NL8300738A - Nieuwe derivaten van 3-keto-delta4.9-19-nor-steroiden, de bereiding daarvan, de toepassing daarvan als geneesmiddelen, de preparaten, die deze verbindingen bevatten, en de verkregen nieuwe intermediairen. - Google Patents

Nieuwe derivaten van 3-keto-delta4.9-19-nor-steroiden, de bereiding daarvan, de toepassing daarvan als geneesmiddelen, de preparaten, die deze verbindingen bevatten, en de verkregen nieuwe intermediairen. Download PDF

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Publication number
NL8300738A
NL8300738A NL8300738A NL8300738A NL8300738A NL 8300738 A NL8300738 A NL 8300738A NL 8300738 A NL8300738 A NL 8300738A NL 8300738 A NL8300738 A NL 8300738A NL 8300738 A NL8300738 A NL 8300738A
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Netherlands
Prior art keywords
radical
hydroxy
phenyl
products
prop
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Application number
NL8300738A
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English (en)
Dutch (nl)
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Roussel Uclaf
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Publication of NL8300738A publication Critical patent/NL8300738A/nl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0096—Alkynyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J61/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by contraction of only one ring by one or two atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/0025—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa substituted in position 16
    • C07J7/003—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
    • C07J7/0075—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified substituted in position 17 alfa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NL8300738A 1982-03-01 1983-02-28 Nieuwe derivaten van 3-keto-delta4.9-19-nor-steroiden, de bereiding daarvan, de toepassing daarvan als geneesmiddelen, de preparaten, die deze verbindingen bevatten, en de verkregen nieuwe intermediairen. NL8300738A (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8203338A FR2522328B1 (fr) 1982-03-01 1982-03-01 Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments
FR8203338 1982-03-01

Publications (1)

Publication Number Publication Date
NL8300738A true NL8300738A (nl) 1983-10-03

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
NL8300738A NL8300738A (nl) 1982-03-01 1983-02-28 Nieuwe derivaten van 3-keto-delta4.9-19-nor-steroiden, de bereiding daarvan, de toepassing daarvan als geneesmiddelen, de preparaten, die deze verbindingen bevatten, en de verkregen nieuwe intermediairen.

Country Status (32)

