NL194264C - Werkwijze voor het winnen van houdbare kamille-extracten, die rijk zijn aan actieve stof. - Google Patents
Werkwijze voor het winnen van houdbare kamille-extracten, die rijk zijn aan actieve stof. Download PDFInfo
- Publication number
- NL194264C NL194264C NL8502554A NL8502554A NL194264C NL 194264 C NL194264 C NL 194264C NL 8502554 A NL8502554 A NL 8502554A NL 8502554 A NL8502554 A NL 8502554A NL 194264 C NL194264 C NL 194264C
- Authority
- NL
- Netherlands
- Prior art keywords
- chamomile
- fresh
- content
- extract
- extraction
- Prior art date
Links
- 239000013543 active substance Substances 0.000 title claims description 25
- 238000000034 method Methods 0.000 title claims description 24
- 235000020221 chamomile extract Nutrition 0.000 title claims description 11
- 238000000605 extraction Methods 0.000 claims abstract description 28
- 238000010438 heat treatment Methods 0.000 claims abstract description 6
- 235000007232 Matricaria chamomilla Nutrition 0.000 claims description 60
- 235000007866 Chamaemelum nobile Nutrition 0.000 claims description 59
- 229940070641 chamomile flowers Drugs 0.000 claims description 30
- 240000003538 Chamaemelum nobile Species 0.000 claims 1
- 239000000284 extract Substances 0.000 abstract description 44
- 244000042664 Matricaria chamomilla Species 0.000 description 59
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 47
- CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 description 30
- 239000000341 volatile oil Substances 0.000 description 21
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 description 19
- XADJWCRESPGUTB-UHFFFAOYSA-N apigenin Natural products C1=CC(O)=CC=C1C1=CC(=O)C2=CC(O)=C(O)C=C2O1 XADJWCRESPGUTB-UHFFFAOYSA-N 0.000 description 18
- 235000008714 apigenin Nutrition 0.000 description 18
- 229940117893 apigenin Drugs 0.000 description 18
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 description 17
- 238000001035 drying Methods 0.000 description 16
- 229940036350 bisabolol Drugs 0.000 description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 description 12
- KZNIFHPLKGYRTM-UHFFFAOYSA-N apigenin Chemical compound C1=CC(O)=CC=C1C1=CC(=O)C2=C(O)C=C(O)C=C2O1 KZNIFHPLKGYRTM-UHFFFAOYSA-N 0.000 description 12
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 description 12
- 239000000126 substance Substances 0.000 description 12
- GXGJIOMUZAGVEH-UHFFFAOYSA-N Chamazulene Chemical compound CCC1=CC=C(C)C2=CC=C(C)C2=C1 GXGJIOMUZAGVEH-UHFFFAOYSA-N 0.000 description 10
- PMRJYBALQVLLSJ-UHFFFAOYSA-N chamazulene Natural products CCC1=CC2=C(C)CCC2=CC=C1 PMRJYBALQVLLSJ-UHFFFAOYSA-N 0.000 description 10
- -1 saturated aliphatic alcohols Chemical class 0.000 description 8
- 241000196324 Embryophyta Species 0.000 description 7
- 229930182478 glucoside Natural products 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- WJHRAVIQWFQMKF-IPYPFGDCSA-N Bisabolol oxide A Chemical compound C1CC(C)=CC[C@H]1[C@@]1(C)OC(C)(C)[C@@H](O)CC1 WJHRAVIQWFQMKF-IPYPFGDCSA-N 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 238000003860 storage Methods 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 4
