BRPI0814781A8 - ''proteína, sequência de ácido nucleico, método para a produção de ácido itacônico, vetor, célula hospedeira, e, uso de um ácido cis-aconítico descarboxilase'' - Google Patents
''proteína, sequência de ácido nucleico, método para a produção de ácido itacônico, vetor, célula hospedeira, e, uso de um ácido cis-aconítico descarboxilase''Info
- Publication number
- BRPI0814781A8 BRPI0814781A8 BRPI0814781A BRPI0814781A BRPI0814781A8 BR PI0814781 A8 BRPI0814781 A8 BR PI0814781A8 BR PI0814781 A BRPI0814781 A BR PI0814781A BR PI0814781 A BRPI0814781 A BR PI0814781A BR PI0814781 A8 BRPI0814781 A8 BR PI0814781A8
- Authority
- BR
- Brazil
- Prior art keywords
- cis
- production
- host cell
- vector
- protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
- C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
PROTEÍNA, SEQUÊNCIA DE ÁCIDO NUCLEICO, MÉTODO PARA A PRODUÇÃO DE ÁCIDO ITACÔNICO, VETOR, CÉLULA HOSPEDEIRA, E, USO DE UM ÁCIDO CIS-ACONÍTICO DESCARBOXILASE. A invenção refere-se à produção de ácido itacônico em microorganismos por introdução em uma célula hospedeira apropriada de um gene codificando para a enzima ácido cis-aconítico descarboxilase, preferivelmente derivada de A. terreus. Outra parte da invenção são as células hospedeiras, preferivelmente de A. niger, providas com os genes acima mencionados.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07112895A EP2017344A1 (en) | 2007-07-20 | 2007-07-20 | Production of itaconic acid |
PCT/NL2008/050499 WO2009014437A1 (en) | 2007-07-20 | 2008-07-21 | Production of itaconic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
BRPI0814781A2 BRPI0814781A2 (pt) | 2014-10-21 |
BRPI0814781A8 true BRPI0814781A8 (pt) | 2017-01-31 |
Family
ID=38787782
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0814781A BRPI0814781A8 (pt) | 2007-07-20 | 2008-07-21 | ''proteína, sequência de ácido nucleico, método para a produção de ácido itacônico, vetor, célula hospedeira, e, uso de um ácido cis-aconítico descarboxilase'' |
Country Status (4)
Country | Link |
---|---|
US (1) | US8440436B2 (pt) |
EP (2) | EP2017344A1 (pt) |
BR (1) | BRPI0814781A8 (pt) |
WO (1) | WO2009014437A1 (pt) |
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WO2008091627A2 (en) | 2007-01-22 | 2008-07-31 | Genomatica, Inc. | Methods and organisms for growth-coupled production of 3-hydroxypropionic acid |
EP2348008A1 (en) | 2007-08-10 | 2011-07-27 | Genomatica, Inc. | Methods for the synthesis of acrylic acid and derivatives from fumaric acid |
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US20110099670A1 (en) * | 2008-02-14 | 2011-04-28 | Andries Jurriaan Koops | Nucleotide sequences coding for cis-aconitic decarboxylase and use thereof |
EP2262826B1 (en) | 2008-03-05 | 2015-09-16 | Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO | Production of itaconic acid |
US7977084B2 (en) | 2008-03-05 | 2011-07-12 | Genomatica, Inc. | Primary alcohol producing organisms |
CN106119112B (zh) | 2008-03-27 | 2021-07-13 | 基因组股份公司 | 用于产生己二酸和其他化合物的微生物 |
AU2009242615A1 (en) | 2008-05-01 | 2009-11-05 | Genomatica, Inc. | Microorganisms for the production of methacrylic acid |
EP2304039B1 (en) | 2008-06-17 | 2019-08-21 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate |
