AR089841A1 - Procedimiento para la regeneracion enzimatica de los cofactores redox - Google Patents
Procedimiento para la regeneracion enzimatica de los cofactores redoxInfo
- Publication number
- AR089841A1 AR089841A1 ARP130100266A ARP130100266A AR089841A1 AR 089841 A1 AR089841 A1 AR 089841A1 AR P130100266 A ARP130100266 A AR P130100266A AR P130100266 A ARP130100266 A AR P130100266A AR 089841 A1 AR089841 A1 AR 089841A1
- Authority
- AR
- Argentina
- Prior art keywords
- oxidized
- reduced
- reaction
- regeneration
- redox
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/36—Dinucleotides, e.g. nicotineamide-adenine dinucleotide phosphate
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/02—Monosaccharides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
Abstract
Procedimiento para la regeneración enzimática de los cofactores redox NAD⁺/NADH y/o, en particular, NADP⁺/NADPH en una reacción de un solo lote, en donde como resultado de al menos otras dos reacciones redox enzimáticamente catalizadas que tienen lugar en el mismo lote de reacción (= reacciones de formación de producto), uno de los cofactores redox se acumula en su forma reducida y el otro su forma oxidada, caracterizado porque, a) en la reacción de regeneración que convierte el cofactor reducido en su forma original oxidada se reduce oxigeno o un compuesto de la fórmula general R¹C(O)COOH y b) en la reacción de regeneración que convierte el cofactor oxidado a su forma original reducida, se oxida un compuesto de la formula general R²CH(OH)R³, teniendo R¹, R² y R³ distintos significados. Reivindicación 1: Procedimiento de regeneración enzimática de factores redox NAD⁺/NADH y/o, en particular NADP⁺/NADPH en una reacción en lote único y dando como resultado al menos otras dos reacciones redox enzimáticamente catalizadas adicionales que tienen lugar en el mismo lote de reacción (reacciones de formación de productos), uno de los dos cofactores redox se acumula en forma reducida y respectivamente el otro en su forma oxidada, caracterizado porque a) en la reacción de regeneración que reconvierte el cofactor reducido en su forma oxidada original, oxígeno o un compuesto de la formula general (1) en donde R¹ representa un grupo alquilo C₁₋₄ o un grupo carboxialquilo C₁₋₄ de una cadena lineal o ramificada es reducido, y b) en la reacción de regeneración que reconvierte el factor oxidado a su forma originalmente reducida se oxida un cicloalcanol C₄₋₈ o un compuesto de la formula general (2) en donde R² y R³ se seleccionan independientemente del grupo que comprende H, alquilo C₁₋₆, donde alquilo es una cadena lineal o ramificada, alquenilo C₁₋₆ en donde alquenilo es de cadena lineal o ramificada y comprende una a tres dobles ligaduras, arilo, particularmente arilo C₆₋₁₂, carboxilo, o carboxialquilo C₁₋₄, particularmente también cicloalquilo, por ejemplo cicloalquilo C₃₋₈.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12450007 | 2012-02-07 | ||
| PCT/EP2012/067781 WO2013117251A1 (de) | 2012-02-07 | 2012-09-12 | Verfahren zur enzymatischen regenerierung von redoxkofaktoren |
| AT12842012A AT513721B1 (de) | 2012-12-10 | 2012-12-10 | Verfahren zur enzymatischen Regenerierung von Redoxkofaktoren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR089841A1 true AR089841A1 (es) | 2014-09-24 |
Family
ID=48946925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130100266A AR089841A1 (es) | 2012-02-07 | 2013-01-29 | Procedimiento para la regeneracion enzimatica de los cofactores redox |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US9644227B2 (es) |
| EP (1) | EP2812439B1 (es) |
| JP (1) | JP6329086B2 (es) |
| KR (1) | KR102022137B1 (es) |
| CN (2) | CN104136620A (es) |
| AR (1) | AR089841A1 (es) |
| AU (1) | AU2013218042B2 (es) |
