BR112014022460A2 - omega-oxidação e -aminação enzimática de ácidos graxos - Google Patents

omega-oxidação e -aminação enzimática de ácidos graxos

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Publication number
BR112014022460A2
BR112014022460A2 BR112014022460A BR112014022460A BR112014022460A2 BR 112014022460 A2 BR112014022460 A2 BR 112014022460A2 BR 112014022460 A BR112014022460 A BR 112014022460A BR 112014022460 A BR112014022460 A BR 112014022460A BR 112014022460 A2 BR112014022460 A2 BR 112014022460A2
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BR
Brazil
Prior art keywords
fatty acid
oxidation
recombinant
omega
ester
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BR112014022460A
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English (en)
Inventor
Hennemann Hans-Georg
Häger Harald
Christoph Pfeffer Jan
Hauberg Michaela
Wessel Mirja
Schaffer Steffen
Haas Thomas
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Evonik Industries Ag
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Application filed by Evonik Industries Ag filed Critical Evonik Industries Ag
Publication of BR112014022460A2 publication Critical patent/BR112014022460A2/pt

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    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/64Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436Fatty acid esters
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    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
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    • C07KPEPTIDES
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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79Transferrins, e.g. lactoferrins, ovotransferrins
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0012Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0016Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with NAD or NADP as acceptor (1.4.1)
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0071Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0077Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
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    • C12P7/42Hydroxy-carboxylic acids
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    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/64Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409Fatty acids
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    • C12Y114/00Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/14Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (1.14.14)
    • C12Y114/14001Unspecific monooxygenase (1.14.14.1)

Abstract

resumo patente de invenção: "omega-oxidação e -aminação enzimática de ácidos graxos". a presente invenção refere-se a um processo para a oxidação de um ácido graxo ou de um éster do mesmo da fórmula (i) h3c - (ch2)n - coor, em que r é selecionado do grupo, que compreende h, metila, etila, propila e butila, em que n é 0 a 30, preferivelmente 6 a 24, que compreende a etapa oxidação do ácido graxo ou do éster do mesmo através do contato com uma citocromo p450-mono-oxigenase da família cyp153, na presença de oxigênio molecular e nad(p)h e de um catalisador de célula inteira, que expressa uma citocromo p450-mono-oxigenase da família cyp153 recombinante, uma álcool desidrogenase recombinante, uma transaminase recombinante e opcionalmente uma ou mais de uma enzima recombinante do grupo que compreende alanina desidrogenase, ferredoxina e ferredoxina redutase, bem como o uso desse catalisador de célula inteira para a oxidação de um ácido graxo ou de um éster do mesmo.
BR112014022460A 2012-03-12 2013-03-12 omega-oxidação e -aminação enzimática de ácidos graxos BR112014022460A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20120159087 EP2639308A1 (de) 2012-03-12 2012-03-12 Enzymatische omega-Oxidation und -Aminierung von Fettsäuren
PCT/EP2013/054928 WO2013135650A1 (de) 2012-03-12 2013-03-12 Enzymatische omega-oxidation und -aminierung von fettsäuren

Publications (1)

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BR112014022460A2 true BR112014022460A2 (pt) 2017-07-04

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Country Status (9)

Country Link
US (1) US9611489B2 (pt)
EP (1) EP2639308A1 (pt)
JP (1) JP2015509730A (pt)
CN (1) CN104169416A (pt)
BR (1) BR112014022460A2 (pt)
CA (1) CA2866215A1 (pt)
HK (1) HK1201870A1 (pt)
SG (2) SG11201405689TA (pt)
WO (1) WO2013135650A1 (pt)

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EP2607490A1 (de) 2011-12-22 2013-06-26 Evonik Industries AG Verfahren zur verbesserten Abtrennung einer hydrophoben organischen Lösung von einem wässrigen Kulturmedium
DE102011090092A1 (de) 2011-12-29 2013-07-04 Evonik Degussa Gmbh Verfahren zur Herstellung eines Formteils aus einer Polyamidformmasse mit verbesserter Hydrolysebeständigkeit
DE102012204181A1 (de) 2012-03-16 2013-09-19 Evonik Degussa Gmbh Elektrisch leitfähigen Kohlenstoff enthaltende Polyamidzusammensetzung
EP2730655A1 (de) 2012-11-12 2014-05-14 Evonik Industries AG Verfahren zur Umsetzung eines Carbonsäureesters unter Verwendung BioH-defizienter Zellen
EP2746397A1 (de) 2012-12-21 2014-06-25 Evonik Industries AG Herstellung von Omega-Aminofettsäuren
DE102013203470A1 (de) 2013-03-01 2014-09-04 Evonik Industries Ag Verfahren zur Herstellung von Ketonen aus Epoxiden

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EP2639308A1 (de) 2013-09-18
CA2866215A1 (en) 2013-09-19
CN104169416A (zh) 2014-11-26
US20150111253A1 (en) 2015-04-23
HK1201870A1 (en) 2015-09-11
WO2013135650A1 (de) 2013-09-19
US9611489B2 (en) 2017-04-04
JP2015509730A (ja) 2015-04-02
SG10201607565QA (en) 2016-10-28

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