AR061304A1 - Produccion de acido glicolico mediante fermentacion a partir de recursos renovables - Google Patents

Produccion de acido glicolico mediante fermentacion a partir de recursos renovables

Info

Publication number
AR061304A1
AR061304A1 ARP070102506A ARP070102506A AR061304A1 AR 061304 A1 AR061304 A1 AR 061304A1 AR P070102506 A ARP070102506 A AR P070102506A AR P070102506 A ARP070102506 A AR P070102506A AR 061304 A1 AR061304 A1 AR 061304A1
Authority
AR
Argentina
Prior art keywords
glycolic acid
order
glyoxylate
glycolate
carbon source
Prior art date
Application number
ARP070102506A
Other languages
English (en)
Original Assignee
Metabolic Explorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolic Explorer Sa filed Critical Metabolic Explorer Sa
Publication of AR061304A1 publication Critical patent/AR061304A1/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/02—Monosaccharides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Un método para la produccion biologica de ácido glicolico a partir de una fuente de carbono fermentable en un microorganismo. En un aspecto se logra un proceso para la conversion de glucosa en ácido glicolico mediante el uso de un organismo recombinado que comprende un huésped E. coli transformado, 1) a fin de atenuar las vías de consumo de glioxilato hacia otros compuestos diferentes de glicolato; 2) a fin de utilizar una glioxilato reductasa de NADPH para convertir glioxilato en glicolato; 3) a fin de atenuar el nivel de todas las enzimas metabolizadoras de glicolato; y 4) a fin de incrementar el flujo en la vía de glioxilato. En otro aspecto, el proceso para la produccion de ácido glicolico a partir de una fuente de carbono fermentable, usando un E. coli recombinado, se perfecciona mediante el incremento de la disponibilidad de NADPH en las células. Opcionalmente, el ácido glicolico producido puede ser purificado a través de una etapa de polimerizacion hasta por lo menos dímeros de ácido glicolico, y recuperado mediante la despolimerizacion a partir de dímeros, oligomeros o polímeros de ácido glicolico. Reivindicacion 1: Un método para la produccion de ácido glicolico, sus derivados o precursores, mediante fermentacion, por medio del cultivo de un microorganismo en un medio de cultivo apropiado que comprende una fuente de carbono; y la recuperacion de ácido glicolico del medio de cultivo.
ARP070102506A 2006-06-09 2007-06-08 Produccion de acido glicolico mediante fermentacion a partir de recursos renovables AR061304A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2006/063046 WO2007140816A1 (en) 2006-06-09 2006-06-09 Glycolic acid production by fermentation from renewable resources

Publications (1)

Publication Number Publication Date
AR061304A1 true AR061304A1 (es) 2008-08-20

Family

ID=37714356

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070102506A AR061304A1 (es) 2006-06-09 2007-06-08 Produccion de acido glicolico mediante fermentacion a partir de recursos renovables

Country Status (14)

Country Link
US (1) US9034615B2 (es)
JP (2) JP5431149B2 (es)
KR (1) KR101519670B1 (es)
CN (1) CN101466841B (es)
AR (1) AR061304A1 (es)
AU (1) AU2007255339A1 (es)
BR (1) BRPI0712876B1 (es)
CA (1) CA2654182A1 (es)
ES (1) ES2691206T3 (es)
IL (1) IL195380A0 (es)
MX (1) MX2008015737A (es)
RU (1) RU2008152832A (es)
WO (2) WO2007140816A1 (es)
ZA (1) ZA200809973B (es)

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Also Published As

Publication number Publication date
ES2691206T3 (es) 2018-11-26
ZA200809973B (en) 2009-09-30
BRPI0712876B1 (pt) 2018-01-23
CN101466841B (zh) 2016-04-27
JP5431149B2 (ja) 2014-03-05
JP2014014364A (ja) 2014-01-30
CN101466841A (zh) 2009-06-24
KR20090029256A (ko) 2009-03-20
CA2654182A1 (en) 2007-12-13
WO2007141316A2 (en) 2007-12-13
MX2008015737A (es) 2008-12-19
RU2008152832A (ru) 2010-07-20
IL195380A0 (en) 2011-08-01
JP2009539361A (ja) 2009-11-19
AU2007255339A1 (en) 2007-12-13
WO2007140816A1 (en) 2007-12-13
KR101519670B1 (ko) 2015-05-21
WO2007141316A3 (en) 2008-03-06
US20090155867A1 (en) 2009-06-18
BRPI0712876A2 (pt) 2012-09-04
US9034615B2 (en) 2015-05-19

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