| BR (1) | BR112014019287B1 (es) |
| CA (1) | CA2862384C (es) |
| ES (1) | ES2742381T3 (es) |
| HK (1) | HK1204010A1 (es) |
| HR (1) | HRP20191514T1 (es) |
| HU (1) | HUE044690T2 (es) |
| IN (1) | IN2014DN07015A (es) |
| LT (1) | LT2812439T (es) |
| MX (1) | MX358771B (es) |
| MY (1) | MY172493A (es) |
| NZ (1) | NZ627477A (es) |
| PH (1) | PH12014501770A1 (es) |
| PL (1) | PL2812439T3 (es) |
| PT (1) | PT2812439T (es) |
| RS (1) | RS59114B1 (es) |
| RU (1) | RU2635087C2 (es) |
| SA (1) | SA113340270B1 (es) |
| SG (1) | SG11201404614XA (es) |
| SI (1) | SI2812439T1 (es) |
| TW (1) | TW201343623A (es) |
| UA (1) | UA117453C2 (es) |
| WO (1) | WO2013117584A1 (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201343623A (zh) | 2012-02-07 | 2013-11-01 | Annikki Gmbh | 使氧化還原輔因子經酶催化再生之方法 |
| AT513928B1 (de) | 2013-02-06 | 2015-06-15 | Annikki Gmbh | Verfahren zur Herstellung von Fructose |
| CA2907576C (en) * | 2013-03-27 | 2021-05-04 | Annikki Gmbh | Method for isomerisation of glucose |
| WO2015153929A2 (en) * | 2014-04-02 | 2015-10-08 | The Regents Of The University Of California | A synthetic biochemistry molecular purge valve module that maintain co-factor balance |
| US9890397B1 (en) | 2015-07-15 | 2018-02-13 | Gaurab Chakrabarti | Hydrogen peroxide production method, system, and apparatus |
| JP6732017B2 (ja) * | 2015-07-24 | 2020-07-29 | アニッキ ゲーエムベーハーＡｎｎｉｋｋｉ Ｇｍｂｈ | 糖混合物から酸化生成物および還元生成物を得るための方法 |
| CN105861613B (zh) * | 2016-03-30 | 2019-12-13 | 中山百灵生物技术有限公司 | 一种熊去氧胆酸制备方法 |
| WO2017202686A1 (de) | 2016-05-23 | 2017-11-30 | Annikki Gmbh | Verfahren zur enzymatischen umwandlung von d-glucose in d-fructose via d-sorbitol |
| WO2018036982A1 (de) * | 2016-08-22 | 2018-03-01 | Pharmazell Gmbh | Chemisch-biokatalytisches verfahren zur herstellung von ursodesoxycholsäure |
| US11203769B1 (en) | 2017-02-13 | 2021-12-21 | Solugen, Inc. | Hydrogen peroxide and gluconic acid production |
| CN106957886A (zh) * | 2017-03-01 | 2017-07-18 | 南京远淑医药科技有限公司 | 一种熊去氧胆酸的制备方法 |
| CN107315038B (zh) * | 2017-07-06 | 2019-06-18 | 江南大学 | 一种批量化对酒类样品中氨基甲酸乙酯快速测定的方法 |
| JP6559745B2 (ja) | 2017-08-23 | 2019-08-14 | 株式会社東芝 | 半導体デバイス検査装置、半導体デバイス検査方法、そのプログラム、半導体装置およびその製造方法 |
| CN108251491A (zh) * | 2018-03-09 | 2018-07-06 | 中山百灵生物技术有限公司 | 一种酶促法合成熊去氧胆酸的方法 |
| BR112020020285A2 (pt) | 2018-04-06 | 2021-01-19 | Braskem S.A. | Mutantes de enzima dependentes de nadh para converter acetona em isopropanol |
| CN109055473A (zh) * | 2018-08-21 | 2018-12-21 | 湖南宝利士生物技术有限公司 | 一种基于酶法偶联技术合成熊去氧胆酸和高手性纯度d-氨基酸的方法 |
| CN111217744A (zh) * | 2018-11-26 | 2020-06-02 | 中国科学院大连化学物理研究所 | 一种d-氨基酸基nad+类似物及其合成和应用 |
| CN109486896A (zh) * | 2018-12-04 | 2019-03-19 | 南京工业大学 | 一种催化拆分制备异甘草酸的方法 |
| CN109486895A (zh) * | 2018-12-04 | 2019-03-19 | 南京工业大学 | 一种催化拆分制备异甘草酸的方法 |
| CN110387360B (zh) * | 2019-06-18 | 2021-12-28 | 华东理工大学 | 羟基类固醇脱氢酶及其在合成熊去氧胆酸前体中的应用 |
| CN111593085A (zh) * | 2020-05-26 | 2020-08-28 | 四川澄华生物科技有限公司 | 一种12-酮基胆酸的制备方法 |
| CN112813128A (zh) * | 2021-01-12 | 2021-05-18 | 中山百灵生物技术股份有限公司 | 一种别熊去氧胆酸的合成方法 |
| KR102504343B1 (ko) | 2021-02-22 | 2023-02-28 | 전남대학교산학협력단 | 단량체 이소시트레이트 디하이드로게나아제에 기반한 nadph 재생 시스템 및 이의 용도 |
| CN116536279B (zh) * | 2022-01-25 | 2023-11-14 | 杭州馨海酶源生物科技有限公司 | 一种基因工程菌及在制备去氢表雄酮上的应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3502141A1 (de) * | 1985-01-23 | 1986-10-16 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., 8000 München | Verfahren zur intrasequentiellen cofaktor-regeneration bei enzymatischen synthesen, insbesondere bei der herstellung von vitamin c |
| CZ20012792A3 (cs) | 1999-12-03 | 2002-03-13 | Kaneka Corporation | Polypeptid, polynukleotid kódující polypeptid, expresní vektor, transformant a způsob přípravy |
| DE10140088A1 (de) | 2001-08-16 | 2003-03-13 | Degussa | NADH-Oxidase aus Lactobacillus |
