BR112014015202A8 - processo para a melhor separação de uma solução orgânica hidrófoba de um meio de cultura aquoso - Google Patents
processo para a melhor separação de uma solução orgânica hidrófoba de um meio de cultura aquosoInfo
- Publication number
- BR112014015202A8 BR112014015202A8 BR112014015202A BR112014015202A BR112014015202A8 BR 112014015202 A8 BR112014015202 A8 BR 112014015202A8 BR 112014015202 A BR112014015202 A BR 112014015202A BR 112014015202 A BR112014015202 A BR 112014015202A BR 112014015202 A8 BR112014015202 A8 BR 112014015202A8
- Authority
- BR
- Brazil
- Prior art keywords
- culture medium
- organic solution
- aqueous culture
- hydrophobic organic
- cell
- Prior art date
Links
- 239000001963 growth medium Substances 0.000 title abstract 7
- 230000002209 hydrophobic effect Effects 0.000 title abstract 6
- 238000000926 separation method Methods 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 102000004190 Enzymes Human genes 0.000 abstract 4
- 108090000790 Enzymes Proteins 0.000 abstract 4
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 229930195729 fatty acid Natural products 0.000 abstract 2
- 239000000194 fatty acid Substances 0.000 abstract 2
- 150000004665 fatty acids Chemical class 0.000 abstract 2
- 238000007254 oxidation reaction Methods 0.000 abstract 2
- 101150071111 FADD gene Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
- C12Y103/99—Oxidoreductases acting on the CH-CH group of donors (1.3) with other acceptors (1.3.99)
- C12Y103/99003—Acyl-CoA dehydrogenase (1.3.99.3)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
resumo patente de invenção: "processo para a melhor separação de uma solução orgânica hidrófoba de um meio de cultura aquoso". a presente invenção refere-se a um processo para a melhor separação de uma solução orgânica hidrófoba de um meio de cultura aquosa, compreendendo as etapas, preparação de um meio de cultura aquoso compreendendo uma célula metabolicamente ativa, o contato do meio de cultura aquoso com uma solução orgânica hidrófoba, separação da solução orgânica hidrófoba do meio de cultura aquoso, em que a célula apresenta uma atividade reduzida de pelo menos uma enzima comparada com o tipo selvagem da célula, que catalisa uma das reações da ß-oxidação de ácidos graxos. além disso, a invenção se refere ao uso de uma célula metabolicamente ativa, que apresenta uma atividade reduzida de uma enzima comparada com o tipo selvagem da célula, que catalisa uma das reações da ß-oxidação de ácidos graxos, preferivelmente de uma enzima selecionada do grupo compreendendo fada, fadb, fadd, fadl e fade, bem como variantes dos mesmos, mais preferivelmente fade ou uma variante do mesmo, para a melhor separação de uma solução orgânica hidrófoba de um meio de cultura aquoso compreendendo a célula metabolicamente ativa.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11195221.4 | 2011-12-22 | ||
EP11195221.4A EP2607490A1 (de) | 2011-12-22 | 2011-12-22 | Verfahren zur verbesserten Abtrennung einer hydrophoben organischen Lösung von einem wässrigen Kulturmedium |
PCT/EP2012/075889 WO2013092547A1 (de) | 2011-12-22 | 2012-12-18 | Verfahren zur verbesserten abtrennung einer hydrophoben organischen lösung von einem wässrigen kulturmedium |
