BR112012005737A8 - Método para a produção de ácido 3-hidróxi-3-metilbutírico a partir de acetona e um composto acetila ativado. - Google Patents
Método para a produção de ácido 3-hidróxi-3-metilbutírico a partir de acetona e um composto acetila ativado.Info
- Publication number
- BR112012005737A8 BR112012005737A8 BR112012005737A BR112012005737A BR112012005737A8 BR 112012005737 A8 BR112012005737 A8 BR 112012005737A8 BR 112012005737 A BR112012005737 A BR 112012005737A BR 112012005737 A BR112012005737 A BR 112012005737A BR 112012005737 A8 BR112012005737 A8 BR 112012005737A8
- Authority
- BR
- Brazil
- Prior art keywords
- acetone
- hydroxy
- activated acetyl
- methylbutyric acid
- compound
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/52—Propionic acid; Butyric acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/03—Acyl groups converted into alkyl on transfer (2.3.3)
- C12Y203/0301—Hydroxymethylglutaryl-CoA synthase (2.3.3.10)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/03—Oxo-acid-lyases (4.1.3)
- C12Y401/03004—Hydroxymethylglutaryl-CoA lyase (4.1.3.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/07—Bacillus
- C12R2001/12—Bacillus polymyxa ; Paenibacillus polymyxa
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/145—Clostridium
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/38—Pseudomonas
- C12R2001/40—Pseudomonas putida
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/832—Bacillus
- Y10S435/838—Bacillus polymyxa
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/842—Clostridium
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/874—Pseudomonas
- Y10S435/877—Pseudomonas putida
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
MÉTODO PARA A PRODUÇÃO DE ÁCIDO 3-HIDRÓXI-3-METILBUTÍRICO A PARTIR DE ACETONA E UM COMPOSTO ACETILA ATIVADO. A presente invenção refere-se a um método para a produção de ácido 3-hidróxi-isovalerato ou HIV) a partir de acetona e um composto que proporcione umk grupo acetila ativado compreendendo a conversão enzimática da acetona e um grupo acetila ativado compreendendo a conversão enzimática da acetona e um composto que proporcione um grupo acetila ativado compreendendo a conversão enzimática da azetona e um composto que proporcione um grupo acetila ativado em ácido 3-hidróxi-3-metilbutírico. A conversão faz uso de uma enzima capaz de catalisar a formação de uma ligação covalente entre o átomo do grupo oxo (isto é, do C=O) da acetona e o grupo metila do composto que proporciona um grupo acetila ativado. Preferivelmente, a enzima empregada no processo é uma enzima com a atividade de uma HMG CoA sintase (EC 2.3.3.10) e/ou de uma proteína PksG e/ou uma enzima com a atividade de uma liase de clivagem/condensação de ligações C-C, tal como uma HMG CoA liase (EC 4.1.4.3.4). Também descritos são organismos capazes de produzir ácido 3-hidróxi-3metilbutírico a partir de acetona, um composto que proporciona um grupo acetila ativado, o uso das enzimas e dos organismos acima mencionado para a produção de ácido 3-hídróxi-3-metilbutírico assim como o uso de acetona para a produção de ácido 3-hidróxi-3-metilbutírico.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09170312A EP2295593A1 (en) | 2009-09-15 | 2009-09-15 | Method for the enymatic production of 3-hydroxy-3-methylbutyric acid from acetone and acetyl-CoA |
| PCT/EP2010/063460 WO2011032934A1 (en) | 2009-09-15 | 2010-09-14 | Method for the enzymatic production of 3-hydroxy-s-methylbutyric acid from acetone and acetyl-coa |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112012005737A2 BR112012005737A2 (pt) | 2015-09-08 |
| BR112012005737A8 true BR112012005737A8 (pt) | 2017-10-10 |
Family
ID=41682449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012005737A BR112012005737A8 (pt) | 2009-09-15 | 2010-09-14 | Método para a produção de ácido 3-hidróxi-3-metilbutírico a partir de acetona e um composto acetila ativado. |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US9017977B2 (pt) |
