UA117453C2 - Спосіб ферментної регенерації окисно-відновних кофакторів nad+/nadh і/або nadp+/nadph - Google Patents

Спосіб ферментної регенерації окисно-відновних кофакторів nad+/nadh і/або nadp+/nadph

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Publication number
UA117453C2
UA117453C2 UAA201409679A UAA201409679A UA117453C2 UA 117453 C2 UA117453 C2 UA 117453C2 UA A201409679 A UAA201409679 A UA A201409679A UA A201409679 A UAA201409679 A UA A201409679A UA 117453 C2 UA117453 C2 UA 117453C2
Authority
UA
Ukraine
Prior art keywords
redox
oxidized
reduced
general formula
compound
Prior art date
Application number
UAA201409679A
Other languages
English (en)
Inventor
Ортвін Ертл
Ніколь Стауніг
Марта Сат
Бернд Маєр
Original Assignee
Анніккі Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2012/067781 external-priority patent/WO2013117251A1/de
Priority claimed from AT12842012A external-priority patent/AT513721B1/de
Application filed by Анніккі Гмбх filed Critical Анніккі Гмбх
Publication of UA117453C2 publication Critical patent/UA117453C2/uk

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/02—Monosaccharides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/36—Dinucleotides, e.g. nicotineamide-adenine dinucleotide phosphate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Винахід стосується способу ферментної регенерації окисно-відновних кофакторів NAD+/NADH і/або NADP+/NADPH у спільній реакції, у якому в результаті щонайменше двох окисно-відновних реакцій, що каталізуються ферментами, і які протікають в одній реакційній масі, окисно-відновні кофактори NADP+/NADPH накопичуються у відновленій формі як NADPH у реакції окислення 2-пропанолу або малату за допомогою спиртової дегідрогенази або малат-дегідрогенази, а окисно-відновні кофактори NAD+/NADH накопичуються в окисленій формі як NAD+ у реакції відновлення кисню або пірувату за допомогою NADH-оксидази або лактат-дегідрогенази.
UAA201409679A 2012-02-07 2013-02-06 Спосіб ферментної регенерації окисно-відновних кофакторів nad+/nadh і/або nadp+/nadph UA117453C2 (uk)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP12450007 2012-02-07
PCT/EP2012/067781 WO2013117251A1 (de) 2012-02-07 2012-09-12 Verfahren zur enzymatischen regenerierung von redoxkofaktoren
AT12842012A AT513721B1 (de) 2012-12-10 2012-12-10 Verfahren zur enzymatischen Regenerierung von Redoxkofaktoren
PCT/EP2013/052313 WO2013117584A1 (de) 2012-02-07 2013-02-06 Verfahren zur enzymatischen regenerierung von redoxkofaktoren

Publications (1)

Publication Number Publication Date
UA117453C2 true UA117453C2 (uk) 2018-08-10

Family

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UAA201409679A UA117453C2 (uk) 2012-02-07 2013-02-06 Спосіб ферментної регенерації окисно-відновних кофакторів nad+/nadh і/або nadp+/nadph

Country Status (29)

Country Link
US (3) US9644227B2 (uk)
EP (1) EP2812439B1 (uk)
JP (1) JP6329086B2 (uk)
KR (1) KR102022137B1 (uk)
CN (2) CN104136620A (uk)
AR (1) AR089841A1 (uk)
AU (1) AU2013218042B2 (uk)
BR (1) BR112014019287B1 (uk)
CA (1) CA2862384C (uk)
ES (1) ES2742381T3 (uk)
HK (1) HK1204010A1 (uk)
HR (1) HRP20191514T1 (uk)
HU (1) HUE044690T2 (uk)
IN (1) IN2014DN07015A (uk)
LT (1) LT2812439T (uk)
MX (1) MX358771B (uk)
MY (1) MY172493A (uk)
NZ (1) NZ627477A (uk)
PH (1) PH12014501770B1 (uk)
PL (1) PL2812439T3 (uk)
PT (1) PT2812439T (uk)
RS (1) RS59114B1 (uk)
RU (1) RU2635087C2 (uk)
SA (1) SA113340270B1 (uk)
SG (1) SG11201404614XA (uk)
SI (1) SI2812439T1 (uk)
TW (1) TW201343623A (uk)
UA (1) UA117453C2 (uk)
WO (1) WO2013117584A1 (uk)