Publications (3)
Publication Number | Publication Date |
---|---|
BR112014015202A8 true BR112014015202A8 (pt) | 2017-06-13 |
BR112014015202A2 BR112014015202A2 (pt) | 2017-06-13 |
BR112014015202B1 BR112014015202B1 (pt) | 2021-11-03 |
Family
ID=47351527
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014015202-0A BR112014015202B1 (pt) | 2011-12-22 | 2012-12-18 | Processo para a melhor separação de uma solução orgânica hidrófoba de um meio de cultura aquoso |
Country Status (11)
Country | Link |
---|---|
US (1) | US9249435B2 (pt) |
EP (3) | EP2607490A1 (pt) |
JP (1) | JP6312117B2 (pt) |
KR (1) | KR102000317B1 (pt) |
CN (2) | CN103254089A (pt) |
BR (1) | BR112014015202B1 (pt) |
CA (1) | CA2799883C (pt) |
ES (1) | ES2688295T3 (pt) |
MX (1) | MX339910B (pt) |
SG (1) | SG11201403495QA (pt) |
WO (1) | WO2013092547A1 (pt) |
Families Citing this family (22)
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DE102006025821A1 (de) | 2006-06-02 | 2007-12-06 | Degussa Gmbh | Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd |
UA112980C2 (uk) | 2011-02-16 | 2016-11-25 | Евонік Дегусса Гмбх | Рідкі катіоніти |
EP2697231B1 (de) | 2011-04-12 | 2015-02-18 | Evonik Degussa GmbH | Kontinuierlich betreibbares verfahren zur herstellung von carbonylverbindungen mittels eines nitroxylradikalhaltigen katalysators |
EP2540170A1 (de) | 2011-06-29 | 2013-01-02 | Evonik Degussa GmbH | Dermatologisch wirksamer Hefeextrakt |
RU2014106109A (ru) | 2011-07-20 | 2015-08-27 | Эвоник Дегусса Гмбх | Окисление и аминирование первичных спиртов |
EP2602328A1 (de) | 2011-12-05 | 2013-06-12 | Evonik Industries AG | Verfahren zur Oxidation von Alkanen unter Verwendung einer AlkB Alkan 1-Monooxygenase |
EP2607479A1 (en) | 2011-12-22 | 2013-06-26 | Evonik Industries AG | Biotechnological production of alcohols and derivatives thereof |
EP2631298A1 (en) | 2012-02-22 | 2013-08-28 | Evonik Industries AG | Biotechnological method for producing butanol and butyric acid |
EP2639308A1 (de) | 2012-03-12 | 2013-09-18 | Evonik Industries AG | Enzymatische omega-Oxidation und -Aminierung von Fettsäuren |
EP2647696A1 (de) | 2012-04-02 | 2013-10-09 | Evonik Degussa GmbH | Verfahren zur aeroben Herstellung von Alanin oder einer unter Verbrauch von Alanin entstehenden Verbindung |
DE102012207921A1 (de) | 2012-05-11 | 2013-11-14 | Evonik Industries Ag | Mehrstufiges Syntheseverfahren mit Synthesegas |
EP2700448A1 (de) | 2012-08-21 | 2014-02-26 | Evonik Industries AG | Verzweigte Fettsäuren als flüssige Kationenaustauscher |
ES2531144T3 (es) | 2012-09-07 | 2015-03-11 | Evonik Industries Ag | Composiciones curables a base de resinas epoxídicas sin alcohol bencílico |
EP2730655A1 (de) | 2012-11-12 | 2014-05-14 | Evonik Industries AG | Verfahren zur Umsetzung eines Carbonsäureesters unter Verwendung BioH-defizienter Zellen |
EP2746400A1 (de) | 2012-12-21 | 2014-06-25 | Evonik Industries AG | Herstellung von Aminen und Diaminen aus einer Carbonsäure oder Dicarbonsäure oder eines Monoesters davon |
EP2746397A1 (de) | 2012-12-21 | 2014-06-25 | Evonik Industries AG | Herstellung von Omega-Aminofettsäuren |
