BR112021018090A2 - Organismo ou micro-organismo recombinante, uso do organismo ou micro-organismo recombinante e método para a produção de isobuteno - Google Patents

Organismo ou micro-organismo recombinante, uso do organismo ou micro-organismo recombinante e método para a produção de isobuteno

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Publication number
BR112021018090A2
BR112021018090A2 BR112021018090A BR112021018090A BR112021018090A2 BR 112021018090 A2 BR112021018090 A2 BR 112021018090A2 BR 112021018090 A BR112021018090 A BR 112021018090A BR 112021018090 A BR112021018090 A BR 112021018090A BR 112021018090 A2 BR112021018090 A2 BR 112021018090A2
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Prior art keywords
coa
microorganism
enzymatically
isobutene
converted
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BR112021018090A
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English (en)
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Florence Martin
Florent Collas
Maria Anissimova
Osama Mahmoud
Romain Chayot
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Global Bioenergies
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
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    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
    • C12P5/026—Unsaturated compounds, i.e. alkenes, alkynes or allenes
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
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    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01008—Phosphate acetyltransferase (2.3.1.8)
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    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01019—Phosphate butyryltransferase (2.3.1.19)
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    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/03—Acyl groups converted into alkyl on transfer (2.3.3)
    • C12Y203/0301—Hydroxymethylglutaryl-CoA synthase (2.3.3.10)
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/02—Phosphotransferases with a carboxy group as acceptor (2.7.2)
    • C12Y207/02001—Acetate kinase (2.7.2.1)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/02—Phosphotransferases with a carboxy group as acceptor (2.7.2)
    • C12Y207/02007—Butyrate kinase (2.7.2.7)
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/02—Phosphotransferases with a carboxy group as acceptor (2.7.2)
    • C12Y207/02014—Branched-chain-fatty-acid kinase (2.7.2.14)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/02—Phosphotransferases with a carboxy group as acceptor (2.7.2)
    • C12Y207/02015—Propionate kinase (2.7.2.15)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/02—Thioester hydrolases (3.1.2)
    • C12Y301/0202—Acyl-CoA hydrolase (3.1.2.20)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/02—Thioester hydrolases (3.1.2)
    • C12Y301/02028—1,4-Dihydroxy-2-naphthoyl-CoA hydrolase (3.1.2.28)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01006—Aconitate decarboxylase (4.1.1.6)
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    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01033—Diphosphomevalonate decarboxylase (4.1.1.33), i.e. mevalonate-pyrophosphate decarboxylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01063—Protocatechuate decarboxylase (4.1.1.63)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/01—Hydro-lyases (4.2.1)
    • C12Y402/01017—Enoyl-CoA hydratase (4.2.1.17), i.e. crotonase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/01—Hydro-lyases (4.2.1)
    • C12Y402/01018—Methylglutaconyl-CoA hydratase (4.2.1.18)
    • C—CHEMISTRY; METALLURGY
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    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/01—Hydro-lyases (4.2.1)
    • C12Y402/01055—3-Hydroxybutyryl-CoA dehydratase (4.2.1.55)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y604/00—Ligases forming carbon-carbon bonds (6.4)
    • C12Y604/01—Ligases forming carbon-carbon bonds (6.4.1)
    • C12Y604/01004—Methylcrotonoyl-CoA carboxylase (6.4.1.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y604/00—Ligases forming carbon-carbon bonds (6.4)
    • C12Y604/01—Ligases forming carbon-carbon bonds (6.4.1)
    • C12Y604/01005—Geranoyl-CoA carboxylase (6.4.1.5)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Abstract

organismo ou micro-organismo recombinante, uso do organismo ou micro-organismo recombinante e método para a produção de isobuteno. é descrito um organismo ou micro-organismo recombinante que tem capacidade de converter enzimaticamente acetil-coa em isobuteno, (a) em que, no dito organismo ou micro-organismo: (i) acetil-coa é enzimaticamente convertido em acetoacetil-coa, (ii) acetoacetil-coa é enzimaticamente convertido em 3-hidroxi-3-metilglutaril-coa, (iii) 3-hidroxi-3-metilglutaril-coa é enzimaticamente convertido em 3-metilglutaconil-coa, (iv) 3-metilglutaconil-coa é enzimaticamente convertido em 3-metilcrotonil-coa, e (v) em que o dito 3-metilcrotonil-coa é convertido em isobuteno: (a) convertendo-se enzimaticamente 3-metilcrotonil-coa em ácido 3-metilcrotônico que é, então, enzimaticamente convertido ainda no dito isobuteno; ou (b) convertendo-se enzimaticamente 3-metilcrotonil-coa em 3-hidroxi-3-metilbutiril-coa que é então, enzimaticamente convertido ainda em ácido 3-hidroxi-3-metilbutírico que é então, enzimaticamente convertido ainda em ácido 3-fosfonoxi-3-metilbutírico que é, então, enzimaticamente convertido ainda no dito isobuteno; (b) em que o dito organismo ou micro-organismo recombinante tem um grupamento aumentado de coenzima a (coa) através do organismo ou micro-organismo a partir do qual o mesmo é derivado devido a: (i) uma captação aumentada de pantotenato; e/ou (ii) uma conversão aumentada de pantotenato em coa. além disso, é descrito o uso de tal organismo ou micro-organismo recombinante para a produção de isobuteno. além disso, é descrito um método para a produção de isobuteno cultivando-se tal organismo ou micro-organismo recombinante em um meio de cultura adequado sob condições adequadas.
BR112021018090A 2019-03-20 2020-03-19 Organismo ou micro-organismo recombinante, uso do organismo ou micro-organismo recombinante e método para a produção de isobuteno BR112021018090A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19163981 2019-03-20
EP19209153 2019-11-14
PCT/EP2020/057607 WO2020188033A1 (en) 2019-03-20 2020-03-19 Improved means and methods for producing isobutene from acetyl-coa

Publications (1)

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BR112021018090A2 true BR112021018090A2 (pt) 2021-11-23

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Country Status (6)

Country Link
US (1) US20220145336A1 (pt)
EP (1) EP3942058A1 (pt)
CN (1) CN113614240A (pt)
BR (1) BR112021018090A2 (pt)
CA (1) CA3127429A1 (pt)
WO (1) WO2020188033A1 (pt)

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EP4144838A1 (en) 2021-09-06 2023-03-08 Global Bioenergies Organisms producing less crotonic acid
WO2023031482A1 (en) 2021-09-06 2023-03-09 Global Bioenergies Organisms producing less crotonic acid
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FR3133129A1 (fr) 2022-03-03 2023-09-08 Biosynthis Composition de maquillage pour les yeux à base de triméthylheptane.
FR3133127A1 (fr) 2022-03-03 2023-09-08 Biosynthis Composition COSMETIQUE APPLICABLE SUR LA PEAU

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US20220145336A1 (en) 2022-05-12
CN113614240A (zh) 2021-11-05
WO2020188033A1 (en) 2020-09-24
EP3942058A1 (en) 2022-01-26
CA3127429A1 (en) 2020-09-24

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