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TW201343623A (zh) 2012-02-07 2013-11-01 Annikki Gmbh 使氧化還原輔因子經酶催化再生之方法
AT513928B1 (de) 2013-02-06 2015-06-15 Annikki Gmbh Verfahren zur Herstellung von Fructose
WO2014154676A1 (de) * 2013-03-27 2014-10-02 Annikki Gmbh Verfahren zur isomerisierung von glucose
EP3636743A1 (en) * 2014-04-02 2020-04-15 The Regents of The University of California A synthetic biochemistry molecular purge valve module that maintains co-factor balance
US9890397B1 (en) 2015-07-15 2018-02-13 Gaurab Chakrabarti Hydrogen peroxide production method, system, and apparatus
US20180216142A1 (en) * 2015-07-24 2018-08-02 Annikki Gmbh Process for enzymatic production of oxidation and reduction products of mixed sugars
CN105861613B (zh) * 2016-03-30 2019-12-13 中山百灵生物技术有限公司 一种熊去氧胆酸制备方法
WO2017202686A1 (de) 2016-05-23 2017-11-30 Annikki Gmbh Verfahren zur enzymatischen umwandlung von d-glucose in d-fructose via d-sorbitol
WO2018036982A1 (de) * 2016-08-22 2018-03-01 Pharmazell Gmbh Chemisch-biokatalytisches verfahren zur herstellung von ursodesoxycholsäure
US11203769B1 (en) 2017-02-13 2021-12-21 Solugen, Inc. Hydrogen peroxide and gluconic acid production
CN106957886A (zh) * 2017-03-01 2017-07-18 南京远淑医药科技有限公司 一种熊去氧胆酸的制备方法
CN107315038B (zh) * 2017-07-06 2019-06-18 江南大学 一种批量化对酒类样品中氨基甲酸乙酯快速测定的方法
JP6559745B2 (ja) 2017-08-23 2019-08-14 株式会社東芝 半導体デバイス検査装置、半導体デバイス検査方法、そのプログラム、半導体装置およびその製造方法
CN108251491A (zh) * 2018-03-09 2018-07-06 中山百灵生物技术有限公司 一种酶促法合成熊去氧胆酸的方法
EP3775178A4 (en) * 2018-04-06 2022-01-05 Braskem S.A. NEW NADH-DEPENDENT ENZYMMUTANTS FOR THE CONVERSION OF ACETONE INTO ISOPROPANOL
CN109055473A (zh) * 2018-08-21 2018-12-21 湖南宝利士生物技术有限公司 一种基于酶法偶联技术合成熊去氧胆酸和高手性纯度d-氨基酸的方法
CN111217744A (zh) * 2018-11-26 2020-06-02 中国科学院大连化学物理研究所 一种d-氨基酸基nad+类似物及其合成和应用
CN109486896A (zh) * 2018-12-04 2019-03-19 南京工业大学 一种催化拆分制备异甘草酸的方法
CN109486895A (zh) * 2018-12-04 2019-03-19 南京工业大学 一种催化拆分制备异甘草酸的方法
CN110387360B (zh) * 2019-06-18 2021-12-28 华东理工大学 羟基类固醇脱氢酶及其在合成熊去氧胆酸前体中的应用
CN111593085A (zh) * 2020-05-26 2020-08-28 四川澄华生物科技有限公司 一种12-酮基胆酸的制备方法
CN112813128A (zh) * 2021-01-12 2021-05-18 中山百灵生物技术股份有限公司 一种别熊去氧胆酸的合成方法
KR102504343B1 (ko) 2021-02-22 2023-02-28 전남대학교산학협력단 단량체 이소시트레이트 디하이드로게나아제에 기반한 nadph 재생 시스템 및 이의 용도
CN116536279B (zh) * 2022-01-25 2023-11-14 杭州馨海酶源生物科技有限公司 一种基因工程菌及在制备去氢表雄酮上的应用

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TW201343623A (zh) 2012-02-07 2013-11-01 Annikki Gmbh 使氧化還原輔因子經酶催化再生之方法

Also Published As

Publication number Publication date
PT2812439T (pt) 2019-09-10
WO2013117584A1 (de) 2013-08-15
CA2862384C (en) 2021-07-13
MX2014009455A (es) 2014-11-12
HRP20191514T1 (hr) 2019-11-29
JP6329086B2 (ja) 2018-05-23
JP2015506707A (ja) 2015-03-05
EP2812439A1 (de) 2014-12-17
US10370691B2 (en) 2019-08-06
KR102022137B1 (ko) 2019-09-17
RU2014136162A (ru) 2016-03-27
MX358771B (es) 2018-09-04
US20170218417A1 (en) 2017-08-03
US11339415B2 (en) 2022-05-24
CA2862384A1 (en) 2013-08-15
BR112014019287A8 (pt) 2017-07-11
US20140377798A1 (en) 2014-12-25
SA113340270B1 (ar) 2015-09-03
KR20140127258A (ko) 2014-11-03
AR089841A1 (es) 2014-09-24
LT2812439T (lt) 2019-10-10
BR112014019287A2 (pt) 2017-06-20
SG11201404614XA (en) 2014-10-30
AU2013218042A1 (en) 2014-08-07
IN2014DN07015A (uk) 2015-04-10
US20190323051A1 (en) 2019-10-24
PH12014501770A1 (en) 2014-11-10
ES2742381T3 (es) 2020-02-14
US9644227B2 (en) 2017-05-09
CN104136620A (zh) 2014-11-05
CN113337568A (zh) 2021-09-03
NZ627477A (en) 2015-12-24
AU2013218042B2 (en) 2016-07-28
HK1204010A1 (en) 2015-11-06
RU2635087C2 (ru) 2017-11-09
PH12014501770B1 (en) 2014-11-10
HUE044690T2 (hu) 2019-11-28
TW201343623A (zh) 2013-11-01
BR112014019287B1 (pt) 2021-07-06
MY172493A (en) 2019-11-27
SI2812439T1 (sl) 2019-10-30
RS59114B1 (sr) 2019-09-30
EP2812439B1 (de) 2019-05-22
PL2812439T3 (pl) 2019-11-29

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