EP2759598A1 (de) | 2013-01-24 | 2014-07-30 | Evonik Industries AG | Verfahren zur Herstellung von alpha, omega-Alkandiol |
EP2944697A1 (en) | 2014-05-13 | 2015-11-18 | Evonik Degussa GmbH | Method of producing nylon |
EP3390622B1 (en) | 2015-12-17 | 2020-05-13 | Evonik Operations GmbH | A genetically modified acetogenic cell |
EP3336180A1 (en) | 2016-07-04 | 2018-06-20 | Evonik Degussa GmbH | Mutant alkb gene |
JP2019523271A (ja) | 2016-07-27 | 2019-08-22 | エボニック デグサ ゲーエムベーハーEvonik Degussa GmbH | N−アセチルホモセリン |
PT4004010T (pt) * | 2019-07-29 | 2024-08-05 | Evonik Operations Gmbh | Método de extração de ácido carbónico, ácidos alifáticos, ésteres e álcoois de um meio aquoso. |
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US6245214B1 (en) | 1998-09-18 | 2001-06-12 | Alliedsignal Inc. | Electro-catalytic oxidation (ECO) device to remove CO from reformate for fuel cell application |
DE10054347A1 (de) | 2000-11-02 | 2002-05-08 | Degussa | Verfahren zur katalytischen Hydrierung organischer Verbindungen und Trägerkatalysatoren hierfür |
DE10142620A1 (de) | 2001-08-31 | 2003-03-20 | Degussa | Ammoximation von Ketonen und Aufarbeitung durch Pervaporation/Dampfpermeation |
DE10142621A1 (de) | 2001-08-31 | 2003-03-20 | Degussa | Aufarbeitung der Ammoximationsprodukte von Ketonen durch Flüssig-Flüssig-Extraktion in einem ternären Lösemittelsystem |
DE50213288D1 (de) | 2002-05-31 | 2009-04-02 | Evonik Degussa Gmbh | Geträgerter Rutheniumkatalysator und Verfahren zur Hydrierung eines aromatischen Amins in Gegenwart dieses Katalysators |
DE10231119A1 (de) | 2002-07-10 | 2004-02-05 | Degussa Ag | Verfahren zur Selektivitätserhöhung der Hydrierung von 4,4'-Diaminodiphenylmethan zu 4,4'-Diaminodicyclohexylmethan in Gegenwart eines N-Alkyl-4,4'-Diaminodiphenylmethans |
DE10247495A1 (de) | 2002-10-11 | 2004-04-22 | Degussa Ag | Verfahren zur Epoxidierung cyclischer Alkene |
EP1424332A1 (en) | 2002-11-26 | 2004-06-02 | Degussa AG | Process for the purification of crude propene oxide |
US6878836B2 (en) | 2003-06-18 | 2005-04-12 | Degussa Ag | Process for the epoxidation of propene |
DE102006017760A1 (de) | 2006-03-24 | 2007-09-27 | Ufz-Umweltforschungszentrum Leipzig-Halle Gmbh | Verfahren zur enzymatischen Herstellung von 2-Hydroxy-2-methylcarbonsäuren |
JP5357011B2 (ja) | 2006-05-11 | 2013-12-04 | エヴォニク インダストリーズ アーゲー | 遺伝的に操作された微生物株を用いる、スフィンゴイド塩基の改善された生産 |
DE102006025821A1 (de) | 2006-06-02 | 2007-12-06 | Degussa Gmbh | Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd |
DE102007021199B4 (de) | 2006-07-17 | 2016-02-11 | Evonik Degussa Gmbh | Zusammensetzungen aus organischem Polymer als Matrix und anorganischen Partikeln als Füllstoff, Verfahren zu deren Herstellung sowie deren Verwendung und damit hergestellte Formkörper |
DE102007027006A1 (de) | 2007-06-08 | 2008-12-11 | Evonik Degussa Gmbh | Mikrobiologische Herstellung von Aldehyden, insbesondere von 3-Hydroxypropionaldehyd |
DE102007052463A1 (de) | 2007-11-02 | 2009-05-07 | Evonik Degussa Gmbh | Fermentative Gewinnung von Aceton aus erneuerbaren Rohstoffen mittels neuen Stoffwechselweges |
DE102007060705A1 (de) * | 2007-12-17 | 2009-06-18 | Evonik Degussa Gmbh | ω-Aminocarbonsäuren oder ihre Lactame, herstellende, rekombinante Zellen |
