MX358771B - Proceso para la regeneracion enzimatica de cofactores redox. - Google Patents
Proceso para la regeneracion enzimatica de cofactores redox.Info
- Publication number
- MX358771B MX358771B MX2014009455A MX2014009455A MX358771B MX 358771 B MX358771 B MX 358771B MX 2014009455 A MX2014009455 A MX 2014009455A MX 2014009455 A MX2014009455 A MX 2014009455A MX 358771 B MX358771 B MX 358771B
- Authority
- MX
- Mexico
- Prior art keywords
- redox
- oxidized
- reduced
- cofactor
- general formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/36—Dinucleotides, e.g. nicotineamide-adenine dinucleotide phosphate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/02—Monosaccharides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
La presente invención se refiere a un proceso para la regeneración enzimática de los cofactores redox NAD+/NADH y NADP+/NADPH en una reacción en un reactor, en donde, como resultado de por lo menos dos reacciones redox catalizadas enzimáticamente adicionales que proceden en el mismo lote de reacción (reacciones de formación de producto), el cofactor redox NAD+/NADH se acumula en su forma reducida como NADH y, el cofactor redox NADP+/NADPH en su forma oxidada como NADP+, el proceso está caracterizado porque: a) en la reacción regeneración la cual convierte el NADH en su forma oxidada original, el oxígeno o piruvato se reduce por medio de una NADH oxidasa o un lactato deshidrogenasa, respectivamente, y b) en la reacción de regeneración, la cual reconvierte el NADP+ en su forma reducida original se oxida 2-propanol o malato por medio de una alcohol deshidrogenasa o un malato deshidrogenasa, respectivamente.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12450007 | 2012-02-07 | ||
| PCT/EP2012/067781 WO2013117251A1 (de) | 2012-02-07 | 2012-09-12 | Verfahren zur enzymatischen regenerierung von redoxkofaktoren |
| AT12842012A AT513721B1 (de) | 2012-12-10 | 2012-12-10 | Verfahren zur enzymatischen Regenerierung von Redoxkofaktoren |
| PCT/EP2013/052313 WO2013117584A1 (de) | 2012-02-07 | 2013-02-06 | Verfahren zur enzymatischen regenerierung von redoxkofaktoren |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014009455A MX2014009455A (es) | 2014-11-12 |
| MX358771B true MX358771B (es) | 2018-09-04 |
Family
ID=48946925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014009455A MX358771B (es) | 2012-02-07 | 2013-02-06 | Proceso para la regeneracion enzimatica de cofactores redox. |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US9644227B2 (es) |
| EP (1) | EP2812439B1 (es) |
| JP (1) | JP6329086B2 (es) |
| KR (1) | KR102022137B1 (es) |
| CN (2) | CN104136620A (es) |
| AR (1) | AR089841A1 (es) |
| AU (1) | AU2013218042B2 (es) |
| BR (1) | BR112014019287B1 (es) |
| CA (1) | CA2862384C (es) |
| ES (1) | ES2742381T3 (es) |
| HK (1) | HK1204010A1 (es) |
| HR (1) | HRP20191514T1 (es) |
| HU (1) | HUE044690T2 (es) |
| IN (1) | IN2014DN07015A (es) |
| LT (1) | LT2812439T (es) |
| MX (1) | MX358771B (es) |
| MY (1) | MY172493A (es) |
| NZ (1) | NZ627477A (es) |
| PH (1) | PH12014501770B1 (es) |
| PL (1) | PL2812439T3 (es) |
| PT (1) | PT2812439T (es) |
| RS (1) | RS59114B1 (es) |
| RU (1) | RU2635087C2 (es) |
| SA (1) | SA113340270B1 (es) |
| SG (1) | SG11201404614XA (es) |
| SI (1) | SI2812439T1 (es) |
| TW (1) | TW201343623A (es) |
| UA (1) | UA117453C2 (es) |