BRPI0922276A2 (pt) | 2008-12-16 | 2015-08-04 | Genomatica Inc | "organismo microbiano de ocorrência não-natural, e , método para produzir isopropanol, 4-hidroxibutirato,e, 1,4-butanodiol." |
EP2425006A4 (en) | 2009-04-30 | 2013-01-23 | Genomatica Inc | ORGANISMS FOR THE MANUFACTURE OF ISOPROPANOL, N-BUTANOL AND ISOBUTANOL |
WO2010127319A2 (en) | 2009-04-30 | 2010-11-04 | Genomatica, Inc. | Organisms for the production of 1,3-butanediol |
KR102036265B1 (ko) | 2009-05-07 | 2019-10-24 | 게노마티카 인코포레이티드 | 아디페이트, 헥사메틸렌디아민 및 6-아미노카프로산의 생합성을 위한 미생물 및 방법 |
US8143036B2 (en) * | 2009-05-11 | 2012-03-27 | Industrial Technology Research Institute | Genetically modified microorganisms for producing itaconic acid with high yields |
KR20120036851A (ko) | 2009-05-15 | 2012-04-18 | 게노마티카 인코포레이티드 | 사이클로헥사논의 제조를 위한 유기체 |
US8420375B2 (en) | 2009-06-10 | 2013-04-16 | Genomatica, Inc. | Microorganisms and methods for carbon-efficient biosynthesis of MEK and 2-butanol |
US8338158B2 (en) | 2009-06-30 | 2012-12-25 | Industrial Technology Research Institute | Cis-aconitate decarboxylase mutants having improved enzymatic activity |
WO2011017560A1 (en) | 2009-08-05 | 2011-02-10 | Genomatica, Inc. | Semi-synthetic terephthalic acid via microorganisms that produce muconic acid |
US8192965B2 (en) * | 2009-08-25 | 2012-06-05 | Industrial Technology Research Institute | Producing Itaconic acid in yeast using glycerol as the substrate |
CN102625845A (zh) | 2009-09-09 | 2012-08-01 | 基因组股份公司 | 协同产生异丙醇与伯醇,二元醇和酸的微生物和方法 |
CA2777459A1 (en) | 2009-10-13 | 2011-04-21 | Genomatica, Inc. | Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-coa, putrescine and related compounds, and methods related thereto |
WO2011050326A1 (en) | 2009-10-23 | 2011-04-28 | Genomatica, Inc. | Microorganisms for the production of aniline |
EP2510102A4 (en) | 2009-12-10 | 2014-01-22 | Genomatica Inc | METHODS AND ORGANIZATIONS FOR THE CONVERSION OF SYNTHESIS GAS OR OTHER CARBONACEOUS GAS SOURCES AND METHANOL TO 1,3-BUTANEDIOL |
SG182686A1 (en) | 2010-01-29 | 2012-08-30 | Genomatica Inc | Microorganisms and methods for the biosynthesis of p-toluate and terephthalate |
US8445244B2 (en) | 2010-02-23 | 2013-05-21 | Genomatica, Inc. | Methods for increasing product yields |
US8048661B2 (en) | 2010-02-23 | 2011-11-01 | Genomatica, Inc. | Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes |
US9023636B2 (en) | 2010-04-30 | 2015-05-05 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of propylene |
BR112012028049A2 (pt) | 2010-05-05 | 2015-11-24 | Genomatica Inc | organismo microbiano de ocorrência não natural e método para produzir butadieno, meio de cultura, butadieno biossintetizado, composição, produto químico orgânico, polímero e uso de butadieno biossintetizado |
EP2607340B1 (en) | 2010-07-26 | 2017-09-06 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of aromatics, 2,4-pentadienoate and 1,3-butadiene |
KR102043381B1 (ko) | 2011-08-19 | 2019-11-11 | 게노마티카 인코포레이티드 | 2,4-펜타디에노에이트, 부타디엔, 프로필렌, 1,3-부탄디올 및 관련 알코올을 생합성하기 위한 미생물과 방법 |
CN103834582B (zh) * | 2012-11-22 | 2016-04-27 | 中国科学院青岛生物能源与过程研究所 | 一种提高衣康酸发酵产量的菌株及其构建和利用菌株生产衣康酸的方法 |
CN104822832A (zh) * | 2012-11-23 | 2015-08-05 | 帝斯曼知识产权资产管理有限公司 | 衣康酸和衣康酸甲酯生产 |