- SYTRJRUSWMMZLV-UHFFFAOYSA-N 4-epimatricin Natural products C1=CC(O)(C)C2C1=C(C)CC(OC(C)=O)C1C2OC(=O)C1C SYTRJRUSWMMZLV-UHFFFAOYSA-N 0.000 description 3
- WJHRAVIQWFQMKF-UHFFFAOYSA-N Bisabolol oxide A Natural products C1CC(C)=CCC1C1(C)OC(C)(C)C(O)CC1 WJHRAVIQWFQMKF-UHFFFAOYSA-N 0.000 description 3
- SYTRJRUSWMMZLV-VQGWEXQJSA-N Matricin Chemical compound [C@@H]1([C@H](CC(C)=C2[C@@H]3[C@](C=C2)(C)O)OC(C)=O)[C@@H]3OC(=O)[C@H]1C SYTRJRUSWMMZLV-VQGWEXQJSA-N 0.000 description 3
- SYTRJRUSWMMZLV-AHWDLOTJSA-N Matricin Natural products O=C(O[C@@H]1[C@H]2[C@H](C)C(=O)O[C@@H]2[C@H]2[C@](O)(C)C=CC2=C(C)C1)C SYTRJRUSWMMZLV-AHWDLOTJSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 150000001298 alcohols Chemical class 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 230000002255 enzymatic effect Effects 0.000 description 3
- 238000007710 freezing Methods 0.000 description 3
- 230000008014 freezing Effects 0.000 description 3
- 238000002803 maceration Methods 0.000 description 3
- 239000001500 (2R)-6-methyl-2-[(1R)-4-methyl-1-cyclohex-3-enyl]hept-5-en-2-ol Substances 0.000 description 2
- 229930189957 Bisabolol oxide Natural products 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- XLYOFNOQVPJJNP-ZSJDYOACSA-N Heavy water Chemical compound [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 229930003944 flavone Natural products 0.000 description 2
- 150000002213 flavones Chemical class 0.000 description 2
- 235000011949 flavones Nutrition 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 238000005325 percolation Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- YTAQZPGBTPDBPW-UHFFFAOYSA-N 2-phenylchromene-3,4-dione Chemical compound O1C2=CC=CC=C2C(=O)C(=O)C1C1=CC=CC=C1 YTAQZPGBTPDBPW-UHFFFAOYSA-N 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 229940119217 chamomile extract Drugs 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000002274 desiccant Substances 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fats And Perfumes (AREA)
- Compounds Of Unknown Constitution (AREA)
- Preparation Of Fruits And Vegetables (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Gears, Cams (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- External Artificial Organs (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Luminescent Compositions (AREA)
- Materials For Medical Uses (AREA)
- Valve-Gear Or Valve Arrangements (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Catalysts (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Mechanical Operated Clutches (AREA)
- Preliminary Treatment Of Fibers (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3434342 | 1984-09-19 | ||
| DE3434342 | 1984-09-19 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NL8502554A NL8502554A (nl) | 1986-04-16 |
| NL194264B NL194264B (nl) | 2001-07-02 |
| NL194264C true NL194264C (nl) | 2001-11-05 |
Family
ID=6245768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8502554A NL194264C (nl) | 1984-09-19 | 1985-09-18 | Werkwijze voor het winnen van houdbare kamille-extracten, die rijk zijn aan actieve stof. |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US4786497A (cs) |
| EP (1) | EP0175185B1 (cs) |
| JP (1) | JPH0641414B2 (cs) |
