analogifremgangsmaate til fremstilling av terapeutisk aktivt 1,2-benzisotia-zolinon-3
NO154920C (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive, nye pyridothienotriaziner.
NO160370C (no) Analogifremgangsmaate for fremstilling av fysiologisk aktive penam-1,1-dioksyd-forbindelser.
NO154396C (no) Analogifremgangsmaate ved fremstilling av nye, terapeutisk aktive halovincamonderivater.
NO152898C (no) Analogifremgangsmaate ved fremstilling av nye terapeutisk aktive substituerte acetofenoner.
NO144457C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive dihydro-1,4-pyridiner