| WO (1) | WO2013117584A1 (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201343623A (zh) | 2012-02-07 | 2013-11-01 | Annikki Gmbh | 使氧化還原輔因子經酶催化再生之方法 |
| AT513928B1 (de) | 2013-02-06 | 2015-06-15 | Annikki Gmbh | Verfahren zur Herstellung von Fructose |
| WO2014154676A1 (de) * | 2013-03-27 | 2014-10-02 | Annikki Gmbh | Verfahren zur isomerisierung von glucose |
| EP3636743A1 (en) * | 2014-04-02 | 2020-04-15 | The Regents of The University of California | A synthetic biochemistry molecular purge valve module that maintains co-factor balance |
| US9890397B1 (en) | 2015-07-15 | 2018-02-13 | Gaurab Chakrabarti | Hydrogen peroxide production method, system, and apparatus |
| US20180216142A1 (en) * | 2015-07-24 | 2018-08-02 | Annikki Gmbh | Process for enzymatic production of oxidation and reduction products of mixed sugars |
| CN105861613B (zh) * | 2016-03-30 | 2019-12-13 | 中山百灵生物技术有限公司 | 一种熊去氧胆酸制备方法 |
| WO2017202686A1 (de) | 2016-05-23 | 2017-11-30 | Annikki Gmbh | Verfahren zur enzymatischen umwandlung von d-glucose in d-fructose via d-sorbitol |
| WO2018036982A1 (de) * | 2016-08-22 | 2018-03-01 | Pharmazell Gmbh | Chemisch-biokatalytisches verfahren zur herstellung von ursodesoxycholsäure |
| US11203769B1 (en) | 2017-02-13 | 2021-12-21 | Solugen, Inc. | Hydrogen peroxide and gluconic acid production |
| CN106957886A (zh) * | 2017-03-01 | 2017-07-18 | 南京远淑医药科技有限公司 | 一种熊去氧胆酸的制备方法 |
| CN107315038B (zh) * | 2017-07-06 | 2019-06-18 | 江南大学 | 一种批量化对酒类样品中氨基甲酸乙酯快速测定的方法 |
| JP6559745B2 (ja) | 2017-08-23 | 2019-08-14 | 株式会社東芝 | 半導体デバイス検査装置、半導体デバイス検査方法、そのプログラム、半導体装置およびその製造方法 |
| CN108251491A (zh) * | 2018-03-09 | 2018-07-06 | 中山百灵生物技术有限公司 | 一种酶促法合成熊去氧胆酸的方法 |
| EP3775178A4 (en) * | 2018-04-06 | 2022-01-05 | Braskem S.A. | NEW NADH-DEPENDENT ENZYMMUTANTS FOR THE CONVERSION OF ACETONE INTO ISOPROPANOL |
| CN109055473A (zh) * | 2018-08-21 | 2018-12-21 | 湖南宝利士生物技术有限公司 | 一种基于酶法偶联技术合成熊去氧胆酸和高手性纯度d-氨基酸的方法 |
| CN111217744A (zh) * | 2018-11-26 | 2020-06-02 | 中国科学院大连化学物理研究所 | 一种d-氨基酸基nad+类似物及其合成和应用 |
| CN109486896A (zh) * | 2018-12-04 | 2019-03-19 | 南京工业大学 | 一种催化拆分制备异甘草酸的方法 |
| CN109486895A (zh) * | 2018-12-04 | 2019-03-19 | 南京工业大学 | 一种催化拆分制备异甘草酸的方法 |
| CN110387360B (zh) * | 2019-06-18 | 2021-12-28 | 华东理工大学 | 羟基类固醇脱氢酶及其在合成熊去氧胆酸前体中的应用 |
| CN111593085A (zh) * | 2020-05-26 | 2020-08-28 | 四川澄华生物科技有限公司 | 一种12-酮基胆酸的制备方法 |
| CN112813128A (zh) * | 2021-01-12 | 2021-05-18 | 中山百灵生物技术股份有限公司 | 一种别熊去氧胆酸的合成方法 |
| KR102504343B1 (ko) | 2021-02-22 | 2023-02-28 | 전남대학교산학협력단 | 단량체 이소시트레이트 디하이드로게나아제에 기반한 nadph 재생 시스템 및 이의 용도 |
| CN116536279B (zh) * | 2022-01-25 | 2023-11-14 | 杭州馨海酶源生物科技有限公司 | 一种基因工程菌及在制备去氢表雄酮上的应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3502141A1 (de) * | 1985-01-23 | 1986-10-16 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., 8000 München | Verfahren zur intrasequentiellen cofaktor-regeneration bei enzymatischen synthesen, insbesondere bei der herstellung von vitamin c |
| CZ20012792A3 (cs) | 1999-12-03 | 2002-03-13 | Kaneka Corporation | Polypeptid, polynukleotid kódující polypeptid, expresní vektor, transformant a způsob přípravy |
| DE10140088A1 (de) | 2001-08-16 | 2003-03-13 | Degussa | NADH-Oxidase aus Lactobacillus |
| AU2003257986A1 (en) | 2002-07-31 | 2004-02-16 | Georgia Tech Research Corporation | Methods and compositions for nad(p)(h) oxidases |
| DE10240603A1 (de) | 2002-09-03 | 2004-03-11 | Degussa Ag | Verwendung von Malat-Dehydrogenase zur NADH-Regenerierung |