| KR (1) | KR900000544B1 (cs) |
| AT (1) | ATE58836T1 (cs) |
| BR (1) | BR8504573A (cs) |
| CA (1) | CA1251142A (cs) |
| CS (1) | CS254346B2 (cs) |
| DD (1) | DD240496A5 (cs) |
| DE (2) | DE3580814D1 (cs) |
| DK (1) | DK161799C (cs) |
| ES (1) | ES8608881A1 (cs) |
| FI (1) | FI79469C (cs) |
| GB (1) | GB2164559B (cs) |
| GR (1) | GR852243B (cs) |
| HU (1) | HU193449B (cs) |
| IE (1) | IE58215B1 (cs) |
| IL (1) | IL76388A (cs) |
| IN (1) | IN164169B (cs) |
| MA (1) | MA20530A1 (cs) |
| MT (1) | MTP970B (cs) |
| MX (1) | MX161477A (cs) |
| MY (1) | MY100507A (cs) |
| NL (1) | NL194264C (cs) |
| NO (1) | NO164276C (cs) |
| PL (1) | PL255422A1 (cs) |
| PT (1) | PT81148B (cs) |
| RO (1) | RO93515B (cs) |
| SU (1) | SU1642947A3 (cs) |
| YU (1) | YU45989B (cs) |
| ZA (1) | ZA857166B (cs) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN163594B (cs) * | 1984-03-16 | 1988-10-15 | Degussa | |
| MX161477A (es) * | 1984-09-19 | 1990-09-28 | Degussa | Procedimiento para extraer los constituyentes de la manzanilla |
| ES2044980T3 (es) * | 1987-02-13 | 1994-01-16 | Asta Medica Ag | Aceites de camomila con un elevado contenido de poliinas naturales y procedimiento para su preparacion. |
| US6300370B1 (en) | 1987-02-13 | 2001-10-09 | Asta Medica Aktiengesellschaft | Camomile oils having a high content of natural poly-ynes and process for their preparation |
| DE3913280C2 (de) * | 1989-04-22 | 1995-02-16 | Paul Haslauer | Bedampfungsgerät |
| EP0496230A1 (de) * | 1991-01-23 | 1992-07-29 | ASTA Medica Aktiengesellschaft | Herstellung eines Kamillenextraktes mit antimikrobiellen Eigenschaften |
| JP2513550B2 (ja) * | 1991-09-24 | 1996-07-03 | 相互印刷工芸株式会社 | カミツレ成分の抽出方法 |
| JP2010163363A (ja) * | 2009-01-13 | 2010-07-29 | Kao Corp | アピゲニン高濃度含有エキスの製造方法 |
| CN102911791A (zh) * | 2012-09-25 | 2013-02-06 | 常州亚环环保科技有限公司 | 一种栀子花精油液的提取方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE609884C (de) * | 1932-12-22 | 1935-02-25 | Ig Farbenindustrie Ag | Verfahren zur Darstellung von haltbaren Kamillenauszuegen |
| GB505983A (en) * | 1937-11-17 | 1939-05-17 | Ig Farbenindustrie Ag | Improvements in the manufacture and production of pharmaceutically active substances |
| FR1015120A (fr) * | 1947-08-13 | 1952-08-27 | Procédé de préparation d'extraits actifs renfermant de l'azulène à partir de camomille ou de plantes analogues | |
| DE1093951B (de) * | 1959-02-12 | 1960-12-01 | Chemiewerk Homburg Zweignieder | Verfahren zur Extraktion proazulenhaltiger Drogen |
| DE1296305B (de) * | 1965-08-26 | 1969-05-29 | Thomae Gmbh Dr K | Verfahren zur Extraktion von Kamille |
| DE2227292C3 (de) * | 1972-06-05 | 1981-01-08 | Degussa Ag, 6000 Frankfurt | Verfahren zur Herstellung von Kamillenextrakten |
| CH572368A5 (cs) * | 1973-03-28 | 1976-02-13 | Sulzer Ag | |
| DE2316363A1 (de) * | 1973-04-02 | 1974-10-17 | Degussa | Verfahren zur herstellung von kamillenextrakten |
| DE2402802C3 (de) * | 1974-01-22 | 1979-06-13 | Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt | Gewinnung einer Kamillendroge mit hohem Chamazulen- und Bisabololgehalt |
| IT1157945B (it) * | 1982-06-02 | 1987-02-18 | Bonomelli Spa | Composizione terapeutica ad attivita' antibatterica a base di una frazione estratta da fiori di camomilla e processo per la preparazione di detta frazione |