EP2241621B1 (en) * | 2007-12-28 | 2012-08-15 | Ikeda Food Research Co. Ltd. | Modified glucose dehydrogenase gene |
DE102008002090A1 (de) | 2008-05-30 | 2009-12-03 | Evonik Degussa Gmbh | Ungesättigte Dicarbonsäuren aus ungesättigten cyclischen Kohlenwasserstoffen und Acrylsäure mittels Metathese, deren Verwendung als Monomere für Polyamide, Polyester, Polyurethane sowie weitere Umsetzung zu DIolen und Diaminen |
DE102008002715A1 (de) | 2008-06-27 | 2009-12-31 | Evonik Röhm Gmbh | 2-Hydroxyisobuttersäure produzierende rekombinante Zelle |
DE102008040193A1 (de) | 2008-07-04 | 2010-01-07 | Evonik Röhm Gmbh | Verfahren zur Herstellung freier Carbonsäuren |
DE102008040415A1 (de) | 2008-07-15 | 2010-01-21 | Evonik Röhm Gmbh | Thermisches Salzspalten von Ammoniumcarboxylaten |
WO2010021711A1 (en) * | 2008-08-18 | 2010-02-25 | Ls9, Inc. | Systems and methods for the production of mixed fatty esters |
DE102009000592A1 (de) | 2009-02-04 | 2010-08-05 | Evonik Degussa Gmbh | Verfahren zur Herstellung von Aminogruppen tragenden, multizyklischen Ringsystemen |
DE102009000661A1 (de) | 2009-02-06 | 2010-08-12 | Evonik Degussa Gmbh | Verfahren zur Herstellung von 2,6-Dioxabicyclo-(3.3.0)-octan-4,8-dion[1S,5S] |
DE102009000662A1 (de) | 2009-02-06 | 2010-08-12 | Evonik Degussa Gmbh | Verfahren zur Herstellung von Aldehyden und Ketonen aus primären und sekundären Alkoholen |
DE102009009580A1 (de) | 2009-02-19 | 2010-08-26 | Evonik Degussa Gmbh | Verfahren zur Herstellung freier Säuren aus ihren Salzen |
DE102009002371A1 (de) | 2009-04-15 | 2010-10-21 | Evonik Goldschmidt Gmbh | Verfahren zur Herstellung von geruchlosen Polyetheralkoholen mittels DMC-Katalysatoren und deren Verwendung in kosmetischen und/oder dermatologischen Zubereitungen |
EP2425007A4 (en) * | 2009-04-27 | 2013-01-02 | Ls9 Inc | PREPARATION OF FATTY ACID ESTERS |
DE102009002811A1 (de) | 2009-05-05 | 2010-11-11 | Evonik Degussa Gmbh | Enzymatisches Verfahren zur Herstellung von Aldehyden |
DE102009046626A1 (de) | 2009-11-11 | 2011-05-12 | Evonik Degussa Gmbh | Candida tropicalis Zellen und deren Verwendung |
DE102009046910A1 (de) | 2009-11-20 | 2011-05-26 | Evonik Degussa Gmbh | Verfahren zur Aufarbeitung eines Laurinlactam enthaltenen Stoffstroms für die Rückgewinnung aller enthaltene Wertstoffkomponenten durch Kombination von Kristallisation mit nachgeschalteter Destillation |
BR122019001300B1 (pt) | 2009-12-23 | 2020-03-03 | Evonik Degussa Gmbh | Processo para produção de adoçantes |
DE102010015807A1 (de) | 2010-04-20 | 2011-10-20 | Evonik Degussa Gmbh | Biokatalytisches Oxidationsverfahren mit alkL-Genprodukt |
DE102010023749A1 (de) | 2010-06-14 | 2011-12-15 | Evonik Degussa Gmbh | Zelle und Verfahren zur Herstellung von Resveratrol |
WO2011157573A2 (de) | 2010-06-14 | 2011-12-22 | Evonik Röhm Gmbh | Ein enzym zur herstellung von methylmalonatsemialdehyd |
DE102010026196A1 (de) | 2010-06-25 | 2011-12-29 | Evonik Degussa Gmbh | Synthese von omega-Aminocarbonsäuren und deren Estern aus ungesättigten Fettsäurederivaten |
UA112980C2 (uk) | 2011-02-16 | 2016-11-25 | Евонік Дегусса Гмбх | Рідкі катіоніти |
DE102011015150A1 (de) | 2011-03-25 | 2012-09-27 | Evonik Degussa Gmbh | Syntese von alpha, omega-Dicarbonsäuren und deren Estern aus ungesättigten Fettsäurederivaten |