Country Link
US (2) US4477445A (ja)
JP (2) JPS58201800A (ja)
KR (1) KR880001870B1 (ja)
AR (1) AR241187A1 (ja)
AT (1) AT396109B (ja)
AU (1) AU562739B2 (ja)
BE (1) BE896042A (ja)
CA (1) CA1206471A (ja)
CH (1) CH657368A5 (ja)
DE (1) DE3307143A1 (ja)
DK (1) DK89783A (ja)
EG (1) EG15881A (ja)
ES (1) ES8401495A1 (ja)
FI (1) FI80049C (ja)
FR (1) FR2522328B1 (ja)
GB (1) GB2118186B (ja)
GR (1) GR78465B (ja)
HU (1) HU193269B (ja)
IE (1) IE54748B1 (ja)
IL (1) IL67920A0 (ja)
IT (1) IT1197592B (ja)
LU (1) LU84667A1 (ja)
MA (1) MA19716A1 (ja)
MX (1) MX7199E (ja)
NL (1) NL8300738A (ja)
PH (1) PH21308A (ja)
PT (1) PT76307B (ja)
SE (1) SE8300308L (ja)
SU (1) SU1340593A3 (ja)
WO (1) WO1983003099A1 (ja)
YU (1) YU47883A (ja)
ZA (1) ZA83982B (ja)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
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FR2528434B1 (fr) * 1982-06-11 1985-07-19 Roussel Uclaf Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament
US5182381A (en) * 1982-03-01 1993-01-26 Roussel Ulcaf Intermediates for 3-keto-19-nor-Δ4,9 -steroids
FR2639045B2 (fr) * 1982-03-01 1994-07-29 Roussel Uclaf Nouveaux produits derives de la structure 3-ceto-delta-4,9-19-nor steroides et leur application comme medicaments
DE3231827A1 (de) * 1982-08-24 1984-03-01 Schering AG, 1000 Berlin und 4709 Bergkamen 11ss-aryl-17(alpha)-alkinyl-17ss-hydroxy-4,9(10)- estradien-3-on-derivate, deren herstellung und diese enthaltende pharmazeutische praeparate
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DE3347126A1 (de) * 1983-12-22 1985-07-11 Schering AG, 1000 Berlin und 4709 Bergkamen 11ss-aryl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate
US4666898A (en) * 1983-12-28 1987-05-19 Jackson Lab. Treatment of obesity, diabetes and other symptoms of hypercorticoidism using etiocholanolones
DE3410880A1 (de) * 1984-03-21 1985-10-03 Schering AG, Berlin und Bergkamen, 1000 Berlin 17-substituierte estradiene und estratriene
DE3438500C1 (de) * 1984-10-18 1986-05-28 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur Herstellung 11ß-substituierter Δ↑9↑-19-Norsteroide
FR2573657B1 (fr) * 1984-11-29 1989-05-12 Roussel Uclaf Produit comprenant une substance antiprogestomimetique et une substance uterotonique
FR2576025B1 (fr) * 1985-01-14 1987-01-23 Roussel Uclaf Nouveaux steroides substitues en position 10, leur procede et les intermediaires de preparation, leur application comme medicaments, les compositions pharmaceutiques les contenant
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FR2598421B1 (fr) * 1986-05-06 1988-08-19 Roussel Uclaf Nouveaux produits 19-nor ou 19-nor d-homo steroides substitues en position 11b par un radical phenyle portant un radical alkynyle, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
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CA1206471A (fr) 1986-06-24
GB2118186A (en) 1983-10-26
CH657368A5 (fr) 1986-08-29
ES520195A0 (es) 1983-12-01
FR2522328A1 (fr) 1983-09-02
FI830652A0 (fi) 1983-02-28
EG15881A (en) 1991-06-30
PH21308A (en) 1987-09-28
JPH02275895A (ja) 1990-11-09
FR2522328B1 (fr) 1986-02-14
FI80049B (fi) 1989-12-29
MX7199E (es) 1987-12-23
DK89783A (da) 1983-09-02
KR880001870B1 (ko) 1988-09-23
US4540686A (en) 1985-09-10
DE3307143A1 (de) 1983-09-08
ES8401495A1 (es) 1983-12-01
SE8300308L (sv) 1983-09-02
AU562739B2 (en) 1987-06-18
IT1197592B (it) 1988-12-06
AU1191383A (en) 1983-09-08
HU193269B (en) 1987-09-28
YU47883A (en) 1986-04-30
IE54748B1 (en) 1990-01-31
LU84667A1 (fr) 1983-09-08
IL67920A0 (en) 1983-06-15
PT76307B (fr) 1986-01-27
AT396109B (de) 1993-06-25
DK89783D0 (da) 1983-02-25
JPH0443920B2 (ja) 1992-07-20
KR840003649A (ko) 1984-09-15
JPH054397B2 (ja) 1993-01-19
WO1983003099A1 (en) 1983-09-15
IT8347820A0 (it) 1983-02-28
FI830652L (fi) 1983-09-02
ZA83982B (en) 1984-03-28
PT76307A (fr) 1983-03-01
GR78465B (ja) 1984-09-27
FI80049C (fi) 1990-04-10
GB8305558D0 (en) 1983-03-30
SU1340593A3 (ru) 1987-09-23
IE830429L (en) 1983-09-01
MA19716A1 (fr) 1983-10-01
BE896042A (fr) 1983-08-29
SE8300308D0 (sv) 1983-01-21
ATA71183A (de) 1992-10-15
JPS58201800A (ja) 1983-11-24
GB2118186B (en) 1986-04-23
AR241187A1 (es) 1992-01-31
US4477445A (en) 1984-10-16

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