| EP (3) | EP2295593A1 (pt) |
| JP (1) | JP5767641B2 (pt) |
| KR (1) | KR101774064B1 (pt) |
| CN (1) | CN102597254B (pt) |
| AU (1) | AU2010297362C1 (pt) |
| BR (1) | BR112012005737A8 (pt) |
| CA (1) | CA2772279C (pt) |
| CO (1) | CO6511238A2 (pt) |
| DK (1) | DK2478109T3 (pt) |
| ES (1) | ES2536548T3 (pt) |
| HK (1) | HK1171250A1 (pt) |
| HU (1) | HUE025695T2 (pt) |
| IL (1) | IL218245A (pt) |
| MX (1) | MX2012003224A (pt) |
| MY (1) | MY159420A (pt) |
| PE (1) | PE20121436A1 (pt) |
| PL (1) | PL2478109T3 (pt) |
| RU (1) | RU2573389C2 (pt) |
| WO (1) | WO2011032934A1 (pt) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2295593A1 (en) * | 2009-09-15 | 2011-03-16 | Philippe Marliere | Method for the enymatic production of 3-hydroxy-3-methylbutyric acid from acetone and acetyl-CoA |
| PT2732031E (pt) | 2011-07-12 | 2015-12-18 | Scientist Of Fortune Sa | Microrganismo recombinante para a produção de metabolitos úteis |
| DE102012105876A1 (de) | 2012-07-02 | 2014-01-02 | Oxea Gmbh | Verfahren zur Herstellung von Terephthalsäure und ihren Derivaten |
| DE102012105874A1 (de) | 2012-07-02 | 2014-01-02 | Oxea Gmbh | Verfahren zur Herstellung von Isononansäurevinylestern |
| DE102012105877A1 (de) | 2012-07-02 | 2014-01-02 | Oxea Gmbh | Verfahren zur Herstellung von Diisobuten |
| DE102012105878A1 (de) | 2012-07-02 | 2014-01-02 | Oxea Gmbh | Verfahren zur Herstellung von Isopentanderivaten |
| DE102012105879A1 (de) | 2012-07-02 | 2014-01-02 | Oxea Gmbh | Verfahren zur Herstellung von Isononylderivaten |
| CA2882276C (en) | 2012-08-28 | 2016-11-01 | Lanzatech New Zealand Limited | Recombinant microorganisms expressing a stereospecific diol dehydratase enzyme |
| EP2929036A1 (en) | 2012-12-07 | 2015-10-14 | Global Bioenergies | Fermentative production of a hydrocarbon |
| EP2929037B1 (en) | 2012-12-07 | 2020-09-09 | Global Bioenergies | Improved fermentation method |
| EP3090043B1 (en) * | 2013-12-31 | 2022-02-02 | Global Bioenergies | 3-hydroxyisovalerate (hiv) synthase variants |
| US20170260548A1 (en) | 2014-09-17 | 2017-09-14 | Scientist of Fortune, S.A. | Method for producing isobutene from 3-methylcrotonyl-coa |
| EP3194605A1 (en) * | 2014-09-17 | 2017-07-26 | Global Bioenergies | Methods for producing 3-hydroxy-3-methylbutyric acid |
| WO2016090373A1 (en) * | 2014-12-05 | 2016-06-09 | Case Western Reserve University | Compositions and methods of modulating s-nitrosylation |
| US11426386B2 (en) | 2014-12-05 | 2022-08-30 | Case Western Reserve University | Compositions and methods of modulating S-nitrosylation |
| US10941423B2 (en) | 2015-06-26 | 2021-03-09 | Global Bioenergies | Method for the production of isoamyl alcohol |
| WO2017017124A1 (en) | 2015-07-28 | 2017-02-02 | Global Bioenergies | Hiv kinase variants |
| CA3051235C (en) | 2015-10-13 | 2022-05-03 | Lanzatech New Zealand Limited | Genetically engineered bacterium comprising energy-generating fermentation pathway |
| CA3002609C (en) | 2015-11-17 | 2023-09-05 | Global Bioenergies | Methods for producing isobutene from 3-methylcrotonic acid |
| EP3433370B1 (en) | 2016-03-22 | 2020-04-29 | Global Bioenergies | Enzymatic method for producing isobutene from 3-methylbutyric acid |
| CN107095885A (zh) * | 2017-04-28 | 2017-08-29 | 青岛东海药业有限公司 | 酪酸梭菌在制备预防或治疗慢性阻塞性肺疾病制剂中的应用 |
| US20210277425A1 (en) | 2017-05-10 | 2021-09-09 | Global Bioenergies | IMPROVED METHODS FOR PRODUCING lSOBUTENE FROM 3-METHYLCROTONIC ACID |
| US11576900B2 (en) | 2017-09-25 | 2023-02-14 | Case Western Reserve University | Compositions and methods of reducing serum cholesterol and PCSK9 |
| EP3502216A1 (en) | 2017-12-21 | 2019-06-26 | Global Bioenergies | Gasoline composition enabling reduced particulate emissions |
| WO2020005938A1 (en) | 2018-06-25 | 2020-01-02 | Case Western Reserve University | Compositions and methods for treating tissue injury |