| WO2004011670A2 (en) | 2002-07-31 | 2004-02-05 | Georgia Tech Research Corporation | Methods and compositions for nad(p)(h) oxidases |
| DE10240603A1 (de) | 2002-09-03 | 2004-03-11 | Degussa Ag | Verwendung von Malat-Dehydrogenase zur NADH-Regenerierung |
| EP1731618A1 (en) | 2005-06-07 | 2006-12-13 | Prodotti Chimici E Alimentari Spa | Process for the selective oxydation of colic acid |
| AT503486B1 (de) * | 2006-04-11 | 2008-05-15 | Iep Gmbh | Verfahren zur enantioselektiven reduktion von steroiden |
| EP1925674A1 (en) | 2006-11-27 | 2008-05-28 | Universiteit van Amsterdam | Regeneration of NADPH and/or NADH cofactors |
| AT506639A1 (de) | 2008-04-01 | 2009-10-15 | Kroutil Wolfgang Dipl Ing Dr T | Verfahren zur deracemisierung von enantiomerengemischen unter verwendung von enzymsystemen |
| IT1398729B1 (it) | 2009-07-01 | 2013-03-18 | F S I Fabbrica Italiana Sint | Processo per la preparazione di testosterone |
| NZ600189A (en) * | 2009-11-30 | 2014-04-30 | Pharmazell Gmbh | Novel 7beta-hydroxysteroid dehydrogenases and their use |
| US8530213B2 (en) | 2009-12-02 | 2013-09-10 | Georgia Tech Research Corporation | Compositions and methods for using NADH oxidases |
| WO2013117251A1 (de) | 2012-02-07 | 2013-08-15 | Annikki Gmbh | Verfahren zur enzymatischen regenerierung von redoxkofaktoren |
| TW201343623A (zh) | 2012-02-07 | 2013-11-01 | Annikki Gmbh | 使氧化還原輔因子經酶催化再生之方法 |
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2013
- 2013-01-28 TW TW102103119A patent/TW201343623A/zh unknown
- 2013-01-29 AR ARP130100266A patent/AR089841A1/es active IP Right Grant
- 2013-02-05 SA SA113340270A patent/SA113340270B1/ar unknown
- 2013-02-06 JP JP2014556034A patent/JP6329086B2/ja active Active
- 2013-02-06 PT PT13703568T patent/PT2812439T/pt unknown
- 2013-02-06 CN CN201380008572.8A patent/CN104136620A/zh active Pending
- 2013-02-06 AU AU2013218042A patent/AU2013218042B2/en active Active
- 2013-02-06 CA CA2862384A patent/CA2862384C/en active Active
- 2013-02-06 UA UAA201409679A patent/UA117453C2/uk unknown
- 2013-02-06 PL PL13703568T patent/PL2812439T3/pl unknown
- 2013-02-06 EP EP13703568.9A patent/EP2812439B1/de active Active
- 2013-02-06 CN CN202110638003.8A patent/CN113337568A/zh active Pending
- 2013-02-06 RS RS20191065A patent/RS59114B1/sr unknown
- 2013-02-06 IN IN7015DEN2014 patent/IN2014DN07015A/en unknown
- 2013-02-06 LT LTEP13703568.9T patent/LT2812439T/lt unknown
- 2013-02-06 WO PCT/EP2013/052313 patent/WO2013117584A1/de active Application Filing
- 2013-02-06 SG SG11201404614XA patent/SG11201404614XA/en unknown
- 2013-02-06 RU RU2014136162A patent/RU2635087C2/ru active
- 2013-02-06 KR KR1020147023136A patent/KR102022137B1/ko active IP Right Grant
- 2013-02-06 US US14/376,512 patent/US9644227B2/en active Active
- 2013-02-06 ES ES13703568T patent/ES2742381T3/es active Active
- 2013-02-06 BR BR112014019287-1A patent/BR112014019287B1/pt active IP Right Grant
- 2013-02-06 NZ NZ627477A patent/NZ627477A/en unknown
- 2013-02-06 SI SI201331563T patent/SI2812439T1/sl unknown
- 2013-02-06 HU HUE13703568 patent/HUE044690T2/hu unknown
- 2013-02-06 MY MYPI2014702060A patent/MY172493A/en unknown
- 2013-02-06 MX MX2014009455A patent/MX358771B/es active IP Right Grant
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2014
- 2014-08-06 PH PH12014501770A patent/PH12014501770A1/en unknown
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2015
- 2015-05-06 HK HK15104308.2A patent/HK1204010A1/xx unknown
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2017
- 2017-04-18 US US15/490,416 patent/US10370691B2/en active Active
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2019
- 2019-06-25 US US16/451,838 patent/US11339415B2/en active Active
- 2019-08-22 HR HRP20191514 patent/HRP20191514T1/hr unknown
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