| EP1731618A1 (en) | 2005-06-07 | 2006-12-13 | Prodotti Chimici E Alimentari Spa | Process for the selective oxydation of colic acid |
| AT503486B1 (de) * | 2006-04-11 | 2008-05-15 | Iep Gmbh | Verfahren zur enantioselektiven reduktion von steroiden |
| EP1925674A1 (en) | 2006-11-27 | 2008-05-28 | Universiteit van Amsterdam | Regeneration of NADPH and/or NADH cofactors |
| AT506639A1 (de) | 2008-04-01 | 2009-10-15 | Kroutil Wolfgang Dipl Ing Dr T | Verfahren zur deracemisierung von enantiomerengemischen unter verwendung von enzymsystemen |
| IT1398729B1 (it) | 2009-07-01 | 2013-03-18 | F S I Fabbrica Italiana Sint | Processo per la preparazione di testosterone |
| JP2013511973A (ja) * | 2009-11-30 | 2013-04-11 | ファルマツェル、ゲーエムベーハー | 新規７β−ヒドロキシステロイドデヒドロゲナーゼおよびその使用 |
| US8530213B2 (en) | 2009-12-02 | 2013-09-10 | Georgia Tech Research Corporation | Compositions and methods for using NADH oxidases |
| WO2013117251A1 (de) | 2012-02-07 | 2013-08-15 | Annikki Gmbh | Verfahren zur enzymatischen regenerierung von redoxkofaktoren |
| TW201343623A (zh) | 2012-02-07 | 2013-11-01 | Annikki Gmbh | 使氧化還原輔因子經酶催化再生之方法 |
-
2013
- 2013-01-28 TW TW102103119A patent/TW201343623A/zh unknown
- 2013-01-29 AR ARP130100266A patent/AR089841A1/es active IP Right Grant
- 2013-02-05 SA SA113340270A patent/SA113340270B1/ar unknown
- 2013-02-06 SI SI201331563T patent/SI2812439T1/sl unknown
- 2013-02-06 US US14/376,512 patent/US9644227B2/en active Active
- 2013-02-06 AU AU2013218042A patent/AU2013218042B2/en active Active
- 2013-02-06 IN IN7015DEN2014 patent/IN2014DN07015A/en unknown
- 2013-02-06 CN CN201380008572.8A patent/CN104136620A/zh active Pending
- 2013-02-06 CN CN202110638003.8A patent/CN113337568A/zh active Pending
- 2013-02-06 LT LTEP13703568.9T patent/LT2812439T/lt unknown
- 2013-02-06 KR KR1020147023136A patent/KR102022137B1/ko active IP Right Grant
- 2013-02-06 RU RU2014136162A patent/RU2635087C2/ru active
- 2013-02-06 PT PT13703568T patent/PT2812439T/pt unknown
- 2013-02-06 BR BR112014019287-1A patent/BR112014019287B1/pt active IP Right Grant
- 2013-02-06 SG SG11201404614XA patent/SG11201404614XA/en unknown
- 2013-02-06 PL PL13703568T patent/PL2812439T3/pl unknown
- 2013-02-06 HU HUE13703568 patent/HUE044690T2/hu unknown
- 2013-02-06 MY MYPI2014702060A patent/MY172493A/en unknown
- 2013-02-06 JP JP2014556034A patent/JP6329086B2/ja active Active
- 2013-02-06 UA UAA201409679A patent/UA117453C2/uk unknown
- 2013-02-06 EP EP13703568.9A patent/EP2812439B1/de active Active
- 2013-02-06 NZ NZ627477A patent/NZ627477A/en unknown
- 2013-02-06 ES ES13703568T patent/ES2742381T3/es active Active
- 2013-02-06 CA CA2862384A patent/CA2862384C/en active Active
- 2013-02-06 RS RS20191065A patent/RS59114B1/sr unknown
- 2013-02-06 WO PCT/EP2013/052313 patent/WO2013117584A1/de active Application Filing
- 2013-02-06 MX MX2014009455A patent/MX358771B/es active IP Right Grant
-
2014
- 2014-08-06 PH PH12014501770A patent/PH12014501770B1/en unknown
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2015
- 2015-05-06 HK HK15104308.2A patent/HK1204010A1/xx unknown
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2017
- 2017-04-18 US US15/490,416 patent/US10370691B2/en active Active
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2019
- 2019-06-25 US US16/451,838 patent/US11339415B2/en active Active
- 2019-08-22 HR HRP20191514 patent/HRP20191514T1/hr unknown
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