| BR112021000598A2 (pt) | 2018-07-27 | 2021-04-13 | Global Bioenergies | Método para produzir frutose-6-fosfato, micro-organismo recombinante, combinação de enzimas, composição e uso do micro-organismo |
| AU2019344066A1 (en) | 2018-09-21 | 2021-04-22 | Case Western Reserve University | Aldoketo reductase inhibitors and uses thereof |
| CN109251940B (zh) * | 2018-10-30 | 2020-10-16 | 浙江华睿生物技术有限公司 | 一种产β-羟基-β-甲基丁酸工程菌的构建方法 |
| BR112021018090A2 (pt) | 2019-03-20 | 2021-11-23 | Global Bioenergies | Organismo ou micro-organismo recombinante, uso do organismo ou micro-organismo recombinante e método para a produção de isobuteno |
| WO2021063958A1 (en) | 2019-09-30 | 2021-04-08 | Global Bioenergies | Improved means and methods for increasing the yield of acetyl-coa from glucose |
| US11059633B2 (en) | 2019-10-31 | 2021-07-13 | Cheer Pack North America | Flip-top closure for container |
| FR3110081B1 (fr) | 2020-05-14 | 2022-09-09 | Global Bioenergies | Composition cosmétique à base d’isododécane biosourcé et son procédé de préparation |
| FR3112477B1 (fr) | 2020-07-15 | 2022-08-26 | Global Bioenergies | Composition cosmétique à base d’isododécane présentant une teneur élévée en 2,2,4,6,6-pentaméthylheptane |
| EP4320253A1 (en) * | 2021-04-06 | 2024-02-14 | Sasya Inc. | Synthesis of beta-hydroxyisovalerate and methods of use |
| WO2023031482A1 (en) | 2021-09-06 | 2023-03-09 | Global Bioenergies | Organisms producing less crotonic acid |
| EP4144838A1 (en) | 2021-09-06 | 2023-03-08 | Global Bioenergies | Organisms producing less crotonic acid |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2245365C2 (ru) * | 1994-01-03 | 2005-01-27 | Генентек Инк. | Тромбопоэтин |
| WO2002094255A1 (de) | 2001-05-18 | 2002-11-28 | Lonza Ag | Verfahren zur herstellung fester formulierungen von natrium-3-hydroxy-3-methylbutyrat |
| US20040106678A1 (en) * | 2002-09-17 | 2004-06-03 | Dobbins Thomas A | Compositions for the parenteral administration of calcium and magnesium |
| WO2007140339A2 (en) * | 2006-05-26 | 2007-12-06 | Amyris Biotechnologies, Inc. | Production of isoprenoids |
| EP2295593A1 (en) * | 2009-09-15 | 2011-03-16 | Philippe Marliere | Method for the enymatic production of 3-hydroxy-3-methylbutyric acid from acetone and acetyl-CoA |
-
2009
- 2009-09-15 EP EP09170312A patent/EP2295593A1/en not_active Withdrawn
-
2010
- 2010-09-14 HU HUE10765977A patent/HUE025695T2/en unknown
- 2010-09-14 US US13/395,293 patent/US9017977B2/en active Active
- 2010-09-14 MY MYPI2012000826A patent/MY159420A/en unknown
- 2010-09-14 BR BR112012005737A patent/BR112012005737A8/pt not_active Application Discontinuation
- 2010-09-14 EP EP15161591.1A patent/EP2940141A1/en not_active Withdrawn
- 2010-09-14 CN CN201080041020.3A patent/CN102597254B/zh active Active
- 2010-09-14 AU AU2010297362A patent/AU2010297362C1/en not_active Ceased
- 2010-09-14 JP JP2012528390A patent/JP5767641B2/ja active Active
- 2010-09-14 PL PL10765977T patent/PL2478109T3/pl unknown
- 2010-09-14 WO PCT/EP2010/063460 patent/WO2011032934A1/en active Application Filing
- 2010-09-14 PE PE2012000335A patent/PE20121436A1/es not_active Application Discontinuation
- 2010-09-14 CA CA2772279A patent/CA2772279C/en not_active Expired - Fee Related
- 2010-09-14 EP EP10765977.3A patent/EP2478109B1/en active Active
- 2010-09-14 DK DK10765977.3T patent/DK2478109T3/en active
- 2010-09-14 RU RU2012114690/10A patent/RU2573389C2/ru not_active IP Right Cessation
- 2010-09-14 ES ES10765977.3T patent/ES2536548T3/es active Active
- 2010-09-14 KR KR1020127006644A patent/KR101774064B1/ko active IP Right Grant
- 2010-09-14 MX MX2012003224A patent/MX2012003224A/es active IP Right Grant
-
2012
- 2012-02-22 IL IL218245A patent/IL218245A/en active IP Right Grant
- 2012-03-14 CO CO12044045A patent/CO6511238A2/es unknown
- 2012-11-22 HK HK12111958.3A patent/HK1171250A1/zh not_active IP Right Cessation
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2015
- 2015-03-14 US US14/658,170 patent/US9556460B2/en active Active
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