| DE3423207C3 (de) * | 1983-06-29 | 1996-09-26 | Asta Medica Ag | Verfahren zur Herstellung einer neuen Kamillensorte (Bezeichnung Manzana) |
| IN163594B (cs) * | 1984-03-16 | 1988-10-15 | Degussa | |
| MX161477A (es) * | 1984-09-19 | 1990-09-28 | Degussa | Procedimiento para extraer los constituyentes de la manzanilla |
-
1985
- 1985-08-16 MX MX206315A patent/MX161477A/es unknown
- 1985-08-29 DE DE8585110864T patent/DE3580814D1/de not_active Expired - Lifetime
- 1985-08-29 AT AT85110864T patent/ATE58836T1/de not_active IP Right Cessation
- 1985-08-29 EP EP85110864A patent/EP0175185B1/de not_active Expired - Lifetime
- 1985-08-29 DE DE19853530790 patent/DE3530790A1/de not_active Ceased
- 1985-09-13 IL IL76388A patent/IL76388A/xx not_active IP Right Cessation
- 1985-09-16 GR GR852243A patent/GR852243B/el unknown
- 1985-09-16 RO RO120125A patent/RO93515B/ro unknown
- 1985-09-17 KR KR1019850006776A patent/KR900000544B1/ko not_active Expired
- 1985-09-17 DD DD85280700A patent/DD240496A5/de not_active IP Right Cessation
- 1985-09-17 FI FI853562A patent/FI79469C/fi not_active IP Right Cessation
- 1985-09-18 MA MA20756A patent/MA20530A1/fr unknown
- 1985-09-18 ZA ZA857166A patent/ZA857166B/xx unknown
- 1985-09-18 NO NO853660A patent/NO164276C/no not_active IP Right Cessation
- 1985-09-18 NL NL8502554A patent/NL194264C/nl not_active IP Right Cessation
- 1985-09-18 CA CA000491049A patent/CA1251142A/en not_active Expired
- 1985-09-18 YU YU147485A patent/YU45989B/sh unknown
- 1985-09-18 GB GB8523097A patent/GB2164559B/en not_active Expired
- 1985-09-18 PL PL25542285A patent/PL255422A1/xx unknown
- 1985-09-18 SU SU853953190A patent/SU1642947A3/ru active
- 1985-09-18 DK DK424185A patent/DK161799C/da not_active IP Right Cessation
- 1985-09-18 ES ES547081A patent/ES8608881A1/es not_active Expired
- 1985-09-18 PT PT81148A patent/PT81148B/pt unknown
- 1985-09-18 MT MT970A patent/MTP970B/xx unknown
- 1985-09-18 JP JP60204584A patent/JPH0641414B2/ja not_active Expired - Fee Related
- 1985-09-18 IE IE230985A patent/IE58215B1/en not_active IP Right Cessation
- 1985-09-18 CS CS856645A patent/CS254346B2/cs not_active IP Right Cessation
- 1985-09-19 BR BR8504573A patent/BR8504573A/pt unknown
- 1985-09-19 HU HU853513A patent/HU193449B/hu unknown
- 1985-12-19 IN IN916/CAL/85A patent/IN164169B/en unknown
-
1987
- 1987-06-18 MY MYPI87000840A patent/MY100507A/en unknown
- 1987-09-08 US US07/096,211 patent/US4786497A/en not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BA | A request for search or an international-type search has been filed | ||
| BB | A search report has been drawn up | ||
| BC | A request for examination has been filed | ||
| CNR | Transfer of rights (patent application after its laying open for public inspection) |
Free format text: ASTA MEDICA AKTIENGESELLSCHAFT;DEGUSSA-HUELS AKTIENGESELLSCHAFT |
|
| SNR | Assignments of patents or rights arising from examined patent applications |
Owner name: VIATRIS GMBH & CO. KG |
|
| V4 | Discontinued because of reaching the maximum lifetime of a patent |
Effective date: 20050918 |