EP2971021A4 (en) | 2013-03-15 | 2016-12-21 | Genomatica Inc | MICROORGANISMS AND METHODS FOR PRODUCING BUTADIENE AND RELATED COMPOUNDS BY ASSIMILATING FORMAT |
EP2981610A1 (en) | 2013-04-05 | 2016-02-10 | Université du Luxembourg | Biotechnological production of itaconic acid |
US9885066B2 (en) | 2013-05-02 | 2018-02-06 | Dutch Dna Biotech B.V. | Organic acid pathway |
TWI628191B (zh) | 2014-03-19 | 2018-07-01 | 財團法人工業技術研究院 | 融合多胜肽、編碼此融合多胜肽之核酸分子、含此核酸分子之載體或細胞以及藉由此細胞產生衣康酸的方法 |
LU92409B1 (en) | 2014-03-21 | 2015-09-22 | Philipps Universit T Marburg | Means and methods for itaconic acid production |
US20170191089A1 (en) * | 2014-05-28 | 2017-07-06 | Dsm Ip Assets B.V. | Itaconic acid and itaconate methylester and dimethylester production |
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DK3194604T3 (da) | 2014-09-18 | 2020-05-25 | Genomatica Inc | Ikke-naturlig mikrobielle organismer med forbedret energisk effektivitet |
US10443077B2 (en) | 2015-02-16 | 2019-10-15 | Dsm Ip Assets B.V. | Fermentation process for producing itaconic acid under nitrogen free conditions |
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EP3533878A1 (en) | 2018-02-28 | 2019-09-04 | Dutch DNA Biotech B.V. | Process for producing citramalic acid employing aspergillus |
US10738333B2 (en) | 2018-04-30 | 2020-08-11 | Ut-Battelle, Llc | Production of itaconic acid and related molecules from aromatic compounds |
CN108795789A (zh) * | 2018-07-02 | 2018-11-13 | 山东省食品发酵工业研究设计院 | 一种高产衣康酸解脂耶氏酵母工程菌株及其构建方法、发酵工艺与应用 |
CN111944706B (zh) * | 2020-08-06 | 2022-06-03 | 中国科学院青岛生物能源与过程研究所 | 一种产衣康酸的重组土曲霉菌株及其构建方法与应用 |
CN112011469B (zh) * | 2020-08-26 | 2022-07-05 | 中国科学院青岛生物能源与过程研究所 | 一种产反式乌头酸的重组土曲霉菌株及其构建方法与应用 |
CN112011468B (zh) * | 2020-08-26 | 2022-07-05 | 中国科学院青岛生物能源与过程研究所 | 一种产反式乌头酸的重组土曲霉及其制备方法与应用 |
CN112029671B (zh) * | 2020-08-26 | 2022-07-05 | 中国科学院青岛生物能源与过程研究所 | 一种产反式乌头酸的重组土曲霉菌株及其制备方法与应用 |
CN112011470B (zh) * | 2020-08-26 | 2022-07-05 | 中国科学院青岛生物能源与过程研究所 | 一种产反式乌头酸的基因工程菌及其构建方法与应用 |
KR102682476B1 (ko) * | 2021-07-19 | 2024-07-04 | 포항공과대학교 산학협력단 | 이타콘산을 생산하는 신규 대사 경로 및 이를 이용한 이타콘산의 생산 방법 |
CN114657075A (zh) * | 2022-02-10 | 2022-06-24 | 天津科技大学 | 一种生产衣康酸的黑曲霉菌株、方法及应用 |
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Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5637485A (en) * | 1993-03-12 | 1997-06-10 | Rhone-Poulenc Chimie | Production of itaconic acid by fermentation |
US6391583B1 (en) * | 1998-12-18 | 2002-05-21 | Wisconsin Alumni Research Foundation | Method of producing antihypercholesterolemic agents |
-
2007
- 2007-07-20 EP EP07112895A patent/EP2017344A1/en not_active Withdrawn
-
2008
- 2008-07-21 US US12/669,955 patent/US8440436B2/en not_active Expired - Fee Related
- 2008-07-21 BR BRPI0814781A patent/BRPI0814781A8/pt not_active Application Discontinuation
- 2008-07-21 EP EP08779045.7A patent/EP2183367B1/en not_active Not-in-force
- 2008-07-21 WO PCT/NL2008/050499 patent/WO2009014437A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
US8440436B2 (en) | 2013-05-14 |
EP2183367A1 (en) | 2010-05-12 |
EP2017344A8 (en) | 2009-05-13 |
EP2017344A1 (en) | 2009-01-21 |
US20100311132A1 (en) | 2010-12-09 |
BRPI0814781A2 (pt) | 2014-10-21 |
WO2009014437A1 (en) | 2009-01-29 |
EP2183367B1 (en) | 2019-05-22 |
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