EP2697231B1 (de) | 2011-04-12 | 2015-02-18 | Evonik Degussa GmbH | Kontinuierlich betreibbares verfahren zur herstellung von carbonylverbindungen mittels eines nitroxylradikalhaltigen katalysators |
EP2557176A1 (en) | 2011-06-15 | 2013-02-13 | Evonik Degussa GmbH | Enzymatic amination |
RU2014106109A (ru) | 2011-07-20 | 2015-08-27 | Эвоник Дегусса Гмбх | Окисление и аминирование первичных спиртов |
EP2739744A1 (de) | 2011-08-05 | 2014-06-11 | Evonik Degussa GmbH | Oxidation und aminierung von sekundären alkoholen |
DE102011110946A1 (de) | 2011-08-15 | 2016-01-21 | Evonik Degussa Gmbh | Biotechnologisches Syntheseverfahren von omegafunktionalisierten Carbonsäuren und Carbonsäure-Estern aus einfachen Kohlenstoffquellen |
DE102011110945A1 (de) | 2011-08-15 | 2013-02-21 | Evonik Degussa Gmbh | Biotechnologisches Syntheseverfahren von organischen Verbindungen mit alkIL-Genprodukt |
EP2730655A1 (de) | 2012-11-12 | 2014-05-14 | Evonik Industries AG | Verfahren zur Umsetzung eines Carbonsäureesters unter Verwendung BioH-defizienter Zellen |
EP2746397A1 (de) | 2012-12-21 | 2014-06-25 | Evonik Industries AG | Herstellung von Omega-Aminofettsäuren |
DE102013203470A1 (de) | 2013-03-01 | 2014-09-04 | Evonik Industries Ag | Verfahren zur Herstellung von Ketonen aus Epoxiden |
-
2011
- 2011-12-22 EP EP11195221.4A patent/EP2607490A1/de not_active Withdrawn
-
2012
- 2012-12-18 WO PCT/EP2012/075889 patent/WO2013092547A1/de active Application Filing
- 2012-12-18 BR BR112014015202-0A patent/BR112014015202B1/pt active IP Right Grant
- 2012-12-18 MX MX2012015064A patent/MX339910B/es active IP Right Grant
- 2012-12-18 EP EP12197644.3A patent/EP2607491A1/de not_active Withdrawn
- 2012-12-18 ES ES12806038.1T patent/ES2688295T3/es active Active
- 2012-12-18 EP EP12806038.1A patent/EP2794898B1/de active Active
- 2012-12-18 SG SG11201403495QA patent/SG11201403495QA/en unknown
- 2012-12-18 KR KR1020147016716A patent/KR102000317B1/ko active IP Right Grant
- 2012-12-20 US US13/721,481 patent/US9249435B2/en active Active
- 2012-12-20 CA CA2799883A patent/CA2799883C/en active Active
- 2012-12-21 CN CN2012105994118A patent/CN103254089A/zh active Pending
- 2012-12-21 CN CN201810198137.0A patent/CN108358800B/zh active Active
- 2012-12-25 JP JP2012281367A patent/JP6312117B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
US20130164797A1 (en) | 2013-06-27 |
WO2013092547A1 (de) | 2013-06-27 |
EP2794898B1 (de) | 2018-08-01 |
KR102000317B1 (ko) | 2019-07-15 |
EP2607490A1 (de) | 2013-06-26 |
SG11201403495QA (en) | 2014-09-26 |
CN103254089A (zh) | 2013-08-21 |
JP6312117B2 (ja) | 2018-04-18 |
EP2607491A1 (de) | 2013-06-26 |
BR112014015202B1 (pt) | 2021-11-03 |
JP2013132295A (ja) | 2013-07-08 |
US9249435B2 (en) | 2016-02-02 |
BR112014015202A2 (pt) | 2017-06-13 |
MX2012015064A (es) | 2013-10-16 |
EP2794898A1 (de) | 2014-10-29 |
CN108358800A (zh) | 2018-08-03 |
ES2688295T3 (es) | 2018-10-31 |
KR20140111653A (ko) | 2014-09-19 |
CN108358800B (zh) | 2023-02-17 |
MX339910B (es) | 2016-06-15 |
CA2799883C (en) | 2020-09-22 |
CA2799883A1 (en) | 2013-06-22 |
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